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- Publikacje 2773 wyników po odfiltrowaniu
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Wyniki wyszukiwania dla: mesh generator
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An Approach to Data Reduction and Integrated Machine Classification
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Design and computational fluid dynamics analysis of the last stage of innovative gas-steam turbine
PublikacjaResearch regarding blade design and analysis of flow has been attracting interest for over a century. Meanwhile new concepts and design approaches were created and improved. Advancements in information technologies allowed to introduce computational fluid dynamics and computational flow mechanics. Currently a combination of mentioned methods is used for the design of turbine blades. These methods enabled us to improve flow efficiency...
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Biomechanical causes for failure of the Physiomesh/Securestrap system
PublikacjaThis study investigates the mechanical behavior of the Physiomesh/Securestrap system, a hernia repair system used for IPOM procedures associated with high failure rates. The study involved conducting mechanical experiments and numerical simulations to investigate the mechanical behavior of the Physiomesh/Securestrap system under pressure load. Uniaxial tension tests were conducted to determine the elasticity modulus of the Physiomesh...
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Nonsense-Mediated mRNA Decay: Pathologies and the Potential for Novel Therapeutics
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Molecular basis of TRF proteins and their interactions with peptides
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Structural analysis and predicting effects of natural mutations on telomerase
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Molecular modeling and evaluation of novel dibenzopyrrole derivatives as telomerase inhibitors and potential drug for cancer therapy
PublikacjaDuring previous years, many studies on synthesis, as well as on anti-tumor, anti-inflammatory and anti-bacterial activities of the pyrazole derivatives have been described. Certain pyrazole derivatives exhibit important pharmacological activities and have proved to be useful template in drug research. Considering importance of pyrazole template, in current work the series of novel inhibitors were designed by replacing central...
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Identification of 1H‐indene‐(1, 3, 5, 6)‐tetrol derivatives as potent pancreatic lipase inhibitors using molecular docking and molecular dynamics approach
PublikacjaPancreatic lipase is a potential therapeutic target to treat diet-induced obesity in humans, as obesity-related diseases continue to be a global problem. Despite intensive research on finding potential inhibitors, very few compounds have been introduced to clinical studies. In this work, new chemical scaffold 1H-indene-(1,3,5,6)-tetrol was proposed using knowledge-based approach, and 36 inhibitors were derived by modifying its...
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Docking simulations, Molecular properties and ADMET studies of novel Chromane6,7diol analogues as potential inhibitors of Mushroom tyrosinase
PublikacjaResearch on inhibition of tyrosinase enzyme has attained significant value, because tyrosinase inhibitors have potential applications in medicine, cosmetics (as whitening agents) and in agriculture (as bioinsecticides). Determination and elucidation of new tyrosinase inhibitors are not only beneficial for medical purposes, but their promising applications in improving food quality and nutritional...
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Structural, functional, and stability change predictions in human telomerase upon specific point mutations,
PublikacjaOverexpression of telomerase is one of the hallmarks of human cancer. Telomerase is important for maintaining the integrity of the ends of chromosomes, which are called telomeres. A growing number of human disease syndromes are associated with organ failure caused by mutations in telomerase (hTERT or hTR). Mutations in telomerase lead to telomere shortening by decreasing the stability of the telomerase complex, reducing its accumulation,...
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Structural and dynamic changes adopted by EmrE, multidrug transporter protein—Studies by molecular dynamics simulation
PublikacjaEmrE protein transports positively charged aromatic drugs (xenobiotics) in exchange for two protons and thus provides bacteria resistance to variety of drugs. In order to understand how this protein may recognize ligands, the monomer and asymmetric apo-form of the EmrE dimer embedded in a heterogeneous phospholipid (POPE + POPG) membrane were studied by molecular dynamics simulations. Dimer is regarded as a functional form of the...
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The structurally similar TRFH domain of TRF1 and TRF2 dimers shows distinct behaviour towards TIN2
PublikacjaThe telomere repeat binding-factor 1 and 2 (TRF1 and TRF2) proteins of the shelterin complex bind to duplex telomeric DNA as homodimers, and the homodimerization is mediated by their TRFH (TRF-homology) domains. We performed molecular dynamic (MD) simulations of the dimer forms of TRF1TRFH and TRF2TRFH in the presence/absence of the TIN2TBM (TIN2, TRF-interacting nuclear protein 2, TBM, TRF-binding motif) peptide. The MD results...
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Extracting functional groups of ALLINI to design derivatives of FDA‐approved drugs: Inhibition of HIV‐1 integrase
PublikacjaHIV‐1 integrase (IN) is crucial for integration of viral DNA into the host genome and a promising target in development of antiretroviral inhibitors. In this work, six new compounds were designed by linking the structures of two different class of HIV‐1 IN inhibitors (active site binders and allosteric IN inhibitors (ALLINIs)). Among newly designed compounds, INRAT10b was found most potent HIV‐1 IN inhibitor considering different...
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Structural and dynamic insights on the EmrE protein with TPP+ and related substrates through molecular dynamics simulations
PublikacjaEmrE is a bacterial transporter protein that forms an anti-parallel homodimer with four transmembrane helices in each monomer. EmrE transports positively charged aromatic compounds, such as TPP+ and its derivatives. We performed molecular dynamics (MD) simulations of EmrE in complex with TPP+, MeTPP+, and MBTPP+ embedded in a membrane. The detailed molecular properties and interactions were analysed for all EmrE-ligand complexes....
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Molecular basis and potential activity of HIV-1 reverse transcriptase toward trimethylamine-based compounds
PublikacjaReverse transcriptase (RT) inhibitors are currently used to treat human immunodeficiency virus (HIV)-1 infections. In this work, novel triethylamine derivatives were designed and studied by rigid and flexible docking and molecular dynamics (MD) approaches. An apo form of HIV-1 RT was also studied by MD simulation to analyze comparative response of protein in ligand-bound and ligand-unbound forms. Among newly designed HIV-1 RT inhibitors,...
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Molecular basis and quantitative assessment of TRF1 and TRF2 protein interactions with TIN2 and Apollo peptides
PublikacjaShelterin is a six-protein complex (TRF1, TRF2, POT1, RAP1, TIN2, and TPP1) that also functions in smaller subsets in regulation and protection of human telomeres. Two closely related proteins, TRF1 and TRF2, make high-affinity contact directly with double-stranded telomeric DNA and serve as a molecular platform. Protein TIN2 binds to TRF1 and TRF2 dimer-forming domains, whereas Apollo makes interaction only with TRF2. To elucidate...
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Virtual spring damper method for nonholonomic robotic swarm self-organization and leader following
PublikacjaIn this paper, we demonstrate a method for self-organization and leader following of nonholonomic robotic swarm based on spring damper mesh. By self-organization of swarm robots we mean the emergence of order in a swarm as the result of interactions among the single robots. In other words the self-organization of swarm robots mimics some natural behavior of social animals like ants among others. The dynamics of two-wheel robot...
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Statyczny generator mocy biernej STATCOM
Aparatura BadawczaStatyczny generator mocy biernej STATCOM
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Architektura bezpieczeństwa systemu netBaltic
PublikacjaW artykule zaprezentowano założenia dotyczące zabezpieczania węzłów sieci realizowanej w ramach systemu netBaltic. Ze względu na dużą różnorodność rozważanych mechanizmów komunikacyjnych architektura bezpieczeństwa została podzielona na kilka elementów – infrastrukturę klucza publicznego (PKI), bezpieczeństwo systemowe węzłów, zabezpieczanie komunikacji w modelu samoorganizującej wieloskokowej sieci kratowej, a także sieci niewrażliwej...
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Organic Rankine cycle as bottoming cycle to a combined Brayton and Clausius - Rankine cycle
PublikacjaA preliminary evaluation has been made of a possibility of bottoming of a conventional Brayton cycle cooperating with the CHP power plant with the organic Rankine cycle installation. Such solution contributes to the possibility of annual operation of that power plant, except of operation only in periods when there is a demand for the heat. Additional benefit would be the fact that an optimized backpressure steam cycle has the advantage...
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Analysing and processing of geotagged social media
PublikacjaThe use of location based data analysing tools is an important part of geomarketing strategies among entrepreneurs. One of the key elements of interest is social media data shared by the users. This data is analysed both for its content and its location information, the results help to identify trends represented in the researched regions. In order to verify the possibilities of analysing and processing of geotagged social media...
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Optimized Space Vector Modulation strategy for five phase voltage source inverter with third harmonic injection
PublikacjaThis paper presents a simple and an effective SVM algorithm for five-phase Voltage-Source Inverters with the possibility to control independently the voltage vectors for fundamental and auxiliary orthogonal subspaces. The essential benefit is that output voltage is generated using only four active voltage vectors with limited numbers of switching. In the proposed solution, four active vectors are arbitrary chosen, independent of...
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Broadband Modeling of Motor Cable Impact on Common Mode Currents in VFD
PublikacjaExamination of conducted EMI generation and propagation in AC motor drives fed by frequency converter requires to consider parasitic capacitances in converters, motor windings and feeding cables to be taken into account. AC motor winding voltage transients and related common mode currents are significantly correlated with resonance effects occurring in converter's load circuits. Intensity levels of these phenomena depend...
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Hydrogen bonding part sigma profile of deep eutectic solvents and pure components
Dane BadawczeThe set includes raw data of hydrogen bonding part sigma profiles of deep eutectic solvents and pure components generated by the ADF COSMO-RS software (SCM, Netherlands).
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Mechanika analityczna, W, M, sem. 01, lato 21/22 (PG_00057017)
Kursy Onlinemech analit
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Mechanika analityczna, W, MTR, sem. 01, lato 22/23 (PG_00057017)
Kursy Onlinemech analit
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Mechanika analityczna, W, MTR, II st., sem. 01, letni 23/24, (PG_00057017)
Kursy Onlinemech analit
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Results of nanoindentation test to calculate residual stress in an eyelet of undercarriage drag strut after laser treatment
Dane BadawczeIn order to determine the residual stress in the laser-processed an eyelet of undercarriage drag strut, a nanoindentation test was performed before and after stress relief annealing. For this purpose, after the hardness test, the sample was subjected to stress relief annealing at 270 °C for 2 hours. Annealing was performed in a vacuum furnace. Hardness...
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Next generation radio communication systems (2022)
Kursy Online -
An interactive system for remote modeling and design validation of hybrid photovoltaic systems
PublikacjaIn the paper a multi-functional demonstrator of the interactive system designed to modeling, monitoring and validation of hybrid photovoltaic systems assisted by fuel cells and thermoelectric generators is presented. The purpose of this paper is to report the system solution expressed in the form of a block diagram. Technical parameters of demonstrator components such as: silicon photovoltaic modules, fuel cells, thermoelectric...
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Multiscale model for blood flow after a bileaflet artificial aortic valve implantation
PublikacjaCardiovascular diseases are the leading cause of mortality in the world, mainly due to atherosclerosis and its consequences. The article presents the numerical model of the blood flow through artificial aortic valve. The overset mesh approach was applied to simulate the valve leaflets motion and to realize the moving mesh, in the aortic arch and the main branches of cardiovascular system. To capture the cardiac system’s response...
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Physical and chemical basis of energy generation - 2023
Kursy Online -
Physical and chemical basis of energy generation - 2024
Kursy Online -
A finite element analysis of thermal energy inclination based on ternary hybrid nanoparticles influenced by induced magnetic field
PublikacjaThe use of hybrid nanoparticles to improve thermal processes is a key method that has implications for a variety of interventions utilized in many sectors. This paper aimed to look into the impacts of ternary nanoparticles on hyperbolic tangent materials to establish their thermal characteristics. Flow describing equations have been explored in the presence of heat production, non-Fourier heat flux, and an induced magnetic field....
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Improving SBR Performance Alongside with Cost Reduction through Optimizing Biological Processes and Dissolved Oxygen Concentration Trajectory
PublikacjaAuthors of this paper take under investigation the optimization of biological processes during the wastewater treatment in sequencing batch reactor (SBR) plant. A designed optimizing supervisory controller generates the dissolved oxygen (DO) trajectory for the lower level parts of the hierarchical control system. Proper adjustment of this element has an essential impact on the efficiency of the wastewater treatment process as well...
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Potential Application of Solar Energy Systems for Electrified Urban Transportation Systems
PublikacjaThe paper presents a novel approach toward the use of solar energy systems in public transportation. The concept of energy generation in PV systems for supplying a trolleybus transportation system is proposed for the city of Gdynia (Poland). The suggested way of energy production allows reducing the environmental harm impact of the municipal transportation system. Moreover, the proposed way of green energy use can be a more profitable...
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Wysokotemperaturowa trwałość stali i złączy spawanych w środowisku spalin
PublikacjaBadano przyczyny zróżnicowanej trwałości eksploatacyjnej dwóch osłon palników generatorów gazów obojętnych. Przeprowadzono badania materiałowe; analizę chemiczną, badania metalograficzne i mikroanalizę warstw wierzchnich. Wykazały one, że osłona, która uległa zniszczeniu po ok. 40 godzinach normalnej eksploatacji generatora była wykonana ze stali niestopowej, natomiast osłona, która przepracowała nieco ponad 6 miesięcy i uległa...
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Possibility to use engine compression ignition engines in floating power plants marine
PublikacjaCompression-ignition engines used in ship technology as main propulsion engines are large units reaching even to 50-60 MW. The engines can be used in power industry for electricity generation in a simple or combined steam turbine system in combined heat and power plants. The leading engine in such an arrangement is an internal-combustion piston engine. The main propulsion engines are used in large piston internal-combustion engines...
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TRANSFER OF ELECTRIC ENERGY [2023/24]
Kursy OnlineCourse content: Basic information on the structure of the power system, the major devices (components) for generation, transmission and distribution of electricity. Active and reactive power generation and their sources. Power supply networks. Tasks, structure, parameters. AC and DC transmission of electricity. Equivalent diagrams of the components of the power system. Steady state load flow calculation: currents, voltage,...
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TRANSFER OF ELECTRIC ENERGY [2022/23]
Kursy OnlineCourse content: Basic information on the structure of the power system, the major devices (components) for generation, transmission and distribution of electricity. Active and reactive power generation and their sources. Power supply networks. Tasks, structure, parameters. AC and DC transmission of electricity. Equivalent diagrams of the components of the power system. Steady state load flow calculation: currents, voltage,...
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Investigation on polypropylene friction stir joint: effects of tool tilt angle on heat flux, material flow and defect formation
PublikacjaTool tilt angle (TTA) is a critical factor that can control material flow in polymeric materials' friction stir joining (FSJ). This study selected a TTA range between 0° to 4° for FSJ of polypropylene (PP) polymer sheet. A modified computational fluid dynamic (CFD) technique was implemented to gain a deep understanding of the effects of TTA during FSJ of PP. The PP joint's internal flow, defect formation, heat generation, and tensile...
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Hybrid systems using hydrodynamic cavitation/ultrasound/Fenton processes for effective treatment of wastewater
PublikacjaThe present situation of rapid growth in industrialization generates complex recalcitrant pollutants that are challenging to degrade by conventional wastewater treatment processes. The new generation pollutants such as non-metals in cosmetics or household cleaning chemicals and radioactive compounds which are recalcitrant are the emerging threat to the ecosystem. The headstrong micro and macro pollutants present in wastewater are...
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Modelling of Geared Multi-Rotor System
PublikacjaIn the paper the method of modelling a speed-varying geared rotor system is presented. The proposed approach enables us to obtain an accurate low-order lumped parameter representation of the investigated system. The final model consists of reduced modal models of an undamped beam/torsional shaft system as well as a spatially lumped model of other linear and nonlinear phenomena including gear mesh interaction.
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A concept of measurement system based on the Z-Wave standard
PublikacjaIn the paper a new concept of measurement system based on the Z-Wave standard is presented. This standard is dedicated to use mainly in home automation systems, but its properties enable to use it in dispersed measurement systems and support wireless communication between measurement nodes in a mesh-type network. In the paper basic metrological aspects of the Z-Wave standard and an example of impedance measurement system are discussed.
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Redox property switching in MOFs with open metal sites for improved catalytic hydrogenation performance
PublikacjaIn this study, a decompression-thermalization strategy was utilized for a Cu-containing metal-organic framework (MOF) to tune its redox and catalytic hydrogenation properties. Remarkably, at just 120 °C, open metal sites (OMSs) were successfully constructed by removing coordinated solvent molecules to generate the daughter MOF-120. The tailored redox property of MOF-120 is correlated with the presence of OMSs. Compared with the...
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Generator energii z fal morskich i oceanicznych
Wynalazki -
Mechanizmy bezpieczeństwa w strefie C systemu netBaltic
PublikacjaW artykule zaprezentowano rozwiązania zaimplementowane do zabezpieczania komunikacji w warunkach sporadycznej i nieciągłej łączności (Delay Tolerant Networking – DTN) w systemie netBaltic - charakterystycznej dla strefy C tego systemu. Ze względu na dużą różnorodność rozważanych mechanizmów komunikacyjnych, architektura bezpieczeństwa całego systemu została podzielona na kilka elementów – infrastrukturę klucza publicznego (PKI),...
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ANALIZA PARAMETRÓW PRZEPŁYWOWYCH CZYNNIKÓW ROBOCZYCH PRZEZ STOPNIE TURBIN GAZOWYCH
PublikacjaW rozdziale przedstawiono charakterystyki statyczne głównych parametrów turbiny gazowej dla częściowych obciążeń. Przebiegi poszczególnych parametrów podano dla różnych konfiguracji turbin gazowych: jednowałowej napędzającej generator elektryczny i jednowałowej z regulacją kąta ustawienia łopatek sprężarki również napędzającej generator elektryczny oraz dwuwałowej turbiny transportowej. Charakterystyki wyznaczono eksperymentalnie,...
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Example of Using Particle Swarm Optimization Algorithm with Nelder–Mead Method for Flow Improvement in Axial Last Stage of Gas–Steam Turbine
PublikacjaThis article focuses principally on the comparison baseline and the optimized flow efficiency of the final stage of an axial turbine operating on a gas–steam mixture by applying a hybrid Nelder– Mead and the particle swarm optimization method. Optimization algorithms are combined with CFD calculations to determine the flowpaths and thermodynamic parameters. The working fluid in this study is a mixture of steam and gas produced...
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Impact of optimization of ALS point cloud on classification
PublikacjaAirborne laser scanning (ALS) is one of the LIDAR technologies (Light Detection and Ranging). It provides information about the terrain in form of a point cloud. During measurement is acquired: spatial data (object’s coordinates X, Y, Z) and collateral data such as intensity of reflected signal. The obtained point cloud is typically applied for generating a digital terrain model (DTM) and a digital surface model (DSM). For DTM...