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Wyniki wyszukiwania dla: Rare genetic diseases
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Review on Current Status of Echinocandins Use
PublikacjaFungal infections are rising all over the world every year. There are only five medical compound classes for treatment: triazoles, echinocandins, polyenes, flucytosine and allylamine. Currently, echinocandins are the most important compounds, because of their wide activity spectrum and much lower sides effects that may occur during therapy with other drugs. Echinocandins are secondary metabolites of fungi, which can inhibit the...
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Optymalizacja i walidacja metody ADSRRS-fingerprinting - konstrukcja zestawu diagnostycznego do różnicowania genetycznego drobnoustrojów
PublikacjaSpośród wszystkich metod typowania mikroorganizmów na szczególną uwagę zasługują metody oparte na analizie całego materiału genetycznego zawartego w komórce. Jedną z nich jest stosunkowo nowa technika ADSRRS-fingerprinting (ang. Amplification of DNA Fragments Surrounding Rare Restriction Sites). Na podstawie naszych badań można stwierdzić, iż charakteryzuje się ona wysokim potencjałem różnicującym, wiarygodnością, powtarzalnością...
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A Comprehensive Experimental and Theoretical Study on the[{(η5-C5H5)2Zr[P(µ-PNEt2)2P(NEt2)2P]}2O Crystalline System
PublikacjaThe structure of tetraphosphetane zirconium complex C52H100N8OP10Zr21 was determined by single crystal X-ray diffraction analysis. The crystal belongs to the monoclinic system, space group P21/c, with a = 19.6452(14), b = 17.8701(12), c = 20.7963(14)Å, α = γ = 90°, β = 112.953(7)°, V = 6722.7(8)Å3, Z = 4. The electronic structure of the organometallic complex has been characterized within the framework of Quantum Chemical Topology....
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New methodology for calculating cost-efficiency of different ways of voting: is internet voting cheaper?
PublikacjaNew ways of voting in elections are being sought by electoral administrations worldwide who want to reverse declining voter turnouts without increasing electoral budgets. This paper presents a novel approach to cost accounting for multi-channel elections based on local elections in Estonia. By doing so, it addresses an important gap in the academic literature in this field. The authors confirm that internet voting was most cost-efficient...
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Bridge Ergonomic Design: A Review
PublikacjaHuman error remains the most common cause of marine incidents and it is worth emphasizing that navigator’s performance is directly affected by ergonomic factors on the bridge. Studies regarding influence of bridge design and work environment on the operator are rare, thus the main purpose of this paper is to fill in this gap. Documents issued by recognized organizations, research publications and additional sources were reviewed...
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Electrolytic deposition of reactive element thin films on Crofer 22 APU and evaluation of the resulting high-temperature corrosion protection properties at 700 °C–900 °C
PublikacjaThis article presents electrolytic deposition of thin Rare Earth (RE) coatings on Crofer 22 APU stainless steel substrates for high temperature applications, such as interconnects in solid oxide cell stacks. The deposition of coatings based on yttrium-, gadolinium-, lanthanum-, and cerium nitrates is discussed. The high temperature corrosion properties of surface-modified steels were examined using thermogravimetry and electrical...
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Zarządzanie opóźnieniami w ruchu kolejowym
PublikacjaZarządzanie opóźnieniami w ruchu kolejowym zostało przedstawione jako wielokryterialny problem optymalizacyjny, do rozwiązania którego został użyty model ogólny (job-shop) szeregowania zadań. W artykule przedstawiono sposób zastosowania trzech algorytmów metaheurystycznych: algorytmu genetycznego (Genetic Algorithm), algorytmu roju (Particle Swarm Optimization) i algorytmu mrówkowego (Ant Colony Optimization) do znalezienia optymalnego...
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Impact of R/X ratio of distribution network on selection and control of energy storage units
PublikacjaThe interest in energy storage is still increasing. Energy storage units are installed in high voltage networks, medium voltage networks and low voltage distribution networks as well. These units are often used to improve power quality. One of the criteria for improving power quality is reducing voltage deviations. Depending on the type of network and specifying its R/X ratio, this criterion can be fulfilled by control of active...
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Optimizing control by robustly feasible model predictive control and application to drinking water distribution systems
PublikacjaThe paper considers optimizing Model Predictive Control (MPC) for nonlinear plants with output constraints under uncertainties. Although the MPC technology can handle the constraints in the model by solving constraint model based optimization task, satisfying the plant output constraints under the model uncertainty still remains a challenge. The paper proposes Robustly Feasible MPC (RFMPC), which achieves feasibility of the outputs...
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From Individual to Collective: Intelligence Amplification with Bio-Inspired Decisional DNA and its Extensions
PublikacjaIn nature, deoxyribonucleic acid (DNA) contains the genetic instructions used in the development and functioning of all known living organisms. The idea behind our vision is to develop an artificial system, an architecture that would support discovering, adding, storing, improving and sharing information and knowledge among agents and organizations through experience. We propose a novel Knowledge Representation (KR) approach in...
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Observation on red blood cells fluctuations by diffraction phase microscopy
PublikacjaNowadays there is quite huge need for more and more precise and effective fast diagnostics methods in hematology diseases. One of the most important blood components are erythrocytes – Red Blood Cells (RBCs). Due to their size they are easy to observe using microscopy. It is commonly known that the shape and lifetime of RBCs allows for early disease identification. Authors present special measurement system for RBCs fluctuations...
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Selected organophosphorus compounds with biological activity. Applications in medicine
PublikacjaThe purpose of this article is to provide an overview of the latest applications of organophosphorus compounds (OPs) that exhibit biological activity. A large family of OPs have become popular in recent years. The practical application of OPs in modern medicine has been attributed to their unique properties. In this article, the methods used to select these compounds will be emphasized. This paper will first outline the findings...
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Regulation of Cellular Redox Homeostasis by (–)-Epicatechin and Cocoa Extracts—A Pilot Study
PublikacjaCocoa polyphenols play an important role in protection against diseases in which oxidative stress is implicated as a causal or contributing factor. The main aim of this study was to elucidate the influence of different cocoa extracts and main cocoa bioactive compound (–)-epicatechin on cell growth and support of antioxidant cellular barrier in colon adenocarcinoma cell line model (HT29). Results show that the tested cocoa bioactivity...
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REGULATION OF CELLULAR REDOX HOMEOSTASIS BY (-)-EPICATECHIN AND COCOA EXTRACTS – PILOT STUDY
PublikacjaCocoa polyphenols play an important role in protection against diseases in which oxidative stress is implicated as a causal or contributing factor. The main aim of this study was to elucidate the influence of different cocoa extracts and main cocoa bioactive compound (–)-epicatechin on cell growth and support of antioxidant cellular barrier in colon adenocarcinoma cell line model (HT29). Results show that the tested cocoa bioactivity...
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Biopsy needles coated with the antimicrobial coatings
PublikacjaDrug delivery systems are used to achieve higher therapeutic effects of medicaments in a specific diseased site with minimal toxicological effect. The used of biopolymers in drug delivery systems ensure the biocompatibility, biodegradability and low immunogenicity. Drug delivery systems enhance the drug delivery actively and can be used in different diseases. In this study, two types of polymer coatings were prepared and were...
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Does previous abdominal surgery affect the course and outcomes of laparoscopic bariatric surgery?
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Cigarette smoking and its impact on weight loss after bariatric surgery: A single center, retrospective study
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The impact of last 15 minutes of surgery on the hemorrhagic complications after laparoscopic sleeve gastrectomy. Case-control study
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Safety and outcomes of laparoscopic sleeve gastrectomy in patients older than 60: a case-control study
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Typing of Candida isolates from patients with invasive infection and concomitant colonization
PublikacjaWe investigated the relationship between colonizing and invasive isolates from patients with candidaemia. Molecular typing was performed using random amplification of polymorphic DNA (RAPD) and multilocus sequence typing (MLST). We found MLST to be sufficient for typing Candida isolates, and that surveillance cultures are helpful in predicting concomitant invasive isolates, but not necessarily the pathogen involved in subsequent...
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Iron overload and HFE gene mutations in Polish patients with liver cirrhosis
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Liver steatosis correlates with iron overload but not with HFE gene mutations in chronic hepatitis C
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Obstructive sleep apnea: An update on mechanisms and cardiovascular consequences
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Analysis of the risk factors for perioperative morbidity after laparoscopic revisional bariatric procedures: results from the multicenter Polish Revision Obesity Surgery Study
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The impact of severe postoperative complications on outcomes of bariatric surgery—multicenter case-matched study
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Fasting Hyperglycemia and Long-term Outcome in Patients with Acute Ischemic Stroke Treated with Mechanical Thrombectomy
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Visual and brainstem auditory evoked potentials in HCV-infected patients before and after interferon-free therapy — A pilot study
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Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids
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Authors’ response to Dr Finsterer's comment “Exclude differentials before diagnosing SARS-CoV-2-associated acute hemorrhagic necrotizing encephalitis” (THEIJID-D-22-00008)
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Use of broad-spectrum antibiotics in children diagnosed with multisystem inflammatory syndrome temporarily associated with SARS-CoV-2 infection in Poland: the MOIS-CoR study
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The case of fatal acute hemorrhagic necrotizing encephalitis in a two-month-old boy with Covid-19.
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Impact of inorganic ions and pH variations on toxicity and endocrine potential of selected environmentally relevant pharmaceuticals
PublikacjaAssessment of the impact of pharmaceutical residues on living organisms is a very complex subject. Apart from taking into account the toxicity of individual compounds, environmental factors should also be taken into account. In this paper, attempts were made to assess the impact of coexisting inorganic ions and changes in pH on the toxicity of ten selected pharmaceuticals. Two bioassays were used to measure the estrogenic and androgenic...
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Revision of Biological Methods for Determination of EDC Presence and Their Endocrine Potential
PublikacjaEndocrine-disrupting compounds (EDC) are chemicals responsible for disturbances in the hormonal balance of organisms. This group of chemicals includes both egzogenic and endogenic substances or their mixtures that impact functioning of natural hormones in organisms. In the available literature one can find information on the application of chromatographic and related techniques in the analysis of environmental samples for detection,...
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Endoscopy video analysis algorithms and their independence of rotation , brightness , contrast , color and blur
PublikacjaThe article presents selected image analysis algorithms for endoscopy videos. Mathematical methods that are part of these algorithms are described, and authors’ claims about the characteristics of these algorithms, such as the independence of rotation, brightness, contrast, etc. are mentioned. Using the common test on the real endoscopic image database and a set of image transformations, the validity of these claims was checked...
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Sulfonamides with hydroxyphenyl moiety: Synthesis, structure, physicochemical properties, and ability to form complexes with Rh(III) ion
PublikacjaSulfonamides are the first successfully synthesized antimicrobial drugs. The mechanism of sulfonamides’ antimicrobial action involves competitive inhibition of folic acid synthesis and prevention of the growth and reproduction of bacteria. Even though they have been applied in therapy for more than 75 years, sulfonamides are still the drugs of choice for the treatment of various diseases. The aim of this work was to synthesize...
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Early Stages of RNA-Mediated Conversion of Human Prions
PublikacjaPrion diseases are characterized by the conversion of prion proteins from a PrPC fold into a disease-causing PrPSC form that is self-replicating. A possible agent to trigger this conversion is polyadenosine RNA, but both mechanism and pathways of the conversion are poorly understood. Using coarse-grained molecular dynamic simulations we study the time evolution of PrPC over 600 μs. We find that both the D178N mutation and interacting...
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Optymalizacja strategii sieci inteligentnych agentów za pomocą programowania genetycznego w systemie rozproszonym realizującym paradygmat volunteer computing
PublikacjaDynamicznie rosnąca złożoność i wymagania w odniesieniu do rozproszonych systemów informatycznych utrudnia zarządzanie dostępnymi zasobami sprzętowymi i programistycznymi. Z tego powodu celem rozprawy jest opracowanie wielokryterialnej metody programowania genetycznego, która pozwala na optymalizację strategii zespołu inteligentnych agentów programistycznych w zakresie zarządzania systemem realizującym paradygmat volunteer computing....
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Superconductivity–Electron Count Relationship in Heusler Phases─the Case of LiPd2Si
PublikacjaWe report superconductivity in the full Heusler compound LiPd2Si (space group Fm3̅m, No. 225) at a critical temperature of Tc = 1.3 K and a normalized heat capacity jump at Tc, ΔC/γTc = 1.1. The low-temperature isothermal magnetization curves imply type-I superconductivity, as previously observed in LiPd2Ge. We show, based on density functional theory calculations and using the molecular orbital theory approach, that while LiPd2Si...
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Nowe stanowiska, rozmieszczenie i ochrona buławnika czerwonego Cephalanthera rubra (L.) Rich. (Orchidaceae) w Puszczy Augustowskiej (NE Polska)
PublikacjaCephalanthera rubra (L.) Rich. is a species under strict protection, very rare in the Suwałki region. In recent years, two sites were discovered in the Wigry National Park. The article presents a description of new localities and the distribution of the red helleborine in the Augustów Primeval Forest.
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Fabrication, Microstructure and High Temperature Corrosion Resistance of Porous Alloys for Solid Oxide Fuel Cells
PublikacjaPorous alloys find use in modern Solid Oxide Fuel Cells as the supporting structures. As they are exposed to high temperatures (> 500°C) an oxide scale forms on their surface due to high temperature corrosion phenomena. Since the ratio between the surface area and volume is much higher than for planar samples, formation of the oxide can lead to a breakaway oxidation after relatively short times. Therefore corrosion properties of...
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A large family of filled skutterudites stabilized by electron count
PublikacjaThe Zintl concept is important in solid-state chemistry to explain how some compounds that combine electropositive and main group elements can be stable at formulas that at their simplest level do not make any sense. The electronegative elements in such compounds form a polyatomic electron-accepting molecule inside the solid, a ‘polyanion’, that fills its available energy states with electrons from the electropositive elements...
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Electronic structure and magnetism of samarium and neodymium adatoms on free-standing graphene
PublikacjaThe electronic structure of selected rare-earth atoms adsorbed on a free-standing graphene was investigated using methods beyond the conventional density functional theory (DFT+U, DFT +HIA, and DFT+ED). The influence of the electron correlations and the spin-orbit coupling on the magnetic properties has been examined. The DFT+U method predicts both atoms to carry local magnetic moments (spin and orbital) contrary to a nonmagnetic...
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Jacek Krenz : City in my eyes
PublikacjaSketch City: Tips and Inspiration for Drawing on Location is the companion for any creative traveler, urban explorer, or budding artist. 50 artists scattered around the globe have been brought together to share tips about their favorite urban settings, including locations in South America, Europe, Canada, Asia, and beyond. Citified sketchers are guiding through techniques for capturing frenetic street scenes as well as the rare...
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CHROMATOGRAPHIC TECHNIQUES IN PHARMACEUTICAL ANALYSIS IN POLAND: HISTORY AND THE PRESENCE ON THE BASIS OF PAPERS PUBLISHED IN SELECTED POLISH PHARMACEUTICAL JOURNALS IN XX CENTURY
PublikacjaFor a long time, chromatographic techniques and techniques related to them have stimulated the development of new procedures in the field of pharmaceutical analysis. The newly developed methods, characterized by improved metrological parameters, allow for more accurate testing of, among others, the composition of raw materials, intermediates and final products. The chromatographic techniques also enable studies on waste generated...
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Synthesis Methods and Favorable Conditions for Spherical Vaterite Precipitation: A Review
PublikacjaVaterite is the least thermodynamically stable anhydrous calcium carbonate polymorph. It exists very rare in nature, e.g. in some rock formations or as a component of biominerals produced by some fishes, crustaceans or birds. Synthetic vaterite particles are proposed as carriers of active substances in medicines, additive in cosmetic preparations as well as adsorbents. Also, their utilization as a pump for microfluidic flow is...
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NEW DESIGNS OF CENTRIFUGAL MAGNETIC FLUID SEALS FOR ROTATING SHAFTS IN MARINE TECHNOLOGY
PublikacjaThe centrifugal magnetic fluid seals have important advantage over the conventional centrifugal seals. They maintain very good sealing capacity at static, medium and high speeds of shaft rotation, with the increased seal lifetime, and minimum torque and static friction. These seals are particularly useful in cases when the angular shaft velocity varies and sometimes decreases to nearly or exactly zero, such as in flywheel applications,...
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Three-dimensional printed trachea helps to design tailored treatment for tracheobronchomalacia
PublikacjaTracheobronchomalacia is a rare respiratory disease that is manifesting by impaired ventilation with expiratory collapse of the tracheal wall due to softening of the supporting cartilage and hypotonia of myoelastic elements [1]. Surgery is the mainstay of treatment. We report the case of 39 -year old man with exacerbation of chronic respiratory distress. The membranous wall of the trachea and the large bronchi was stretched to...
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Structural, electrical, and magnetic study of La-, Eu-, and Er- doped bismuth ferrite nanomaterials obtained by solution combustion synthesis
PublikacjaIn this work, the multiferroic bismuth ferrite materials Bi0.9RE0.1FeO3 doped by rare-earth (RE = La, Eu, and Er) elements were obtained by the solution combustion synthesis. Structure, electrical, and magnetic properties of prepared samples were investigated by X-ray photoelectron spectroscopy, Mössbauer spectroscopy, electrical hysteresis measurement, broadband dielectric spectroscopy, and SQUID magnetometry. All obtained nanomaterials...
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One-step recovery of REE oxalates in electro-leaching of spent NdFeB magnets
PublikacjaRecovery of rare-earth elements (REEs) from spent NdFeB magnets is receiving great attention because of high amount of neodymium and potential risk of environmental pollution. In this study, a novel environment-friendly hydrometallurgical route is proposed for efficient recovery of REEs during electrochemical leaching with sulfuric and oxalic acids. With proper adjustment of the electrolyte composition and operating conditions,...
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Investigating beliefs in anti-vax conspiracy theories among medical students
PublikacjaAbstract: While the doctors’ role in immunization is essential, their lack of knowledge or vaccine hesitancy may affect their ability to communicate effectively and educate patients about vaccination, vaccine hesitancy, and vaccine conspiracy theories. This, in turn, may hinder health policy aimed at fighting infectious diseases. Vaccine hesitancy is prevalent not only among the general population but also among healthcare...