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Wyniki wyszukiwania dla: IBUPROFEN AND ITS METABOLITES
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The culture of excellence and its dimensions in higher education
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Alcohol dehydrogenase and its simple inorganic models
PublikacjaW pierwszej części pracy przeglądowej przedstawiono aktualny stan wiedzy nt mechanizmu działania zależnej od cynku dehydrogenazy alkoholowej. Następnie omówiono dane strukturalne i spektroskopowe uzyskane przy pomocy prostych związków modelowych - na ogół tiolanów cynku i niektórych innych metali przejściowych. Opisano również próby zastosowania prostych kompleksów nieorganicznych naśladujących budowę miejsca aktywnego dehydrogenazy...
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Onychophagia: A synopsis of nail biting and its management
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Maxwell's approach to effective conductivity and its limitations
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Glycyrrhetinic acid and its derivatives in infectious diseases
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Biofilm formation and its regulation in Staphylococcus aureus
PublikacjaInfections caused by the major human and animal pathogen, Staphylococcus aureus are becoming an important problem due to its emerging resistance mechanisms and variety of virulence factors. Biofilm formation is considered to be one of the most important factor attributed to high pathogenicity of S. aureus. Described in the literature methods used in identification of biofilm forming abilities of bacteria consist of phenotypic and...
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Emotion recognition and its application in software engineering
PublikacjaIn this paper a novel application of multimodal emotion recognition algorithms in software engineering is described. Several application scenarios are proposed concerning program usability testing and software process improvement. Also a set of emotional states relevant in that application area is identified. The multimodal emotion recognition method that integrates video and depth channels, physiological signals and input devices...
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Detection of person presence and its activity in the bathtub
PublikacjaA practical application of a bioimpedance technique for a detection of a bathing person is presented in the paper. It addresses the possibility of supervising people in the bathtub without voiding of their intimacy. The measurement system installed in a fiber-glass or a plastic bathtub is able to detect a presence of the bathing person, to estimate its activity and thus to detect potentially dangerous events. In the paper a principle...
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General Cytotoxicity and Its Application in Nanomaterial Analysis
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Religious social action and its organizational profiles
PublikacjaPurpose Social action implemented by the Church via its affiliated entities, foundations and associations may be viewed as a uniform activity. In reality, however, several organizational profiles exist that depend on the origin of these organizations (lay or religious), the scope of their activities (local or general) and their dependence on resources (whether from public administration or civil society). The paper aims to discuss...
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The culture of excellence and its dimensions in higher education
PublikacjaPurpose To recognize the existing state of knowledge on a culture of excellence (CoE) in higher education institutions (HEIs) and to define the CoE in HEI and the dimensions that make up that culture. A subsidiary goal is to propose a qualitative tool to measure CoE maturity. Design/methodology/approach The study was based on the qualitative method, the preferred reporting system of systematic reviews and meta-analysis (PRISMA)....
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A mobile hospital – its advantages and functional limitations
PublikacjaThe idea of a mobile hospital is not entirely new – the need for their use, ranging from military field hospitals to the charity or mass disaster tent cities, shows how much they are needed. While these cases can be reduced to a portable ambulatory unit with a limited scope of outpatient medical activities, a fully functional hospital is a system with a high degree of complexity far exceeding a regime of compact objects. Solutions...
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THE FUNCTION OF GREENERY IN A SKYSCRAPER: THE PLACEMENT AND ITS INFLUENCE
PublikacjaThe contrast between the high rise buildings; with their mostly geometric shapes, and the organic form of the greenery was visible even in the idea of a skyscraper. Yet the realizations and recent projects show emerging interest and the link between them. To better understand the developing function of the greenery in the context of a skyscraper, both literature and case studies are conducted. The aim is to relate the location...
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On symmetric extendibility of quantum states and its applications
PublikacjaThis dissertation is focused on analysis of the symmetric extendibility of quantum states and its applications in the quantum information theory, with special attention paid to the area of quantum entanglement distillation, quantum channels theory, quantum security, and monogamy of quantum entanglement in time. We analyze geometry of the set of symmetric extendible states, i.e. such states that possess symmetric extensions and...
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Biotransformation of Modified Benzylisoquinoline Alkaloids: Boldine and Berberine and In Silico Molecular Docking Studies of Metabolites on Telomerase and Human Protein Tyrosine Phosphatase 1B
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Differences in the Concentration of Vitamin D Metabolites in Plasma Due to the Low-Carbohydrate-High-Fat Diet and the Eastern European Diet—A Pilot Study
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Harman and norharman, metabolites of entomopathogenic fungus Conidiobolus coronatus (Entomopthorales), disorganize development of Galleria mellonella (Lepidoptera) and affect serotonin-regulating enzymes
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The possibility to use multi-walled carbon nanotubes as a sorbent for dispersive solid phase extraction of selected pharmaceuticals and their metabolites: Effect of extraction condition
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Human red blood cells targeted metabolome analysis of glycolysis cycle metabolites by capillary electrophoresis using an indirect photometric detection method
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Spatial distribution of pharmaceuticals in conventional wastewater treatment plant with Sludge Treatment Reed Beds technology
PublikacjaPharmaceutical residues are an emerging environmental problem. It is strongly confirmed that pharmaceuticals are present in soils and environmental waters (surface, marine and even groundwater), and that wastewater treatment plant (WWTP) effluents are the main source of pharmaceuticals in the watershed. The aim of this studywas to recognize the spatial distribution and seasonal changes of selected pharmaceuticals in conventional WWTP...
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Diminshed toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells
PublikacjaThe narrow "therapeutic window" of anti-tumour therapy may be the result of drug metabolism leading to the activation or detoxification of antitumour agents. The aim of this work is to examine (i) whether the diminished toxicity of a potent antitumour drug, C-1748, 9-(2'-hydroxyethylamino)-4-methyl-1-nitroacridine, compared with its 4-demethyl analogue, C-857, results from the differences between the metabolic pathways for the...
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Non-Targeted Metabolite Profiling Reveals Host Metabolomic Reprogramming during the Interaction of Black Pepper with Phytophthora capsici
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Redundantly Actuated 3RRR Parallel Planar Manipulator - Numerical Analyses of its Dynamics Sensitivity on Modifications of its Platform’s Inertia Parameters
PublikacjaIn the paper, numerical analyses, as well as dynamics of a complex mechanism, are presented. Two objectives are crucial for the paper: inverse dynamic model is needed (dedicated to be use in the model predictive controller); an identification method is searched (some trajectory parameters are controlled, when specific trajectory is tracked under an open-loop model-based control), as selected parameters must be identified for the...
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Levels of hemoglobin and lipid peroxidation metabolites in blood, catalase activity in erythrocytes and peak expiratory flow rate in subjects with passive exposure to tobacco smoke
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CYP3A4-dependent cellular response does not relate to CYP3A4-catalysed metabolites of C-1748 and C-1305 acridine antitumor agents in HepG2 cells
PublikacjaHigh CYP3A4 expression sensitizes tumor cells to certain antitumor agents while for others it can lower their therapeutic ef fi cacy. We have elucidated the in fl uence of CYP3A4 overexpression on the cellular response induced by antitumor acridine derivatives, C-1305 and C-1748, in two hepatocellular carcinoma (HepG2) cell lines, Hep3A4 stably transfected with CYP3A4 isoenzyme, and HepC34 expressing empty vector. The compounds...
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Urine metabolic fingerprinting using LC–MS and GC–MS reveals metabolite changes in prostate cancer: A pilot study
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The structure of demand and its economic consequences for urban transport
PublikacjaThe structure of demand for urban transport services, determined by the share of passengers entitled to free and reduced fares, is an important factor influencing its economic condition. The aim of this article is to present the results of research into the structure of demand for urban transport as well as its economic consequences. The article begins by considering the nature of the determinants and consequences of the public...
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Hydration of urea and its derivatives - Volumetric and compressibility studies
PublikacjaThe densities and sound velocities at T = (288.15, 293.15, 298.15, 303.15 and 308.15) K have been measured for aqueous solutions of urea, N,N-dimethylurea, N,N-diethylurea, N-propylurea, N-butylurea. From these data the apparent molar volumes, V the apparent molar isentropic compressions, KS,, and the Passynski solvation numbers of solutes have been determined. The concentration dependencies of the calculated quantities, their...
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Tick-borne encephalitis – lipid peroxidation and its consequences
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Tick-borne encephalitis - lipid peroxidation and its consequences
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Densimetric and ultrasonic characterization of urea and its derivatives in water
PublikacjaW oparciu o pomiary gęstości dla serii roztworów jak i rozpuszczalnika wykonanych w temperaturach 15, 20, 25, 30 i 35oC wyznaczono pozorne molowe objętości mocznika, N-metylomocznika, N,N'-dimetylomocznika, N,N,N',N'-tetrametylomocznika, N-etylomocznika, N,N'-dietylomocznika jak i N-butylomocznika w wodzie. Dodatkowe pomiary szybkości dźwięku przeprowadzone w temperaturze 25oC pozwoliły obliczyć ściśliwości adiabatyczne, pozorne...
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Impact of ITS services on the safety and efficiency of road traffic
PublikacjaThis paper describes the project entitled: “Impact of the use of Intelligent Transport Systems on the level of road safety” (agreement no. DZP/RID-I-41/7/NCBR/2016), implemented as part of the Road Innovations Development (RID) programme, funded by the National Centre for Research and Development and the General Directorate for National Roads and Motorways (GDDKiA). The project is run by a consortium comprising the Motor Transport...
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Dual-wavelength laser polarimeter and its performance capabilities
PublikacjaA dual-wavelength optical polarimetric approach has been proposed as a means of elimination of the systematic errors and estimation of the optical anisotropy parameters for a single DKDP crystal. Our HAUP-related polarimeter uses two semiconductor lasers with the neighbouring wavelengths of 635 nm and 650 nm. Based on the temperature dependence analysis of small characteristic azimuths of light polarization with respect to the...
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Flow maldistribution and its mitigation in mini heat exchangers
PublikacjaIn the present paper, a detailed numerical investigation has been carried out to analyze the flow maldistribution in 50 parallel 1 mm x 1 mm rectangular minichannels and 1 mm depth minigap section with rectangular, trapezoidal, triangular or concave mani-folds in Z-type flow configuration (16 different cases). The working medium was ethanol and the mass flow rate was 5×10-4 kg/s. Both sections was heated from the bottom side. Heat...
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Potential for ITS/ICT Solutions in Urban Freight Management
PublikacjaThe article presents a study on applying ITS solutions in planning and management of urban freight transport in Gdynia. The traffic management system Tristar which is under implementation and its related systems show a potential to assist in development of freight transport measures. Recommendations for urban freight policy development supplementing Gdynia's Sustainable Urban Mobility Plan were used as a basis for identification...
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Has EGNOS its own place in maritime navigation?
PublikacjaGNSS (in fact it usually means GPS) is at the moment the fundamental means of positioning for any variants of navigation. However some attributes of it can be not sufficient for every users or in some tasks, so there are any cases when this system needs support. From the mariner point of view pure GPS properties perfectly fulfils expectations of sailors at the open sea, however there are lot of cases, when accuracy of the system...
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Unbalanced Sphingolipid Metabolism and Its Implications for the Pathogenesis of Psoriasis
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Porous structure of clinoptilolite and problems connected with its characterization.
PublikacjaPrzedstawiono: stan wiedzy nt technik oznaczania porowatości i powierzchni właściwej różnego typu materiałów, oraz wyniki badań fizykochemicznych naturalnych zeolitów pochodzących z obszaru Zakarpacia (Ukraina).
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Characteristics of the Radunia river and its catchment in view of WFD
PublikacjaCelem Ramowej Dyrektywy Wodnej (RDW), między innymi problemami jest ochrona śródlądowych wód powierzchniowych, zabezpieczenie przed dalszym pogorszenien ich stanu i poprawa stanu ekosystemów wodnych. Badania Rzeki Raduni i jej zlewni zostały wykonane przez Instytut Budownictwa Wodnego i Politechnikę Gdańską. Dotyczyły one wód śródlądowych (rzeki, jeziora, zbiorniki), ich hydrologii, hydrauliki i jakości wody. Rzeka jest istotna...
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Computer modeling of perceptual masking and its audiology applications
PublikacjaW referacie zaprezentowano podstawy perceptualne słyszenia pozwalające na stworzenie nowych modeli kodowania dźwięku, w szczególności do zastosowania w protezach słuchu.
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Amphotericin B and Its New Derivatives - Mode of Action
PublikacjaAmphotericin B (AmB) is a well known antifungal and antiprotozoal antibiotic used in the clinic for several decades. Clinicalapplications of AmB, however, are limited by its nephrotoxicity and many other acute side effects which are not acceptable by patientswhen their life is not threaten. In order to improve the therapeutic index of this drug, lipid formulations have been introduced and manyefforts have been made to obtain less...
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Route vertical alignment design in the process of its regulation
PublikacjaRegulacja toru kolejowego ma za zadanie dostosowanie niewłaściwego lub też zdeformowanego położenia osi toru do położenia odpowiadającego parametrom technicznym wymaganym dla danej linii kolejowej. Projekt regulacji wykonywany jest na podstawie pomiaru geodezyjnego wysokości toków szynowych metodą punktów stałych, tzn. w oparciu o umieszczone na słupach wskaźniki regulacji osi toru, których wysokość jest znana. Wykonany w ten sposób...
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Targeting of p53 and its homolog p73 by protoporphyrin IX
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Entrepreneurial Failure: A Synthesis and Conceptual Framework of its Effects
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Melatonin: A Cutaneous Perspective on its Production, Metabolism, and Functions
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Geotechnical Properties of Phosphogypsum and Its Use in Road Engineering
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The photophysics of β-homo-tyrosine and its simple derivatives
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Internet of Robotic Things: Its Domain, Methodologies, and Applications
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Bile conjugation and its effect on in vitro lipolysis of emulsions
PublikacjaBile Salts (BS) are responsible for stimulating lipid digestion in our organism. Gut microbiota are responsible for the deconjugation process of primary conjugated to secondary unconjugated BS. We use two structurally distinct BS and characterize the rate of lipolysis as a compound parameter. A static in-vitro digestion model as well as meta-analysis of literature data has been performed to determine the most influential factors...
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Rhodotorulic Acid and its Derivatives: Synthesis, Properties, and Applications
PublikacjaSiderophores are low molecular weight compounds produced by microorganisms to scavenge iron in iron-deficient environments. Rhodotorulic acid (RA), a natural hydroxamate siderophore, plays a vital role in iron acquisition for fungi and bacteria. As the simplest natural hydroxamate siderophore, RA exhibits a high affinity for ferric ions, enabling it to form stable complexes that facilitate iron uptake and transport within microorganisms....