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Using bioanalysis for cancer diagnosis and prognosis
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Neural network breast cancer relapse time prognosis
PublikacjaPrzedstawiono architekturę i wyniki testowania sztucznej sieci neuronowej w prognozowaniu czasu nawrotu choroby u kobiet chorych na raka piersi. Sieć neuronowa uczona była na danych zgromadzonych przez 20 lat. Dane opisują grupę 439 pacjentów za pomocą 40 parametrów. Spośród tych parametrów wybrano 6 najistotniejszych: liczbę przerzutowych węzłów chłonnych, wielkość guza, wiek, skalę według Blooma oraz stan receptorów estrogenowych...
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Survival time prognosis under a Markov model of cancer development
PublikacjaIn this study we look at a breast cancer data set of women from Pomerania region collected in year 1987-1992 in the Medical University of Gdańsk. We analyze the clinical risk factors in conjunction with Markov model of cancer development. We evaluate Artificial Neural Network (ANN) survival time prediction via a simulation study.
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CD73 Expression as a Potential Marker of Good Prognosis in Breast Carcinoma
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An inherited NBN mutation is associated with poor prognosis prostate cancer
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Probabilistic prognosis of cliffslide along Baltic Sea coast in Poland.
PublikacjaAnaliza stateczności wybrzeży klifowych metodą probabilistyczną. Określnie stref zagrożonych utratą stateczności.
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Tocilizumab Improves the Prognosis of COVID-19 in Patients with High IL-6
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Tocilizumab Improves the Prognosis of COVID-19 in Patients with High IL-6
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Urothelial bladder carcinoma in young patients is characterized by a relatively good prognosis
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Primary splenic angiosarcoma: a very rare and aggressive neoplasm with a poor prognosis
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Ezrin--a useful factor in the prognosis of nephrotic syndrome in children: an immunohistochemical approach
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The impact of the Polish mass breast cancer screening program on prognosis in the Pomeranian Province
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Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: a WSES observational study
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The impact of cytogenetic evolution and acquisition of del(17p) on the prognosis of multiple myeloma patients
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Ischemic stroke in general practice - risk factors, prognosis - prospective single center study
PublikacjaBackground. Ischemic stroke is one of the leading causes of death and disability in Poland, in the European Union and in the United States. Awareness related to the risk factors, particularly the modifiable ones, is of crucial importance in general practice and may improve early and long-term prognoses. Objectives. The aim of this study was to assess the risk factors and half-year survival rate in patients with ischemic stroke...
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Metabolomics in Atrial Fibrillation: Unlocking Novel Biomarkers and Pathways for Diagnosis, Prognosis, and Personalized Treatment
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The significance of VEGF-C/VEGFR-2 interaction in the neovascularization and prognosis of nephroblastoma (Wilms' tumour)
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A potency of plasminogen activation system in long-term prognosis of endometrial cancer: a pilot study
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Prognosis after acute coronary syndrome in relation with ventricular–arterial coupling and left ventricular strain
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Administration of tocilizumab to patients with high concentrations of IL-6 in the course of COVID-19 is associated with a better prognosis
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Cytokeratin 8 in venous grafts: A factor of unfavorable long-term prognosis in coronary artery bypass grafting patients
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Keratin 7 expression in lymph node metastases but not in the primary tumour correlates with distant metastases and poor prognosis in colon carcinoma
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Expression of stem cell and mesenchymal markers in circulating tumor cells is associated with poor prognosis of early breast cancer patients
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Euthyroid sick syndrome as a prognostic indicator of COVID-19 pulmonary involvement, associated with poorer disease prognosis and increased mortality
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Gemcitabine-Based Treatment in Poor Prognosis Patients with Relapsed and Refractory Hodgkin Lymphoma and Non-Hodgkin Lymphoma – a Multicenter Polish Experience
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Caveolin 2: a facultative marker of unfavourable prognosis in long-term patency rate of internal thoracic artery grafts used in coronary artery bypass grafting. Preliminary report
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Badanie rozkładów parametrów sygnału mowy w zastosowaniach do prognozowania prawdopodobieństwa popełnienia błędów w systemach identyfikacji mówców = Examining distribution of speech signal parameters for the prognosis of error probability in speaker verification systems
PublikacjaPrzedmiotem pracy jest system identyfikacji mówców w sposób zależny od tekstu ("text dependent''). Dokonano analizy wielu różnych wypowiedzi kilkudziesięciu mówców. Zastosowana metoda parametryzacji to metoda oparta na wynikach analizy cepstralnej sygnału mowy. Zdefiniowane zostały nowe parametry skojarzone z elementarnymi zdarzeniami w procesie weryfikacji mówców. Na tej podstawie dokonano estymacji funkcji gęstości prawdopodobieństwa...
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Modelling processes for Polish civil aviation market
PublikacjaThe present , paper is the first step in research of Polish civil aviation market, focusing on the area of civil, legacy airlines. First, the market is described with its players, current conditions and its main problems. Next, the tools which are currently used for the prognosis processes are presented. Finally, the idea of a new model (fuzzy model) for the process of prognosis is presented.
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Result of the 6-min walk test is an independent prognostic factor of surgically treated non-small-cell lung cancer
PublikacjaPathological tumour, node and metastasis (TNM) stage remains the most significant prognostic factor of non-small-cell lung cancer (NSCLC). Meanwhile, age, gender, pulmonary function tests, the extent of surgical resection and the presence of concomitant diseases are commonly used to complete the prognostic profile of the patient with early stage of NSCLC. The aim of this study is to assess how the result of a 6-min walk test (6MWT)...
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Geo-engineering computer simulation seems attractive but is it the real world?
PublikacjaCorrect formulation of the differential equation system for equilibriom conditions of subsoil, especially in terms of controlled numerical calculation, is discussed. The problem of solution stability is also considered. The solution of problems, which are ill-posed, have no practical value in the majority of cases and is this way the engineering prognosis can lead to real disaster. The object of this paper is quite relevant if...
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TOWARD A FUZZY MODEL OF POLISH INTERNET MORTGAGE MARKET
PublikacjaThis article presents our continuing efforts to develop a model of the Internet-based mortgage market in Poland. It sums up modeling research done over the last 4 years, also showing the stages and the process of building and verifying the proposed model consisting of three submodels. The submodels are described for three market situations; that is, a stable market, financial crisis, and economic boom. The proposed model variables...
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THE CASE OF MANAGEMENT CONCEPTS IN CIVIL AVIATION BUSINESS.
PublikacjaThe article presents the changes in management concepts used in civil aviation business in last 25 years. There is a need to make prognosis and support decision-making processes with different models but each model is adapted to current management concept. This article will present the changes and possible future trends in management concepts with the description of strengths and weaknesses of each of them. These might be used...
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Wavelet transform analysis reveals differences between patients with impaired LVEF and healthy individuals
PublikacjaHeart failure (HF) is a global pandemic. It af- fects 64 million people worldwide, with stead- ily increasing incidence, morbidity, mortality, and economic burden [1]. Forecasts indicate continued rising prevalence, especially among the elderly and in low-to-middle socio-de- mographic index regions [2]. Left ventricular ejection fraction (LVEF) significantly impacts HF treatment and prognosis [3]. The sequence of physiological...
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Extended Reflexive Ontologies for the Generation of Clinical Recommendations
PublikacjaDecision recommendations are a set of alternative options for clinical decisions (e.g., diagnosis, prognosis, treatment selection, follow-up, and prevention) that are provided to decision makers by knowledge-based Clinical Decision Support Systems (k-CDSS) as aids. We propose to follow a ‘‘reasoning over domain’’ approach for the generation of decision recommendations by gathering and inferring conclusions from production rules....
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Identification of ship’s hull mathematical model with numerical methods
PublikacjaThe modern maritime industry is moving toward the development of technology that will allow for full or partial autonomy of ship operation. This innovation places high demands on ship performance prediction techniques at the design stage. The researchwork presented in the article is related to the design stage of the ship and concerns methods for prognosis and evaluation of the specific operational condition of the ship, namely...
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COVID-19 severity forecast based on machine learning and complete blood count data
PublikacjaProper triage of COVID-19 patients is a key factor in eective case management, especially with limited and insucient resources. In this paper, we propose a machine-aided diagnostic system to predict how badly a patient with COVID-19 will develop disease. The prognosis of this type is based on the parameters of commonly used complete blood count tests, which makes it possible to obtain data from a wide range of patients.We chose...
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COVID-19 severity forecast based on machine learning and complete blood count data
PublikacjaProper triage of COVID-19 patients is a key factor in eective case management, especially with limited and insucient resources. In this paper, we propose a machine-aided diagnostic system to predict how badly a patient with COVID-19 will develop disease. The prognosis of this type is based on the parameters of commonly used complete blood count tests, which makes it possible to obtain data from a wide range of patients.We chose...
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Immune escape of B-cell lymphoblastic leukemic cells through a lineage switch to acute myeloid leukemia
PublikacjaAcute leukemia (AL) with a lineage switch (LS) is associated with poor prognosis. The predisposing factors of LS are unknown, apart from KMT2A rearrangements that have been reported to be associated with LS. Herein, we present two cases and review all 104 published cases to identify risk factors for LS. Most of the patients (75.5%) experienced a switch from the lymphoid phenotype to the myeloid phenotype. Eighteen patients (17.0%)...
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Human subarachnoid space width oscillations in the resting state
PublikacjaAbnormal cerebrospinal fluid (CSF) pulsatility has been implicated in patients suffering from various diseases, including multiple sclerosis and hypertension. CSF pulsatility results in subarachnoid space (SAS) width changes, which can be measured with near-infrared transillumination backscattering sounding (NIR-T/BSS). The aim of this study was to combine NIR-T/BSS and wavelet analysis methods to characterise the dynamics of the...
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Pathogenesis of psoriasis in the “omic” era. Part III. Metabolic disorders, metabolomics, nutrigenomics in psoriasis
PublikacjaPsoriasis is a systemic disease that is strictly connected with metabolic disorders (insulin resistance, atherogenic dyslipidemia, arterial hypertension, and cardiovascular diseases). It occurs more often in patients with a more severe course of the disease. Obesity is specially an independent risk factor and it is associated with a worse treatment outcome because of the high inflammatory activity of visceral fatty tissue and...
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Pathogenesis of psoriasis in the “omic” era. Part II. Genetic, genomic and epigenetic changes in psoriasis
PublikacjaPsoriasis is a multifactorial disease in which genetic, environmental and epigenetic factors regulating gene expression play a key role. In the “genomic era”, genome-wide association studies together with target genotyping platforms performed in different ethnic populations have found more than 50 genetic susceptible markers associated with the risk of psoriasis which have been identified so far. Up till now, the strongest association...
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Comparison of near infrared spectroscopy (NIRS) and near-infrared transillumination-backscattering sounding (NIR-T/BSS) methods
PublikacjaThe aim of the study was to compare simultaneously recorded a NIR-T/BSS and NIRS signals from healthy volunteers. NIR-T/BSS is a device which give an ability to non-invasively detect and monitor changes in the subarachnoid space width (SAS). Experiments were performed on a group of 30 healthy volunteers (28 males and 2 females, age 30.8 ± 13.4 years, BMI = 24.5 ± 2.3 kg/m2). We analysed recorded signals using analysis methods based...
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Climate change impact on groundwater resources in sandbar aquifers in southern Baltic coast
PublikacjaShallow coastal aquifers are vulnerable hydrosystems controlled by many factors, related to climate, seawater‑freshwater interactions and human activity. Given on‑going climate change, sea level rise and increasing human impact, it is especially true for groundwater resources situated in sandbars. We developed numerical models of unsaturated zone water flow for two sandbars in northern Poland: the Vistula Spit and the Hel Spit...
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Results from a Genome-Wide Association Study (GWAS) in Mastocytosis Reveal New Gene Polymorphisms Associated with WHO Subgroups
PublikacjaMastocytosis is rare disease in which genetic predisposition is not fully understood. The aim of this study was to analyze associations between mastocytosis and single nucleotide polymorphisms (SNPs) by a genome-wide association study (GWAS) approach. A total of 234 patients were enrolled in our study, including 141 with cutaneous mastocytosis (CM; 78 children and 63 adults) and 93 with systemic mastocytosis (SM, all adults)....
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Management of Complex Root Fractures in Young Patients—Case Series and a Literature Review
PublikacjaRoot fractures are defined as injuries involving dentine, cementum, and the pulp. They are rare, and they account for 0.5–7% of the dental injuries in the permanent teeth. Root fractures may be the result of direct trauma to the teeth or indirect trauma to the oral cavity. Their incidence is highest in the group of adolescent patients aged 11 to 20 years. The purpose of the paper is to review the literature supported by a case...
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Naturally-derived hydrogels for 3D pancreatic tumor models: A short review
PublikacjaStatistics suggest a high proportion of mortality rate by pancreatic cancer, which is a solid tumor characterized by high heterogeneity and the presence of a complex extracellular matrix. The very low effectiveness of pancreatic cancer treatment roots in the high metastatic potential and drug resistance of this tumor. Therefore, the quest for efficient cellular models enabling precise mimicking in vivo conditions, and anticancer...
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Detection of circulating tumor cells by means of machine learning using Smart-Seq2 sequencing
PublikacjaCirculating tumor cells (CTCs) are tumor cells that separate from the solid tumor and enter the bloodstream, which can cause metastasis. Detection and enumeration of CTCs show promising potential as a predictor for prognosis in cancer patients. Furthermore, single-cells sequencing is a technique that provides genetic information from individual cells and allows to classify them precisely and reliably. Sequencing data typically...
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Technical and Economic Analysis of the Implementation of Selected Variants of Road Investment
PublikacjaThe aim of the article is to analyze three variants of modernization and reconstruction of a road intersection, which in practice is the cause of numerous collisions and accidents. Detailed design solutions are presented for them. The aim of the analyses is to indicate an effective solution that, taking into account technical modifications of the road system elements, will ensure the functionality of the road system to the highest...
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Catheter-induced coronary artery and aortic dissections. A study of the mechanisms, risk factors, and propagation causes
PublikacjaBackground: Only the incidence, management, and prognosis of catheter-induced coronary artery and aortic dissections have been systematically studied until now. We sought to evaluate their mechanisms, risk factors, and propagation causes. Methods: Electronic databases containing 76,104 procedures and complication registries from 2000– –2020 were searched and relevant cineangiographic studies adjudicated. Results: Ninety-six dissections...
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Antitumor 1-nitroacridine derivative C-1748 induces significant apoptosis in pancreatic cancer cells.
PublikacjaPancreatic cancer is the fifth leading cause of cancer death and has the lowest survival rate of any solid cancer in the industrial countries. The poor prognosis of pancreatic cancer results from its tendency for late presentation, aggressive invasion, early metastasis, and resistance to chemotherapy. Gemcitabine still remains the best chemotherapeutic agent available for the treatment of advanced pancreatic cancer. However, gemcitabine...