Wyszukiwarka
Filtry
wszystkich: 1773
-
Katalog
- Publikacje 1385 wyników po odfiltrowaniu
- Czasopisma 177 wyników po odfiltrowaniu
- Konferencje 1 wyników po odfiltrowaniu
- Osoby 34 wyników po odfiltrowaniu
- Wynalazki 2 wyników po odfiltrowaniu
- Projekty 1 wyników po odfiltrowaniu
- Zespoły Badawcze 1 wyników po odfiltrowaniu
- Kursy Online 39 wyników po odfiltrowaniu
- Wydarzenia 14 wyników po odfiltrowaniu
- Dane Badawcze 119 wyników po odfiltrowaniu
wyświetlamy 1000 najlepszych wyników Pomoc
Wyniki wyszukiwania dla: REGENERATIVE DRUGS
-
Optimization of the geometry of the crankshaft for an internal combustion engine with heat regeneration
Publikacja -
Separation of effluents from regeneration of a cation exchanger by membrane distillation
Publikacja -
Groundwater quality regeneration in the discharge zone of the Gdansk aquifer system
PublikacjaEksploatacja wód podziemnych w rejonie Gdańska prowadzona jest głównie w strefie drenażu wód na nizinach nadmorskich. Wieloletni, intensywny pobór spowodował niekorzystne zmiany w ich jakości, są one głównie związane z zasoleniem wód podziemnych intruzjami wód morskich. Sytuacja ta dotyczy zwłaszcza pietra czwartorzędowego. Spadek wilekości eksploatacji, który obserwuje się od lat 90. prowadzi poprawy jakości wód podziemnych, a...
-
Urban regeneration vs. urban sprawl - is the ''compact city'' possible?
PublikacjaArtykuł dotyczy zagadnień zrównoważonego rozwoju miast i konceptu ''miasta kompaktowego''. Poruszone zostały zagadnienia zasad urbanistycznych współczesnego rozwoju miasta oraz problem rewitalizacji urbanistycznej.
-
Street Art and Urban Regeneration. Case Study Gdansk and Rome.
PublikacjaStreet art plays an important role in urban planning as a transforming engine to regenerate the public spaces and in the processes of participation. The article analyzes two main topics. The first one focuses on the urban serving as a support for spatial and cultural strategies in urban redevelopment projects. The second one is related to the potential of micro urban interventions as a strategy for a wider involvement of inhabitants...
-
NEIGHBOURHOOD SPORT AS A TOOL OF URBAN REGENERATION - A WARSAW CASE STUDY
PublikacjaThere are many connections between sport and urban regeneration. They can be observed while organizing top-down projects, such as sporting mega-events. But sport and urban renewal can also be linked within bottom-up sport initiatives, ones that relate mostly to physical recreation or sport for all. The main goals of physical activity is caring for health, improving fitness, practicing hobbies, and achieving social integration....
-
Participatory Budgeting in Poland – Missing Link in Urban Regeneration Process
PublikacjaIn last thirty years Poland has gone a long way toward democracy and decentralization. Role of public participation in planning is increasing rapidly and recently many new instruments of empowering the community is being introduced, participatory budgeting is one of the most important. On the other hand, urban regeneration is one of the most important challenges of polish cities are facing. Technical and transport infrastructure...
-
Participatory approach to urban regeneration processes in polish cities and regions
PublikacjaThe paper presents the impact of EU Cohesion Policy 2014-2020 on regeneration processes which are implemented in Polish towns, cities and metropolis when emphasizing general formal and legal framework including examination of the possible distribution of EU funds for regeneration projects within the regional operational programmes. The paper focuses on different approaches to the implementation of Cohesion Policy in Polish regions....
-
Wet H2S corrosion and degradation of pipeline in amine regeneration system
PublikacjaThe paper presents the results of NDT examinations, metallographic tests and risk assessment of degradation related to corrosion of amine regeneration unit in a desulphurisation system. Intensive corrosion resulting from acid gases environment upon water condensation causes perforation of the pipeline. Detailed analysis reveals cracking related to the mechanism of wet H2S. Hydrogen penetration, resulting from the wet H2S process,...
-
Fentanyl and its derivatives as a group of new psychoactive substances (designer drugs)
Publikacja -
Expression of alternatively spliced variants of the Dclk1 gene is regulated by psychotropic drugs
Publikacja -
Assessment of sleep disorders and use of psychoactive drugs among Polish students
Publikacja -
New data on antihypertensive drugs and risk of cancer: should we worry?
Publikacja -
TIME to face the reality about evening dosing of antihypertensive drugs in hypertension
Publikacja -
Environmentally Oriented Models and Methods for the Evaluation of Drug x Drug Interaction Effects
PublikacjaThis detailed review compares known and widely used methods for drug interaction estimation, some of which now have historical significance. Pharmaceutical application has been noted as far back as several thousand years ago. Relatively late in the 20th century, however, researchers became aware that their fate and metabolism, which still remain a great challenge for environmental analysts and risk assessors. For the patient’s...
-
Increase of the effective energy from the radiant tube equipped with regenerative system in comparison with conventional recuperative system
PublikacjaPrzedstawiono wyniki badań eksperymentalnych spalania HiTAC (High Temperature Air Combustion) z użyciem rury promieniującej w celu porównania systemu palników regeneracyjnych z konwencjonalnym systemem rekuperacyjnym.
-
Polyurethanes Crosslinked with Poly(vinyl alcohol) as a Slowly-Degradable and Hydrophilic Materials of Potential Use in Regenerative Medicine
PublikacjaNovel, slowly-degradable and hydrophilic materials with proper mechanical properties and surface characteristics are in great demand within the biomedical field. In this paper, the design, synthesis, and characterization of polyurethanes (PUR) crosslinked with poly(vinyl alcohol) (PVA) as a new proposition for regenerative medicine is described. PVA-crosslinked PURs were synthesized by a two-step polymerization performed in a solvent...
-
Application of Navigated Ultrasound for Assessment of the Anterior Pelvic Plane in Patients With Degenerative Hip Diseases
Publikacja -
Generative Process Planning with Reasoning Based on Geometrical Product Specification
Publikacja -
The Impact of Generative AI and ChatGPT on Creating Digital Advertising Campaigns
PublikacjaThe use of AI-based solutions is currently discussed in relation to various industries. The proliferation of tools based on generative artificial intelligence (GAI), including the emergence of ChatGPT, has resulted in testing as a first step and implementations in further areas of business life, including marketing, as a second step. Still only a few studies have analysed and evaluated specific solutions for different areas of...
-
Generative Process Planning with Reasoning based on Geometrical Product Specification
PublikacjaThe focus of this paper is on computer aided process planning for parts manufacture in systems of definite process capabilities, involving the use of multi-axis machining centers for parts shaping and grinding machines for finishing. It presents in particular a decision making scheme for setup determination as a part of generative process planning. The planning procedurę consists of two stages. The first stage is associated with...
-
A review on computer‐aided chemogenomics and drug repositioning for rational COVID ‐19 drug discovery
PublikacjaApplication of materials capable of energy harvesting to increase the efficiency and environmental adaptability is sometimes reflected in the ability of discovery of some traces in an environment―either experimentally or computationally―to enlarge practical application window. The emergence of computational methods, particularly computer-aided drug discovery (CADD), provides ample opportunities for the rapid discovery and development...
-
Cogenerative micro power plants - a new direction for development of power engineering?
PublikacjaW pracy przedstawiono rozważania dotyczące perspektywy mikrosiłowni domowych w gospodarce rozproszonej. Przedstawiono oryginalne kryterium doboru czynnika roboczego w mikrosiłowni oraz przedstawiono sprawności cieplne i egzergetyczne obiegów Clausiusa-Rankina realizujących pracę mikrosiłowni.
-
Epigenetic regulation and regeneration: the search for differentially methylated genes in the MRL mouse
PublikacjaThe MRL mouse is an inbred laboratory strain, which was developed in the 60’s of the 20th century and has been extensively used as a model of lupus erythematosus. The regenerative abilities of the strain were discovered in the 90' when the MRL mouse was shown to close 2 mm hole punches made in the ear pinnae four weeks after injury without scarring. The phenomenon has not been observed in other mouse strains, where the holes...
-
Process modeling inside cylinder in an internal combustion engine with heat regeneration
Publikacja -
Treatment of effluents from the regeneration of ion exchangers using the MD process
Publikacja -
Osmotic membrane distillation with continuous regeneration of stripping solution by natural evaporation
Publikacja -
Amine-Based Ionic Liquid for CO2 Capture and Electrochemical or Thermal Regeneration
Publikacja -
Successfull urban regeneration project: Gdansk-Letnica district case study
PublikacjaThe paper presents the process of urban regeneration of Gdansk Letnica district, a project that from a very short time perspective can be described as successful. The paper present a brief district's history as well as analysis of circumstances that may have influenced Gdansk authorities' decision of starting an urban regeneration project.
-
Interaction of selected drugs with food in the group of patients over 60 years of age
Publikacja -
Studies of human and veterinary drugs' fate in environmental solid samples- analytical problems.
PublikacjaW różnych ośrodkach naukowych na całym świecie trwają prace nad poznaniem losu środowiskowego zanieczyszczeń z grupy farmaceutyków. Obecność pozostałości farmaceutycznych w poszczególnych elementach środowiska stanowi nowe wyzwanie zarówno z punktu widzenia technologii oczyszczania wód i ścieków jak i analityków, których zadaniem jest opracowanie nowych metodyk analitycznych. W publikacji przedstawiono problemy z jakimi stykają...
-
The Comparison Between the Calculated and HPLC-Predicted Lipophilicity Parameters for Selected Groups of Drugs
Publikacja -
Activity evaluation of some psychoactive drugs with the application of QSAR/QSPR modeling methods
Publikacja -
European Society of Hypertension Working Group on Obesity: obesity drugs and cardiovascular outcomes
Publikacja -
Stable and degradable microgels linked with cystine for storing and environmentally triggered release of drugs
PublikacjaEnvironmentally sensitive, degradable microgels based on poly(N-isopropylacrylamide) (pNIPA) crosslinked with the diacryloyl derivative of cystine (BISS) were synthesized by applying surfactant-free emulsion polymerization. pNIPA contributed the sensitivity to temperature to the microgels and the cross-linker made them degradable and sensitive to pH. The morphology of the microgels was investigated by using scanning and transmission...
-
Detrimental effects of chemotherapeutics and other drugs on the endothelium: A call for endothelial toxicity profiling
Publikacja -
Impact of selected drugs and their binary mixtures on the germination of Sorghum bicolor (sorgo) seeds
PublikacjaThe aim of this study was to assess the toxicological potential of binary drug mixtures and individual drugs under different pH conditions with different inorganic ion additions on the germination of Sorghum bicolor (sorgo) seeds. To assess whether the given drug mixtures were more phytotoxic than the individual compounds, concentration addition (CA) and independent action (IA) approaches were applied to estimate the predicted...
-
The role of glucuronidation in drug resistance
PublikacjaThe final therapeutic effect of a drug candidate, which is directed to a specific molecular target strongly depends on its absorption, distribution, metabolism and excretion (ADME). The disruption of at least one element of ADME may result in serious drug resistance. In this work we described the role of one element of this resistance: phase II metabolism with UDP-glucuronosyltransferases (UGTs). UGT function is the transformation...
-
Sequence variants of p21 gene of the MRL/MpJ mouse: a possible association with the deficit of p21 protein and regenerative phenotype.
PublikacjaThe MRL/MpJ mouse is known for its enhanced regeneration abilities that manifested themselves by scarless ear-hole wound closure. The deficit of p21 found in the MRL is associated with the regenerative capacity as the p21 gene knockout in a mouse strain unrelated to the MRL mouse results in an ear-hole closure effect, similar to that observed in the MRL mouse. Cdkn1a gene encodes p21 protein, a cyclin-dependent kinase inhibitor,...
-
Neotenic phenomenon in gene expression in the skin of Foxn1- deficient (nude) mice - a projection for regenerative skin wound healing
PublikacjaMouse fetuses up to 16 day of embryonic development and nude (Foxn1- deficient) mice are examples of animals that undergo regenerative (scar-free) skin healing. The expression of transcription factor Foxn1 in the epidermis of mouse fetuses begins at embryonic day 16.5 which coincides with the transition point from scar-free to scar-forming skin wound healing. In the present study, we tested the hypothesis that Foxn1 expression...
-
Cancer stem cells and escape from drug-induced premature senescence in human lung tumor cells: implications for drug resistance and in vitro drug screening models
PublikacjaBadania z użyciem modelu komórek nowotworu płuc A549 wykazały, że komórki te po traktowaniu lekami uszkadzającymi DNA zatrzymują proliferację i wchodzą w stan starzenia komórkowego. Jednak post-inkubacja tych komórek prowadzi do powrotu do stanu proliferacji małej frakcji komórek. Wykazaliśy, że frakcja ta związana jest z obecnością komórek pierwotnych nowotworu w populacji komórek A549. Powrót do stanu proliferacji komóek A549...
-
Postmortem analysis of human bone marrow aspirate - Quantitative determination of SSRI and SNRI drugs
Publikacja -
Electroanalytical and spectroscopic procedures for examination of interactions between double stranded DNA and intercalating drugs
PublikacjaPrzedstawiono metodę elektrochemicznego opisu oddziaływań dsDNA ze związkiem biologicznie czynnym w warunkach, w których zarówno badany związek jak i cząsteczka DNA są w roztworze elektrolitu. Opracowano warunki pomiaru, gdzie ani związek, ani DNA nie adsorbuje na elektrodzie. Wykazano, podobnie jak podczas badania innymi metodami, że oddziaływania są dwojakiego rodzaju: elektrostatyczne i poporzez interkalację.
-
Clinical Relevance of Gut Microbiota Alterations under the Influence of Selected Drugs—Updated Review
Publikacja -
Non-steroidal anti-inflammatory drugs are safe with respect to the transcriptome of human dermal fibroblasts
Publikacja -
Effect of chemical structure on complexation efficiency of aromatic drugs with cyclodextrins: The example of dibenzazepine derivatives
PublikacjaIt is widely believed that the hydrophobic effect governs the binding of guest molecules to cyclodextrins (CDs). However, it is also known that high hydrophobicity of guest molecules does not always translate to the formation of stable inclusion complexes with CDs. Indeed, a plethora of other factors can play a role in the efficiency of guest–CD interactions, rendering structure-based prediction of the complexation efficiency with...
-
Application of BiOClnBrm photocatalyst to cytostatic drugs removal from water; mechanism and toxicity assessment
PublikacjaThe photocatalytic activity of series of BiOClnBrm photocatalysts toward degradation and mineralization of the cytostatic drugs 5-fluorouracil (5-FU) and imatinib mesylate (IMA) both singly and in their mixture under simulated solar and visible light irradiation has been investigated. Screening test revealed that among BiOClnBrm photocatalysts synthesized by a solvothermal method, the one with molar 1.3Cl/0.7Br ratio was the most...
-
Integration of protein tethering in a rapid and label-free SERS screening platform for drugs of abuse
PublikacjaSurface enhanced Raman spectroscopy (SERS) has emerged as a promising technique for the rapid and ultrasensitive detection of molecular species such as drugs of abuse in biofluids. Yet, it remains a significant challenge to create a viable screening tool for multiple drug classes, owing to the lack of affinity of certain species for the SERS substrate and to the matrix interference in complex media. Here we report a protein tethering...
-
Development of potential candidate reference materials for drugs in bottom sediment, cod and herring tissues
PublikacjaRegular use of a reference material and participation in a proficiency testing program can improve the reliability of analytical data. This paper presents the preparation of candidate reference materials for the drugs metoprolol, propranolol, carbamazepine, naproxen, and acenocoumarol in freshwater bottom sediment and cod and herring tissues. These reference materials are not available commercially. Drugs (between 7 ng/g and 32...
-
Monosubstituted hydrazone β-cyclodextrin derivatives for pH-sensitive complex formation with aromatic drugs
PublikacjaA new and convenient synthetic pathway was developed to produce monosubstituted cyclodextrins with high yields. Each of the β-cyclodextrin derivatives described in this work has an aromatic substituent connected with cyclodextrin core by a pH-sensitive hydrazone linker and a carbon chain. Carbon chains differ in lengths having one or three carbon atoms. The correlation between water solubility and linker length was determined using...