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Wyniki wyszukiwania dla: REACTIVE METABOLITE
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Alterations in the metabolism of tryptophan in patients with chronic hepatitis C six months after pegylated interferon-α 2a treatment
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Inulin-type fructans trigger changes in iron concentration and activity of bone metabolism biomarkers in blood plasma of growing pigs
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Cytochrome P450 izoenzymes involved in metabolism of antitumor 9-amino-1-nitroacridine derivatives, C-857, C-1748
PublikacjaPraca jest częścią szerszych badań zmierzających do poznania molekularnego mechanizmu metabolicznej transformacji przeciwnowotworowych pochodnych 9-amino-1-nitroakrydyny. W naszym zespole wyselekcjonowano pochodną nowej generacji, która w porównaniu z poprzednimi wykazała znacznie obniżoną toksyczność ogólną. W wyniku przeprowadzonych badań wykazaliśmy, że nowa pochodna jest znacznie mniej podatna na metabolizm katalizowany przez...
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Drug-drug interaction potential of antitumor acridine agent C-1748: The substrate of UDP-glucuronosyltransferases 2B7, 2B17 and the inhibitor of 1A9 and 2B7
PublikacjaBackground The compound 9-(2′-hydroxyethylamino)-4-methyl-1-nitroacridine (C-1748), the promising antitumor agent developed in our laboratory was determined to undergo phase I metabolic pathways. The present studies aimed to know its biotransformation with phase II enzymes – UDP-glucuronosyltransferases (UGTs) and its potential to be engaged in drug-drug interactions arising from the modulation of UGT activity. Methods UGT-mediated...
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Analysis of carboxylic acid metabolites from the tricarboxylic acid cycle in Bacillus subtilis cell extract by capillary electrophoresis using an indirect photometric detection method
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Balancing energy consumption in limited power grid with active front-end and three phase dual active bridge system
PublikacjaPaper deals with simulation analysis of bidirectional power converters system for charging station of electric vehicle in condition of limited power source in city infrastructure. In case of incapability to provide additional power supply through the grid by virtue of historical, architectural and economic reasons it is possible to solve this issue by implementation of mobile battery-powered supply source. The proposed bidirectional...
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Journal of Biologically Active Products from Nature
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C-Reactive Protein and White Blood Cell Count in Non-Infective Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis
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Inverse Nonlinear Eigenvalue Problem Framework for the Synthesis of Coupled-Resonator Filters With Nonresonant Nodes and Arbitrary Frequency-Variant Reactive Couplings
PublikacjaA novel, general circuit-level description of coupledresonator microwave filters is introduced in this article. Unlike well-established coupling-matrix models based on frequency-invariant couplings or linear frequency-variant couplings (LFVCs), a model with arbitrary reactive frequencyvariant coupling (AFVC) networks is proposed. The engineered formulation is more general than prior-art ones—with the only restriction that the coupling...
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International Journal of Osteoporosis and Metabolic Disorders
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Clinical Immunology, Endocrine and Metabolic Drugs
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Current Opinion in Endocrine and Metabolic Research
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COMPARATIVE ANALYSIS OF ACTIVE GEODETIC NETWORKS IN POLAND
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Active monitoring as cognitive control of grinders design
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Optimization of active circuits for substrate noise suppression
PublikacjaZakłócenia generowane przez szybkie podukłady cyfrowe w mieszanych systemach analogowo-cyfrowych realizowanych na wspólnym podłożu stają się dużym problemem. W pracy zaproponowano metodę optymalizacji aktywnych układów tłumienia zakłóceń. Zilustrowano skuteczność działania metody na wybranym układzie i uzyskano ponad 9 dB poprawę tłumienia zakłóceń na częstotliwości 1GHz w porównaniu do znanych rozwiązań.
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A simple modular active power electronic transformer
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Baltic cyanobacteria – a source of biologically active compounds
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Photo-acoustic response of active biological systems
PublikacjaZbadano dwie próbki organiczne gatunku Trunculariopsis trunculus,jedną wilgotną, drugą - suchą. W obu przypadkach zaobserwowanointensywne szerokie pasma absorpcyjne w zakresie widzialnym (żółtymi poniżej 330 nm). Widma foto-akustyczne zawierają wszystkie pasma uznane za związane z aktywnością biologiczną.
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Implementation of Active Dynamic Thermography in medical diagnostics
PublikacjaW pracy przedstawiono wyniki badań wdrożeniowych Aktywnej Termografii Dynamicznej w diagnostyce wybranych chorób.
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Analysis of Properties of an Active Linear Gesture Sensor
PublikacjaBasic gesture sensors can play a significant role as input units in mobile smart devices. However, they have to handle a wide variety of gestures while preserving the advantages of basic sensors. In this paper a user-determined approach to the design of a sparse optical gesture sensor is proposed. The statistical research on a study group of individuals includes the measurement of user-related parameters like the speed of a performed...
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Research on Linear Actuators for Active Foil Bearings
PublikacjaActive foil bearings are a kind of gas foil bearing. They contain actuators which allow for modification of the bearing sleeve size and the shape of the lubrication gap. Rotor vibrations can be actively controlled by these changes. It is possible, among other things, to reduce the starting torque, control the vibration amplitude at different speeds and improve operational safety. Prototypes of active foil bearings are being developed...
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Active Suppression of Nonstationary Narrowband Acoustic Disturbances
PublikacjaIn this chapter, a new approach to active narrowband noise control is presented. Narrowband acoustic noise may be generated, among others, by rotating parts of electro-mechanical devices, such as motors, turbines, compressors, or fans. Active noise control involves the generation of “antinoise”, i.e., the generation of a sound that has the same amplitude, but the opposite phase, as the unwanted noise, which causes them to interfere...
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Comparison of active proximity radars for the wearable devices
PublikacjaTwo methods of object position and movement estimation in relation to the user of smart glasses were investigated. An active infrared and ultrasonic methods of the obstacle detection were presented and compared. Application of these methods depend on active transducers type (physical medium used), geometry and surface properties of detected objects and their movement direction and speed. In the article properties of both detectors...
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Comparative molecular modelling of biologically active sterols
PublikacjaMembrane sterols are targets for a clinically important antifungal agent – amphotericin B. The relatively specific antifungal action of the drug is based on a stronger interaction of amphotericin B with fungal ergosterol than with mammalian cholesterol. Conformational space occupied by six sterols has been defined using the molecular dynamics method to establish if the conformational features correspond to the preferential interaction...
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Modeling of active fiber Bragg grating sensors
PublikacjaW artykule omówiono działanie przetwornika hydrofonu wykorzystującego profilowaną membranę sprzężoną z aktywną światłowodową siatką Bragga. W wyniku modelowania, wykonanego Metodą Elementów Skończonych, stwierdzono występowanie gradientów naprężeń wzdłuż siatki. Opracowano program do modelowania pasywnych i aktywnych światłowodowych siatek Bragga wykorzystujący metodę modów sprzężonych. Przedstawiono charakterystyki widmowe pasywnych...
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Synthesis of parametric images in the medical active thermography
PublikacjaArtykuł przedstawia zastosowanie nowej metody syntezy obrazów w termografii dla potrzeb opisu ilościowego właściwości termicznych tkanek. opis taki umożliwia różnicowanie przypadków medycznych. Metodę zastosowania dla licznych pomiarów fantomowych oraz in vitro. Przedstawiono i omówiono rezultaty prac.
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A boost topology active power factor corrector.
PublikacjaPrzedstawiono układ analogowego aktywnego korektora zbudowanego na układzie scalonym kontrolera PWM oraz tranzystorem MOS jako okresowo przełączonym kluczem. Układ korektora zapewnia pobór prądu z sieci energetycznej w postaci przebiegu prawie sinusoidalnego o małych zniekształceniach i w fazie z sinusoidalnym napięciem sieci.
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CURRENT DRUG METABOLISM
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Glutathione-mediated conjugation of anticancer drugs: an overview of reaction mechanisms and biological significance for drug detoxification and bioactivation.
PublikacjaThe effectiveness of many anticancer drugs depends on the creation of specific metabolites that may alter their therapeutic or toxic properties. One significant route of biotransformation is a conjugation of electrophilic compounds with reduced glutathione, which can be non-enzymatic and/or catalyzed by glutathione-dependent enzymes. Glutathione usually combines with anticancer drugs and/or their metabolites to form more polar...
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PREVALENCE OF METABOLIC SYNDROME AMONG PATIENTS WITH SCHIZOPHRENIA FROM LONG CARE UNIT IN FORENSIC PSYCHIATRY PROGRAM: AN OBSERVATIONAL STUDY
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“Positive Regulation of RNA Metabolic Process” Ontology Group Highly Regulated in Porcine Oocytes Matured In Vitro: A Microarray Approach
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Metabolic Evaluation of Urine from Patients Diagnosed with High Grade (HG) Bladder Cancer by SPME-LC-MS Method
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Cross-linking of sodium caseinate-structured emulsion with transglutaminase alters postprandial metabolic and appetite responses in healthy young individuals
PublikacjaThe physico-chemical and interfacial properties of fat emulsions influence lipid digestion and may affect postprandial responses. The aim of the present study was to determine the effects of the modification of the interfacial layer of a fat emulsion by cross-linking on postprandial metabolic and appetite responses. A total of fifteen healthy individuals (26·5 (sem 6·9) years and BMI 21·9 (sem 2·0) kg/m2) participated in a cross-over...
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Harman and norharman, metabolites of the entomopathogenic fungus Conidiobolus coronatus (Entomophthorales), affect the serotonin levels and phagocytic activity of hemocytes, insect immunocompetent cells, in Galleria mellonella (Lepidoptera)
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Pyriculins A and B, two monosubstituted hex-4-ene-2,3-diols and other phytotoxic metabolites produced by Pyricularia grisea isolated from buffelgrass (Cenchrus ciliaris )
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Study of the Active Carbon from Used Coffee Grounds as the Active Material for a High-Temperature Stable Supercapacitor with Ionic-Liquid Electrolyte
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Fused FeCo catalysts for hydrogen production by means of the ammonia decomposition reaction
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Synthesis of antimicrobial silver nanoparticles through a photomediated reaction in an aqueous environment
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Reaction of thio and seleno phosphoric acid derivatives with O-thioacylated hydroxylamine
PublikacjaZbadano reakcję siarkowych i selenowych analogów kwasu O,O-neopentylidenofosforowego z O-tiopiwaloilo-N-tert-butylohydroksyloaminą, w której to następuje rozszczepienie wiązania N-O. Znaleziono korelację pomiędzy potencjałem utleniającym anionu pochodnej kwasu fosforowego a przebiegiem badanej reakcji.
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Theoretical description of fundamental-harmonic impedance of a two-step electrode reaction
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Relative product diversification in the course of economic development: import-export analysis.
PublikacjaThis paper contributes to trade diversification literature by comparing changes in relative (i.e. assessed in comparison with world patterns) heterogeneity of import and export structures in the process of economic development. In particular, by focusing on the diversification of imports, we add a missing piece to already analysed export trends. We use highly disaggregated trade statistics (4963 product lines) for 163 countries...
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Studies on the application of the Passerini reaction and enzymatic procedures to the synthesis of tripeptide mimetics
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Product diversification, relative specialisation and economic development: Import–export analysis
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Kinetic studies of complexation reaction of polyoxaalkyl phosphates with Fe(III) in ethanol
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Photocatalytic performance of titania nanospheres deposited on graphene in coumarin oxidation reaction
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Bilateral multi-issue negotiation of execution contexts by proactive document agents
PublikacjaA proactive document can react to its actual environment by autonomously selecting and performing actions integrated into its body and interact with its user. When migrating over a network of execution devices it may encounter diverse execution contexts, each one set up according to temporal characteristics of a receiving device and preferences of its owner. A concept to augment proactive documents with negotiation capability is...
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Market orientation and hotel performance: The mediating effect of creative marketing programs
PublikacjaThis work investigates the indirect effects between market orientation and hotel performance through creative marketing programs. The focus is on exploring the indirect effects between 1) customer orientation, competitor orientation, and cross-functional integration; and 2) hotel financial performance through two aspects of creative marketing programs, namely, novelty and meaningfulness. Through an empirical analysis using structural equation...
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Chiral Schiff base complexes as an effective catalyst in Diels-Alder reaction
PublikacjaDiels Alder reaction is a very important tool in carbon-carbon bond formation. It is a cycloaddition between a conjugated diene and a second compound called dienophile. Where one or more heteroatoms are present in the diene and/or dienophile framework, the cycloaddition is called hetero-Diels-Alder reaction (HDA). The asymmetric Diels-Alder reaction is among the most powerful available methodologies for that construction of optically...
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Non-Wave Variations in Temperature Caused by Sound in a Chemically Reacting Gas
PublikacjaA weakly nonlinear generation of non-acoustic modes in the field of sound in a gas is considered. An exotericchemical reaction of A->B type, which takes place in a gas, may be reversible or not. Two types of sound areconsidered, low-frequency and high-frequency as compared with the characteristic time of a chemical reaction.For both these cases, the governing equations of non-acoustic modes are derived and conclusions of the efficiencyof...
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Product diversification, relative specialisation and economic development: import-export analysis.
PublikacjaThis paper contributes to trade diversification literature by comparing changes in relative (i.e. assessed in comparison with world patterns) heterogeneity of import and export structures in the process of economic development. In particular, by focusing on the diversification of imports, we add a missing piece to already analysed export trends. We use highly disaggregated trade statistics (4963 product lines) for 163 countries...