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Search results for: antidiabetic activity
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Novel N-(aryl/heteroaryl)-2-chlorobenzenesulfonamide derivatives: synthesis and anticancer activity evaluation
PublicationA new series of N-(aryl/heteroaryl)-2-chlorobenzenesulfonamide derivatives 4-21 have been synthesized, and evaluated at the National Cancer Institute (USA) for their in vitro activities against a panel of 60 different human cancer cell lines. Among them, compounds 16, 20 and 21 exhibited remarkable cytotoxic activity against numerous human cancer cell lines. We found that sulfonamide derivative 21 appeared to be more selective...
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The evidence for the impact of policy on physical activity outcomes within the school setting: A systematic review
PublicationPurpose Despite the well-established health benefits of physical activity (PA) for young people (aged 4–19 years), most do not meet PA guidelines. Policies that support PA in schools may be promising, but their impact on PA behavior is poorly understood. The aim of this systematic review is to ascertain the level and type of evidence reported in the international scientific literature for policies within the school setting that...
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Ultrasonic-assisted Electrodeposition of Cu-Sn-TiO2 Nanocomposite Coatings with Enhanced Antibacterial Activity
PublicationCopper-based coatings are known for their high antibacterial activity. In this study, nanocomposite Cu–Sn–TiO2 coatings were obtained by electrodeposition from an oxalic acid bath additionally containing 4 g/dm3 TiO2 with mechanical and ultrasonic agitation. Ultrasound treatment was performed at 26 kHz frequency and 32 W/dm3 power. The influence of agitation mode and the current load on the inclusion and distribution of the TiO2...
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The Influence of External Additional Loading on the Muscle Activity and Ground Reaction Forces during Gait
PublicationAsymmetrical external loading acting on the usculoskeletal system is generally considered unhealthy. Despite this knowledge, carrying loads in an asymmetrical manner like carrying on one shoulder, with one hand, or on the strap across the torso is a common practice. This study is aimed at presenting the effects of the mentioned load carrying methods on muscle activity assessed by using thermal field and ground reaction forces....
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Optical activity and electro-optic effect of l-arginine doped KDP single crystals
PublicationWe have used the modified polarimetric methods to study optical activity (OA) in the potassium dihydrogenphosphate (KDP) crystals doped with 0.7, 1.4 and 3.8 wt% L-arginine (L-arg) amino acid. Crystals were grown by the temperature reduction method. Small changes of the absolute eigen waves ellipticity and OA values in doped crystals were noted. We have experimentally determined the signs of OA in the [1 00] and [01 0] directions...
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The Impact of the Antigenic Composition of Chimeric Proteins on Their Immunoprotective Activity against Chronic Toxoplasmosis in Mice
PublicationToxoplasmosis may pose a serious threat for individuals with weakened or undeveloped immune systems. However, to date, there is no specific immunoprophylaxis for humans. Thus, the aim of this study was to evaluate the immunogenicity of three trivalent—SAG2-GRA1-ROP1L (SGR), SAG1L-MIC1-MAG1 (SMM), and GRA1-GRA2-GRA6 (GGG)—and two tetravalent—SAG2-GRA1-ROP1-GRA2 (SGRG) and SAG1-MIC1-MAG1-GRA2 (SMMG)—chimeric T. gondii proteins, as...
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Antibacterial Activity and Cytocompatibility of Bone Cement Enriched with Antibiotic, Nanosilver, and Nanocopper for Bone Regeneration
PublicationBacterial infections due to bone replacement surgeries require modifications of bone cement with antibacterial components. This study aimed to investigate whether the incorporation of gentamicin or nanometals into bone cement may reduce and to what extent bacterial growth without the loss of overall cytocompatibility and adverse effects in vitro. The bone cement Cemex was used as the base material, modified either with gentamicin...
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Size-Controlled Synthesis of Pt Particles on TiO2 Surface: Physicochemical Characteristic and Photocatalytic Activity
PublicationDifferent TiO2 photocatalysts, i.e., commercial samples (ST‐01 and P25 with minority of rutile phase), nanotubes, well‐crystallized faceted particles of decahedral shape and mesoporous spheres, were used as supports for deposition of Pt nanoparticles (NPs). Size‐controlled Pt NPs embedded in TiO2 were successfully prepared by microemulsion and wet‐impregnation methods. Obtained photocatalysts were characterized using XRD, TEM,...
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Xanthone synthetic derivatives with high anticandidal activity and positive mycostatic selectivity index values
PublicationWith the current massive increases in drug-resistant microbial infection as well as the significant role of fungal infections in the death toll of COVID-19, discovering new antifungals is extremely important. Natural and synthetic xanthones are promising derivatives, although only few reports have demonstrated their antifungal mechanism of action in detail. Newly synthetized by us xanthone derivative 44 exhibited strong antifungal...
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Chitosan, Collagen and Gelatin in the design of novel materials with antimicrobial acticity
PublicationMedical devices containing and releasing antiinfective agents directly on the site of injury are a common group of materials available and widely used in treating difficult to heal wounds. Sustained contact of the active agent to the damaged tissue, needed to inhibit infection and preservation of microbiological purity of the wound, is provided by the immobilization antimicrobial agents on the surface of the matrix material or...
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Synthesis and reactivity of O-acyl selenophosphates
PublicationThe synthesis of several new O-acyl selenophosphates were investigated. The stability and reactivity of the products were studied and related to their structure.
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Synthesis and reactivity of O-acyl selenophosphates.
PublicationMieszane bezwodniki kwasów monoselenofosforowych >P(Se)O-C(O)- w zależności od podstawników na atomie fosforu oraz karbonylowym atomie węgla izomeryzują do układów Se-mostkowych >P(O)Se-(O)C- oraz ulegają dekarboksylacji (dekarbonylacji i dekarboksylacji) do estrów Se-alkilowych >P(O)Se-. W eksperymantach krzyżowych następuje wzajemna wymiana grup acylowych pomiędzy cząsteczkami bezwodników.
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Synthesis and reactivity of O-acyl selenophosphates
PublicationPrzeprowadzono syntezę nowych selenofosforanów acylu. Badano stabilność i reaktywność tych bezwodników w odniesieniu do ich struktury.
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Professional activity, gender and disease-related emotions: The impact on parents' experiences in caring for children with phenylketonuria
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Tuning of the Anti-Breast Cancer Activity of Betulinic Acid via Its Conversion to Ionic Liquids
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No apparent effect of invasive alien goldenrod on soil microbial communities or soil fauna feeding activity
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New Method for Photoactive Cement Preparation—Selected Mechanical Properties and Photocatalytic Activity of New Materials
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Glycerolic Licorice Extracts as Active Cosmeceutical Ingredients: Extraction Optimization, Chemical Characterization, and Biological Activity
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Aqueous Extracts of Selected Potentilla Species Modulate Biological Activity of Human Normal Colon Cells
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Effect of Tytanit® on the Physiological Activity of Wild Strawberry (Fragaria vesca L.) Grown in Salinity Conditions
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Application of QSAR Analysis and Different Quantum Chemical Calculation Methods in Activity Evaluation of Selected Fluoroquinolones
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Antitumor Activity of Novel Benzensulfonamide Derivatives in View of their Physiochemical Properties Searched by Principal Component Analysis
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Surface Properties and Photocatalytic Activity of KTaO3, CdS, MoS2 Semiconductors and Their Binary and Ternary Semiconductor Composites
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Awareness of patients suffering from selected chronic diseases of the importance of physical activity in treating their disorders
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Melatonin stimulates the activity of protective antioxidative enzymes in myocardial cells of rats in the course of doxorubicin intoxication
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Applying Hidden Markov Models to Visual Activity Analysis for Simple Digital Control Panel Operations
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Rod-shaped gold nanoparticles exert potent candidacidal activity and decrease the adhesion of fungal cells
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Surface properties and photocatalytic activity of KTaO3, CdS, MoS2 semiconductors and their binary and ternary semiconductor composites
PublicationSingle semiconductors such as KTaO3, CdS MoS2 or their precursor solutions were combined to form novel binary and ternary semiconductor nanocomposites by the calcination or by the hydro/solvothermal mixed solutions methods, respectively. The aim of this work was to study the influence of preparation method as well as type and amount of the composite components on the surface properties and photocatalytic activity of the new semiconducting...
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Longitudinal tracking of muscle sympathetic nerve activity and its relationship with blood pressure in subjects with prehypertension
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Acute Effects of Electronic and Tobacco Cigarette Smoking on Sympathetic Nerve Activity and Blood Pressure in Humans
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Contribution of Tonic Chemoreflex Activation to Sympathetic Activity and Blood Pressure in Patients With Obstructive Sleep Apnea
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A twin study of heritability of plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) mass and activity
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An independent relationship between muscle sympathetic nerve activity and pulse wave velocity in normal humans
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Impact of Subsurface Application of Compound Mineral Fertilizer on Soil Enzymatic Activity under Reduced Tillage
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Myrosinase activity in different plant samples; optimisation of measurement conditions for spectrophotometric and pH-stat methods
PublicationMyrosinase found in Brassicaceae plants, is the enzyme responsible for hydrolysis of glucosinolates. As a result a variety of biologically active metabolites are liberated, whose importance in crop protection and especially in cancer chemoprevention is rapidly gaining recognition. The growing practical application of glucosinolate degradation products requires that sensitive and reliable methods of myrosinase activity determination...
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Lanthanide co-doped TiO2: the effect of metal type and amount on surface properties and photocatalytic activity
PublicationPreparation of new rare earth metal-containing TiO2 nanocomposites (Nd3+/Er3+, Nd3+/Eu3+, Eu3+/Ho3+-TiO2) using sol–gel route and their photoactivity under visible and ultraviolet light is reported. The obtained photocatalysts were subsequently characterized by Brunauer–Emmett–Teller (BET) method, UV–Vis diffuse-reflectance spectroscopy (DRS), luminescence spectroscopy, X-ray photoelectron spectroscopy (XPS) and X-ray powder diffraction...
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Composition and In Vitro Effects of Cultivars of Humulus lupulus L. Hops on Cholinesterase Activity and Microbial Growth
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Phototransformation of sulfamethoxazole under simulated sunlight: Transformation products and their antibacterial activity toward Vibrio fischeri
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Synthesis and biological activity of novel mycophenolic acid conjugates containing nitro-acridine/acridone derivatives
PublicationOpracowano warunki reakcji kwasu mykofenolowego z aminowymi pochodnymi akrydyn i akrydonów. Tak otrzymane koniugaty zostały scharakteryzowane, a następnie przebadane in vitro pod względem aktywności przeciwbiałaczkowej oraz immunosupresyjnej.
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Perovskite-type KTaO3–reduced graphene oxide hybrid with improved visible light photocatalytic activity
PublicationNovel rGO–KTaO3 composites with various graphene content were successfully synthesized using a facile solvothermal method which allowed both the reduction of graphene oxide and loading of KTaO3 nanocubes on the graphene sheets. The as-prepared photocatalysts were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM) with energy dispersive X-ray analysis (EDX), Fourier...
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Synthesis and biological activity of ester derivatives of mycophenolic acid and acridines/acridones as potential immunosuppressive agents
PublicationImproved derivatives of mycophenolic acid (MPA) are necessary to reduce the frequency of adverse effects, this drug exerts in treated patients. In this study, MPA was coupled with N-(x-hydroxyalkyl)-9-acridone-4-carboxamides or N-(x-hydroxyalkyl)acridine-4-carboxamides to give respective ester conjugates upon Yamaguchi protocol. This esterification required protection of phenol group in MPA. Designed conjugates revealed higher...
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Inspired by Nature: The Use of Plant-derived Substrate/Enzyme Combinations to Generate Antimicrobial Activity in situ
PublicationThe last decade has witnessed a renewed interest in antimicrobial agents. Plants have received particular attention and frequently rely on the spontaneous enzymatic conversion of an inactive precursor to an active agent. Such two-component substrate/enzyme defence systems can be reconstituted ex vivo. Here, the alliin/alliinase system from garlic seems to be rather effective against Saccharomyces cerevisiae, whilst the glucosinolate/myrosinase...
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Professional activity, gender and disease-related emotions: The impact on parents' experiences in caring for children with phenylketonuria
PublicationIntroduction: Clinical management of rare diseases often fails to acknowledge the challenges faced by caregivers.Whilst management of phenylketonuria (PKU) may not be considered as dire as other conditions, most studiesprimarily concentrate on clinical issues, dietary adherence, or the quality of life of the PKU patients, leavingcaregivers in the background. The aim of the study was to evaluate the psychosocial...
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Preparation of carbon-coated Magneli phases TinO2n−1 and their photocatalytic activity under visible light
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Preparation, Structure and Catalytic Activity of Pt–Pd Bimetallic Nanoparticles on Multi-Walled Carbon Nanotubes
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Facile Deposition of Pd Nanoparticles on Carbon Nanotube Microparticles and Their Catalytic Activity for Suzuki Coupling Reactions
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Photocatalytic Activity of TiO2 Modified with Hexafluorometallates—Fine Tuning of Redox Properties by Redox-Innocent Anions
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New Insight into the Synthesis and Biological Activity of the Polymeric Materials Consisting of Folic Acid and β‐Cyclodextrin
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Are the short cationic lipopeptides bacterial membrane disruptors? Structure-Activity Relationship and molecular dynamic evaluation
PublicationShort cationic lipopeptides are amphiphilic molecules that exhibit antimicrobial activity mainly against Grampositives. These compounds bind to bacterial membranes and disrupt their integrity. Here we examine the structure-activity relation (SAR) of lysine-based lipopeptides, with a prospect to rationally design more active compounds. The presented study aims to explain how antimicrobial activity of lipopeptides is affected by...
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Spectral Characteristic and Preliminary Anticancer Activity in vitro of Selected Rhodanine‐3‐carboxylic Acids Derivatives
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