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Function and Frustration of Multi-Drug ABC Exporter Protein and Design of Model Proteins for Drug Delivery Using Protein Hydration Thermodynamics
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Screening of potential inhibitors for COVID-19 main protease from phytoconstituents of Tectona grandis Linn: application of molecular modeling studies
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Identification and characterization of single-stranded-DNA-binding proteins from Thermus thermophilus and Thermus aquaticus - new arrangement of binding domains
PublikacjaOkreślono molekularne właściwości białek SSB-podobnych z Thermus thermophi-lus i T. aquaticus. Zbadano aktywność białek oraz termostabilność. Ponadto, dowiedziono homodimeryczność obu białek i ustalono minimalną sekwencję wiążącą ssDNA.
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Development of potent and effective SARS-CoV-2 main protease inhibitors based on maleimide analogs for the potential treatment of COVID-19
PublikacjaIn the present work, we report a new series of potent SARS-CoV-2 Main Protease (Mpro) inhibitors based on maleimide derivatives. The inhibitory activities were tested in an enzymatic assay using recombinant Mpro (3CL Protease from coronavirus SARS-CoV-2). Within the set of new Mpro inhibitors, 6e demonstrated the highest activity in the enzymatic assay with an IC50 value of 8.52 ± 0.44 mM. The IC50 value for Nirmatrelvir (PF-07321332,...
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Evaluation of long‑term immunity and protection against T. gondii after immunization with multivalent recombinant chimeric T. gondii proteins
PublikacjaToxoplasmosis caused by the opportunistic, cosmopolitan protozoan Toxoplasma gondii is one of the most common parasitoses in the world. Although it may prove dangerous or even fatal for immunocompromised individuals, immunoprophylaxis for humans is still nonexistent. Thus, the aim of the current work was to assess the ability of two immunogenic recombinant chimeric T. gondii proteins, SAG2-GRA1-ROP1 (SGR) and SAG1-MIC1-MAG1-GRA2...
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Intensive blood pressure lowering prevents mild cognitive impairment and possible dementia and slows development of white matter lesions in brain: the SPRINT Memory and Cognition IN Decreased Hypertension (SPRINT MIND) study
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Isolation of multidrug resistant coliforms and their bacteriophages from swine slurry
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Exposure to (1 → 3)-β-D-glucans in swine farms
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Holistic Approach to the Diagnosis and Treatment of Patients with Tumor Metastases to the Spine
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Comparison of Pteridine Normalization Methods in Urine for Detection of Bladder Cancer
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Urine composition as a source of information about occupational exposure to chemicals
PublikacjaIn the article there is presented review of data concerning application of human urine samples to analytical studies conducted in order to gain information on occupational exposure. The parameters characterizing the most commonly used techniques of xenobiotics isolation and preconcentration (organic compounds and metals) from urine samples and techniques of analytes determination in properly prepared extract samples of human urine.
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A New Technique of Spine Disease Treatment Supported by ADRSK1 Device
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Marinating and Salting of Herring, Nitrogen Compounds’ Changes in Flesh and Brine
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Volatile organohalogen compounds in human urine: the effect of environmental exposure
PublikacjaW pracy przedstawiono wyniki oznaczania lotnych związków chlorowcoorganicznych w próbkach moczu pochodzących m.in. od dawcow narazonych na kancerogeny w miejscu pracy i dawcow spozywajacych wode poddana procesowi uzdatniania przez chlorowanie. Do izolacji i wzbogacania analitów z moczu, posiadającego skomplikowaną matrycę, wykorzystano technikę analizy fazy nadpowierzchniowej nad cienką warstwą cieczy z samoczynną generacją ciekłego...
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Remotely accessible Web-based GIS for real time monitoring and apping of the marine environment
PublikacjaPrzedstawiono internetowy GIS do integracji, przetwarzania i wizualizacji pochodzących z wielu źródeł danych o różnych komponentach środowiska morskiego, w tym o zanieczyszczeniach. Jako przykład przedstawiono wyniki trójwymiarowego modelowania rozprzestrzeniania się wylewu olejowego w morzu, a także dane pochodzące z akustycznego badania zasobów żywych w Bałtyku.
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Combined spline wavelet decomposition for 3d seafloor imaging from multibeam sonar echoes
PublikacjaThe paper proposes combined spline-wavelet approach to the raw echoes seaflor imaging from Multibeam Sonar System (MBSS) records. Wavelet representation is closely related to image representation, due to its unique approximations properties. Splines have the best approximation properties among all known wavelets of a given order, so they are best suited for approximating of smooth seafloor surface. Additionaly, wavelet bases have...
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Endophytic microbiota and ectomycorrhizal structure of Alnus glutinosa Gaertn. at saline and nonsaline forest sites
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Dynamics of Microbiome Changes in the Endometrium and Uterine Cervix during Embryo Implantation: A Comparative Analysis
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An Experimental Study of Emission and Combustion Characteristics of Marine Diesel Engine with Fuel Injector Malfunctions
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An experimental study of emission and combustion characteristics of marine diesel engine with fuel pump malfunctions
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A comparison of the target tracking in marine navigational radars by means of GRNN filter and numerical filter
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Determining manoeuvre detection threshold of GRNN filter in the process of tracking in marine navigational radars
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The impact of military activities on the concentration of mercury in soils of military training grounds and marine sediments
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Mercury in marine fish, mammals, seabirds, and human hair in the coastal zone of the southern Baltic
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Effect of Different Forms of Silicon on Growth of Spring Wheat Cultivated in Organic Farming System
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Murine Model Imitating Chronic Wound Infections for Evaluation of Antimicrobial Photodynamic Therapy Efficacy
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Selected analytical challenges in the determination of pharmaceuticals in drinking/marine waters and soil/sediment samples
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Application of fourier series to determine the measurements error of harmonics with selected power quality analyzers
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MicroRNA profiling in a case-control study of African American women with uterine serous carcinoma
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An analysis of the causes and consequences of firefighters’ accidents at work in the State Fire Service in 2010 – 2016
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Maintenance Interval Adjustment Based on the Experience, Case Study of Marine Air Compressor System
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Cooperative response to marine hazardous and noxious substances and oil spill incidents in the ASEAN region
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Expert elicitation of a navigation service implementation effects on ship groundings and collisions in the Gulf of Finland
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Analogues of muramyl dipeptide (MDP) and tuftsin limit infection and inflammation in murine model of sepsis
PublikacjaBadano koniugaty MDP z tuftsyną oraz pochodną tuftsyny w leczeniu ciężkich infekcji bakteryjnych takich jak posocznica. Oceniano aktywność żerną komórek układu fagocytów jednojądrzastych, wpływ na klirens bakteryjny kluczowych organów wewnętrznych oraz ekspresję genów dla cytokin pro- i antyzapalnych charakterystycznych dla odpowiedzi immunologicznej w posocznicy i indukowanych działaniem analizowanych zwiazków. W badaniach in...
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Real-time web-based gis for analysis, visualization, and integration of marine environment data
PublikacjaWizaulizacja i integracja przestrzennych danych morskich zbieranych przez różnego rodzaju sensory i pochodzących z różnych źródeł stanowi istotny aspekt monitorowania środowiska morskiego. Ta praca przedstawia system GIS powstały na Katedrze Systemów Geoinformatycznych na Politechnice Gdańskiej. System umożliwia integrecję i wizualizację różnego rodzaju danych morskich, w szczególności pochodzących z sensorów akustycznych takich,...
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Influence of Bearing Bush Geometry on Properties of Water Lubricated Marine Main Shaft Bearings
PublikacjaW pracy przedstawiono wpływ geometrii smarowanego wodą, okrętowego łożyska ślizgowego wału głównego na jego własności hydrodynamiczne.Wykazano, że wielkość luzu łożyskowego, położenie oraz liczba rowków smarnych mają znaczący wpływ na nośnosć łożyska.
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A JEE-based modelling and execution environment for workflow applications with just-in-time service selection
PublikacjaArtykuł prezentuje model scenariusza z dynamicznym wyborem usług do wykonania zadań scenariusza. Adekwatność rozwiązania została zaprezentowana dla zastosowań naukowych i biznesowych w warunkach kiedy dostępność usług się zmienia i usługi powinny być wybierane w trakcie działania scenariusza a nie przed jego rozpoczęciem. Pokazano, że dla scenariusza naukowego z powtarzalnymi symulacjami, algorytm dobiera usługi, aby zminimalizować...
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Alternative diagnostic method applied on marine diesel engines having limited monitoring susceptibility
PublikacjaThe paper presents a method of technical state evaluation of working spaces of a marine diesel engine at the limited control susceptibility. The method foresees making a diagnosis of the engine's working spaces on the basis of measurements of the exhaust gas pressure in the channels connecting engine cylinders with the turbocharger's turbine. Diagnostic measurements are carried out at representative (comparative) steady loads depending...
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Performance analysis of power swing blocking feature in ABB 670 series impedance relays
PublikacjaThis paper presents test results of a distance protection’s PSD power swing detection feature in ABB 670 series relays. A RED670 relay was tested, which is part of the hydroelectric set protection in Żarnowiec Pumped Storage Plant. The power swing blocking feature’s performance was analysed on the basis of the results of object tests made with an Omicron digital tester. Also presented are simulation results that illustrate the...
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Problems of modelling toxic compounds emitted by a marine internal combustion engine in unsteady states
PublikacjaContemporary engine tests are performed based on the theory of experiment. The available versions of programmes used for analysing experimental data make frequent use of the multiple regression model, which enables examining effects and interactions between input model parameters and a single output variable. The use of multi-equation models provides more freedom in analysing the measured results, as those models enable simultaneous...
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Influence of bush wear in water lubricated marine stern tube bearings with shaft misalignment
PublikacjaWater lubricated propeller shaft bearings are frequently employed on modern ships due to their advantages such as durability, simplicity and low price. Specific working conditions on ships cause shaft misalignment which often results in rapid wearing of bush and shaft. Shaft misalignment could be an effect of manufacturing or assembly faults but sometimes it appears due to hull or shaft deformation. The wearing process has influence...
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Tacit Knowledge Sharing and Personal Branding. How to Derive Innovation From Project Teams?
PublikacjaInnovation, relationships, cooperation, and knowledge are key factors which determine a competitive advantage in the networked economy. A network serves as a contemporary form of market process coordination. Network economy, according to the idea of prosumerism, is founded on collaboration of individual creators based on a network of values instead of hierarchical dependencies. Another feature of a network is that it imposes symmetry...
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Interactive visualization of marine pollution monitoring and forecasting data via a Web-based GIS
PublikacjaArtykuł prezentuje zastosowanie sieciowego Systemu Informacji Geograficznej do monitoringu i prezentacji wyników modelowania plam ropy na morzu. Omawiany system wykorzystuje technologie ESRI ArcIMS (Arc Internet Map Server) oraz Open Source GeoServer z biblioteką klienta OpenLayers w celu wizualizacji i mapowania rozprzestrzeniania się wycieku ropy w dwóch wybranych obszarach Morza Egejskiego w Grecji. Przedstawiony GIS stanowi...
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Evaluation of working spaces' technical condition of marine diesel engine on the basis of operation research
PublikacjaThe paper presents the method of evaluation of the technical state of working spaces of a marine diesel engine at the reduced control susceptibility. The method foresees making diagnosis on the basis of the measurements of exhaust gas pressure in the channels connecting engine cylinders with turbocharger's turbine. In the beginning of the article the research objects are characterized i.e. ZVIEZDA main engine of M401 type and the...
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Possibilities of the performance improvement of the aero- and marine propulsion units equipped with combustion piston engines
PublikacjaWithin the paper there have been presented the authors' opinions concerning possibilities and needs of the performance optimization of the aero- and marine units powered by piston engines both of ''classic'' and contemporary construction. There have been also discussed the reserves contained within combustion piston engines which enable its performance improvement (the power and specific fuel consumption) as well as the fulfillment...
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Assessment of fitness for service of Cr-Mo steel tubes in catalytic reforming charge heaters
PublikacjaIn this paper characteristic features of metal dusting corrosion in high temperature gas mixtures of high carbon activity in catalytic reforming units, including Continuous Catalyst Regeneration (CCR) platformer are presented. Examples of 2.25Cr-1Mo and 9Cr-1Mo steel tubes at advanced stages of metal dusting process after long-term service in charge heaters are used to prove that destructive examinations are necessary to provide...
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Efficiency of service recovery in scale-free optical networks under multiple node failures
PublikacjaIn this paper we examine the properties of scale-free networks in case of simultaneous failures of two networknodes. Survivability assumptions are as follows: end-to-end path protection with two node-disjoint backup pathsfor each working path. We investigate three models of scale-free networks generation: IG, PFP and BA.Simulations were to measure the lengths of active and backup paths and the values of service recovery time.We...
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Stability evaluation of the marine propulsion unit mechanical system bymeans of vibrations measurements and their analysis.
PublikacjaIn paper selected issues concerning vibration diagnosis of the mechanical system within marine propulsion units have been given. The analysis of vibration parameters was carried out on the basis of experimental examinations of a real object in which an exceedance of the allowable vibration's level had been observed. In the beginning, the vibration apparatus being on laboratory equipment of the Department of Ship Power Plants of...
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Stability evaluation of the marine propulsion unit's mechanical system by means of vibration measurements and their analysis
PublikacjaIn this paper selected issues concerning vibration diagnosis of the mechanical system within marine propulsion units have been given. The analysis of vibration parameters was carried out on the basis of experimental examinations of a real object in which an exceedance of the allowable vibration's level had been observed. In the beginning, the vibration apparatus being on laboratory equipment of the Department of Ship Power Plants...
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Service and Path Discovery Extensions for Self-forming IEEE 802.11s Wireless Mesh Systems
PublikacjaWith the rapid growth of the quantity and capabilities of end-user electronic devices, both stationary and mobile, they are employed in increasing number of applications. In this situation, wireless network technologies begin to play a crucial role as networks access technologies, as cable-based solutions tend to be of limited utility in case of easily portable or mobile devices. Resulting development of wireless technologies reached...