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Search results for: LIP
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High-throughput Evaluation of Lipophilicity and Acidity by New Gradient HPLC Methods
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Modeling of chromatographic lipophilicity of food synthetic dyes estimated on different columns
PublicationBadano parametry retencyjne wybranych syntetycznych barwników żywności z wykorzystaniem techniki RP-HPLC z wykorzystaniem kolumn z chemicznie modyfikowanym wypełnieniem typu C-8, C-16, C-18 oraz CN.Uzyskane wyniki mogą być podstawą do stwierdzenia, że badane związki charakteryzują się podobnymi parametrami retencyjnymi w stosunku do kolumn z fazą stacjonarną typu C-8, C-16 oraz C-18.
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The impact of lipophilicity on environmental processes, drug delivery and bioavailability of food components
PublicationLipophilic properties of the compound allow to predict its fate in living organisms and to propose the models of chemicals transport and accumulation in the ecosystem. Lipophilicity is also useful as the characteristic of chemicals in respect to their optimal attributes for specific biological and non-biological tasks. The lipophilicity descriptors define the potency of endo- and xenobiotics to metabolic transformations and their...
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Assembly of Lipopolysaccharide in Escherichia coli Requires the Essential LapB Heat Shock Protein
PublicationHere, we describe two new heat shock proteins involved in the assembly of LPS in Escherichia coli, LapA and LapB (lipopolysaccharide assembly protein A and B). lapB mutants were identified based on an increased envelope stress response. Envelope stress responsive pathways control key steps in LPS biogenesis and respond to defects in the LPS assembly. Accordingly, the LPS content in ΔlapB or Δ(lapA lapB) mutants was elevated, with...
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Development of chromatographic and mass spectrometry conditions for untargeted lipidomic analysis of human breast milk
PublicationHuman breast milk (HBM) is a complex biofluid containing components which are essential for the proper growth of the newborn (for example nutrients such as carbohydrates, proteins, lipids) and also bioactive substances. According to the literature, most of studies involving HBM nutrients investigations focused essentially on the determination of proteins. The molecular composition of lipids in HBM is not well known as the protein...
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Comparative Lipidomic Study of Human Milk from Different Lactation Stages and Milk Formulas
PublicationIn this report, we present a detailed comparison of the lipid composition of human milk (HM) and formula milk (FM) targeting different lactation stages and infant age range. We studied HM samples collected from 26 Polish mothers from colostrum to 19 months of lactation, along with FM from seven brands available on the Polish market (infant formula, follow-on formula and growing-up formula). Lipid extracts were analysed using liquid...
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Characterization of various drinking waters by new potentiometric taste sensor with lipid, lipid-like polymer membranes
PublicationA new sensing system comprising five all-solid-state electrodes with lipid, lipid like-polymer membranes was applied for rapid qualitative and quantitative analysis of various drinking waters. The results elaborated by chemometric methods revealed sensitivity to CO2 content in drinking water, suggesting that this sensing system could be used as a taste sensor. The ability of taste sensor to perform quantitative analysis of minerals...
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Practice in the Field of Thermal Retrofitting in Historic Buildings and Preservation of the Authentic Tissue of Façades of Historic Buildings in Poland
PublicationThe pursuit to reduce emissions of harmful substances to the atmosphere resulting from the combustion of fuels for heating purposes makes a building more ecological and environmentally friendly. All operations aimed to limit emissions of pollutants into the atmosphere are motivated by the growing environmental awareness of developed societies and alarming reports on the global warming and its effects. In Poland, legal regulations...
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Purification of the Air in the Historic Cities of Towns
PublicationAir pollution observed from the beginning of the industrial age has had a negative impact on the health, quality and life expectancy of the inhabitants of urban agglomerations. The problem of particulate and gaseous pollutants in PM 10 fine particulate matter and PM 2.5 suspended in air is a particular threat. The emission of harmful substances is spatially and temporally differentiated in the urban area and depends on the degree...
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The Space for Preservation and Dilapidation of Historical Houses in Modlimowo Village in the Light of Post-Dependence Studies and Historical Politics after 1945
PublicationThe main purpose of this article is to present the results of the research on spatial degradation of Modlimowo village. Modlimowo is an example of a settlement form typical of the Western Pomerania region. Until 1945, half-timbered buildings of Modlimowo village constituted a wellpreserved architectural and cultural heritage of this region. Over the past 25 years, changes in the spatial layout of Modlimowo Village irreversibly...
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Comprehensive methodology for Staphylococcus aureus lipidomics by liquid chromatography and quadrupole time-of-flight mass spectrometry
PublicationStaphylococcus aureus is a common pathogen known to cause relatively minor infections as well as severe disorders in humans. Although there is fair amount of published data concerning various aspects of its biology, epidemiology, genetics, etc., there is still a scarce amount of data presenting reliable and thorough investigations regarding high-throughput analysis of total S. aureus lipid content. Therefore, the aim of this study...
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The dispersive micro-solid phase extraction method for MS-based lipidomics of human breast milk*
PublicationA simple and rapid microextraction method ensuring high lipidome coverage was developed for liquid chromatography mass spectrometry (LC-MS)-based lipidomics of human breast milk. The dispersive microsolid phase extraction (D-µ-SPE) technique, coupled with the design of experiment (DoE) method, enabled the study of the influence of several conditions (desorption solvent, stationary phase ratio, and sorption and desorption time)...
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Inhibitory syntazy glukozamino-6-fosforanu o zwiększonej lipofilowości i ich peptydy - synteza i właściwości biologiczne
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Arginine-, d-arginine-vasopressin, and their inverso analogues in micellar and liposomic models of cell membrane: CD, NMR, and molecular dynamics studies
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Dynamika molekularna oddziaływań przeciwgrzybowych heptaenów aromatycznych i ich izomerów all-trans ze sterolami w błonach lipidowych
PublicationAromatyczne heptaeny (AH) należą do grupy makrolidów polienowych o działaniu przeciwgrzybowym. Antybiotyki z tej grupy były pierwszymi, które zostały wykorzystane w terapii układowych infekcji grzybiczych. Amfoterycyna B (AmB) oraz nystatyna, czyli niearomatyczni przedstawiciele makrolidów heptaenowych, mają istotne znaczenie kliniczne w leczeniu, odpowiednio, grzybic wewnętrznych i zewnętrznych. Molekularne podstawy mechanizmu...
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Aberrations in Lipid Expression and Metabolism in Psoriasis
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Localization and Orientation of Xanthophylls in a Lipid Bilayer
PublicationXanthophylls (polar carotenoids) play diverse biological roles, among which are modulation of the physical properties of lipid membranes and protection of biomembranes against oxidative damage. Molecular mechanisms underlying these functions are intimately related to the localization and orientation of xanthophyll molecules in lipid membranes. In the present work, we address the problem of localization and orientation of two xanthophylls...
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Water Behavior Near the Lipid Bilayer
PublicationIn this chapter, we focus on the dynamics of water molecules situated in the vicinity of a phospholipid bilayer. Using a molecular dynamics simulation method, we studied interactions between water and the bilayer and tracked trajectories of the water molecules. Based on the hypothesis that molecules trapped inside the bilayer make different motions than the ones which are either attached to the surface or move freely in the water...
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The Influence of Polysaccharides/TiO2 on the Model Membranes of Dipalmitoylphosphatidylglycerol and Bacterial Lipids
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Central nervous system prophylaxis with intrathecal liposomal cytarabine in diffuse large B‑cell lymphomas
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Induction of immune responses in sheep by vaccination with liposome-entrapped DNA complexes encoding Toxoplasma gondii MIC3 gene
PublicationToxoplasma gondii is a parasite that has been extensively studied due to its medical and veterinary importance in terminating pregnancies. Consequently, a satisfactory vaccine is required to control itsadverse effects on pregnant animals. The microneme protein, MIC3, is a major adhesion protein that binds to the surface of host cells and parasites, and is therefore a potential vaccine against T. gondii.The viability of MIC3 as...
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THE EFFECT OF WATER ACTIVITY AND TEMPERATURE ON THE GROWTH AND LIPOLYTIC ACTIVITY OF PENICILLIUM CHRYSOGENUM (THOM) AND EUROTIUM HERBARIORUM (WIGG.) STRAINS
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Jolanta Katarzyna Borucka-Lipska dr inż.
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Tłuszcz mleka kobiecego – skład, synteza i funkcja kwasów tłuszczowych oraz pochodnych lipidów
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Wpływ konfiguracji geometrycznej oktadecenowych kwasów tłuszczowych w żywności na szybkość utleniania lipidów.
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Hyperosmolarity adversely impacts recombinant protein synthesis by Yarrowia lipolytica—molecular background revealed by quantitative proteomics
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Triplet–Triplet Annihilation Upconverting Liposomes: Mechanistic Insights into the Role of Membranes in Two-Dimensional TTA-UC
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Triplet–Triplet Annihilation Upconverting Liposomes: Mechanistic Insights into the Role of Membranes in Two-Dimensional TTA-UC
PublicationTriplet−triplet annihilation upconversion (TTA-UC) implemented in nanoparticle assemblies is of emerging interest in biomedical applications, including in drug delivery and imaging. As it is a bimolecular process, ensuring sufficient mobility of the sensitizer and annihilator to facilitate effective collision in the nanoparticle is key. Liposomes can provide the benefits of two-dimensional confinement and condensed concentration...
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Synthesis of Trehalose by the Erythritol-Producing Yeast Yarrowia lipolytica Co-Displaying Maltooligosyltrehalose Synthase and Maltooligosyltrehalose Trehalohydrolase
PublicationIndustrial trehalose production faces economic challenges with costly enzyme preparations, prompting the exploration of eco-friendly alternatives. Here, we established a coupled functional sugar production line leveraging erythritolproducing cells as an innovative enzyme preparation for trehalose synthesis. The erythritol-producing Yarrowia lipolytica was modified to express a fusion protein consisting of maltooligosyltrehalose synthase...
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Grade of service determination methodology in IP networks with SIP protocol
PublicationAlthough Grade of Service is very important in VoIP providers evaluation, We wasn't able to find any paper regarding the topic of measuring GoS variables for IP networks utilizing SIP, which are defined like for PSTN/ISDN/GSM networks (post-selection delay, answering delay, release delay, or probability of end-to-end blocking). Due to the lack of research in this field, it was necessary to start from defining measures and cover...
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Novel Potent Muscarinic Receptor Antagonists: Investigation on the Nature of Lipophilic Substituents in the 5- and/or 6-Positions of the 1,4-Dioxane Nucleus
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Polymeric membrane-modified voltammetric sensors for lipophilic analytes with nanomolar detection limit: Key parameters influencing the response characteristics
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Koncert Lipali Akustycznie
EventsZespół Tomka "Lipy" Lipnickiego zagra swoje utwory w akustycznych aranżacjach. Dla tych, którzy nie zetknęli się jeszcze z akustycznym obliczem Lipali ten koncert będzie prawdziwą muzyczną niespodzianką!
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Influence of adalimumab on interleukin 12/23 signalling pathways in human keratinocytes treated with lipopolysaccharide A
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A new animal model of (chronic) depression induced by repeated and intermittent lipopolysaccharide administration for 4months
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The Comparison Between the Calculated and HPLC-Predicted Lipophilicity Parameters for Selected Groups of Drugs
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Micellar liquid chromatography for lipophilicity determination of new biologically active 1,3‐purinodiones
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The lipophilicity estimation of 5-arylidene derivatives of (2-thio)hydantoin with antimycobacterial activity
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Hydrazone Linker as a Useful Tool for Preparing Chimeric Peptide/Nonpeptide Bifunctional Compounds
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Rural Landscapes of Roman (northern) Liburnia: Diachronic Development of Organisation and the Economy in Extra-Urban Territories in the Light of Recent Archaeological Research
PublicationThe archaeology of Roman rural landscapes in the province of Dalmatia, and especially northern Liburnia, has until recently focused on single-site or single-monument analyses, allowing for only geographically patchy and chronologically limited conclusions. Considering the results of recent research in the wider Kvarner and sub-Velebit area, the paper discusses issues of Roman extra-urban territorial organization, the formation...
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Supplementation of garlic lowers lipids and increases antioxidant capacity in plasma of rats
PublicationZbadano bioaktywność surowego i gotowanego czosnku (Allium sativium L.). Stwierdzono, że gotowanie czosnku w temperaturze 100 °C przez 20 minut nie wpływa na jego bioaktywność.Samcom szczurów (z badanej populacji) podzielonym losowo na 10 grup, podawano żywność z różnym dodatkiem czosnku. Natomiast grupa kontrolna była karmiona dietą podstawową złożoną ze skrobi pszenicznej, oleju sojowego, celulozy, minerałów i mieszaniny witamin....
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EFFECT OF WATER ACTIVITY AND TEMPERATURE ON GROWTH AND LIPOLYTIC ACTIVITY OF PENICILLIUM CHRYSOGENUM STRAINS IN LIQUID CULTURE MEDIA WITH PLANT OILS
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Analiza wezbrania rzeki Kaczej w Gdyni po opadzie z 14 lipca 2016 roku
PublicationW połowie lipca 2016 r. w Trójmieście, zanotowano opad atmosferyczny o sumie przekraczającej 150 mm. Opadom deszczu od godzin popołudniowych dnia 14 lipca do godzin rannych 15 lipca towarzyszył okresami bardzo silny i gwałtowny wiatr początkowo z kierunku północno-wschodniego następnie z kierunku północno-zachodniego. Opisana sytuacja hydro-meteorologiczna spowodowała znaczne wezbrania w rzekach i potokach rejonu Zatoki Gdańskiej,...
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Characterization of antimicrobial and hemolytic properties of short synthetic cationic lipopeptides based on QSAR/QSTR approach
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Are the short cationic lipopeptides bacterial membrane disruptors? Structure-Activity Relationship and molecular dynamic evaluation
PublicationShort cationic lipopeptides are amphiphilic molecules that exhibit antimicrobial activity mainly against Grampositives. These compounds bind to bacterial membranes and disrupt their integrity. Here we examine the structure-activity relation (SAR) of lysine-based lipopeptides, with a prospect to rationally design more active compounds. The presented study aims to explain how antimicrobial activity of lipopeptides is affected by...
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Roxithromycin-loaded lipid nanoparticles for follicular targeting
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Optical properties of a series of pyrrolyl-substituted porphyrazines and their photoinactivation potential against Enterococcus faecalis after incorporation into liposomes
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Heavy duty vehicle fuel consumption modelling using artificial neural networks
PublicationIn this paper an artificial neural network (ANN) approach to modelling fuel consumption of heavy duty vehicles is presented. The proposed method uses easy accessible data collected via CAN bus of the truck. As a benchmark a conventional method, which is based on polynomial regression model, is used. The fuel consumption is measured in two different tests, performed by using a unique test bench to apply the load to the engine. Firstly,...
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Assessment of Lipophilicity Indices Derived from Retention Behavior of Antioxidant Compounds in RP-HPLC
PublicationReverse phase high pressure liquid chromatography was employed in order to evaluate the lipophilicity of antioxidant compounds from different classes, such as phenolic acids, flavanones, flavanols, flavones, anthocyanins, stilbenes, xantonoids, and proanthocyanidins. The retention time of each compound was measured using five different HPLC columns: RP18 (LiChroCART, Purosphere RP-18e), C8 (Zorbax, Eclipse XDBC8), C16-Amide (Discovery...
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Interactions of amphotericin B derivatives with lipid membranes - a molecular dynamics study
PublicationW pracy analizowano oddziaływanie dwóch nisko-toksycznych pochodnych amfoterycyny B (związki SAmE i PAmE) z modelami błon lipidowych. Badania wykonane zostały za pomocą dynamiki molekularnej. Modele błon oprócz fosfolipidów DMPC zawierały odpowiednio cholesterol (model błony zwierzęcej) lub ertosterol (model błony grzybowej). Analiza wyników wykazała, że obie pochodne amfoterycyny B zachowują się inaczej w błonie cholesterolowej...