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Wyniki wyszukiwania dla: antitumor agents
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ENHANCING SOCIAL CAPITAL DEVELOPMENT THROUGHOUT CULTURAL EVENTS. A CASE STUDY OF EASTERN POLAND
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Detection and localization of selected acoustic events in 3D acoustic field for smart surveillance applications
PublikacjaA method for automatic determination of position of chosen sound events such as speech signals and impulse sounds in 3-dimensional space is presented. The events are localized in the presence of sound reflections employing acoustic vector sensors. Human voice and impulsive sounds are detected using adaptive detectors based on modified peak-valley difference (PVD) parameter and sound pressure level. Localization based on signals...
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Calix[4]arenes appended with thioamide moieties as powerful tool for heavy metals recognition
PublikacjaSelectivity of new thioamide derivatives was assessed using those ligands as sensor materials in ion-selective membrane electrodes and tested towards Pb2+ - selectivity. The influence of the nature of the thioamide function (linear, branched or cyclic substituents) on their ionophoric properties was investigated. Electrodes based on cyclic thioamide moieties are promising analytical tools for monitoring Pb2+ concentration in natural...
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DZIAŁANIE AGENTÓW AUTONOMICZNYCH W SIECI TYPU ICN W OBECNOŚCI SYSTEMU REPUTACYJNEGO
PublikacjaCelem pracy jest przeprowadzenie symulacji sieci informacyjno-centrycznej (ICN) z agentami autonomicznymi. Architektura sieci została zmodyfikowana aby umożliwić kooperację pomiędzy agentami. Kooperacja ta przyjmuje formę porozumień nazwanych kontraktami – pojedynczy kontrakt zakłada iż dany agent będzie przetrzymywał w pamięci podręcznej daną treść przez określony czas. Do symulowanego środowiska wprowadzono agenty zachowujące...
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Monitorowanie procesu wytwarzania oprogramowania z wykorzystaniem hierarchii agentów typu Web Farming.
PublikacjaW artykule przedstawiono zastosowanie technologii Web Farming do procesów zarządzania projektami informatycznymi w firmie komputerowej. Idea polega na nadzorowaniu przebiegu projektu w tle poprzez agentów uruchomionych na komputerach uczestników projektu. W celu zdefiniowania procesu, zwanego procesem SoFar, proponuje się język PMDL, który będzie podstawą także do generowania kodu agentów. Przedstawiono możliwości zastosowania...
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Public valuation of social impacts. The comparison between mega and non-mega sporting events
PublikacjaThe main aim of this study is to assign value to intangible effects,including social impacts, which appear when organising sportingevents of various scales in the city of Gdansk located in northernPoland. A survey was conducted to determine the city residents’willingness-to-pay (WTP) using the contingent valuation method(CVM). The average WTP values, which ranged between PLN 6.04and PLN 46.34, show that the scale of the sporting...
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Optymalizacja zasobów chmury obliczeniowej z wykorzystaniem inteligentnych agentów w zdalnym nauczaniu
PublikacjaRozprawa dotyczy optymalizacji zasobów chmury obliczeniowej, w której zastosowano inteligentne agenty w zdalnym nauczaniu. Zagadnienie jest istotne w edukacji, gdzie wykorzystuje się nowoczesne technologie, takie jak Internet Rzeczy, rozszerzoną i wirtualną rzeczywistość oraz deep learning w środowisku chmury obliczeniowej. Zagadnienie jest istotne również w sytuacji, gdy pandemia wymusza stosowanie zdalnego nauczania na dużą skalę...
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IS SMALLER BETTER? THE VALUATION OF SOCIAL IMPACTS OF DIFFERENTLY SIZED SPORTING EVENTS. THE CASE OF GDAŃSK
PublikacjaIntroduction. There is a discourse in the international literature regarding the impact of large sporting events on the place where they are held. In the last few years, particular emphasis has been laid on intangible effects, including social impacts that may occur not only in the case of mega sporting events but also in smaller sporting events. Therefore, the main aim of this paper is to estimate the monetary value of intangible...
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Forecasted climate changes and their influence on cities and regions in 2050 in terms of extreme hydrological events
PublikacjaGlobal climate change is a problem which arises numerous theories and uncertainties, especially in terms of speculated human impact. Independent from the fact, what is the main driver for the changes, some of the climate shifts are visible already nowadays. Both contemporary and future cities will have to face such problems. Although climate change may cause numerous effects on different fields, a special stress in this article...
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Numerical investigation on dynamic response of a steel lattice tower under various seismic events
PublikacjaThe present paper presents the results of the numerical study designed to investigate the soil-structure flexibility effects on modal parameters (i.e. fundamental frequencies) and time-history analysis response (represented by the top relative displacements) of a 46.8 m high steel lattice tower subjected to a number of ground motions including also one mining tremor. In addition to the fixed-base condition, three different soil...
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Analyses of wave records from the Southern Baltic Sea with the emphases on large wave events
PublikacjaW pracy przedstawiono wyniki analizy pomiarów szeregów czasowych falowania uzyskanych z boi pomiarowych Waverider, umieszczonych w kilku miejscach linii brzegowej Morza Bałtyckiego. Celem badań było wskazanie okresów i regionów możliwego pojawiania się fal maksymalnych. Rozważano wpływ czasu trwania sztormu i kierunku wiatru na powstawanie pojedynczych oraz grup fal ekstremalnych.
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EXPERT OPINION ON THERAPEUTIC PATENTS
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The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part III: Polymorphisms of genes involved in Tregs’ activation and function
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Reputacja i zaufanie w systemach teleinformatycznych z podmiotami anonimowymi podejście dynamiczne
PublikacjaAbstrakcją współczesnego systemu teleinformatycznego jest system wieloagentowy z autonomicznymi, racjonalnymi i wirtualnie anonimowymi agentami wchodzącymi we wzajemne interakcje dla wymiany usług. W referacie uzasadniono konieczność projektowania dla niego podsystemu budowy reputacji i zaufania oraz odpowiednich analiz w ujęciu dynamicznym. Dokonano przeglądu motywacyjnie zgodnych mechanizmów uczciwego raportowania usług oraz...
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VUV photofragmentation of the six-membered heterocyclic molecules containing oxygen
PublikacjaCancer is a significant public health concern worldwide, which results in millions of deaths each year. The standard cure routine for cancer is surgery, and nowadays, radiotherapy or a hadrontherapy. Depending on the type of cancer, patients may undergo additional treatment, including targeted therapy. A combination of radio- or hadron-therapy with proper drug treatment can inhibit the proliferation of cancer cells and thus can...
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Disruption of homocitrate synthase genes in Candida albicans affects growth but not virulence
PublikacjaDwa geny, LYS21 i LYS22, kodujące izoformy syntazy homocytrynianowej, enzymu katalizującego pierwszy wyjątkowy etap w szlaku biosyntezy lizyny, zostały rozbite z komórkach Candida albicans z wykorzystaniem strategii ''SAT flipper''. Podwójny mutant lys21delta/lys22delta nie wykazywał aktywności syntazy homocytrynianowej, natomiast charakteryzował się auksotrofią wzrostową wobec lizyny w podłożach minimalnych, co można było odwrócić...
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Defect in Mitochondrial NADH-Dehydrogenase Genes in Canine Mast Cell Tumours
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Epigenetic regulation and regeneration: the search for differentially methylated genes in the MRL mouse
PublikacjaThe MRL mouse is an inbred laboratory strain, which was developed in the 60’s of the 20th century and has been extensively used as a model of lupus erythematosus. The regenerative abilities of the strain were discovered in the 90' when the MRL mouse was shown to close 2 mm hole punches made in the ear pinnae four weeks after injury without scarring. The phenomenon has not been observed in other mouse strains, where the holes...
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Selected mitochondrial genes as species markers of the Arctic Contracaecum osculatum complex
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Amplification of the PDGFRA, KIT and KDR genes in glioblastoma: a population-based study
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Genes of cellular components of morphogenesis in porcine oocytes before and after IVM
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Genes involved in glucocorticoid receptor signalling affect susceptibility to mood disorders
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The Role of Dopaminergic Genes in Probabilistic Reinforcement Learning in Schizophrenia Spectrum Disorders
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Microarray analysis of differentially expressed genes in cells resistant to HIV-1
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Activities of genes controlling sphingolipid metabolism in human fibroblasts treated with flavonoids
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Modulation of expression of genes involved in glycosaminoglycan metabolism and lysosome biogenesis by flavonoids
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Direct cloning of heavy metal resistance genes from metagenomic DNA
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Influence of Escherichia coli on Expression of Selected Human Drug Addiction Genes
PublikacjaThe impact of enteric microflora on the expression of genes associated with cocaine and amphetamine addiction was described. Human genome-wide experiments on RNA transcripts expressed in response to three selected Escherichia coli strains allowed for significant alteration (p > 0.05) of the linear regression model between HT-29 RNA transcripts associated with the KEGG pathway:hsa05030:Cocaine addiction after 3 h stimulation with...
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A universal method for the identification of genes encoding amatoxins and phallotoxins in poisonous mushrooms
PublikacjaABSTRACT Background. As the currently known diagnostic DNA targets amplified in the PCR assays for detection of poisonous mushrooms have their counterparts in edible species, there is a need to design PCR primers specific to the genes encoding amanitins and phallotoxins, which occur only in poisonous mushrooms. Objective. The aim of the study was testing of PCR-based method for detection of all genes encoding hepatotoxic cyclic...
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Chitosan/poly(4-vinylpyridine) coatings formed on AgNPs-decorated titanium
PublikacjaElectrophoretic deposition (EPD) of chitosan/poly(4-vinylpyridine) (chit/P4VP) coatings on titanium substrates previously decorated with silver nanoparticles (AgNPs) was performed at different content of P4VP in the suspension and different voltage values. The results revealed that the composite coatings were formed, well-adjacent to the titanium substrate, of suitable roughness, hydrophilicity, and corrosion resistance. The voltage...
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Typology and comparative analysis of black tents built in tradition of iranian tribes
PublikacjaThis study focused on the habits and way of life of nomads in the Iranian Highlands, but their homes, called Black Tents, were of the main interest. The research explored the construction of the Black Tents and the way of shaping the space in which family life takes place. It concerned the architectural forms of tents, structures and materials from which they are erected, as well as interior furnishings and objects that determine...
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Algorithms and Tools for Intelligent Control of Critical Infrastructure Systems
PublikacjaCritical Infrastructure Systems (CIS) are spatially distributed and of a network structure. The dynamics are nonlinear, uncertain and with several time scales. There is a variety of different objectives to be reliably met under a wide range of operational conditions. The operational conditions are influenced by the disturbance inputs, operating ranges of the CIS, faults in the sensors and actuators and abnormalities occurring in...
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Regenerative Drug Discovery Using Ear Pinna Punch Wound Model in Mice
PublikacjaThe ear pinna is a complex tissue consisting of the dermis, cartilage, muscles, vessels, and nerves. Ear pinna healing is a model of regeneration in mammals. In some mammals, including rabbits, punch wounds in the ear pinna close spontaneously; in common-use laboratory mice, they remain for life. Agents inducing ear pinna healing are potential regenerative drugs. We tested the effects of selected bioactive agents on 2 mm ear pinna...
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Międzynarodowe Agendy Badawcze MAB - spotkanie informacyjne ON-LINE
Wydarzeniatransmisja on-line w jęz. angielskim na kanale Fundacji na Rzecz Nauki Polskiej na portalu YouTube; w trakcie spotkania istnieje możliwość zadawania pytań drogą elektroniczną - e-mail: infodaymab@fnp.org.pl; zapis transmisji będzie dostępny na portalu YT natychmiast po zakończeniu spotkania. Agenda spotkania: kwestie dotyczące programu, możliwości i...
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CYP3A4 overexpression enhances apoptosis induced by anticancer agent imidazoacridinone C-1311, but does not change the metabolism of C-1311 in CHO cells
PublikacjaWe examine whether CYP3A4 overexpression influences the rate and pattern of antitumor imidazoacridinone C-1311 metabolism, in relation to the impact of this overexpression on cell cycle progression and final cellular response of CHO cells following C-1311 treatment. Methods: Three CHO cell lines: CHO-WT, wild type, CHO-HR, overexpressing cytochrome P450 reductase (CPR) and CHO-HR-3A4, coexpressing CPR and CYP3A4 were applied....
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Prospective study of brentuximab vedotin in relapsed/refractory Hodgkin lymphoma patients who are not suitable for stem cell transplant or multi-agent chemotherapy
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Recent Patents on Endocrine Metabolic & Immune Drug Discovery
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The use of innovative application in creating new marketing space for cultural and entertainment events in the local market
PublikacjaThe following article describes the problems concerning marketing of mass events in the local market and potential solutions. In the first part the barriers that occur in communication between the organizers and the articipants are defined. In the process of identifying problems the results of research conducted for the needs article were used. In following sections the solution with use of Smartphone app is shown. The features that...
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The determinants of the Region's and its SMEs' Competitive Position in the Context of Mega Events - the Case of the Euro 2012
PublikacjaIn this paper a modified Preuss model was used to assess the factors to enhance the competitiveness of the region and the SMEs located in the region. To accomplish the above, six types of event-structure were applied: infrastructure, knowledge, networks, culture, image and emotions. They were described in detail in reference to the case of Euro 2012 in Poland in general and Pomeranian region in particular. Finally the Authors take...
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Detection, classification and localization of acoustic events in the presence of background noise for acoustic surveillance of hazardous situations
PublikacjaEvaluation of sound event detection, classification and localization of hazardous acoustic events in the presence of background noise of different types and changing intensities is presented. The methods for discerning between the events being in focus and the acoustic background are introduced. The classifier, based on a Support Vector Machine algorithm, is described. The set of features and samples used for the training of the...
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An investigation on the chemistry of the R2P=P ligand: reactions of a phosphanylphosphinidene complex of tungsten(VI) with electrophilic reagents
PublikacjaThe nucleophilic properties of the title compound [(2,6-i-Pr2C6H3N)2(Cl)W(η2-t-Bu2PvP)]Li·3DME (1) were investigated in reactions with selected electrophilic reagents such as MeI, M(CO)5THF (M = Cr, Mo, W), AlCl3, and GaCl3. Methylation of 1 by MeI yields phosphanylphosphido complexes [(2,6-i-Pr2C6H3N)2W(X)(1,2-η-t-Bu2PvP–CH3)] (X = Cl, I) (2-Cl/2-I) with the formation of a new P–C bond. Moreover, 1 reacts with electrophilic compounds...
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Model of identification of events and accident scenarios for a method of risk and safety assessment of ships in damaged conditions
PublikacjaW pracy opisano podstawowe problemy związane z identyfikacją zdarzeń i scenariuszy wypadku oraz modelowaniem ryzyka dla alternatywnej metody oceny bezpieczeństwa statków w stanie uszkodzonym. Zastosowano podejście do bezpieczeństwa statków oparte na ocenie zachowania się statku i ocenie ryzyka wypadku. Wskazano możliwości zastosowania modelowania do analizy bezpieczeństwa statków na etapie projektowania, w czasie eksploatacji i...
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Telomere Length and Risk of Major Adverse Cardiac Events and Cancer in Obstructive Sleep Apnea Patients
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Evaluating the challenges and needs of parents caring for children with Williams syndrome: A preliminary study from Poland
PublikacjaBackground: Although physical, cognitive and behavioural manifestations of Williams syndrome(WS) affect every dimension of caregivers lives, no studies on the parental experiences of caringfor a WS child have to date been carried out in Poland.Methods: In order to identify the challenges and needs of Polish carers of WS children a survey wasconducted...
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Trinuclear Complexes Derived from R/S Schiff Bases – Chiral Single‐Molecule Magnets
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Trinuclear Complexes Derived from R/S Schiff Bases – Chiral Single‐Molecule Magnets
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Professional activity, gender and disease-related emotions: The impact on parents' experiences in caring for children with phenylketonuria
PublikacjaIntroduction: Clinical management of rare diseases often fails to acknowledge the challenges faced by caregivers.Whilst management of phenylketonuria (PKU) may not be considered as dire as other conditions, most studiesprimarily concentrate on clinical issues, dietary adherence, or the quality of life of the PKU patients, leavingcaregivers in the background. The aim of the study was to evaluate the psychosocial...
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Application of a commercially available derivatization instrument and commonly used reagents to HPLC on-line determination of antioxidants
PublikacjaThis study demonstrates the potential of a commercially available derivatization instrument coupled with HPLC for separation and on-line determination of antioxidants detected with widely used screening reagents - DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS (2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) or FCR (Folin-Ciocalteu's phenol reagent ). As the result of optimization, key parameters of the analytical procedure,...
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The organophosphorus sulfenyl bromides as versatile reagents for cysteine derivatives functionalization by unsymmetrical disulfide bond formation
PublikacjaWe have developed a convenient method for the synthesis of L-cysteine unsymmetrical disulfides under mild conditions with good to excellent yields. Described method is based on the straightforward preparation of the organophosphorus sulfenyl bromide readily available from bis-(5,5-dimethyl-2-thiono-1,3,2-dioxaphosphorinanyl) disulfide. The unsymmetrical disulfides can be obtained for L-cysteine derivatives and thiols bearing neutral...
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The central server of the Border Guard's distributed multimedia system for monitoring and visualisation of ongoing and archival events
PublikacjaThe paper presents the architecture and functionalities of the central server (CENTER) of the distributed system for the Polish Border Guard (BG) for monitoring maritime areas. The overall system has been extended to incorporate, apart from map data, also different multimedia elements such as video from cameras or audio from telephone connections operated by BG units. This requires new system elements: Archive Servers for storing...