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Antitumor triazoloacridinone C-1305 as a potent FLT3 tyrosine kinase inhibitor in human acute myeloid leukemia (AML) cells.
PublikacjaJednym z defektów molekularnych u pacjentów z ostrą białaczką szpikową (AML) jest konstytutywna aktywacja receptoroweej kinazy tyrozynowj FLT3.Najczęstszą mutacją genu kodującego FLT3 jest wewnętrzna tandemowa duplikacja ITD we fragmencie okołobłonowym receptora. W pracy zbadano, czy przeciwnowotworowy triazoloakrydon C-1305 może być inhibitorem kinazy tyrozynowej FLT3. Badania przeprowadzono na dwóch liniach komórkowych białaczek...
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Accuracy of spirometry performed by general practitioners
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Predicting the critical micelle concentration of aqueous solutions of ionic liquids and other ionic surfactants
PublikacjaNiektóre ciecze jonowe, szczególnie te będące kombinacją organicznego i nieorganicznego jonu, wykazują strukturalne podobieństwo do surfaktantów. Krytyczne stężenie micelizacji jest podstawowym parametrem w chemii powierzchni i nauce o koloidach. Parametr ten został zmierzony dla wielu cieczy jonowych, jednakże ze względu na ogromną ilość możliwych kombinacji anionów i kationów jego eksperymentalny pomiar dla wszystkich struktur...
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Do not die, become senescent: a new type of cellular resistance induced by topoisomerase II inhibitors in tumor cells with functional p53
PublikacjaJednym z efektów wywoływanych przez związki przeciwnowotworowe w komórkach nowotworowych jest trwałe zahamowanie wzrostu, związane z pojawieniem się markerów procesu starzenia komórkowego. Proponuje się, że może to być nowy sposób na zahamowanie postępu choroby nowotworowej. W naszych badaniach wykazujemy, że zahamowanie wzrostu indukowane przez związki z grupy inhibitorów topoizomerazy II w komórkach raka płuc A549 jest związane...
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Simulation of willow productivity based on radiation use efficiency, shoot mortality and shoot age
PublikacjaPraca przedstawia model matematyczny produktywności plantacji wiklinowych. Dokonano oceny efektywności wykorzystania radiacji słonecznej przez badane plantacje, optymalnie nawadniane i nawożone. Wyniki obliczeń i pomiarów wykazują dużą zgodność, chociaż nie zawszespełnione było wymaganie dotyczące optymalnych warunków wzrostu.
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Processing of 1-nitroacridine-induced DNA-DNA cross-links by topoisomerase I is associated with enhanced cellular survival: a possible role of topoisomerase I in the removal of DNA cross-links
PublikacjaW tej pracy wykazujemy, że modyfikacje plazmidu indukowane przez wzrastające dawki 1-nitroakrydyn (nitracrine i związek C-857) prowadzą do zahamowania aktywności katalitycznej topoizomerazy I. Hamowanie to związane jest z pojawieniem się pojedynczoniciowych uszkodzeń DNA i tworzeniem kowalencyjnych kompleksów topoizomeraza I-DNA. Nie obserwowano takich efektów dla topoizomerazy typu II.Dalsze badania wykazały, że jedna z 1-nitroakrydyn...
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Application of adjusted subpixel method (ASM) in HRCT measurements of the bronchi in bronchial asthma patients and healthy individuals
PublikacjaBackground: Recently, we described a model system which included corrections of high-resolution computedtomography (HRCT) bronchial measurements based on the adjusted subpixel method (ASM).Objective: To verify the clinical application of ASM by comparing bronchial measurements obtained bymeans of the traditional eye-driven method, subpixel method alone and ASM in a group comprised ofbronchial asthma patients and healthy individuals.Methods:...
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Preparation and characterization of rigid polyurethane-polyglycerolnanocomposite foams
PublikacjaThis work reports on the preparation of polyurethane-polyisocyanurate (PUR-PIR) foams containing different polyglycerols and layered silicate nanoclays. The rigid polyurethane foams were obtained in a laboratory scale, in a single step method, from a two-component system with a NCO to OH groups ratio equal to two. The reaction mixture consisted of the proper amounts of a commercial oligoetherpolyol, polyglycerol, catalysts, water,...
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Modulation of CYP19 expression by cabbage juices and their active components: indole-3-carbinol and 3,30-diindolylmethene in human breast epithelial cell lines
PublikacjaThe aim of this study was to evaluate the effect of white cabbage and sauerkraut juices of different origin and indole-3-carbinol (I3C) and diindolylmethane (DIM) on expression of CYP19 gene encoding aromatase, the key enzyme of estrogen synthesis.Remarkable differences in the effect on CYP19 transcript and protein level were found between the cab- bage juices (in 2.5-25 mL/L concentrations) and indoles (in 2.5-50 lM doses) in...
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Acute effects of two caffeine doses on bar velocity during the bench press exercise among women habituated to caffeine: a randomized, crossover, double-blind study involving control and placebo conditions
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Insight into the Effect of ZIF‐8 Particle Size on the Performance in Nanocarbon‐Based Supercapacitors
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Carbon‐Nanotube‐Based Stimuli‐Responsive Controlled‐Release System
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Proteinase release from activated neutrophils in mechanically ventilated patients with non-COVID-19 and COVID-19 pneumonia
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Needs assessment of people 75+ living in a nursing home or family home environment
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Changes in subcellular localization of visfatin in human colorectal HCT-116 carcinoma cell line after cytochalasin B treatment
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2018 ESC/ESH Guidelines for the management of arterial hypertension
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Take a Blood Pressure Pill or Benefit from Renal Denervation?
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Effects of renal denervation on kidney function and long-term outcomes: 3-year follow-up from the Global SYMPLICITY Registry
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Final Farewell to Alberto Zanchetti MD
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Reference intervals for common carotid intima-media thickness measured with echotracking: relation with risk factors
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Supercritical fluid extraction of algae enhances levels of biologically active compounds promoting plant growth
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Towards more (un)balanced trade. Production linkages between China and the Visegrad countries: country-level and sector-level analysis
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Recommendations for the management of patients with obstructive sleep apnoea and hypertension
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Microbeam radiation therapy: Tissue dose penetration and BANG-gel dosimetry of thick-beams’ array interlacing
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Comparison of blind intubation with different supraglottic airway devices by inexperienced physicians in several airway scenarios: a manikin study
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A comparison of McGrath MAC® and standard direct laryngoscopy in simulated immobilized cervical spine pediatric intubation: a manikin study
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Comparison of Miller laryngoscope and UEScope videolaryngoscope for endotracheal intubation in four pediatric airway scenarios: a randomized, crossover simulation trial
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Clinical effectiveness of primary prevention implantable cardioverter-defibrillators: results of the EU-CERT-ICD controlled multicentre cohort study
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The COVID-19 pandemic in the Middle East and North Africa. Old demons in a new bottle
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Challenges in QCD matter physics --The scientific programme of the Compressed Baryonic Matter experiment at FAIR
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H-2D products do not affect lysis of Kk target cells by Kk-specific cytotoxic T cells
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Why Do Companies Stay Private? Determinants for IPO Candidates to Consider in Poland and the Czech Republic
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Fundamental Characterization, Photophysics and Photocatalysis of a Base Metal Iron(II)‐Cobalt(III) Dyad
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Preparation and characterization of rigid polyurethane -polyglycerol nanocomposite foams
PublikacjaThis work reports on the preparation of polyurethane–polyisocyanurate (PUR–PIR) foams containing different polyglycerols and layered silicate nanoclays. The rigid polyurethane foams were obtained in a laboratory scale, in a single step method, from a two-component system with a NCO to OH groups ratio equal to two. The reaction mixture consisted of the proper amounts of a commercial oligoetherpolyol, polyglycerol, catalysts, water,...
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Modified Peptide Molecules As Potential Modulators of Shelterin Protein Functions; TRF1
PublikacjaIn this work, we present studies on relatively new and still not well-explored potential anticancer targets which are shelterin proteins, in particular the TRF1 protein can be blocked by in silico designed "peptidomimetic" molecules. TRF1 interacts directly with the TIN2 protein, and this protein-protein interaction is crucial for the proper functioning of telomere, which could be blocked by our novel modified peptide molecules....
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BODIPY‐Perylene Charge Transfer Compounds; Sensitizers for Triplet‐Triplet Annihilation Up‐conversion
PublikacjaBODIPY heterochromophores, asymmetrically substituted with perylene and/or iodine at the 2 and 6 positions were prepared and investigated as sensitizers for triplet-triplet annihilation up conversion (TTA-UC). Single-crystal X-ray crystallographic analyses show that the torsion angle between BODIPY and perylene units lie between 73.54 and 74.51, though they are not orthogonal. Both compounds show intense, charge transfer absorption...
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Effect of low-temperature plasma on chitosan-coated PEEK polymer characteristics
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The impact of lignin addition on the properties of hybrid microspheres based on trimethoxyvinylsilane and divinylbenzene
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A polynomial algorithm for solving a general max‐min fairness problem
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Complexity of resilient network optimisation
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Cellular and molecular basis of thyroid autoimmunity
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Spontaneous unilateral exophthalmos after a vaginal delivery
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C90 PATHOLOGICAL CHARACTERISTICS OF UROTHELIAL CELL CARCINOMA OF THE BLADDER IN YOUNG PATIENTS
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Survival at the Frontier of Holy War: Political Expansion, Crusading, Environmental Exploitation and the Medieval Colonizing Settlement at Biała Góra, North Poland
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Linear and branched polyester resins based on dimethyl-2,5-furandicarboxylate for coating applications
PublikacjaIn this study, novel bio-based hydroxyl-functional (co)polyesters from dimethyl-2, 5-furandicarboxylate (DMF), 2,3-butanediol, and a variety of comonomers viz. glycerol, pentaerythritol or trimethylolpropane are prepared using a solvent-free, bulk polycondensation technique. Extensive molecular and thermal characterization was performed to elucidate the properties of these materials. The materials showed suitable properties for solvent-borne...
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Rigid polyurethane foams from a polyglycerol-based polyol
PublikacjaRigid polyurethane foams (rPUs) were synthesized by replacing 35 and 70 wt.% of petrochemical polyol with polyglycerol. Two types of polyglycerol with different molecular weights and hydroxyl numbers were used to obtain new ‘‘green’’ polyurethane–polyglycerol foams. The foams were prepared by a single step method for the ratio of NCO/OH groups equal to 2. rPUs synthesized with polyglycerol showed regular cellular structure, with...
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The influence of pre- and postharvest treatments on selected biological and epigenetic activities of Brassica sprouts
PublikacjaIntroduction The Brassica vegetables are rich in glucosinolates (GLs), which are enzymatically hydrolysed to bioactive isothiocynates (ITC) and indoles, regarded as the most promising chemopreventing agents. However, in the majority of brassica sprouts the GL conversion into these beneficial derivatives occurs at the level of about 1 %, while in cabbage leaves exceeds 70%. Since sprouts represent plant material, which is frequently...
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Synthesis and characterisation of polyurethane elastomers with semi-products obtained from polyurethane recycling
PublikacjaIn this work polyurethane elastomers were synthesised by using different mixtures of a petrochemical and glycerolysate polyols and 4,4-diphenylmethane diisocyanate (MDI). Glycerolysate polyol was produced from polyurethane foam decomposition using crude glycerine as a decomposition agent. The structure and thermal properties of obtained semi-product were similar to the polyol used in the synthesis of original foam. Glycerolysate...
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Gross Exports Versus Value-Added Exports: Determinants and Policy Implications for Manufacturing Sectors in Selected CEE Countries
PublikacjaThis article assesses the impact of selected determinants on both value-added exports and gross exports for seven CEE economies, based on thirteen manufacturing subsectors for the years 1995–2011. The results show a decrease in domestic value-added, especially in high-tech industries. The impact of the determinants, except for vertical specialization, is similar for exports in value-added and in gross terms. The results indicate...
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Microwave radiation in the synthesis of urethane prepolymers
PublikacjaThis paper describes the use of microwave radiation in the synthesis of urethane prepolymers in bulk (without solvent). The prepolymers were synthesized using 1,6-hexamethylene diisocyanate (HDI) and poly (ε-caprolactone) diol (PCL) at a molar ratio of 4:1. The reaction was carried out without a catalyst in the reactor with a conventional heating system (oil bath) or in the microwave reactor (MW Reactor NOVA 09) at temperatures...