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Wyniki wyszukiwania dla: PHARMACOLOGICAL REGENERATION
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Discovery of small-molecule regenerative drugs using a model of complex tissue injury in mice. Transcriptomic responses of neurodevelopmental genes during pharmacologically induced regeneration
PublikacjaDespite significant development in regenerative medicine, there is a deficit of effective therapies for wound healing and tissue regeneration. Research performed using animal wound models allows for a better understanding of this complex process, searching for compounds with pro-regenerative properties, and assessing their efficacy and safety. Unfortunately, the lack of adequate preclinical models proves to be an issue as no animal...
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New possible pharmacological targets for statins and ezetimibe
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Nocturnal Enuresis: A Synopsis of Behavioral and Pharmacological Management
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Potentilla—A review of its phytochemical and pharmacological profile
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Competence of Polish primary‐care doctors in the pharmacological treatment of hypertension
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Ficus plants: State of the art from a phytochemical, pharmacological, and toxicological perspective
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Structural and Pharmacological Characterization of Phenylalanine-Based AMPA Receptor Antagonists at Kainate Receptors
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Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases
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Insight into heart regeneration
PublikacjaThe mammalian heart is thought to be incapable of regeneration because of the limited ability of cardiomyocytes. to proliferate. However, it has been recently shown that the neonatal murine heart is able to restore its normal function after coronary artery ligation or even partial resection. Unfortunately, this feature is lost in a few days after birth, although lower vertebrates as zebrafish or newt, retain this ability until adulthood. Therefore,...
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The role of epigenetics in regeneration
PublikacjaComplex changes in chromatin structure and at the transcriptional level occur from the creation of a single parental gamete throughout fertilization, embryo development and the life of an adult organism. Epigenetic changes, such as methylation and hydroxymethylation of DNA or histone methylation and acetylation, are an important part of these processes. Epigenetic regulation has an essential influence on gene expression level. DNA...
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Synthesis, Pharmacological Evaluation, and Computational Studies of Cyclic Opioid Peptidomimetics Containing β3-Lysine
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Pharmacological Profile and Molecular Modeling of Cyclic Opioid Analogues Incorporating Various Phenylalanine Derivatives
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New Insights into Dietary Supplements Used in Sport: Active Substances, Pharmacological and Side Effects
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Non-Pharmacological Treatments for Insulin Resistance: Effective Intervention of Plant-Based Diets—A Critical Review
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Efficacy of the Whole-Body Cryotherapy as Add-on Therapy to Pharmacological Treatment of Depression—A Randomized Controlled Trial
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Desert Endemic Plants in Algeria: A Review on Traditional Uses, Phytochemistry, Polyphenolic Compounds and Pharmacological Activities
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Imidazoacridinone-dependent lysosomal photodestruction: a pharmacological Trojan horse approach to eradicate multidrug-resistant cancers
PublikacjaMultidrug resistance (MDR) remains a primary hindrance to curative cancer therapy. Thus, introduction of novel strategies to overcome MDR is of paramount therapeutic significance. Sequestration of chemotherapeutics in lysosomes is an established mechanism of drug resistance. Here, we show that MDR cells display a marked increase in lysosome number. We further demonstrate that imidazoacridinones (IAs), which are cytotoxic fluorochromes,...
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Polydopamine Biomaterials for Skin Regeneration
PublikacjaDesigning biomaterials capable of biomimicking wound healing and skin regeneration has been receiving increasing attention recently. Some biopolymers behave similarly to the extracellular matrix (ECM), supporting biointerfacial adhesion and intrinsic cellular interactions. Polydopamine (PDA) is a natural bioadhesive and bioactive polymer that endows high chemical versatility, making it an exciting candidate for a wide range of...
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Identity and authenticity in urban regeneration
PublikacjaArtykuł dotyczy zagadnienia relacji pomiędzy kwestiami ochrony autentyzmu a budowy jego tożsamości w programach rewitalizacji urbanistycznej.
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Pharmacological characterization and binding modes of novel racemic and optically active phenylalanine-based antagonists of AMPA receptors
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Cross-talk between DNA damage and cell survival checkpoints during G2 and mitosis: pharmacological implications
PublikacjaW pracy wyjaśnialiśmy rolę surwiwiny w ochronie komórek w czasie przejścia między G2 i mitozą, traktowanych związkiem uszkadzającym DNA. Jako model komórkowy wybraliśmy komórki ludzkiej białaczki MOLT-4, które wykazują zwiększoną ekspresję białka surwiwiny i niefunkcjonalnym p53. Ekspozycja tych komórek na melfalan, klasyczny związek uszkadzający DNA, prowadzi do uruchomienia punktu kontrolnego w G2 i zablokowania progresji cyklu...
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Urban Waterfront Regeneration: Origins of the Issue
PublikacjaThis paper deals with the origins of the issue of urban waterfront regeneration. The process of city-water interface was described with references to the three generations of port structures.
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Challenges of Cogeneration
PublikacjaPrzedstawiono problemy skojarzonego wytwarzania ciepła i energii elektrycznej w Polsce. Omówiono układy technologiczne i problemy sprawności wytwarzania skojarzonego. podano przykłady problemów, które powinny być rozwiązane w nowych warunkach ekonomicznych zarówno w dziedzinie optymalizacji ekonomicznej jak i technologicznej.
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Neutrophil proteinase 3 and dipeptidyl peptidase I (cathepsin C) as pharmacological targets in granulomatosis with polyangiitis (Wegener granulomatosis)
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Editorial: Food/Diet Supplements From Natural Sources: Current Status and Future Challenges From a Pharmacological Perspective
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From Regenerative Buildings to Regenerative Urban Projects: Design frameworks to scale up within the area of regenerative practice
PublikacjaIn this chapter, a discussion will be presented of design frameworks and assessment tools that are useful for boosting the scale jumping of regenerative design practices and the paradigm shift. Our main objectives will be to identify existing design and assessment frameworks, to describe the way they work and how they can contribute to scale-jumping regenerative design, as well as to identify shortcomings and opportunities. We...
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Market Regeneration in Line with Sustainable Urban Development
PublikacjaThis article presents the study of the optimal design solutions for regeneration of marketplaces. It examines the design variants for the revitalisation of the marketplace, in particular, investment in their modernisation in order to find the most optimal model for transforming these public spaces to have a significant impact on the city’s development. The research is a comparative analysis of the implementation of regeneration...
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Sources of investment risk in urban regeneration projects
PublikacjaThe scope of the article includes multidimensional risk analysis of urban regeneration projects, whose base is to identify areas of its occurrence. Authors thoroughly analyze the sources of potential threats and attempts to answer the question, what is their contribution into overall urban regeneration’ investment risk. The target concept will be used to assess the level of investment risk at the stage of initiation, preparation...
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Places of worship, spiritual healing and urban regeneration
PublikacjaMany researchers demonstrated that it is possible to help people achieve mental and physical regeneration with proper architecture, urban and landscape planning. The term therapeutic landscapes could also be applied to places of worship, where people gather for spiritual healing and renewal. Public space that they offer is inclusively open to all. Addition- ally, they serve to reinvigorate the places where they are located. Shrines...
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Urban development and regeneration in Poland - contemporary issues
PublikacjaArtykuł obejmuje skrótowe omówienie współczesnych procesów rozwoju i rewitalizacji miast w Polsce. Zaprezentowano w nim zarówno procesy planowe jak i zachodzące spontanicznie, a także typologie obszarów poddawanym współczesnym procesom przekształceń
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Definition of urban regeneration projects in Russian cities
PublikacjaUrban regeneration is extremely important process for Russian cities, which faced to the challenges of post-industrial economy. In an attempt, to explain needs of urban regeneration in Russian megacities author analyzed the social and economic trends and some historic features of Russian cities development. The article identified the key areas for regeneration such as the regeneration of historic core, the regeneration of the urban...
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Pharmacological treatment of a depressive episode and recurrent depressive disorder – guidelines of the Polish Psychiatric Association and the National Consultant for Adult Psychiatry
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Recent phytochemical and pharmacological advances in the genus Potentilla L. sensu lato – An update covering the period from 2009 to 2020
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Epigenetic inhibitor zebularine activates ear pinna wound closure in the mouse
PublikacjaBackground:Most studies on regenerative medicine focus on cell-based therapies and transplantations.Small-molecule therapeutics, though proved effective in different medical conditions, have not been extensivelyinvestigated in regenerative research. It is known that healing potential decreases with development and devel-opmental changes are driven by epigenetic mechanisms, which suggests epigenetic repression of regenerativecapacity.Methods:We...
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Ultrasound assisted rapid synthesis of mefenamic acid based indole derivatives under ligand free Cu-catalysis: Their pharmacological evaluation
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Glucosylceramide Mimics: Highly Potent GCase Inhibitors and Selective Pharmacological Chaperones for Mutations Associated with Types 1 and 2 Gaucher Disease
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Pharmacological Classification and Activity Evaluation of Furan and Thiophene Amide Derivatives Applying Semi-Empirical ab initio Molecular Modeling Methods
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Studies on the orientation effect of crystallites and its application to cocrystal screening of selected pharmacologically active compounds
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Polylysine for Skin Regeneration: A Review of Recent Advances and Perspectives
PublikacjaThere have been several attempts to find promising biomaterials for skin regeneration, among which polylysine (a homopolypeptide) has shown benefits in the regeneration and treatment of skin disorders. This class of biomaterials has shown exceptional abilities due to their macromolecular structure. Polylysine-based biomaterials can not only be used as tissue engineering scaffolds for skin regeneration, but also as drug carriers...
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A Review on Deactivation and Regeneration of Catalysts for Dimethyl Ether Synthesis
Publikacjahe deactivation of catalysts and their regeneration are two very important challenges that need to be addressed for many industrial processes. The most quoted reasons for the deterioration of dimethyl ether synthesis (DME) concern the sintering and the hydrothermal leaching of copper particles, their migration to acid sites, the partial formation of copper and zinc hydroxycarbonates, the formation of carbon deposits, and surface...
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Comparative Analysis of Contemporary Regeneration of Waterfronts in Port Cities
PublikacjaThe paper includes comparative analysis of the selected waterfront case studies in cities around Europe and North America.
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Public Lighting in a Context of Regeneration Processes in Polish Cities
PublikacjaThe purpose of this paper is to reflect on the role of electric lighting design in urban regeneration processes. The landscape of the modern city is the result of an accumulation of the various physical, economic, social and cultural layers over the centuries. Urban lighting may be described as one of the physical layers which due recent developments in the technology of efficient light sources overcomes a major evolution. With...
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ANALYSIS OF THE INCREASE OF CONSTRUCTION COSTS IN URBAN REGENERATION PROJECTS
PublikacjaThe subject of this paper is the analysis and evaluation of the reasons for construction costs increases in urban regeneration projects. The analysis considers major refurbishments of real estates’, as well as heavy repair and modernization of the road system. For the period mentioned, the costs from works and expenditure schedules were compared with the costs of additional works, which shows the percentage cost increase in relation...
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Regeneration of marine engine valves using laser surfacing
PublikacjaThis article presents an analysis of the applicability of laser surfacing of the exhaust valve face of a marine diesel engine using cobalt-based powder. After preparation by machining, the selected valves were subjected to laser surfacing using a high-power ROFIN DL020 laser. The EuTroLoy 16012 powder was used in the surfacing process. One of the valves was cut and subjected to metallographic examination and hardness measurements,...
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Intelligent artificial joint and regeneration problems in articular joints
PublikacjaPraca przedstawia zasady działania inteligentnych sztucznych stawów biodrowych człowieka oraz problemy regeneracji chrząstek stawowych w stawach naturalnych człowieka. Postuluje się wagę podjętych badań w powyższym problemie.Zwrócono uwagę na problemy związane ze sterowaniem własności sztucznych stawów biodrowych oraz z identyfikacją impulsów przekazywanych naturalnym połączeniom stawowym człowieka.
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Next Generation Digital
PublikacjaThe paper outlines the major objectives of the MENAID research project, eimed at novel architectures of digital documents. Such documents will enable reduction of information overflow and strain, a major threat to the growth of a digital society. They will be forward compatible, technology neutral and lightweight, allowing workers of network organizations to use personal devices of any type.
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Optimization of the geometry of the crankshaft for an internal combustion engine with heat regeneration
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Separation of effluents from regeneration of a cation exchanger by membrane distillation
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Wet H2S corrosion and degradation of pipeline in amine regeneration system
PublikacjaThe paper presents the results of NDT examinations, metallographic tests and risk assessment of degradation related to corrosion of amine regeneration unit in a desulphurisation system. Intensive corrosion resulting from acid gases environment upon water condensation causes perforation of the pipeline. Detailed analysis reveals cracking related to the mechanism of wet H2S. Hydrogen penetration, resulting from the wet H2S process,...
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Groundwater quality regeneration in the discharge zone of the Gdansk aquifer system
PublikacjaEksploatacja wód podziemnych w rejonie Gdańska prowadzona jest głównie w strefie drenażu wód na nizinach nadmorskich. Wieloletni, intensywny pobór spowodował niekorzystne zmiany w ich jakości, są one głównie związane z zasoleniem wód podziemnych intruzjami wód morskich. Sytuacja ta dotyczy zwłaszcza pietra czwartorzędowego. Spadek wilekości eksploatacji, który obserwuje się od lat 90. prowadzi poprawy jakości wód podziemnych, a...