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Search results for: ANTI-CANCER AGENTS
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Evaluation and cellular responses of modulators of TRF1/TRF2 protein’s function as potential anticancer drugs interfering with telomeric shelterin’s function
PublicationA number of proteins that interact with telomeres have been identified in human cells, indicating the high plasticity of human nucleoprotein complex organization. The most important complex is the "shelterin" complex, which consists of six proteins: TRF1, TRF2, TIN2, POT1, TPP1. The TRF1 and TRF2 directly bind to telomeric double-stranded DNA and the TIN2 protein. The TIN2 protein also binds to the TPP1 protein, stabilizing the...
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Creating a radiological database for automatic liver segmentation using artificial intelligence.
PublicationImaging in medicine is an irreplaceable stage in the diagnosis and treatment of cancer. The subsequent therapeutic effect depends on the quality of the imaging tests performed. In recent years we have been observing the evolution of 2D to 3D imaging for many medical fields, including oncological surgery. The aim of the study is to present a method of selection of radiological imaging tests for learning neural networks.
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Soiling Effect Mitigation Obtained by Applying Transparent Thin-Films on Solar Panels: Comparison of Different Types of Coatings
PublicationDust accumulation on the front cover of solar panels is closely linked to location and orientation of photovoltaic (PV) installation. Its build-up depends on the module tilt angle, frequency of precipitation, humidity, wind strength and velocity, as well as grain size. Additionally, soil composition is determined by solar farm surroundings such as local factories, agricultural crops, and traffic. Over time, molecules of atmospheric...
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Usage of Two-Center Basis Function Neural Classifiers in Compact Smart Resistive Sensors
PublicationA new solution of the smart resistance sensorwith the Two-Center Basis Function (TCBF) neuralclassifier, for which the resistance sensor is a component ofan anti-aliasing filter of an ADC is proposed. Thetemperature measurement procedure is based on excitationof the filter by square impulses, sampling time response ofthe filter and processing measured voltage values by theTCBF classifier. All steps of the measurement procedure...
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AFM-assisted investigation of conformal coatings in electronics
PublicationPurpose – This paper aims to presents a new method of investigation of local properties of conformal coatings utilized in microelectronics. Design/methodology/approach – It is based on atomic force microscopy (AFM) technique supplemented with the ability of local electrical measurements, which apart from topography acquisition allows recording of local impedance spectra, impedance imaging and dc current mapping. Potentialities...
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The protection and monitoring of a distribution piping network for potable water supply
PublicationPurpose – The purpose of this paper is to implement the corrosion protection method for steel pipes used in a municipal water-pipe network. Results of an inhibitor protection system installed on the system are presented. Inhibitor protection was required due to the high corrosivity of the water collected by a surface intake, which had resulted in a large number of failures and low water quality, due to the presence of corrosion...
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Study of anticorrosion and microwave absprption properties of NiZn ferrite pigments
PublicationPurpose - The purpose of this paper is to report the electrochemical verification of anticorrosive properties of NiZn ferrites as pigments in protective coatings and evaluation of their microwave absorbing properties. Design/methodology/approach - Ferrites, represented by formula NixZn(1-x)Fe2O4, where x=0, 0.2, 0.4, 0.6, 0.8, 1.0, were synthesized using a ceramic method. The samples of ferrites were examined by X-ray diffraction...
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Instantaneous impedance evaluation of dissolution of aisi 304 stainless steel during intergranular corrosion
PublicationCelem pracy było uzyskanie informacji dotyczących zróżnicowania parametrów elektrycznych uzyskanych na podstawie zarejestrowanych chwilowych widm impedancyjnych w zakresie aktywacji i reaktywacji roztwarzania wysokostopowej stali austenitycznej AISI podczas postępującego procesu korozji międzykrystalicznej. Badania prowadzono z wykorzystaniem dynamicznej elektrochemicznej spektroskopii impedancyjnej (DEIS). Pomiary wykonywano ''on-line''...
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Cyclic analysis of thermal impedance of a passive layer of aluminium in a neutral borate buffer solution
PublicationW pracy przedstawiono wyniki badań warstwy pasywnej tworzącej się na stopie 1050 A w warunkach zmieniającej się temperatury. Zmiany realizowano w sposób cykliczny zwiększając a następnie zmniejszając temperaturę. W czasie zmian temperatury prowadzono badania metodę dynamicznej elektrochemicznej spektroskopii impedancyjnej. Stwierdzono największe zmiany parametrów elektrycznego schematu zastępczego w czasie pierwszego cyklu zmian....
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Potential changes in an electric field and electrolytic corrosion.
PublicationSources have been described of corrosively hazardous electric fields and methods of determination of the corrosion hazard to metal structures caused by electrolytic corrosion. Results of potential and impedance investigations in the field of stray currents flowing out of a tram traction and in the presence of a defined electric field of low frequency have been presented. Uncertainties have been indicated relating to the generally...
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The effect of the temperature change rate on determination of the criticalpitting temperature of stainless steels
PublicationPrzedstawiono wyniki badań wpływu szybkości zmian temperatury na wyznaczaną krytyczną temperaturę korozji wżerowej. Badania stali 316L przeprowadzono metodą termometrii cyklicznej. Stwierdzono, że zwiększenie szybkości zmian temperatury związane jest ze zwiększeniem wyznaczonej temperatury krytycznej. Zależność krytycznej temperatury korozji wżerowej od szybkości korozji ma charakter liniowy. Wartości krytycznej temperatury korozji...
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The stationarity characteristics of electrochemical current noise
PublicationPrzedstawiono rezultaty analizy szumu elektrochemicznego generowanego podczas korozji stali 0H18N9 w roztworze 0.1 M H2SO4+0,006 M Cl-. Rejestry uzyskano w warunkach potencjostatycznych. W szumie zaobserwowano trendy i sygnały przejściowe, charakterystyczne dla korozji wżerowej. Trend został usunięty za pomocą aproksymacji wielomianem trzeciego stopnia. Analiza statystyczna wykazała niestacjonarny bądź słabo stacjonarny charakter...
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Conducting composites as cable anodes in cathodic protection: a literature summary
PublicationPrzedstawiono podstawową charakterystykę systemu ochrony katodowej z wykorzystaniem anod kablowych. Anody kablowe różnią się od klasycznych systemów anodowych sposobem instalacji anod. System anodowy oparty na anodach kablowych nie jest instalowany punktowo; anoda umieszczana jest w niewielkiej odległości od chronionej konstrukcji i biegnie wzdłuż trasy konstrukcji. Materiałem anodowym proponowanego rozwiązania jest elastyczny...
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Study of the formation of calcareous deposits on cathodically protected steel in Baltic sea water
PublicationPurpose – The purpose of this paper is to investigate whether the sedimentation of calcareous deposits occurs on cathodically protected steel in Baltic sea water. Design/methodology/approach – Steel electrodes were cathodically polarized in natural Baltic sea water at potential þ0.150 V vs Zn electrode in potentiostatic mode. During exposure chronoamperometric measurements were carried out. After the exposure, the electrode’s surface...
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Aspects of intergranular corrosion of AISI 321 stainless steel in high-carbon-containing environments
PublicationPurpose – The purpose of this paper is to present a case study of unexpected sensitization to intergranular corrosion of highly resistant AISI 321 steel in petrochemical conditions, where it was subjected to the simultaneous influence of elevated temperature of 250°C and vapors from the asphalt production process. Design/methodology/approach – Corrosion coupons were exposed in an installation carrying asphalt vapors. To identify...
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Localized impedance measurements of AA2024 and AA2024-T3 performed by means of AFM in contact mode
PublicationPurpose: The purpose of this paper is to present the results of an atomic force microscopy (AFM) based approach to local impedance spectroscopy (LIS) measurement performed on AA2024 and AA2024-T3 aluminium alloys. Design/methodology/approach: AFM-LIS measurements were performed ex-situ without the electrolyte environment, so in fact the electrical not electrochemical impedance was obtained. Findings: Relative local impedance values...
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Studying the effectiveness of a modernized cathodic protection system for an offshore platform
PublicationPrzedstawiono dokonaną modernizację starego systemu ochrony katodowej nóg platformy morskiej oraz omówiono wykonane badania skuteczności przeciwkorozyjnej zastosowanego rozwiązania. Modernizacja polegała na podłączeniu do nóg platformy układów anod galwanicznych umieszczonych na dnie morza. Skuteczność działania systemu oceniono na podstawie pomiarów profili potencjałowych nóg platformy. Po podłączaniu kolejnych układów anod...
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Study of anticorrosion and microwave absorption properties of NiZn ferrite pigments
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The effect of the temperature change rate on determination of the critical pitting temperature of stainless steels
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The application of Gabor transformation in the harmonic analysis of corrosion processes
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The impedance method of monitoring the degradation of rubber linings in applications where progressive deterioration is the predominant failure mechanism
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Durability evaluation of Ni‐Cr‐Mo super alloys in a simulated scrubbed flue gas environment
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Evaluation and characterisation of the condition of individual components of cathodic protection systems
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Corrosion resistance evaluation of Al‐based alloys by means of dynamic electrochemical impedance spectroscopy
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Electrochemical investigations of stainless steels used in flue‐gas desulphurization units
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The temperature dependencies of susceptibility of 654SMO and 316L stainless steels to pitting
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Detection and time/frequency analysis of electric fields in the ground
PublicationThis paper sets out to detect and characterize electric fields in the ground (such as stray current fields) using a tandem time/frequency method of signal analysis. Results were obtained from investigations performed in the presence of a generated electric field with controlled variable characteristics, and in the presence of an electric field generated by a tramline. The analysis of measurement registers was performed using Short‐Time...
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The determination and identification of stray current source influences on buried pipelines using time/frequency analysis
PublicationZaprezentowano metodę detekcji źródła interferencji prądów błądzących na rurociągach podziemnych w aglomeracjach miejskich z wykorzystaniem łącznej analizy czasowo-częstotliwościowej mierzonych sygnałów. Badania przeprowadzono na rurociągu podziemnym zlokalizowanym w sąsiedztwie dwóch trakcji elektrycznych: tramwajowej i kolejowej. Wyniki analiz zaprezentowano w formie spektrogramów, które ilustrują zmiany spektralnej gęstości...
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Corrosion resistance evaluation of Al-based alloys by means of dynamic electrochemical impedance spectroscopy
PublicationW pracy przedstawiono wyniki badań stopów aluminium wykonane za pomocą dynamicznej elektrochemicznej spektroskopii. Na podstawie uzyskanych widm impedancyjnych zostały pokazane zmiany parametrów elektrycznego schematu zastępczego z potencjałem. Stwierdzono, że dodatek magnezu do badanego stopu obniża właściwości przeciwkorozyjne stopu.
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Localized impedance measurements of AA2024 and AA2024‐T3 performed by means of AFM in contact mode
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The application of Gabor transformation in the harmonic analysis of corrosion processes.
PublicationZaproponowana została nowa metoda analizy widmowej niestacjonarnych procesów korozyjnych. Analizie poddany został układ modelujący pierwszorzędową reakcję elektrodową. Wykazano, że w przypadku pobudzenia układu liniowo zmieniającym się potencjałem z nałożoną składową sinusoidalną przekształcenie Fouriera nie odzwierciedla zmian amplitudy powstających składowych harmonicznych. Jako rozwiązanie zaproponowana została analiza...
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Evaluation of Health Hazard Due to Emission of Volatile Organic Compounds from Various Processing Units of Wastewater Treatment Plant
PublicationThe paper describes an attempt at health risk assessment and odour concentration determination in the most important units of a wastewater treatment plant. The cancer risk (CR) and hazard index (HI) parameters in selected measurement locations were calculated based on the results of chromatographic analyses (GCxGC-TOF-MS) and the United States Environmental Protection Agency (US EPA) guidelines. No exceedance of the CR and HI acceptable...
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Deep Learning-Based Cellular Nuclei Segmentation Using Transformer Model
PublicationAccurate segmentation of cellular nuclei is imperative for various biological and medical applications, such as cancer diagnosis and drug discovery. Histopathology, a discipline employing microscopic examination of bodily tissues, serves as a cornerstone for cancer diagnosis. Nonetheless, the conventional histopathological diagnosis process is frequently marred by time constraints and potential inaccuracies. Consequently, there...
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Comprehensive Review of Fluorescence Applications in Gynecology
PublicationSince the introduction of indocyanine green (ICG) as a fluorophore in near-infrared imaging, fluorescence visualization has become an essential tool in many fields of surgery. In the field of gynecology, recent new applications have been proposed and found their place in clinical practice. Different applications in gynecology were investigated, subcategorized, and overviewed concerning surgical applications and available dyes....
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An application of multi-agent system for ship’s power systems design
PublicationDesign process of transport ship power system consists of structure (topology) and component elements selection. Compliance with the requirements for static components does not guarantee optimal dynamic characteristics of entire power system. Design steps are difficult to formalize and as a consequence to this reason expert and multi-agent systems are used for solving selected design issues. In the paper distributed multi-agent...
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Low-volume label-free SARS-CoV-2 detection with the microcavity-based optical fiber sensor
PublicationAccurate and fast detection of viruses is crucial for controlling outbreaks of many diseases; therefore, to date, numerous sensing systems for their detection have been studied. On top of the performance of these sensing systems, the availability of biorecognition elements specific to especially the new etiological agents is an additional fundamental challenge. Therefore, besides high sensitivity and selectivity, such advantages...
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History-based dynamic weight voting for multi-agent systems
PublicationTaking decision in multi-agent systems may involve voting. Two basic voting protocols are surveyed in the paper. Then, a new history-based dynamic weight voting is proposed. This voting protocol allows for identification of the agents which contribute to the correct system decision. The proposed solution is contrasted with majority voting and with weighted average voting, to show its advantages
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Biosurfactants - Biodegradability, toxicity, efficiency in comparison with synthetic surfactants
PublicationBiosurfactants are natural surface active agents produced by variety of bacteria yeast and fungi. A review of their biodegradability, toxicity and efficiency is presented in order to compare their properties with synthetic surfactants. Due to their high efficiency in many applications and environmentally friendly character we tried to apply them in oil refining process. The efficiency of biosurfactants in this application was very...
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Pharmaceutical applications of surfactants
PublicationIn this study we focused on biological activity of various surfactants. According to our research, they con act both as carriers as well as therapeutic agents. Depending on their concentration, they can create different structures in a solution, which influence their properties. Liposomes have a significant role in drug delivery system. Surfactants in from of bilayer are analogous to natural biological cell membrane.
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Increasing efficiency of technological process by limiting impact of corrosive environment on operation of spiral classifiers
PublicationMost of the technological operations related to the preparation of the output to be enriched and to the production of the final copper concentrate take place with the use of water environment. Water management, besides using innovative technical and technological solutions, is a significant factor in the whole copper ore enrichment process. Mine water resources and surface water of the tailing pond named "Żelazny Most" are the...
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A rapid-response ultrasensitive biosensor for influenza virus detection using antibody modified boron-doped diamond
PublicationAccording to the World Health Organization (WHO), almost 2 billion people each year are infected worldwide with flu-like pathogens including influenza. This is a contagious disease caused by viruses belonging to the family Orthomyxoviridae. Employee absenteeism caused by flu infection costs hundreds of millions of dollars every year. To successfully treat influenza virus infections, detection of the virus during the initial development...
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Yerba Mate - A Long but Current History
PublicationBearing in mind the growing interest in Yerba Mate, a comprehensive study has been prepared containing the most important aspects and possibilities of its use. The introduction of the work contains the species characteristics of Yerba Mate, as well as information about the origin and places of cultivation. The next part focuses on the analysis of the composition, pointing to purine alkaloids, polyphenols, saponins, and minerals...
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Analytics of airport runoff water samples
PublicationThe everyday activities at airports, such as aircraft and ground vehicle washing, cleaning, de/anti-icing operations, fuelling, and fuel combustion, removing weeds are the main sources of airport industrial wastes. Runoff waters from airport areas constitute a serious environmental problem as they contribute to air, water, and soil pollution. The paper supplies general information on the technologies for treating airport runoff...
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Game with a Purpose for Verification of Mappings Between Wikipedia and WordNet
PublicationThe paper presents a Game with a Purpose for verification of automatically generated mappings focusing on mappings between WordNet synsets and Wikipedia articles. General description of idea standing behind the games with the purpose is given. Description of TGame system, a 2D platform mobile game with verification process included in the game-play, is provided. Additional mechanisms for anti-cheating, increasing player’s motivation...
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Bilateral Multi-Issue Negotiation Between Active Documents and Execution Devices
PublicationMobile document-agents are often in conflict with execution devices when attempting to perform activities of the business process they implement, since preferences of device owners may change depending on their current location and the actual class of the device in use. The paper proposes a bilateral negotiation mechanism based on a simple bargaining game that can effectively resolve such conflicts without any third party support.
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In Vitro and In Vivo Imaging-Based Evaluation of Doxorubicin Anticancer Treatment in Combination with the Herbal Medicine Black Cohosh
PublicationAs a substitution for hormone replacement therapy, many breast cancer patients use black cohosh (BC) extracts in combination with doxorubicin (DOX)-based chemotherapy. In this study, we evaluated the viability and survival of BC- and DOX-treated MCF-7 cells. A preclinical model of MCF-7 xenografts was used to determine the influence of BC and DOX administration on tumor growth and metabolism. The number of apoptotic cells after...
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Young Shoots of White and Red Headed Cabbages Like Novel Sources of Glucosinolates as Well as Antioxidative Substances
PublicationMost literature data indicate that the diet rich in plant products reduces the risk of developing chronic non-communicable diseases and cancer. Brassica vegetables are almost exclusively synthesizing glucosinolates. Glucosinolates are higher in sprouts than in mature plants, being related to the activity of the specific myrosinase involved in the degradation of glucosinolates during developmental stages. This study compares the...
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Induction of chirality in 4,4'-azopyridine by halogen-bonding interaction with optically active ditopic donors
PublicationOptically active ditopic halogen bond donors bearing two 4-iodotetrafluorophenyl groups were obtained by reaction of chiral diols with iodopentafluorobenzene. Co-crystallization of these donors with anti-4,4′-azopyridine afforded binary complexes containing infinite chains of the alternating component molecules connected by halogen bonds. The solid state CD measurements confirmed that complexation induces optical activity of the...
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First report on echinocandin resistant Polish Candida isolates
PublicationPurpose: Candida spp. are ranked as one of the four major causative agents of fungal infections. The number of infections caused by Candida species resistant to fluconazole, which is applied as the first line drug in candidiasis treatment, increases every year. In such cases the application of echinocandin is necessary. Echinocandin susceptibility testing has become a routine laboratory practice in many countries due to the increasing...
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Efficient parallel implementation of crowd simulation using a hybrid CPU+GPU high performance computing system
PublicationIn the paper we present a modern efficient parallel OpenMP+CUDA implementation of crowd simulation for hybrid CPU+GPU systems and demonstrate its higher performance over CPU-only and GPU-only implementations for several problem sizes including 10 000, 50 000, 100 000, 500 000 and 1 000 000 agents. We show how performance varies for various tile sizes and what CPU–GPU load balancing settings shall be preferred for various domain...