Filtry
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Wyniki wyszukiwania dla: SKIN RESISTANCE
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Cancer-selective, single agent chemoradiosensitising gold nanoparticles
PublikacjaTwo nanometre gold nanoparticles (AuNPs), bearing sugar moieties and/or thiol-polyethylene glycol-amine (PEG-amine), were synthesised and evaluated for their in vitro toxicity and ability to radiosensitise cells with 220 kV and 6 MV X-rays, using four cell lines representing normal and cancerous skin and breast tissues. Acute 3 h exposure of cells to AuNPs, bearing PEG-amine only or a 50:50 ratio of alpha-galactose derivative and...
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Molecular targets for antifungals in amino acid and protein biosynthetic pathways
PublikacjaFungi cause death of over 1.5 million people every year, while cutaneous mycoses are among the most common infections in the world. Mycoses vary greatly in severity, there are long-term skin (ringworm), nail or hair infections (tinea capitis), recurrent like vaginal candidiasis or severe, life-threatening systemic, multiorgan infections. In the last few years, increasing importance is attached to the health and economic problems...
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Colored Tattoo Ink Screening Method with Optical Tissue Phantoms and Raman Spectroscopy
PublikacjaDue to the increasing popularity of tattoos among the general population, to ensure their safety and quality, there is a need to develop reliable and rapid methods for the analysis of the composition of tattoo inks, both in the ink itself and in already existing tattoos. This paper presents the possibility of using Raman spectroscopy to examine tattoo inks in biological materials. We have developed optical tissue phantoms mimicking...
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Emulsifying blends based on natural fats for eco-design of O/W emulsions
PublikacjaEmulsifier blends are most often used to stabilize and modulate the properties of cosmetic and pharmaceutical emulsions, such as skin care or application-related consistency. However, the rational design of such emulsifier blends is often not well understood, especially when their ingredients are natural raw materials. This study aimed to analyze the influence of natural fatty ingredients selected as emulsifiers on the emulsion...
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Marine polymers in tissue bioprinting: Current achievements and challenges
PublikacjaBioprinting has a critical role in tissue engineering, allowing the creation of sophisticated cellular scaffolds with high resolution, shape fidelity, and cell viability. Achieving these parameters remains a challenge, necessitating bioinks that are biocompatible, printable, and biodegradable. This review highlights the potential of marine-derived polymers and crosslinking techniques including mammalian collagen and gelatin along...
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A design framework and a digital toolset supporting the early-stage explorations of responsive kinetic building skin concepts
PublikacjaIn this paper we present the first phase of our research on the development of a framework for early-stage responsive kinetic building skin design. The aims of this study were: to formulate a methodological and instrumental basis for the construction of the framework, to conduct an initial pre-assessment of its features, and finally to provide the first example of how the framework could be applied in practice. Importantly, at...
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Modelling of some stealth features for a small navy ship at the concept design stage.
PublikacjaIn this paper the basic research problems associated with modelling the basic stealth features for a small navy ship at the concept design stage are introduced. Amongst the major stealth features considered are: the modification of the immersed ship hull form by a rapid change of the ship loading condition, and modification of the ship boundary layer by the hull skin cover. The other stealth features of the ship are not presented...
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PCR test for Microsporum canis identification
PublikacjaMicrosporum canis, for which the natural hosts are cats and dogs, is the most prevalent zoophilic agent causing tinea capitis and tinea corporis in humans. We present here a diagnostic PCR test for M. canis, since its detection and species identification is relevant to the choice of treatment and to the understanding of a probable source of infection. An M. canis-specific PCR was evaluated using 130 clinical isolates of dermatophytes...
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Towards large-scale application of nanoporous materials in membranes for separation of energy-relevant gas mixtures
PublikacjaMembranes containing nanoporous materials (such as zeolites, metal–organic materials and 2D materials such as graphene derivatives) may allow more efficient separation of gas mixtures relevant to emerging energy technologies. For example, such membranes could be applied in the separation of gases containing mixtures of carbon dioxide (CO2) and hydrogen (H2). However, these membranes are currently at a relatively low technology...
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A significance of multi slip condition for inclined MHD nano-fluid flow with non linear thermal radiations, Dufuor and Sorrot, and chemically reactive bio-convection effect
PublikacjaThe aim of this research is to discuss the significance of slip conditions for magnetized nanofluid flow with the impact of nonlinear thermal radiations, activation energy, inclined MHD, sorrot and dufour, and gyrotactic micro motile organisms over continuous stretching of a two-dimensional sheet. The governing equations emerge in the form of partial differential equations. Since the resultant governing differential equations...
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Synergistic Effects of Propolis Combined with 2-Phenoxyethanol and Antipyretics on the Growth of Staphylococcus aureus
PublikacjaThe present investigation aimed to assess the combinational effect of commonly usedantipyretics and antiseptics with ethanolic extracts of propolis (EEPs) on the growth inhibition ofStaphylococcus aureus. The broth microdilution checkerboard assay revealed synergistic interactionsbetween all investigated antipyretics, namely acetylsalicylic acid, ibuprofen, and acetaminophen,with EEPs samples. The values of the fractional inhibitory...
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Self-Supervised Learning to Increase the Performance of Skin Lesion Classification
PublikacjaTo successfully train a deep neural network, a large amount of human-labeled data is required. Unfortunately, in many areas, collecting and labeling data is a difficult and tedious task. Several ways have been developed to mitigate the problem associated with the shortage of data, the most common of which is transfer learning. However, in many cases, the use of transfer learning as the only remedy is insufficient. In this study,...
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Technology of an adhesive silicone film as drug carrier in transdermal therapy I. Analytical methods used for characterization and design of the universal elastomer layers
PublikacjaSilicone polymers possess unique properties, which make them suitable for many different applications, for example in the pharmaceutical and medical industry. To create an adhesive silicone film, the appropriate silicone components have to be chosen first. From these components two layers were made: an adhesive elastomer applied on the skin, and a non-adhesive elastomer on the other side of the film. The aim of this study was...
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Exposure scenario and risk assessment of infants and newborns to bisphenols and their derivatives from diapers
PublikacjaNewborns and infants are more sensitive to harmful compounds such as bisphenols and their derivatives because of their not fully developed detoxification mechanism. Exposure to these substances can lead to developmental problems and health consequences in adulthood. Since disposable baby diapers are used from the first days of life and remain in contact with the baby skin, it seems important to monitor the levels of endocrine disrupting chemicals...
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Biopolymer-based composites for tissue engineering applications: A basis for future opportunities
PublikacjaBiomimetic scaffolds supporting tissue regeneration are complex materials with multifunctional characteristics. The unique biocompatibility and biodegradability of biopolymers make them excellent candidates for tissue engineering and regenerative medicine. Biopolymers, which have a wide range of properties, can be obtained from different natural sources. Depending on the target tissue, biopolymers can be engineered to meet a series...
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Chitosan-protein scaffolds loaded with lysostaphin as potential antistaphylococcal wound dressing materials.
PublikacjaAIMS: The development of technology for preparing chitosan-protein scaffolds loaded with lysostaphin, which potentially could be used as dressing for wound treatment and soft tissue infections caused by Staphylococcus aureus. METHODS AND RESULTS: The unique technology of chitosan solubilization using gaseous CO(2) instead of organic or inorganic acids was used for the incorporation of lysostaphin, the enzyme that exhibits bactericidal...
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Specific detection of Alternaria alternata by PCR and real-time PCR
PublikacjaFungi of Alternaria genus are cosmopolitan organisms, which spores can be found in the air, soil, water, clothing and food. They commonly occur as saprotrophs on the plant remains, contributing to the decomposition of organic matter. Additionally, they are components of the normal human and animal skin flora. Alternaria spp. are also known human allergens, causing hay fever and allergic reactions that can lead to the development...
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Pathogenesis of psoriasis in the “omic” era. Part II. Genetic, genomic and epigenetic changes in psoriasis
PublikacjaPsoriasis is a multifactorial disease in which genetic, environmental and epigenetic factors regulating gene expression play a key role. In the “genomic era”, genome-wide association studies together with target genotyping platforms performed in different ethnic populations have found more than 50 genetic susceptible markers associated with the risk of psoriasis which have been identified so far. Up till now, the strongest association...
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The Use of Liquid Crystal Thermography in Selected Technical and Medical Applications—Recent Development
PublikacjaThermochromic liquid crystals (TLC) and true-colour digital image processing have been successfully used in non-intrusive technical, industrial and biomedical studies and applications. Thin coatings of TLC at surfaces are utilized to obtain detailed temperature distributions and heat transfer rates for steady or transient processes. Liquid crystals also can be used to make the temperature and velocity fields in liquids visible...
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Some Aspects of Shear Behavior of Soft Soil–Concrete Interfaces and Its Consequences in Pile Shaft Friction Modeling
PublikacjaThis paper examines the stiffness degradation and interface failure load on soft soil–concrete interface. The friction behavior and its variability is investigated. The direct shear tests under constant normal load were used to establish parameters to hyperbolic interface model which provided a good approximation of the data from instrumented piles. Four instrumented piles were used to obtain reference soil–concrete interface behavior....
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Exploring the influence of personal factors on physiological responses to mental imagery in sport
PublikacjaImagery is a well-known technique in mental training which improves performance efficiency and influences physiological arousal. One of the biomarkers indicating the amount of physiological arousal is skin conductance level (SCL). The aim of our study is to understand how individual differences in personality (e.g. neuroticism), general imagery and situational sport anxiety are linked to arousal measuring with SCL in situational...
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Evaluating Accuracy of Respiratory Rate Estimation from Super Resolved Thermal Imagery
PublikacjaNon-contact estimation of Respiratory Rate (RR) has revolutionized the process of establishing the measurement by surpassing some issues related to attaching sensors to a body, e.g. epidermal stripping, skin disruption and pain. In this study, we perform further experiments with image processing-based RR estimation by using various image enhancement algorithms. Specifically, we employ Super Resolution (SR) Deep Learning (DL) network...
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Antibacterial polyurethanes, modifed with cinnamaldehyde, as potential materials for fabrication of wound dressings
PublikacjaThe epidermis is a skin layer, which protects an organism from the different factors of external environment. Therefore, the fast and effective regeneration of epidermis is important. Potential materials used for epidermis regeneration may be polyurethane scaffolds in form of the thin permeable layers. One and main disadvantage of such polyurethane scaffolds are their lack of antibacterial and antifungal properties. The great proposition...
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Uniqueness or uniformity - studies of media architecture
PublikacjaA development of media architecture is presented in light of to such phenomena as aesthetization, consumerism and digitization. This article deals with media architecture in commercial spaces. Media solutions impact on the architectural skin, making it into visible and dynamic points of the image of a post-modern city. This article presents the specificity of media solutions, depending on the function of commercial activity buildings...
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Thermosensitive composite based on agarose and chitosan saturated with carbon dioxide. Preliminary study of requirements for production of new CSAG bioink.
PublikacjaThis study introduces a method for producing printable, thermosensitive bioink formulated from agarose (AG) and carbon dioxide-saturated chitosan (CS) hydrogels. The research identified medium molecular weight chitosan as optimal for bioink production, with a preferred chitosan hydrogel content of 40–60 %. Rheological analysis reveals the bioink's pseudoplastic behavior and a sol-gel phase transition between 27.0 and 31.5 °C. The...
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Evolution of the nanostructure of Pt and Pt–Co polymer electrolyte membrane fuel cell electrocatalysts at successive degradation stages probed by X-ray photoemission
PublikacjaWe present a set of XPS (X-ray photoemission spectroscopy) measurements and detailed data-analysis of electrodes for polymer electrolyte membrane fuel cell (PEMFC) based on carbon supported catalysts (Pt and Pt–Co) subjected to a step-like potential cycling (accelerated degradation test). The results of the measurements complete and corroborate parallel TEM (transmission electron microscopy), XRD (X-ray diffraction) and XAS (X-ray...
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Active IR-Thermal Imaging in Medicine
PublikacjaIn this paper we summarize results of several research projects devoted to development of new diagnostic methods and procedures based on quantitative infrared thermography in medical applications. First, basics of active dynamic thermography are presented. Described are both, instrumentation and software comprising measurement procedures including collection of series of IR-images after external excitation, data treatment with...
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Environmental problems and health risks with disposable baby diapers: Monitoring of toxic compounds by application of analytical techniques and need of education
PublikacjaDue to the widespread use of disposable diapers in healthy babies as well as children prone to allergiesand premature babies with reduced immunity, disposable diapers should only be made of non-toxic andnatural ingredients. Unfortunately, disposable diaper manufacturers are reluctant to present their exactchemical composition, claiming that their trade secrets apply. However, several reports show thatdisposable diapers of well-known...
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Functionalized Peptide Fibrils as a Scaffold for Active Substances in Wound Healing
PublikacjaTechnological developments in the field of biologically active peptide applications in medicine have increased the need for new methods for peptide delivery. The disadvantage of peptides as drugs is their low biological stability. Recently, great attention has been paid to self-assembling peptides that can form fibrils. Such a formulation makes bioactive peptides more resistant to enzymatic degradation and druggable. Peptide fibrils...
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Studies on the formation of formaldehyde during 2-ethylhexyl 4-(dimethylamino)benzoate demethylation in the presence of reactive oxygen and chlorine species
PublikacjaIn order to protect the skin from UV radiation, personal care products (PCPS) often contain chemical UV-filters. These compounds can enter the environment causing serious consequences on the water ecosystems. The aim of this study was to examine, the effect of different factors, such as UV light, the presence of NaOCl and H2O2 on the formaldehyde formation during popular UV filter, 2-ethylhexyl 4-(dimethylamino)benzoate (ODPABA)...
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Double layer adhesive silicone dressing as a potential dermal drug delivery film in scar treatment
PublikacjaThe present studies focused on the evaluation of design of an adhesive silicone film intended for scar treatment. Developed silicone double layer film was examined in terms of its future relevance to therapy and applicability on the human skin considering properties which included in vitro permeability of water vapor and oxygen. In order to adapt the patches for medical use in the future there were tested such properties as...
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Multi-layered tissue head phantoms for noninvasive optical diagnostics
PublikacjaExtensive research in the area of optical sensing for medical diagnostics requires development of tissue phantoms with optical properties similar to those of living human tissues. Development and improvement of in vivo optical measurement systems requires the use of stable tissue phantoms with known characteristics, which are mainly used for calibration of such systems and testing their performance over time. Optical and mechanical...
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A fast and convenient method for analysis of collagen hydrolysis products Szybka i dogodna metoda analizy produktów hydrolizy kolagenu
PublikacjaPolypeptides produced by hydrolysis of collagen from minced animal hide and skin scraps were studied by mass spectrometry (MS) in conjunction with electrophoresis to det. their mol. mass. The degree of peptides ionisation was ca 50+. This allowed for observation of the large polypeptide chains with mass analyzers with a relatively low m/z range. The electrospray and atm. pressure photoionization techniques were used. The polypeptide...
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Polysaccharide-based Nanocomposites for Biomedical Applications: A Critical Review
PublikacjaPolysaccharides (PSA) are taking specific position among biomaterials for advanced applications in medicine. Nevertheless, poor mechanical properties is known as the main drawback of PSA, which highlights need for PSA modification. Nanocomposites PSA (NPSA) are a class of biomaterials widely used as biomedical platforms, but despite their importance and worldwide use have not been reviewed. Herein we critically reviewed application...
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PVA-Based Films with Strontium Titanate Nanoparticles Dedicated to Wound Dressing Application
PublikacjaBioactive materials may be applied in tissue regeneration, and an example of such materials are wound dressings, which are used to accelerate skin healing, especially after trauma. Here, we proposed a novel dressing enriched by a bioactive component. The aim of our study was to prepare and characterize poly(vinyl alcohol) films modified with strontium titanate nanoparticles. The physicochemical properties of films were studied,...
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Advanced nanomaterials and metal-organic frameworks for catalytic bio-diesel production from microalgal lipids – A review
PublikacjaIncreasing energy demands require exploring renewable, eco-friendly (green), and cost-effective energy resources. Among various sources of biodiesel, microalgal lipids are an excellent resource, owing to their high abundance in microalgal biomass. Transesterification catalyzed by advanced materials, especially nanomaterials and metal-organic frameworks (MOFs), is a revolutionary process for overcoming the energy crisis. This review...
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Bioaccumulation of Metals in Tissues of Marine Animals, Part I: the Role and Impact of Heavy Metals on Organisms
PublikacjaHeavy metals contribute to the anthropogenic contamination of marine ecosystems. Some of them are essential to the life processes of organisms; others are toxic, even at low concentrations. They penetrate organisms via food, respiratory pathways or the skin. The extent to which metals penetrate organisms is measured by the bioconcentration and bioaccumulation factors and also by their transport between organisms at different trophic...
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Polyurethane based hybrid ciprofloxacin-releasing wound dressings designed for skin engineering purpose
PublikacjaPurpose Even in the 21st century, chronic wounds still pose a major challenge due to potentially inappropriate treatment options, so the latest wound dressings are hybrid systems that enable clinical management, such as a hybrid of hydrogels, antibiotics and polymers. These wound dressings are mainly used for chronic and complex wounds, which can easily be infected by bacteria. Materials and methods Six Composite Porous Matrices...
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Honey antibacterial activity: A neglected aspect of honey quality assurance as functional food
PublikacjaBackground Honey is considered as a functional food with health-promoting properties. Its potent antibacterial and antibiofilm effects are the major attributes of so called ‘medical-grade honey’ which is topically used for the treatment of burns, wounds and skin disorders. Nevertheless, the current set of honey quality parameters adopted in the European Union do not include its biological properties. Furthermore, in light of the...
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Data augmentation for improving deep learning in image classification problem
PublikacjaThese days deep learning is the fastest-growing field in the field of Machine Learning (ML) and Deep Neural Networks (DNN). Among many of DNN structures, the Convolutional Neural Networks (CNN) are currently the main tool used for the image analysis and classification purposes. Although great achievements and perspectives, deep neural networks and accompanying learning algorithms have some relevant challenges to tackle. In this...
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Psychophysiological strategies for enhancing performance through imagery – skin conductance level analysis in guided vs. self-produced imagery
PublikacjaAthletes need to achieve their optimal level of arousal for peak performance. Visualization or mental rehearsal (i.e., Imagery) often helps to obtain an appropriate level of activation, which can be detected by monitoring Skin Conductance Level (SCL). However, different types of imagery could elicit different amount of physiological arousal. Therefore, this study aims: (1) to investigate differences in SCL associated with two instructional...
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A pilot study with flow mediated skin fluorescence: A novel device to assess microvascular endothelial function in coronary artery disease
PublikacjaBackground: Endothelial dysfunction is one of the earliest vascular manifestations in the pathogenesis of cardiovascular disease. Noninvasive, simple and inexpensive methods of endothelial function assessment are therefore needed. Methods: Microvascular endothelial function was assessed in coronary artery disease (CAD) patients by flow mediated skin fluorescence (FMSF), based on measurements of NADH fluorescence intensity during...
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Piezoelectric Transducer for Mechanical Assessment of Soft Tissues. Concept, Implementation and Analysis
PublikacjaThe main goal of this work was following: preparation of a new concept, implementation and analysis of the piezoelectric resonant sensor/actuator for measuring the aging process of human skin. The research work has been carried out in the framework of cooperation between the INP-ENSEEIHT-LAPLACE, Toulouse, France, and at the Gdansk University of Technology, Faculty of Electrical and Control Engineering, Research Group of...
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Significance of Dermoscopy in Association with Clinical Features in Differentiation of Basal Cell Carcinoma and Benign Trichoblastic Tumours
PublikacjaBackground: Although basal cell carcinoma (BCC) can, in the majority of cases, be diagnosed based on clinical and dermoscopic assessment, a potential overlap with benign adnexal skin tumours seems to exist, including trichoblastic tumours (TT). Methods: Retrospective analysis of clinical and dermoscopic features of benign TT and BCC cases was performed to develop a diagnostic algorithm with a potential utility in clinical practice....
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Investigation on domestic fruits seed oils in personal care emulsion systems
PublikacjaThe use of fruit seed oils in personal care products is of significance to both their function and image. Poland is an important processor of fruit products within the EU, and thus has a large availability of seeds from domestic fruits, which are normally considered to be a waste material. Unfortunately, current literature is scarce of the suitability of these oils for topical use in the form of cosmetic emulsions. Published data...
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Dibutyl phthalate disrupts conserved circadian rhythm in Drosophila and human cells
PublikacjaPeople are constantly exposed to phthalates, due to their common use in the production of plastics, pharmaceuticals, cosmetics and skin care products. The ability of phthalates to disrupt endocrine signaling, leading to developmental, reproductive and metabolic defects, has been studied, yet how phthalates interfere with these biological functions is still unclear. To uncover DBP interacting molecular pathways, we raised Drosophila...
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A device for measuring heat flux on a rocket skin surface
PublikacjaA novel method for measuring heat flux on a surface is presented. It is an extensive upgrade of currently known heat flux sensors used mostly in civil engineering. As the thermal environment of launchers, especially sounding rocket can have an enormous negative effect on payload, careful considerations have to be taken in the process of preparing insulation. Usually, thermal data provided by the launch vehicle manufacturer is limited...
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Smart Materials in Architecture: Useful Tools with Practical Applications or Fascinating Inventions for Experimental Design?
PublikacjaFor at least several decades smart or so-called intelligent materials, being the result of great advancements in material engineering, appear in architecture in different applications. Most of them are called "smart" because of their inherent properties: a real-time response to environmental stimuli. There are also those considered to be "smart" due to smart design: their original structure or the composition of their materials...
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Genome-Wide DNA Methylation and Gene Expression in Patients with Indolent Systemic Mastocytosis
PublikacjaMastocytosis is a clinically heterogenous, usually acquired disease of the mast cells with a survival time that depends on the time of onset. It ranges from skin-limited to systemic disease, including indolent and more aggressive variants. The presence of the oncogenic KIT p. D816V gene somatic mutation is a crucial element in the pathogenesis. However, further epigenetic regulation may also affect the expression of genes that...
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Direct design of Controlled Modulus Columns (CMC) based on in-situ testing
PublikacjaIn this paper, the serviceability limit state and bearing capacity of tension screw displacement piles were analyzed using the results of static pile load tests, carried out on the test plot near the Elbląg city, and field, and laboratory tests. The paper presents the methodology of determining the pile load-settlement curve using different types of t-z transfer functions. The new method of constructing the pile load-settlement...