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Antiproliferative, Antiangiogenic, and Antimetastatic Therapy Response by Mangiferin in a Syngeneic Immunocompetent Colorectal Cancer Mouse Model Involves Changes in Mitochondrial Energy Metabolism
PublikacjaIn spite of the current advances and achievements in cancer treatments, colorectal cancer (CRC) persists as one of the most prevalent and deadly tumor types in both men and women worldwide. Drug resistance, adverse side effects and high rate of angiogenesis, metastasis and tumor relapse remain one of the greatest challenges in long-term management of CRC and urges need for new leads of anticancer drugs. We demonstrate that CRC...
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Modelowanie i symulacja ruchu pojazdu zabytkowego podczas hamowania
PublikacjaOpracowano model samochodu zabytkowego z wykorzystaniem metody masa-sprężyna, służącego do symulacji procesu hamowania pojazdu zabytkowego z możliwością pomiaru drogi hamowania. Konfiguracja sieci połączeń między punktami mas elementów zawieszenia oraz opony okazuje się mieć bardzo duży wpływ na zachowanie symulowanego samochodu podczas hamowania. Poprawność symulacji sprawdzono porównując wyniki uzyskane z symulacji oraz z pomiarów...
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Modelowanie losowych imperfekcji geometrycznych przestrzennych konstrukcji metalowych
PublikacjaImperfekcje geometryczne zbiorników, silosów i powłok siatkowych mogą znaczą-co wpłynąć na ich nośność, a więc powinny być one uwzględniane w obliczeniach komputerowych i w procesie projektowania. Wykazano, że przy podstawowych obcią-żeniach, działających na tego typu konstrukcje, tj. podciśnieniu oraz naporu wiatru i śniegu (w przypadku powłok siatkowych), wykazują wyraźne różnice w porównaniu z analogicznymi wynikami dla tych...
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Ab-initio study of electrical and optical properties of allylamine
PublikacjaThe Density functional theory is one of most promising methodology in fast and accurate calculations of electrical and optical properties from the atomic basis. In this paper, we calculate electrical and optical properties of allylamine (2-propen 1- amine) in terms of accuracy and speed of calculations obtained by selection of DFT-1/2 method with ultrasoft Vanderbilt pseudopotentials. Comparison of density of states between...
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Testing the Diagnostic Utility of Recombinant Toxoplasma Gondii Chimeric Antigens – Generated Datasets
PublikacjaThe datasets titled Toxoplasma gondii recombinant chimeric antigens – IgM and IgG ELISAs – mouse serum samples and Toxoplasma gondii recombinant chimeric antigens – IgG and IgM ELISAs – human serum samples contain absorbance measurements obtained during serological tests using mouse and human sera in enzyme-linked immunosorbent assay (ELISA) tests based on recombinant chimeric antigens. The datasets allows a comparison of absorbance...
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A Review on Deactivation and Regeneration of Catalysts for Dimethyl Ether Synthesis
Publikacjahe deactivation of catalysts and their regeneration are two very important challenges that need to be addressed for many industrial processes. The most quoted reasons for the deterioration of dimethyl ether synthesis (DME) concern the sintering and the hydrothermal leaching of copper particles, their migration to acid sites, the partial formation of copper and zinc hydroxycarbonates, the formation of carbon deposits, and surface...
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Electron energy-loss spectroscopy of excited states of the diazine molecules: Pyridazine
PublikacjaExcitation of the valence electronic states of the pyridazine molecules in the gas phase have been studied using the technique of electron energy-loss spectroscopy. Varying the electron scattering conditions, the residual electron energy and scattering angle, enabled the optically-allowed and -forbidden excitations to be differentiated. The measured energy-loss spectra enabled the vertical excitation energies of the observed states...
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Qualitative evaluation of distributed clinical systems supporting research teams working on large-scale data
PublikacjaInthispaper,fivecontemporaryscalablesystemstosupportmedicalresearchteams are presented. Their functionalities extend from heterogeneous unstructured data acquisition through large-scale data storing, to on-the-fly analyzing by using robust methods. Such kinds of systems can be useful in the development of new medical procedures and recommendation rules for decision support systems. A short description of each of them is provided....
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Multidisciplinary Open System Transferring Knowledge for R2B Development
PublikacjaDespite many efforts, there is still a serious problem in transferring knowledge from research to business. The problem is especially visible in Poland – the cooperation of R2B is ineffective. We are trying to solve this problem using some IT support. The manuscript presents some solutions developed at the Gdańsk University of Technology. In particular, the platform called “MOST Knowledge” is deeply described. Its layer architecture,...
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Jahn-Teller and related conical intersections in the benzene radical cation and the monofluoro derivate
PublikacjaThe multi-state multi-mode vibronic interactions in the benzene radical cation and its monofluoro derivative have been investigated theoretically, based on high-level electronic structure calculations for the system parameters and a quantum treatment of the nuclear motion. The available experimental data are well reproduced. The interplay of different vibronic coupling mechanisms is pointed out leading to multiple nonadiabatic...
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Comparative analysis of balancing of V6 engines with common- and split-pin crankshafts
PublikacjaAn analysis of balancing of V6 engines equipped with split-pin crankshafts with any cylinder bank angle based on the mathematical relations derived in the paper was carried out. A comparison of the quality of their balancing with engines equipped with common-pin crankshafts was also carried out. The bank angle ranges beneficial for balancing of moments of inertia forces in reciprocating motion were determined. A mathematical relation...
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Ab-initio study of electrical and optical properties of allylamine
PublikacjaThe Density functional theory is one of most promising methodology in fast and accurate calculations of electrical and optical properties from the atomic basis. In this paper, we calculate electrical and optical properties of allylamine (2-propen 1- amine) in terms of accuracy and speed of calculations obtained by selection of DFT-1/2 method with ultrasoft Vanderbilt pseudopotentials. Comparison of density of states between molecule...
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New sample preparation strategies for comprehensive lipidomics of human breast milk
PublikacjaGLOBAL PROFILING ANALYSIS OF HUMAN BREAST MILK (HBM) LIPIDS IS HINDERED BY COMPLEX COMPOSITION OF HBM. THIS PROBLEM IS HUGE FROM ANALYTICAL POINT OF VIEW, SINCE DUE TO THAT DETECTION OF ALL HBM LIPIDS DURING ONE ANALYTICAL RUN IS LIMITED. THUS, SAMPLE PREPARATION STEP CONSTITUTES A CRUCIAL STEP IN UNTARGETED LIPIDOMIC ANALYSIS OF HBM, ESPECIALLY WHEN SEMI-QUANTITATIVE ANALYSIS IS ASSUMED. HEREIN, WE PRESENT A COMPARISON OF PUBLISHED...
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A Stand for Measurement and Prediction of Scattering Properties of Diffusers
PublikacjaIn this paper we present a set of solutions which may be used for prototyping and simulation of acoustic scattering devices. A system proposed is capable of measuring sound field. Also a way to use an open source solution for simulation of scattering phenomena occurring in proximity of acoustic diffusers is shown. The result of our work are measurement procedure and a prototype of the simulation script based on FEniCS - an open source...
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Handwritten signature verification system employing wireless biometric pen
PublikacjaThe handwritten signature verification system being a part of the developed multimodal biometric banking stand is presented. The hardware component of the solution is described with a focus on the signature acquisition and on verification procedures. The signature is acquired employing an accelerometer and a gyroscope built-in the biometric pen plus pressure sensors for the assessment of the proper pen grip and then the signature...
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3D Acoustic Field Intensity Probe Design and Measurements
PublikacjaThe aim of this paper is two-fold. First, some basic notions on acoustic field intensity and its measurement are shortly recalled. Then, the equipment and the measurement procedure used in the sound intensity in the performed research study are described. The second goal is to present details of the design of the engineered 3D intensity probe, as well as the algorithms developed and applied for that purpose. Results of the intensity...
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An Approach to Mean Path Loss Model Estimation for Off-Body Channels
PublikacjaThis paper presents an approach to estimation of the mean path loss model parameters in off-body Body Area Networks channels. In this approach, the path loss exponent is constrained to a value obtained for the line-of-sight (LoS) propagation in the co-polarised channel, considering a generalised static scenario. The comparison of the goodness of fit between the proposed approach and other approaches, for a set of measurements obtained...
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Reliable method of assessing fracture properties of asymmetric bonded joints
PublikacjaTwo methods of assessing fracture properties of adhesive joints were studied. Two wedge tests: with continuous deflection and with force measurements were compared. Asymmetric geometry of the bonded joint was considered, i.e. two different plates of aluminium alloys: Al-Cu and Al-Mg, were bonded with epoxy DGEBA adhesive. The analytical model is shown to estimate the values of fracture properties: crack position and critical fracture...
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Investigation of the aerodynamics of an innovative verticalaxis wind turbine
PublikacjaThis paper presents a preliminary three dimensional analysis of the transient aerodynamic phenomena occurring in the innovative modification of classic Savonius wind turbine. An attempt to explain the increased efficiency of the innovative design in comparison with the traditional solution is undertaken. Several vorticity measures such as enstrophy, absolute helicity and the integral of the velocity gradient tensor second invariant...
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Titania nanotubes infiltrated with conducting polymer PEDOT modified by Prussian Blue – a novel type of organic-inorganic heterojunction characterised with enhanced photoactivity.
PublikacjaA highly ordered p–n heterojunction was formed based on titania nanotubes containing a conducting polymer with Prussian blue matrix. The study demonstrates, for the first time, cases when a composite based on titania array scaffolding and Prussian blue embedded in PEDOT exhibits reversible FeII/FeIII redox activity. Highly enhanced photoactivity and capacitance of the obtained material are depicted in comparison to pristine titania....