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Synthesis and biological evaluation of fluorinated N-benzoyl and N-phenylacetoyl derivatives of 3-(4-aminophenyl)-coumarin-7-O-sulfamate as steroid sulfatase inhibitors
PublikacjaIn the present work, we report convenient methods for the synthesis of 3-(4-aminophenyl)-coumarin-7-O-sulfamate derivatives N-acylated with fluorinated analogues of benzoic or phenylacetic acid as steroid sulfatase (STS) inhibitors. The design of these potential STS inhibitors was supported by molecular modeling techniques. Additionally, computational docking methods were used to determine the binding modes of the synthesized inhibitors...
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Statystyka Społeczna (on-line)
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Zachowania organizacyjne (on-line)
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The contactless method of chip-to-chip high-speed data transmission monitoring
PublikacjaThis paper presents a technique of decoupling differential signals transmitted in a pair of microstrip lines on a printed circuit board (PCB), using dedicated coupler for high speed data transmission monitoring in chip-to-chip interconnections. The coupler used for signal probing is overlayed on the pair of microstrip lines under test, and provides a signal to the next blocks of the measurement system without disturbing transmission...
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The Courts Public image - The Desired Direction of Change
PublikacjaThis paper proposes to scientifically explore notions of court identity, principles of shaping a court system's image, and best practices in positive court image development relating to thhe courts in Poland
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Weronika Maria Mazurkiewicz dr inż. arch.
OsobyJest adiunktem na Wydziale Architektury Politechniki Gdańskiej w Katedrze Urbanistyki i Planowania Regionalnego oraz czynnym architektem urbanistą.Od 2018 roku jest również członkiem Zarządu Towarzystwa Urbanistów Polskich oraz stowarzyszenia AESOP (Thematic Group for Public Spaces and Urban Cultures). Odbyła staże badawcze w kilku instytucjach badawczych w tym University of Ljubljana, University of Technology of Wiena, University...
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Self-advocates with intellectual disability about their work as social educators – a qualitative Polish study
PublikacjaThe paper presents the opinions of self-advocates with mild intellectual disability about their work as social educators – public self-advocates raising disability awareness. Six semi-structured individual interviews were conducted. Data was analyzed within the framework of Interpretative Phenomenological Analysis. The themes which emerged from the interviews comprise: the motives of educators to work as self-advocates, opportunities...
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THIRD-ORDER EXPONENTIAL INTEGRATOR FOR LINEAR KLEIN–GORDON EQUATIONS WITH TIME AND SPACE-DEPENDANT MASS
PublikacjaAllowing for space- and time-dependance of mass in Klein–Gordon equations re- solves the problem of negative probability density and of violation of Lorenz covariance of interaction in quantum mechanics. Moreover it extends their applicability to the domain of quantum cosmology, where the variation in mass may be accompanied by high oscillations....
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THIRD-ORDER EXPONENTIAL INTEGRATOR FOR LINEAR KLEIN–GORDON EQUATIONS WITH TIME AND SPACE-DEPENDANT MASS
PublikacjaAllowing for space- and time-dependance of mass in Klein–Gordon equations re- solves the problem of negative probability density and of violation of Lorenz covariance of interaction in quantum mechanics. Moreover it extends their applicability to the domain of quantum cosmology, where the variation in mass may be accompanied by high oscillations....
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Mathematical modelling and computer simulation of activated sludge systems.Second edition
PublikacjaMathematical Modelling and Computer Simulation of Activated Sludge Systems – Second Edition, provides, from the process engineering perspective, a comprehensive and up-to-date overview regarding various aspects of the mechanistic (“white box”) modelling and simulation of advanced activated sludge systems performing biological nutrient removal. In the new edition of the book, a special focus is given to nitrogen removal and an overview...
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The imidazoacridinone C-1311 induces p53-dependent senescence or p53-independent apoptosis and sensitizes cancer cells to radiation
PublikacjaC-1311 is a small molecule, which has shown promise in a number of preclinical and clinical studies. However, the biological response to C-1311 exposure is complicated and has been reported to involve a number of cell fates. Here, we investigated the molecular signaling which determines the response to C-1311 in both cancer and non-cancer cell lines. For the first time we demonstrate that the tumor suppressor, p53 plays a key role...
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Secondary arc modelling for single pole reclosing analyses
PublikacjaThe paper discusses two evaluation methods of single pole auto-reclosing process effectiveness in HV transmission lines. Secondary arc current and recovery voltage calculation results obtained by load flow calculation are compared to the results obtained by the time domain simulations. Moreover, a nonlinear secondary arc model implementation is presented. The paper presents the study results for the three types of EHV transmission...
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Anticancer and antimicrobial properties of novel η6-p-cymene ruthenium(ii) complexes containing a N,S-type ligand, their structural and theoretical characterization
PublikacjaRuthenium(II) complexes are lately of great scientific interest due to their chemotherapeutic potential asanticancer and antimicrobial agents. Here we present the synthesis of new pyrazole carbothioamidederivatives and their four arene–ruthenium complexes. The title compounds were characterized with theapplication of IR, NMR, mass spectrometry, elemental analysis and X-ray diffraction. Additionally, for newcomplexes DFT calculations...
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Jerzy Proficz dr hab. inż.
OsobyJerzy Proficz – dyrektor Centrum Informatycznego Trójmiejskiej Akademickiej Sieci Komputerowej (CI TASK) na Politechnice Gdańskiej. Uzyskał stopień naukowy doktora habilitowanego (2022) w dyscyplinie: Informatyka techniczna i telekomunikacja. Autor i współautor ponad 50 artykułów w czasopismach i na konferencjach naukowych związanych głównie z równoległym przetwarzaniem danych na komputerach dużej mocy (HPC, chmura obliczeniowa). Udział...
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Rozpoznawanie oraz lokalizacja w obrazie przewodów linii wysokiego napięcia
PublikacjaW pracy przedstawiono opracowany algorytm rozpoznawania oraz lokalizacji przewodów linii wysokiego napięcia na podstawie obrazu horyzontalnego. Procedura detekcji przewodu została podzielona na trzy etapy. Pierwszy etap zawiera algorytm wykrywania krawędzi wykazujący największą czułość na krawędzie poziome, a jednocześnie brak czułości na krawędzie pionowe. Efektem jest znaczna redukcja liczby wykrytych krawędzi w porównaniu do...
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A Power-Efficient Digital Technique for Gain and Offset Correction in Slope ADCs
PublikacjaIn this brief, a power-efficient digital technique for gain and offset correction in slope analog-to-digital converters (ADCs) has been proposed. The technique is especially useful for imaging arrays with massively parallel image acquisition where simultaneous compensation of dark signal non-uniformity (DSNU) as well as photo-response non-uniformity (PRNU) is critical. The presented approach is based on stopping the ADC clock by...
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Paweł Robert Surowiec mgr lic.
OsobyPhD student at The John Paul II Catholic University of Lublin (Poland), STL degree (specialisation: Ecumenism) awarded in 2022. Roman Catholic priest ordained in 2017. He is interested in the works and theology of saint John Henry Newman (1801-1890). A graduate of catholic Higher Theological Seminary of the Diocese of Sandomierz (Poland) and the John Paul II Catholic University of Lublin. He likes to spend time actively - in prayer,...
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A Control Theoretical Approach to Spectral Factorization is Unstable
PublikacjaLocal stability analysis of a recently proposed recursive feedback-based approach to spectral factorization is performed. The method is found not to give stability guarantees. Interestingly enough, its global behavior often allows one to obtain reasonable approximations of spectral factorizations if a suitable stopping criterion is employed.
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Earthwork calculations in various field conditions
PublikacjaThe article characterizes the continuation of ongoing work on the MUGO computer program. The analyzes refer to the modernization of railway lines and directly to the earthwork calculations. The methodology of calculating the earthwork size in the areas of fills and cuts is discussed in detail.
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Experimental research on marine oil-lubricated stern tube bearing
PublikacjaBearings of propeller shafts are very crucial elements of the propulsion system of each of the ships. The safety of shipping depends on their durability and reliability. The new legal restrictions mean that today we are looking for environmentally friendly solutions. That is why water-lubricated bearings are becoming more and more popular. So, will oil-lubricated shaft bearings belong to the past? The bearing with a white metal...
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Żegluga towarowa na Wiśle
PublikacjaKoncepcje rozwoju drogi wodnej WISŁY.Bariery utrudniaące rozwój transportu wodnego i przesłanki przemawiające za aktywizacją dróg wodnychb w Polsce.Propozycja drogi wodnej na Wiśle jako elementu łańcucha transportowego z terminalami kontenerowymi w porcie Gdańskim, Bydgoszczy,Warszawie oraz docelowo w rejonie Krakowa jako elementu przyszłego kanału Śląskiego. Koncepcja centrum logistycznego w Bydgoszczy
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Novel N-(aryl/heteroaryl)-2-chlorobenzenesulfonamide derivatives: synthesis and anticancer activity evaluation
PublikacjaA new series of N-(aryl/heteroaryl)-2-chlorobenzenesulfonamide derivatives 4-21 have been synthesized, and evaluated at the National Cancer Institute (USA) for their in vitro activities against a panel of 60 different human cancer cell lines. Among them, compounds 16, 20 and 21 exhibited remarkable cytotoxic activity against numerous human cancer cell lines. We found that sulfonamide derivative 21 appeared to be more selective...
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THE CIRCUS SITE
PublikacjaThe location of project is a site of over 1,2 ha, situated on the southern fringes of Gdynia formerly used as an area to host a Circus. Here artists were performing for the public, newcomers were meeting the locals, the temporality of the event was enhancing the experience of exchange. Circus used to be the place where people live, work and create art. Currently the site stays empty but surely not for long. Its potential, attractive...
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The complete lists of 1D reversible number-conserving cellular automata with radius one of up to 7 states
Dane BadawczeThis dataset contains complete lists of all one-dimensional reversible number-conserving k-ary cellular automata with radius one of up to 7 states, i.e. with state sets {0,1}, {0,1,2}, {0,1,2,3}, {0,1,2,3,4}, {0,1,2,3,4,5} and {0,1,2,3,4,5,6}.
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Analysis of cell cycle distribution
Dane BadawczeThe dataset comprehensively details the distribution of A549, H226, and H460 cell lines in various cell cycle phases following treatment with the IC90 concentration of selected anthraquinones. The analysis was performed using the Flowing Software 2.
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Environmental Policy
Kursy OnlineThis course deals with key issues associted with understanding and shaping the environmental policy. Both the general description of the topic and detailed considerations regarding how to shape and execute the environmental policies at the municpal level will be discussed
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Joanna Czerska dr inż.
OsobyJoanna Czerska jestem człowiekiem, którego misją i pasją jest rozwój ludzi i organizacji. Moje motto to: „Nie ma takiej fantazji, której wola i rozum ludzki nie zdołałby przekształcić w rzeczywistość.” William Shakespeare W życiu kieruję się wartościami szacunku, pracy zespołowej i pozytywnego nastawienia. To one mnie definiują i decydują o tym jakim jest człowiekiem.Moja przygoda z Lean rozpoczęła się, podczas pisania pracy...
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Collision-induced luminescence spectra of pyridine bombarded by 1000 eV He+ cations
PublikacjaHere we show collision-induced luminescence spectra measured for collisions of the He+cations with thearomatic six-membered ring of the pyridine molecule (C5H5N). Distinct emission bands due to the CH(A2Δ→X2Πr;B2Σ+→X2Πr;C2Σ+→X2Πr), CN(B2Σ+→X2Σ+), C2(d3Πg→a3Πu), and NH(A3Π→X3Σ−) transitions, aswell as atomic H, He, and C lines have been observed. Apart from the He atoms, all the emitters arise from thefragmentation of the pyridine...
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Methodology of assessing the production capacity of selected shipyards
PublikacjaW ramach projektu EUREKAΣ!2772 powstały projekty wstępne czterech statków dowozowych (Short Shiping). Dla jednego z nich należało zdefiniować optymalne warunki wykonania, wskazać wstępnie stocznie spełniające kryterium minimum zdolności wykonawczych. Do tego celu opracowano metodykę wskaźnikową, bazującą na wskaźnikach technologicznych i konstrukcyjnych. W oparciu o nie przeprowadzono analizę możliwości produkcyjnych wybranych...
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Mateusz Muchlado dr
OsobyMateusz Muchlado - adiunkt w Katedrze Inżynierii Zarządzania i Jakości. Stopień doktora nauk o zarządzaniu i jakości uzyskał w roku 2020 na Wydziale Zarządzania i Ekonomii Politechniki Gdańskiej broniąc pracę pt. "Outsourcing w wybranych podmiotach leczniczych województwa pomorskiego". Związany z Politechniką Gdańską od 2010 roku, absolwent kierunku "International Management", studiował w latach 2011-2012 na Otto-Friedrich-Universität...
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Mixed ionic polaron transport and rapid crystallization in (Bi, Pb)-Sr-Ca-Cu-O glass.
PublikacjaPrzedstawiono rezultaty pomiarów zmiennoprądowego przewodnictwa elektrycznego w szkłach (Bi,Pb)-Sr-Ca-Cu-O. Zaobserwowano dwa mechanizmy przewodnictwa.Zaproponowano hopping małych polaronów i dyfuzję jonów Cu(I) jako mechanizmy przewodnictwa.
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Zieleń miejska Gdyni okresu międzywojennego oraz problematyka jej zachowania = Urban greenery of Gdynia of interwar period and the issues of its retaining
PublikacjaURBAN GREENERY OF GDYNIA OF INTERWAR PERIOD AND THE ISSUES OF ITS RETAINING The subject of this article is the urban greenery arrangement in interwar Gdynia and the issues of its retaining after the II World War. The article will concern retaining the authenticity and integrity of the historic urban greenery of Gdynia, both greenery layouts and the plant material creating it. The author of the article will present in what...
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Analytical approach for membrane action in laterally-restrained reinforced concrete square slabs under uniformly distributed loads
PublikacjaLaterally-restrained reinforced concrete slabs can mobilise compressive membrane action and subsequent tensile membrane action under extreme loading conditions, thereby enhancing the load resistance under uniformly distributed loads. Previous analytical study focuses primarily on tensile membrane action in simply-supported slabs. This paper describes an analytical approach for membrane action in laterally-restrained square slabs....
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Identification of 1H‐indene‐(1, 3, 5, 6)‐tetrol derivatives as potent pancreatic lipase inhibitors using molecular docking and molecular dynamics approach
PublikacjaPancreatic lipase is a potential therapeutic target to treat diet-induced obesity in humans, as obesity-related diseases continue to be a global problem. Despite intensive research on finding potential inhibitors, very few compounds have been introduced to clinical studies. In this work, new chemical scaffold 1H-indene-(1,3,5,6)-tetrol was proposed using knowledge-based approach, and 36 inhibitors were derived by modifying its...
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Phosphate tricyclic coumarin analogs as steroid sulfatase inhibitors: synthesis and biological activity.
PublikacjaIn the present work, we report convenient methods for the synthesis and biological evaluation of phosphate tricyclic coumarin derivatives as potential steroid sulfatase inhibitors. The described synthesis includes the straightforward preparation of 7-hydroxy-2,3-dihydro-1H-cyclopenta[c]chromen-4-one, 3-hydroxy-7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one and 3-hydroxy-8,9,10,11-tetrahydro-7H-cyclohepta[c]chromen-6-one modified...
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Approximation strategies for routing edge disjoint paths in complete graphs
PublikacjaPraca dotyczy problemu ścieżek krawędziowo rozłącznych w nieskierowanych grafach pełnych, dla którego podano nowe algorytmy przybliżone: 3.75-przybliżony (model off-line) i 6.47-przybliżony (model on-line). Stosując podobną metodologię, uzyskano algorytm 4.5-przybliżony (off-line) i 6-przybliżony (on-line) dla problemu routingu i kolorowania ścieżek w grafach pełnych.
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A new method of fault loop resistance measurement in low voltage systems with residual current devices
PublikacjaThis paper presents a new method of fault loop resistance measurement in low voltage systems with residual current devices. The method enables measuring fault loop resistance without nuisance tripping of residual current devices, by application an unconventional waveform of measurement current. It is important for proper verification of the effectiveness of protection against electric shock.
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Chronoimpedancyjne monitorowanie procesu elektrochemicznego osadzania metali wykonywany metodą on-line
ProjektyProjekt realizowany w Katedra Elektrochemii, Korozji i Inżynierii Materiałowej zgodnie z porozumieniem UMO-2014/13/N/ST4/03891 z dnia 2015-02-12
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Influence of an applied bearing system on behaviour of multi-span footbridge
PublikacjaThe cycle overpass in Gdynia is a box structure over 300 metres long, 10-span. It was opened for bicycle traffic in the second half of 2013. At the end of its construction, there was failure due to excessive horizontal displacement of the system. A number of bearings exceeded the range of permissible transverse shifts thus it was necessary to temporarily protect the spans from slipping. The FEM analysis of the original solution...
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Protection of Earthing Reactor Connected to the Star Point of a High Voltage Shunt Reactor
PublikacjaThe article presents the problem of protection of earthing reactors connected to the star point of shunt reactors in high voltage lines, with particular regard to the detection of internal faults. Model analyses for an actual system commissioned in 2015, which is intended to be provided with earthing reactors, are included.
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Synthesis and antiproliferative activity of conjugates of adenosine with muramyl dipeptide and nor-muramyl dipeptide derivatives
PublikacjaWe synthesized a series of MDP(D,D) and nor-MDP(D,D) derivatives conjugated with adenosine through a spacer as potential immunosuppressants. New conjugates were evaluated on two leukemia cell lines (Jurkat and L1210) and PBMC from healthy donors.
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Mikroekonomia nst msu_on-line
Kursy OnlinePodstawy mikroekonomii dla msu 4. sem. - 2h zajęć prowadzi w formule on-line dr Aniela Mikulska.
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Mikroekonomia nst ZI_on-line
Kursy OnlineZajęcia prowadzone on-line na 2 semestrze kierunku ZI, 2h wykładu i 2h ćwiczeń przez ms teams prowadzi dr Aniela Mikulska.
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Assessing pathways into a low carbon and climate responsible Gdansk
PublikacjaA basic question today is the sense of the use new ideas in shaping Polish cities- not as technologically advanced as others. The key is to understand good practices in designing and implementing new approaches. The comparative research Glasgow and Gdansk has been undertaken by Gdansk Development Agency in Jan 2014
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Zarządzanie strategiczne (wykład on-line)
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Integracja gospodarcza Europy on-line
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Zarządzanie strategiczne (ćwiczenia on-line)
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Inhomogeneity of low-noise wearing courses evaluated by tire/road noise measurements using the close-proximity method
PublikacjaPerforming numerous analyses of tire/road noise measurements on low-noise pavements during the last several years, the authors observed significant inhomogeneity of the wearing course in numerous cases, while similar problems were almost non-existent when dense pavements were measured. Three main causes of low-noise pavement inhomogeneity can be defined. The first one is imperfections in the technology used for asphalt mix production...
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Problem wspólnotowego kształtowania środowiska mieszkaniowego
PublikacjaCommunity based shaping of housing environmentA sustainable development of housing environment depends on socio-economical context. Interest towards locality in western countries has a completely different basis than in the post-communist ones. Social capital, which shows e.g. in trust, as well as ecological awareness are totally different. We do not belong to saturated societies. There is a distinct issue of community shaping...
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Open Strategy for Digital Business. Managing in ICT-Driven Environments
PublikacjaThis book offers the reader a novel perspective on how digital contexts and open strategy approaches – the act of opening up strategic initiatives beyond company managers to involve front-line employees, stakeholders, and entrepreneurs – are related. Going beyond the claim that digital media drives open strategy by containing a detailed analyses of the interrelations between the two, the authors examine how ICT have diffused globally...