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Higher responsiveness to rosuvastatin in polygenic versus monogenic hypercholesterolaemia: a propensity score analysis
PublikacjaBackground The underlying monogenic defect in familial hypercholesterolemia (FH) can be detected in ∼40% of cases. The majority of mutation-negative patients have a polygenic cause of high LDL-cholesterol (LDL-C) due to having inherited a greater than average number of common LDL-C raising single nucleotide polymorphisms (SNPs). Purpose We sought to investigate, whether the monogenic or polygenic defect in FH is associated with...
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Cast Iron Staircase in Aleksandrów Kujawski (Poland) - History, Construction, Architectural Form
PublikacjaThe text presents historic cast iron staircase, which is situated inside the railway station building in Aleksandrów Kujawski. Since the moment of creation in the 19th century for a long time that station, located at the border of Prussia and Kingdom of Poland, was an important transit point. Nowadays it is situated in the central of Poland. The staircase was built in 1870’s as a result of an extension of the railway station building...
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Application of Traction Supply System for Charging Electric Cars
PublikacjaThe development of electromobility involves the development of electric cars charging infrastructure. The increase of the number of chargers poses new demands for the AC power grid, especially in regard to its capacity of delivering high peak power. As an alternative for the public AC power grid, urban electrified transportation systems (trams, trolleybuses, and metro) can be used for supplying electric cars chargers. The article...
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Central carbon metabolism influences fidelity of DNA replication in Escherichia coli
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Bulky DNA adducts in human sperm: relationship with fertility, semen quality, smoking, and environmental factors
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The relationship between 8-oxo-7,8-dihydro-2′-deoxyguanosine level and extent of cytosine methylation in leukocytes DNA of healthy subjects and in patients with colon adenomas and carcinomas
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Oxidative DNA damage in cancer patients: a cause or a consequence of the disease development?
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8-Oxoguanine incision activity is impaired in lung tissues of NSCLC patients with the polymorphism of OGG1 and XRCC1 genes
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Are 8-oxoguanine (8-oxoGua) and 5-hydroxymethyluracil (5-hmUra) oxidatively damaged DNA bases or transcription (epigenetic) marks?
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DNA repair is responsible for the presence of oxidatively damaged DNA lesions in urine
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Preliminary studies on DNA retardation by MutS applied to the detection of point mutations in clinical samples
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Conservation and diversity of MutS proteins
PublikacjaThe homologues of MutS, mismatch repair protein, exist in all prokaryotes, with the exception of Actinobacteria, Mollicutes and part of the Archaea. Multiple alignments of 316 MutS amino acid sequences from 169 species revealed conserved residues and sequence motifs distinguishing MutS homologues. All MutS homologues show high conservation within the ATPase domain. MutS1, the homologue responsible for DNA mismatch recognition,...
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Conserved motifs of MutL proteins
PublikacjatThe MutL protein is best known for its function in DNA mismatch repair (MMR). However, there isevidence to suggest that MutL is not only the linker connecting the functions of MutS and MutH in MMR,but that it also participates in other repair systems, such as Very Short Patch (VSP), Base Excision (BER)and Nucleotide Excision Repair (NER). This study set out to identify the most highly conserved aminoacid sequence motifs in MutL...
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A BODIPY‐Based Molecular Rotor in Giant Unilamellar Vesicles: A Case Study by Polarization‐Resolved Time‐Resolved Emission and Transient Absorption Spectroscopy
PublikacjaBODIPY and BODIPY-derived systems are widely applied as fluorophores and as probes for viscosity detection in solvents and biological media. Their orientational and rotational dynamics in biological media are thus of vital mechanistic importance and extensively investigated. In this contribution, polarization-resolved confocal microscopy is used to determine the orientation of an amphiphilic BODIPY-cholesterol derivative in homogeneous...
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Test Execution Logging and Visualization Techniques
PublikacjaTraditionally, log traces of test cases ex ecution are stored in textual format and their analysis is done in a post- execution phase. Our approach bases on the concept of gr aphical presentation of te st execution which enables better analysis of log traces and also gives the opportunity to consider them on-line. In particular, we discuss the graphical symbols we chose, we pres ent the logging interface we defined a nd describe...
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Niemetryczne zdjęcia cyfowe w fotogrametrii bliskiego zasięgu w systemie Topcon PI - 3000
PublikacjaReferat jest opisem możliwośći opracowania obiektu architektonicznego w systemie Topcon Image Surveying Station PI - 3000. Prezentuje możliwości współczesnej fotogrametrii cyfrowej opartej na niemetrycznych obrazach pozyskanych z amatorskich aparatów cyfrowych.
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Gdańsk 2019 Jana z Kolna street - video data
Dane BadawczeGdańsk 2019 Jana z Kolna street - video data
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UAV Survey Images - orthophotomap - Gdynia Container Terminal Night Time- MP1
Dane BadawczeDataset description: Raw images from photogrammetric survey. Object: Parking place near by Gdynia Container Terminal - night artificial light photosLocation: Gdynia, Pomerania, PolandDrone type: DJI Mavic Pro 1Flight plan: Single Grid - free flightTarget Product: OrthophotoDate: 14.10.2020Direct georeferencing: yesMetadata data: yes/GPSGCP: Yes - Description...
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Terrestrial Survey Images - 3D Exterior Model - Gdansk Church Pw. Św. Wojciecha - NICON D5300
Dane BadawczeDataset description: Raw images from photogrammetric survey. Object: Kościół Rzymskokatolicki Pw. Św. WojciechaLocation: Gdansk, Pomerania, PolandDrone type: N/A (terrestrial images)Flight plan: Free - walk around the object with camera. 3 images taken at the point.Target Product: 3D ModelDate: 02.04.2022Direct georeferencing: yesMetadata data: yes/GPSGCP:...
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Determination of viscosity changes in dietary supplement solutions depending on temperature.
Dane BadawczeThe rheological characteristics of dietary supplement solutions were made based on viscosity measurement using a Brookfield viscometer, using the LV SC4 - 18 spindle and a shear rate of 53 s-1 (Fig.1).
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Genetic Positioning of Fire Stations Utilizing Grid-computing Platform
PublikacjaA chapter presents a model for determining near-optimal locations of fire stations based on topography of a given area and location of forests, rivers, lakes and other elements of the site. The model is based on principals of genetic algorithms and utilizes the power of the grid to distribute and execute in parallel most performance-demanding computations involved in the algorithm.
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Modelling the loss of time caused by traffic incidents on motorways
PublikacjaFor each road incident important factors like location, capacity reduction, traffic management, duration of road incidents and amount of traffic should be defined. All performer operations and effects of incidents affect the capacity of the road, average speed, time loss, vehicle queues and traffic jams. In the article road incidents were divided into planned and unexpected. Statistical analysis prepared using the database of traffic...
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Guided ultrasonic waves for detection of debonding in bars partially embedded in grout
PublikacjaThis paper deals with theoretical, numerical and experimental investigations of guided wave propagation in multilayered cylindrical bars with pre-existing debonding. The research focuses on a complex description of the nature of the wave phenomena occurring in a debonded specimen with a special emphasis on the influence of the location of damage on the wave conversion and diffraction. Experimental non-destructive and destructive...
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Signal Propagation in Electromagnetic Media Modelled by the Two-Sided Fractional Derivative
PublikacjaIn this paper, wave propagation is considered in a medium described by a fractional-order model, which is formulated with the use of the two-sided fractional derivative of Ortigueira and Machado. Although the relation of the derivative to causality is clearly specified in its definition, there is no obvious relation between causality of the derivative and causality of the transfer function induced by this derivative. Hence, causality...
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Failures and a concept of corrosion protection system for spiral classifiers at KGHM Polska Miedź S.A. Ore Concentration Plant
PublikacjaThe Ore Concentration Plant, where the process of flotation is carried out as well as the final production of copper concentrate, plays a key role in the entire production line of KGHM Polska Miedź S.A. Majority of operations related to the run-of-mine preparation to copper flotation enrichment are carried out in a water environment. The maintaining of production process continuity requires to pursue minimisation of many production...
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Implementation of control system and tracking objects in a Quadcopter
PublikacjaIn this paper, we implement a quadcopter assembly with control and navigation module. The project also includes the design of the control panel for the operator which consists of a set of the micro-controller and the glove equipped with sensors and buttons. The panel has a touch screen which displays current parameters such as vehicle status, including information about orientation and geographical coordinates. The concept of quadcopter...
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Position and Orientation Estimation in Radio Network With Groups of Locally Synchronized Nodes
PublikacjaThis article presents a positioning system with groups of locally synchronized nodes. A mobile object is equipped with a group of several synchronized receivers that are able to measure the difference in the time of arrival of signals from reference transmitters. The reference transmitters are synchronized only in local groups, with no global synchronization between groups. It is assumed that the synchronous operation of transmitters...
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Optymalizacja efektywności hamowania odzyskowego w transporcie szynowym przez sterowanie czasem przyjazdu na stację
PublikacjaArtykuł nawiązuje do poprzednich prac autorów, w których przedstawiono model organizacji ruchu kooperujących pociągów z uwzględnieniem optymalizacji wykorzystania energii zwracanej do sieci jezdnej. W przedstawionej pracy zmodyfikowano model zmieniając główną zmienną sterującą, mającą wpływ na efektywne wykorzystanie energii, z czasu odjazdu na czas przyjazdu pociągu na stację lub przystanek. Optymalizacja dokonywana jest przez...
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Morse inequalities via Conley index theory
PublikacjaThe relation known as the Morse inequalities can be extended to a more general setting of flows on a locally compact metric spaces (Conley index) as well as dynamical systems on Hilbert spaces (LS-index). This paper is a discourse around this extension. Except the part concerning the LS-index the material is self-contained and has a character of a survey.
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Selected acoustic images of the Gdansk Bay
PublikacjaThe main goal of the paper is to describe the results of sounding the Gdansk Bay seabed by using a parametric sub-bottom profiler, multibeam echosounder and side scan sonar. Quality of dsata obtained during trials depends interalia on a proper location of antenna to reduce influence of pitch, roll and heave motions as well as ship noise.
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Reactive Energy Billing in Operator Tariffs in Poland
PublikacjaThe paper describes the current method of reactive energy billing in the tariffs of distribution grid operators in Poland. The current solutions are subject to critical assessment. Issues related to the motivation effect of the current solutions on consumers are analysed. Problems that occur in relation with connecting distributed generators to the distribution grid and challenges related to prosumer billing are indicated.
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Measurement of the tram rail profile during a year of operation
Dane BadawczeThe aim of the work was to analyze the wear of rails during operation and to analyze the supplementation of heavy metals in the soil around the tram route, originating from wearing out rails and tram wheels.The dataset contains measurements of rail head coordinates in 9 research sections made in 8 measurement series. The wear of the rails in selected...
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Spatial Differences in the Chemical Composition of Surface Water in the Hornsund Fjord Area: A Statistical Analysis with A Focus on Local Pollution Sources
PublikacjaSurface catchments in Svalbard are sensitive to external pollution, and yet what is frequently considered external contamination may originate from local sources and natural processes. In this work, we analyze the chemical composition of surface waters in the catchments surrounding the Polish Polar Station in Svalbard, Hornsund fjord area. We have pooled unpublished and already published data describing surface water composition...
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Video traffic data - Interchange Bielany (A4-5) - weaving, Poland
Dane BadawczeThe data includes video traffic data registered with 12 video cameras at weaving area (weaving section type A) of the Bielany interchange within A4 motorway in Poland (interchange of motorway A4 and nacional road 5), located in the Silesian Agglomeration.The data covers the one day: 07.06.2017 (motorway A4)
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Video traffic data - Interchange Slowackiego (S8-Slowackiego), Poland
Dane BadawczeThe data includes video traffic data registered with 4 video cameras at entry or exit lanes of the Slowackiego interchange within S8 expressway in Poland (interchange of expressway S8 and Slowackiego street), located in the Warsaw Agglomeration. The data covers the one day: 10-11.05.2017 (expressway S8).
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Video traffic data - Interchange Broniewskiego (S8-Broniewskiego), Poland
Dane BadawczeThe data includes video traffic data registered with 4 video cameras at entry or exit lanes of the Broniewskiego interchange within S8 expressway in Poland (interchange of expressway S8 and Broniewskiego street), located in the Warsaw Agglomeration. The data covers the two days: 10-11.05.2017 (expressway S8).
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Secure access control and information protection mechanisms in radio system for monitoring and acquisition of data from traffic enforcement cameras
PublikacjaThe study presents the architecture of the Radio System for Monitoring and Acquisition of Data from Traffic Enforcement Cameras (in short: RSMAD), particularly concerning access control and protection of confidential data. RSMAD security structure will be discussed in relation to network security issues. Additionally, the paper presents the results of the work associated with the modelling of potential threats to system security.
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Image as a key factor of brand value at social media
PublikacjaThe paper aims to investigate the relationship between social media presence and activities and brand value for the most valuable Global Brands 2012 (Interbrandt 2013). Social media communication is an innovative way of communication. Brand value is a key performance indicator of brand strategy for managers. Brand and category image realized to be the key factor of investigated relation.
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Concept of Compatibility Region for the Evaluation of IR UWB Electromagnetic Compatibility
PublikacjaThis paper presents a new proposal for the unified evaluation of ultra wideband and narrowband radio communication systems electromagnetic compatibility, called “compatibility region”. The idea of compatibility region is based on the relation between the ratio of narrowband to ultra wideband signal power in a receiver and some transmission quality indicators (bit error rate, effective data rate).
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<i>N,N</i>'-diphenylthiourea acetone monosolvate
PublikacjaIn the title compound, C13H12N2S·C3H6O, the phenyl rings of the thiourea molecule are in syn and anti positions in relation to the C=S bond. Two molecules are connected by N-HS=C hydrogen bonds into a centrosymmetric dimer. An additional N-HO=C hydrogen bond to the acetone solvent molecule and some weak C-H interactions reinforce the crystal structure.
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Cyclic voltammetry curves for FTO/PANI:WO3 nanocomposite
Dane BadawczeThis dataset contains the results of kinetic electrochemical studies, carried out with cyclic voltammetry (CV) of FTO/PANI:WO3 nanocomposite at various scan rates: 10, 20, 50, 75, 100 and 200 mV/s. The electrolyte was 1M H2SO4 solution. The measurements were performed in a three electrode setup, and with Ag|AgCl|3M KCl as the reference electrode and...
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Share of gross value added by factors of production prices generated by the enterprise sector in Poland and in the EU countries in the GDP of individual countries
Dane BadawczeCompanies operating in the EU countries are characterized by a greater contribution to the creation of GDP than Polish enterprises. Discrepancies in shaping the described value also result from a different industry structure of companies. In other EU countries, more companies are involved in services, and in Poland, enterprises conducting commercial...
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On rotary inertia of microstuctured beams and variations thereof
PublikacjaWe discuss the classic rotary inertia notion and extend it for microstructured beams introducing new microinertia parameters as an additional dynamic response to microstructure changes. Slender structures made of beam- or platelet-lattice metamaterials may exhibit not only large translations and rotations but also general deformations of inner structure. Here we considered a few examples of beam-like structures and derive their...
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The Application of Fluidic Sealing in Shrouded Gas Turbine Blades
PublikacjaThis paper presents a study conducted on a new gas turbine designed to limit leakage in the labyrinth seal. The slots in the fin are used to generate a bypass flow, which obstructs the flow in the gap above the fin. The method was tested numerically and experimentally beforehand using a simplified model without rotation or blade passages. In this paper, the validation of the method using a model of a turbine stage is shown. Reynolds-averaged...
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<i>N,N,N</i>-Trimethyl-N-(methyl 5-deoxy-2,3-<i>O</i>-isopropylidene-β-D-ribofuranosid-5- yl)ammonium 4-methylbenzenesulfonate sesquihydrate.
PublikacjaThe structure of the title compound, [C12H24NO4][C7H7O3S]·1.5H2O, contains alternating layers parallel to (001) of hydrophobic and polar character, stabilized by C-H...O hydrogen bonding. The furan ring adopts an envelope conformation with the C(OMe) atom as the flap, and the dioxolane ring is twisted about one of the O-C(methine) bonds. A comparison to related compounds is presented. The tosylate-O atoms were disordered over two...
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Longitudinally magnetized left-handed cylindrical ferrite coupled line junction for nonreciprocal devices
PublikacjaThis paper presents investigations of longitudinally magnetized left-handed cylindrical ferrite coupled line junction for nonreciprocal devices. The proposed junction is formed as a quasi periodic arrangement of N unit cells. Each unit cell is realized as a cascade of short cylindrical ferrite coupled lines with reactance circuit composed of series capacitors and parallel inductors. The left-handed cylindrical junction with π/4...
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Machine-learning-based precise cost-efficient NO2 sensor calibration by means of time series matching and global data pre-processing
PublikacjaAir pollution remains a considerable contemporary challenge affecting life quality, the environment, and economic well-being. It encompasses an array of pollutants—gases, particulate matter, biological molecules—emanating from sources such as vehicle emissions, industrial activities, agriculture, and natural occurrences. Nitrogen dioxide (NO2), a harmful gas, is particularly abundant in densely populated urban areas. Given its...
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Evaluation of Pavement Temperatures in Poland During Winter Conditions
PublikacjaThe paper presents the analysis of pavement temperatures from meteorological stations located at the Polish national roads during the impact of low winter temperatures. Presented issue is particularly important in view of the problem of low-temperature cracks that occur in the asphalt pavement under the influence of low temperatures. For each location of meteorological station there were analysed measurements of the temperature...
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Corrosion monitoring as a factor increasing the safety of hydrotechnical infrastructure
PublikacjaWater distribution systems at KGHM S.A. are of great importance for the efficient production of copper and environmental protection. For failures leading to perforation and leakage, the corrosion processes are responsible. This paper aims to assess corrosion on the basis of the analysis of the exposure of the Hydrotechnical Plant pipelines. To this end, the system of transfer and deposition of post-flotation waste as well as the...
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New First - Path Detector for LTE Positioning Reference Signals
PublikacjaIn today's world, where positioning applications reached a huge popularity and became virtually ubiquitous, there is a strong need for determining a device location as accurately as possible. A particularly important role in positioning play cellular networks, such as Long Term Evolution (LTE). In the LTE Observed Time Difference of Arrival (OTDOA) positioning method, precision of device location estimation depends on accuracy...