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Search results for: IN VITRO BIODEGRADATION
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Natural Products Counteracting Cardiotoxicity during Cancer Chemotherapy: The Special Case of Doxorubicin, a Comprehensive Review
PublicationCardiotoxicity is a frequent undesirable phenomenon observed during oncological treatment that limits the therapeutic dose of antitumor drugs and thus may decrease the effec-‐‑ tiveness of cancer eradication. Almost all antitumor drugs exhibit toxic properties towards cardiac muscle. One of the underlying causes of cardiotoxicity is stimulation of oxidative...
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Influence of different cultivation systems on bioactivity of asparagus
PublicationEvaluation of functional and bioactive compounds of Asparagus officinalis L. growing in conventional and organic greenhouse and conventional open –field farming was the aim of this research. Polyphenols in cladodes grown conventionally were higher than organic. Flavonoids and carotenoids were the highest in cladodes in open field. Organic spears were richer in total phenolics (+6.9% and +19.1%) and flavonoids (+4.7% and 16.8%)...
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Influence of the ionic strength on the amyloid fibrillogenesis of hen egg white lysozyme
PublicationThe study investigates the role of the electrostatic interactions in the fibrillation of the hen egg white lysozyme (HEWL). In order to achieve this aim the influence of the cations Na+, Mg2+ and Al3+ on the amyloid fibril formation and amorphous aggregation was tested. The amyloids are formed in the solution without added salt but the Thioflavin T fluorescence gives the false-negative result. In these conditions, the HEWL fibrils...
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Investigation of an elutable N-propylphosphonic acid chitosan derivative composition with a chitosan matrix prepared from carbonic acid solution
PublicationPorous chitosan composites using CO2 dissolution procedure and including water soluble N-propylphosphonic chitosan derivative (p-CHI) were obtained and characterized. In contrast to the control material, composites containing modified chitosan distinguished by a rapid moisture absorption and good adhesion to the skin. The FTIR analysis confirmed the presence of propylphosphonic group in the structure of the polymer. The porosity...
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Synthesis and Biological Evaluation of Acridine/Acridone Analogs as Potential Anticancer Agents
PublicationAcridine and acridone analogues were prepared by Ullmann condensation and then cyclization reaction. As a result of nucleophilic substitution reaction 1-nitro-9-phenoxyacridine or 1-chloro-4-nitro-9(10H)-acridone with the corresponding peptides, the planned acridine derivatives (10a-c, 12, 17-a-d, 19) have been obtained. The cytotoxic activity of the newly obtained analogs were evaluated against melanotic (Ma) and amelanotic (Ab)...
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The Application of Satellite Image Analysis in Oil Spill Detection
PublicationIn recent years, there has been an increasing use of satellite sensors to detect and track oil spills. The satellite bands, namely visible, short, medium infrared, and microwave radar bands, are used for this purpose. The use of satellite images is extremely valuable for oil spill analysis. With satellite images, we can identify the source of leakage and assess the extent of potential damage. However, it is not yet clear how to...
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Seasonal changes in organotin compounds in water and sediment samples from the semi-closed Port of Gdynia
PublicationThe effect of seasonal changes on the distribution of organotin compounds (OTC) in the sediments and seawaterfrom the docks of the Port of Gdynia was investigated. Sediment and seawater samples were collectedfrom four industrial docks in February (winter) and June (summer) in 2009. The samples were analyzed forbutyltin, phenyltin, octyltin, and tricyclohexyltin (total of 9 OTC derivatives). The fine fraction (b0.063 mm)accumulated...
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The antitumor compound triazoloacridinone C-1305 inhibits FLT3 kinase activity and potentiates apoptosis in mutant FLT3-ITD leukemia cells.
PublicationAim: FMS-like receptor tyrosine kinase (FLT3) is expressed in some normal hematopoietic cell types and plays an important role in the pathogenesis of acute myeloid leukemia (AML). In this study, we examined the effects of triazoloacridinone C-1305, an antitumor compound, on AML cells with different FLT3 status in vitro. Methods: A panel of human leukemic cell lines with different FLT3 status was used, including FLT3 internal tandem...
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Highly effective degradation of selected groups of organic compounds by cavitation based AOPs under basic pH conditions
PublicationCavitation has become on the most often applied methods in a number of industrial technologies. In the case of oxidation of organic pollutants occurring in the aqueous medium, cavitation forms the basis of numerous advanced oxidation processes (AOPs). This paper presents the results of investigations on the efficiency of oxidation of the following groups of organic compounds: organosulfur, nitro derivatives of benzene, BTEX, and...
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Influence of mussels (Mytilus galloprovincials) from polluted and non-polluted areas on some atherosclerosis indices in rats fed cholesterol
PublicationBadano wpływ diety z dodatkiem małży z obszarów zanieczyszczonych i obszarów czystych ekologicznie na niektóre objawy arteriosklerozy u szczurów.Na podstawie wyników badań in vitro, małże pochodzące z obszarów zanieczyszczonych charakteryzują sie większą zawartością protein, metali ciężkich oraz przeciwutleniaczy.Badania przeprowadzono na 28 szczurach podzielonych na 4 grupy. Szczury z grupy kontrolnej otrzymywały podstawową diete...
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Biofilm formation and its regulation in Staphylococcus aureus
PublicationInfections caused by the major human and animal pathogen, Staphylococcus aureus are becoming an important problem due to its emerging resistance mechanisms and variety of virulence factors. Biofilm formation is considered to be one of the most important factor attributed to high pathogenicity of S. aureus. Described in the literature methods used in identification of biofilm forming abilities of bacteria consist of phenotypic and...
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Towards β-selectivity in functional estrogen receptor antagonists
PublicationBased on the benzo[b]naphtho[1,2-d]furan and benzo[b]naphtho[1,2-d]thiophene frameworks, a series of ligands with different basic side chains (BSCs) has been synthesized and pharmacologically evaluated. Also, their binding modes have been modelled using docking techniques. It was found that the introduction of a BSC in these systems brings about a decrease of affinity for both estrogen receptors α and β in an in vitro competitive...
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Rozdział 10.2 Metody oznaczania właściwości przeciwutleniających próbek żywności
PublicationWystępowanie większości chorób cywilizacyjnych może być rezultatem stresu oksydacyjnego prowadzącego do różnorodnych zmian w ludzkim organizmie, wywołanych działaniem tzw. reaktywnych form tlenu. Z tego też powodu pojawiło się olbrzymie zapotrzebowanie na szybkie testy umożliwiające pomiar całkowitej zawartości przeciwutleniaczy czy też ogólnej siły przeciwutleniającej produktów żywnościowych a w szczególności świeżych warzyw...
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Haemocompatibility Of Non-Functionalized And Plasmachemical Functionalized Detonation Nanodiamond Particles
PublicationThe purpose of this paper is to present the innovative design of microwave plasma system for modification of detonation nanodiamond particles (DNP) using a special rotating drum placed inside the reactor. Nanodiamond particles manufactured by detonation method reveal the biological activity depending on surface functionalization. Plasmachemical modification of detonation nanodiamond particles gives the possibility of controlling...
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Hybrid analogues of SFTI-1 modified in P1 position by β- and γ-amino acids and N-substituted β-alanines
PublicationA series of compounds containing either non-proteinogenic beta-/gamma-amino acids or N-substituted beta-alanine residues (beta-peptoid units) in P-1 specificity position were synthesized based on the structure of sunflower trypsin inhibitor 1 (SFTI-1). The compounds were synthesized on a solid support; the N-substituted beta-alanines (beta Nhlys and beta Nhphe) were introduced into a peptidomimetic chain via a two-step approach...
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imPlatelet classifier: image‐converted RNA biomarker profiles enable blood‐based cancer diagnostics
PublicationLiquid biopsies offer a minimally invasive sample collection, outperforming traditional biopsies employed for cancer evaluation. The widely used material is blood, which is the source of tumor-educated platelets. Here, we developed the imPlatelet classifier, which converts RNA-sequenced platelet data into images in which each pixel corresponds to the expression level of a certain gene. Biological knowledge from the Kyoto Encyclopedia...
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Wastewater Engineering 2021/22 (Environmental Engineering, II stopnia, stacjonarne, II semestr))
e-Learning CoursesWastewater sources and flows Wastewater characterization based on physical and biodegradation criteria Preliminary treatment unit operations (screens, grit chambers, primary clarifiers) Biological processes (suspended growth vs. attached growth, hybrid systems, granular sludge) for wastewater treatment Principles of biological nutrient removal (nitrification, denitrification, enhanced biological P removal, anammox) Implementation...
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Wastewater Engineering 2022/23 (Environmental Engineering, II stopnia, stacjonarne, II semestr))
e-Learning CoursesWastewater sources and flows Wastewater characterization based on physical and biodegradation criteria Preliminary treatment unit operations (screens, grit chambers, primary clarifiers) Biological processes (suspended growth vs. attached growth, hybrid systems, granular sludge) for wastewater treatment Principles of biological nutrient removal (nitrification, denitrification, enhanced biological P removal, anammox) Implementation...
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Wastewater Engineering 2023/24 (Environmental Engineering, II stopnia, stacjonarne, II semestr)
e-Learning CoursesWastewater sources and flows Wastewater characterization based on physical and biodegradation criteria Preliminary treatment unit operations (screens, grit chambers, primary clarifiers) Biological processes (suspended growth vs. attached growth, hybrid systems, granular sludge) for wastewater treatment Principles of biological nutrient removal (nitrification, denitrification, enhanced biological P removal, anammox) Implementation...
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IT project management in business 2023
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Applications of AI methods in enterprise
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[IMe] Advanced numerical methods in mechanics
e-Learning Courses{mlang pl} Dyscyplina: IMe Zajęcia obowiązkowe dla doktorantów I roku Prowadzący: K. Tesch, A. Żak Liczba godzin: 45 Forma zajęć: wykład/laboratorium {mlang} {mlang en} Discipline: IMe Obligatory course for 1st year PhD students Academic teacher: K. Tesch, A. Żak Total hours of training: 45 teaching hours Course type: lecture/Laboratories {mlang}
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Spectroscopy Methods in Nanotechnology - laboratory 2022
e-Learning CoursesCourse for 2nd degree Students of Nanotechnology, specialization Nanostructures and computer simulations in materials science, sem. 2.
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FINANCIAL MANAGEMENT IN ENTERPRISE [2021/22]
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[ILiT, IŚGiE] Mathematical methods in engineering
e-Learning Courses{mlang pl} Dyscyplina: ILiT, IŚGiE Zajęcia obowiązkowe dla doktorantów I roku Prowadzący: P. Kłosowski Liczba godzin: 15 Forma zajęć: wykład {mlang} {mlang en} Discipline: ILiT, IŚGiE Obligatory course for 1st-year PhD students Academic teacher: P. Kłosowski Total hours of training: 15 teaching hours Course type: lecture {mlang}
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Internet Technology in Infosystems - Laboratory 2022
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[IMe] Advanced numerical methods in mechanics
e-Learning Courses{mlang pl} Dyscyplina: IMe Zajęcia obowiązkowe dla doktorantów I roku Prowadzący: K. Tesch, A. Żak Liczba godzin: 45 Forma zajęć: wykład/laboratorium {mlang} {mlang en} Discipline: IMe Obligatory course for 1st year PhD students Academic teacher: K. Tesch, A. Żak Total hours of training: 45 teaching hours Course type: lecture/Laboratories {mlang}
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Spectroscopy Methods in Nanotechnology - laboratory 2023
e-Learning CoursesCourse for 2nd degree Students of Nanotechnology, specialization Nanostructures and computer simulations in materials science, sem. 2.
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22/23_winter_ Legislative technique in planning
e-Learning CoursesThe objective of the module is for students to understand the principles of legislative technique and to be able to apply them correctly in the planning documents they draw up.
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Image Processing in Robotics (2021/2022)
e-Learning CoursesFor ISD M.Sc. (II degr.) 2 sem. Participants are to learn image processing algorithms related to transformation, filtration, feature detection (image descriptors), image processing algorithms in robotic industrial systems.
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[ILiT, IŚGiE] Mathematical methods in engineering
e-Learning Courses{mlang pl} Dyscyplina: inżynieria lądowa i transport; inżynieria środowiska, górnictwo i energetyka Zajęcia obowiązkowe dla doktorantów I i II roku Prowadzący: dr inż. Roger Sauer, prof. PG Liczba godzin: 15 Forma zajęć: wykład {mlang} {mlang en} Discipline: civil engineering and transport; environmental engineering, mining and power engineering Obligatory course for 1st and 2nd-year PhD students Academic teacher: dr...
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Nutrient removal in municipal wastewater treatment
e-Learning CoursesThis series of lectures and interactive teaching sessions will cover all the important aspects of nutrient removal in municipal wastewater treatment. There will be five sessions. The topics of the sessions are: 1) Nutrient removal – why, how and what has been achieved?; 2) Biological treatment processes and conventional nitrogen removal; 3) Shortcut nitrogen removal processes and climate implication of nitrogen removal; 4) Biological...
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ICT in management (summer 2022/2023)
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[IMe] Advanced numerical methods in mechanics
e-Learning Courses{mlang pl} Dyscyplina: IMe Zajęcia obowiązkowe dla doktorantów I roku Prowadzący: K. Tesch, A. Żak Liczba godzin: 45 Forma zajęć: wykład/laboratorium {mlang} {mlang en} Discipline: IMe Obligatory course for 1st year PhD students Academic teacher: K. Tesch, A. Żak Total hours of training: 45 teaching hours Course type: lecture/Laboratories {mlang}
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[Soft Skills] Workshop in research ethics
e-Learning Courses{mlang pl} Dyscyplina: Wszystkie dyscypliny Zajęcia obowiązkowe dla doktorantów III roku Prowadzący: Liczba godzin: 5 Forma zajęć: warsztaty {mlang} {mlang en} Discipline: All disciplines Obligatory course for 3rd year PhD students Academic teacher: Total hours of training: 5 teaching hours Course type: workshops {mlang}
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IT project management in business 2022
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Modelling methods in design (CAD, FEM)
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FINANCIAL MANAGEMENT IN ENTERPRISE [2023/24]
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FINANCIAL MANAGEMENT IN ENTERPRISE [2020/21]
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Advances in biomedical engineering (2023/2024)
e-Learning Courses{mlang pl} Dyscyplina: Inżynieria biomedyczna Zajęcia obowiązkowe dla doktorantów I i II roku Prowadzący: prof. dr hab. Piotr Szweda Liczba godzin: 30 {mlang} {mlang en} Discipline: Biomedical Engineering Obligatory course for 1st and 2-nd year PhD students Academic teacher: prof. dr hab. inż. Piotr Szweda Total hours of training: 30 teaching hours {mlang}
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Course restoration in progress copy 1
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Identification of Changes in Signals - 2023
e-Learning CoursesIdentification of Changes in Signals (practice) Identyfikacja Zmian w Sygnałach (ćw.)
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Spectroscopy Methods in Nanotechnology - laboratory 2024
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Mathematical Methods in Engineering 2023/2024
e-Learning CoursesJest to pomocnicza formatka do tworzenia kursów wspomagających nauczanie stacjonarne na WILiŚ. Formatka została utworzona i udostępniona przez CNE. Uwaga: W celu wykorzystania i modyfikacji należy: 1) skopiować kurs wzorcowy 2) dopiero w kopii nanosić zmiany.
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Instrumental Techniques in Environmental Biology - wykład
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Modern Technologies in Construction 2023/24
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Application of AI Methods in Enterprise
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23/24_winter_ Legislative technique in planning
e-Learning CoursesThe objective of the module is for students to understand the principles of legislative technique and to be able to apply them correctly in the planning documents they draw up.
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IT Project Management in Business - 2024
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Contemporary Theories in Architecture 2023/24
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