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Search results for: INTERNAL BRANDING
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How do sterols determine the antufungal activitiy of amphotericin B? Free energy of binding between the drug and its membrane targets.
PublicationAmphotericin B (AmB) is a well-known polyene antibiotic used to treat systemic fungal infections. It is commonly accepted that the presence of sterols in the membrane is essential for the AmB biological activity, that is, for the formation of transmembrane ion channels. The selective toxicity of AmB for fungal cells is attributed to the fact that it is more potent against fungal cell membranes containing ergosterol than against...
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The influence of combination of binding agents on fatigue properties of deep cold in-place recycled mixtures in Indirect Tensile Fatigue Test (ITFT)
PublicationThe publication presents fatigue properties of cold recycled mixtures for eight combinations of binding agents (cement and bituminous emulsion). Cold recycled mixtures were evaluated in Indirect Tensile Fatigue Test (ITFT) at the temperature of 20 C in controlled stress mode. As a function of horizontal stress, fatigue life is strongly influenced by combination of the binding agents. When fatigue life is analyzed as a function...
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Structure-function analysis of decay-accelerating factor: identification ofresidues important for binding of the Escherichia coli Dr adhesin and complement regulation
PublicationZidentyfikowano ważne dla wiązania adhezyny Dr uropatogennych Escherichiacoli reszty aminokwasowe w ludzkim receptorze DAF SCR-3.
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Crack monitoring in concrete beams under bending using ultrasonic waves and coda wave interferometry: the effect of excitation frequency on coda
PublicationConcrete is one of the most widely used construction materials in the world. In recent years, various non-destructive testing (NDT) and structural health monitoring (SHM) techniques have been investigated to improve the safety and control of the current condition of concrete structures. This study focuses on micro-crack monitoring in concrete beams. The experimental analysis was carried out on concrete elements subjected to three-point...
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Computational analysis of substituent effects on proton affinity and gas-phase basicity of TEMPO derivatives and their hydrogen bonding interactions with water molecules
PublicationThe study investigates the molecular structure of 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) and its derivatives in the gas phase using B3LYP and M06-2X functional methods. Intermolecular interactions are analyzed using natural bond orbital (NBO) and atoms in molecules (AIM) techniques. NO2-substituted TEMPO displays high reactivity, less stability, and softer properties. The study reveals that the stability of TEMPO derivatives...
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FE calculations of a deterministic and statistical size effect in concrete under bending within stochastic elasto-plasticity and non-local softening
PublicationW artykule przedstawiony wyniki obliczeń MES deterministycznego i statystycznego efektu skali w belkach betonowych podczas zginania. Zastosowano model w ramach stochastycznej sprężysto-plastyczności i nielokalnego osłabienia. Belki były geometrycznie podobne. Wyniki porównano z modelem efektu skali Bazanta.
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Przemoc w stosunkach ukraińsko-rosyjskich w opinii polskiej prasy codziennej
PublicationThe five most widely read Polish newspapers informing about the creation Maidan in Kiev and protests against decisions of the Ukrainian authorities revealed the existence of internal political violence. The external violence is associated with the inclusion of Russia into the conflict. Since the turn of 2013/2014 in Ukrainian-Russian relations were recorded examples of economic violence.
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Rozumienie cechą inteligentnego przedsiębiotstwa
PublicationW artykule podniesiono istotę pojęcia ‘rozumienie’ w aspekcie inteligentnego przedsiębiorstwa. Przeprowadzone badania teoretyczne i empiryczne pozwoliły na wyłonienie rozumienia wewnętrznego i zewnętrznego. Rozumienie wewnętrzne w inteligentnym przedsiębiorstwie dotyczy sfer: pracowników oraz całego przedsię-biorstwa. Natomiast rozumienie zewnętrzne skierowane jest na otoczenie i potrze-bę dostosowania przedsiębiorstwa.
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Assessment of crack resistance of S355J2+N steel according to SEP 1390 standard
PublicationThe aim of the study was to evaluate the weldability of S355J2+N steel by bending test according to SEP 1390. In the specimen from S355J2+N steel 3 external cracks were found, 1 of which were stopped in the fusion line and 2 in heat affected zone. Results of bending test for investigated grade of steel are positive.
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Comparative analysis of mechanical conditions in bone union following first metatarsophalangeal joint arthrodesis with varied locking plate positions: A finite element analysis
PublicationFirst metatarsophalangeal joint arthrodesis is a typical medical treatment performed in cases of arthritis or joint deformity. The gold standard for this procedure is arthrodesis stabilisation with the dorsally positioned plate. However, according to the authors’ previous studies, medially positioned plate provides greater bending stiffness. It is worth to compare the mechanical conditions for bone formation in the fracture callus...
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CO2 Capture by Virgin Ivy Plants Growing Up on the External Covers of Houses as a Rapid Complementary Route to Achieve Global GHG Reduction Targets
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Analysis of EN 1993-1-6 guidelines about determining amplitudes of equivalent imperfections of steel cylindrical shells subjected to uniform external pressure
PublicationCivil engineering structures should be designed with reference to relevant standards. One of them is a Eurocode 3 standard EN 1993-1-6:2007: Design of steel structures Part 1-6: Strength and Stability of Shell Structures. According to this standard, the value of buckling load can be determined using different approaches: classical hand calculations (stress design) and geometrical and material non-linear analysis of an imperfect...
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Advanced Control With PLC—Code Generator for aMPC Controller Implementation and Cooperation With External Computational Server for Dealing With Multidimensionality, Constraints and LMI Based Robustness
PublicationThe manufacturers of Programmable Logic Controllers (PLC) usually equip their products with extremely simple control algorithms, such as PID and on-off regulators. However, modern PLCs have much more efficient processors and extensive memory, which enables implementing more sophisticated controllers. The paper discusses issues related to the implementation of matrix operations, time limitations for code execution within one PLC...
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Decomposition of the induced magnetism degaussing problem for fast determination of currents in demagnetization coils wrapped outside an object under arbitrary external field conditions
PublicationSafe passage of ships in the presence of sea mines can be ensured by limiting or reducing the ship’s magnetic footprint. For vessels with plastic hulls, the main component that requires magnetic damping is the engine. Demagnetization of such an object can be achieved by wrapping it with coils and setting the direct current appropriately. For each specific geographic location, the currents in the coils can be determined iteratively...
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Zastosowanie metody równań całkowych w analizie pola ekranującego obiektów ferromagnetycznych.Application of integral equations method to shield field analysis of ferromagnetic object.
PublicationDuże obiekty ferromagnetyczne, jakimi są okręty, powodują zaburzenia w rozkładzie ziemskiego pola ma-gnetycznego. Dla zredukowania tego zaburzenia na okrętach umieszcza się specjalne uzwojenia, których ce-lem jest wytworzenie pola magnetycznego usuwającego zmiany wywołane obecnością ferromagnetyka w zewnętrznym polu ziemskim. Obliczania rozkładu tych uzwojeń wiąże się z koniecznością znalezienia rozkładu pola magnetycznego.Zastosowanie...
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Probing the binding selected metal ions and biologically active substances to the antimicrobial peptide LL-37 using DSC, ITC measurements and calculations
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Three-dimensional fractographic analysis of total fracture areas in 6082 aluminium alloy specimens under fatigue bending with controlled damage degree
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Analysis of interactions responsible for vasopressin binding to human neurohypophyseal hormone receptors—molecular dynamics study of the activated receptor–vasopressin–Gα systems
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Enormously large (approaching 14 eV!) electron binding energies of [HnFn+1]- (n= 1–5, 7, 9, 12) anions
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Activation of N2O and SO2 by the P–B Bond System. Reversible Binding of SO2 by the P–O–B Geminal Frustrated Lewis Pair
PublicationHerein, we present the first transformation of borylphosphine into borylphosphinite using nitrous oxide. Borylphosphine reacts with N2O via insertion of a single oxygen atom into the P−B bond and formation of a P−O−B bond system. Borylphosphine and borylphosphinite capture SO2 and activate it in an irreversible and reversible manner, respectively.
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Mechanism of Binding of Antifungal Antibiotic Amphotericin B to Lipid Membranes: An Insight from Combined Single-Membrane Imaging, Microspectroscopy, and Molecular Dynamics
PublicationAmphotericin B is a lifesaving polyene antibiotic used in the treatment of systemic mycoses. Unfortunately, the pharmacological applicability of this drug is limited because of its severe toxic side effects. At the same time, the lack of a well-defined mechanism of selectivity hampers the efforts to rationally design safer derivatives. As the drug primarily targets the biomembranes of both fungi and humans, new insights into the...
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The correlation of fractal dimension to fracture surface slope for fatigue crack initiation analysis under bending-torsion loading in high-strength steels
PublicationIn this study, the fractal dimension of fatigue fracture surfaces is investigated in order to find an alternative failure loading indicator. Some of many metrological factors are generalized by reducing the fracture surface structure to one factor and develop an entire fracture surface procedure by analyzing the impact of surface slope and calculation resolution. Three notched geometries are studied under cyclic bending-torsion:...
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Recycling of Industrial Waste as Soil Binding Additives—Effects on Soil Mechanical and Hydraulic Properties during Its Stabilisation before Road Construction
PublicationTo improve the in situ soil stabilization, different chemical additives are used (ion exchange compounds, additives based on H2SO4 or vinyl polymers, and organic additives using lignosul- fonates). One interesting alternative is the production of additives from various waste materials. The extensive testing of waste-based blends with soil was performed; the mechanical (unconfined compressive strength (UCS)) and hydraulic (capillary...
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Recycling of Polyurethanes
PublicationPolyurethane waste can be recycled by mechanical methods (i.e., grinding and applying as a filler or pressing with a bonding agent) and chemical methods (mainly by e.g., glycolysis, hydrolysis, or aminolysis). There is also possibility to the recover energy from polyurethanes waste (by incineration, gasification, and pyrolysis).
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Numerical Model of Femur Part
PublicationThe aim of the study is to create a new more accurate method of femur part modelling by using the finite element method. According to this new method, a femur part is treated as a complex structure composed of trabecular bone (internal part) and cortical bone (external part). The internal part is modelled as a scaffold, thus the external part is modelled as a coat (i.e. covering). Applying the programme ABAQUS, there were created...
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Temporal Changes in Complexity of Cardiovascular Regulation during Head-Up Tilt Test by Entropic Measures of Fluctuations of Heart Period Intervals and Systolic Blood Pressure
PublicationTemporal changes in complexity of cardiovascular regulation during head-up tilt test by entropic measures of fluctuations of heart period intervals and systolic blood pressure
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Urban city lights. Light pollution as one of the effects of incorrectly designed external illumination. How can a successful lighting masterplan diminish its impact?
PublicationIn the modern world, artificial lighting brings many tangible benefits such as the ability to extend working hours and so increase production, recreational use of the city after dark, or the possibility to travel regardless of the time of day. However, this flexibility comes at a price and negatively impacts on the environment. One such negative phenomenon is Light Pollution ‐ a term used to describe excessive nighttime artificial...
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Analiza metodamii chemii obliczeniowej właściwości molekularnych i oddziaływań w układach supramolekularnych pochodnych amfoterycyny B
Publication.
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Smart grid technologies in electric traction: Mini inverter station
PublicationThe growing number of trams and trolleybuses equipped with recuperation systems contribute to the increase in the amount of energy recovered during braking. It raises questions about the possibility of its usage. One of such possibilities is the use of smart grid technology. The paper presents a case study of the use of braking energy in the trolleybus system for external loads by implementing mini inverter stations. Analysis is...
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Conformational latitude – activity relationship of KPPR tetrapeptide analogues toward their ability to inhibit binding of vascular endothelial growth factor 165 to neuropilin‐1
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Micro-cracking pattern recognition of hybrid CNTs/GNPs cement pastes under three-point bending loading using acoustic emission technique
PublicationThe generation of microcracks has an important influence on the behaviour of concrete structures. In this study, the acoustic emission (AE) technique was used to investigate the fracture phenomena and micro-cracking behavior of hybrid carbon nanotubes (CNTs, the 1-D allotrope of carbon atoms) and graphene nanoplatelets (GNPs, 2D monolayer of sp2-hybridized carbon atoms), cement composites under three-point bending loading. In...
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Inhibition of inflammatory response in human keratinocytes by magnetic nanoparticles functionalized with PBP10 peptide derived from the PIP2-binding site of human plasma gelsolin
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Lower rim substituted p-tert-butylcalix[4]arene; Part 14. Synthesis, structures and binding studies of calix[4]arene thioamides
PublicationA number of p-tert-butylcalix[4]arene thioamides were synthesized and characterized by 1H-NMR and elemental analysis. Compounds 1-5 are O-substituted derivatives with -CH2-C(=S)-N-X groups, where NX = morpholidyl, NEt2, NHC2H4Ph, NHCH2Ph and NHEt,respectively. The X-ray structures of the ligands 1, 3, 5 and of the complex 3Pb(ClO4)2, (compound 6), are presented and their slightly distorted cone conformation is established. The...
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Design, Chemical Synthesis and Kinetic Studies of Trypsin Chromogenic Substrates Based on the Proteinase Binding Loop of Cucurbita maxima Trypsin Inhibitor (CMTI-III)
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Dynamics of changes in iron concentration and total iron binding capacity in blood plasma of goat kids during their first month of life (Short Communication)
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Notch fatigue analysis and life assessment using an energy field intensity approach in 7050-T6 aluminium alloy under bending-torsion loading
PublicationThis paper studies the fatigue crack initiation and fatigue crack propagation of notched cylindrical bars made of 7050-T6 aluminium alloy subjected to multiaxial bending-torsion loading. The sites of crack initiation and the angles of crack initiation were successfully predicted from the distribution of the first principal stress at the notch surface. Fatigue crack initiation lives were computed through the new concept of energy...
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Exploring thiophene-2-acetate and thiophene-3-acetate binding modes towards the molecular and supramolecular structures and photoluminescence properties of Pb(ii) polymers
PublicationTo evaluate the impact of the flexible positional isomeric ligands thiophene-2-acetate (2tpacCOO) andthiophene-3-acetate (3tpacCOO) on the construction and self-assembly process of Pb(II) polymers, twonovel compounds, [Pb(2tpacCOO)2(H2O)]n(1) and [Pb(3tpacCOO)2]n(2), were preparedviaanonhydro-thermal method with respect to green chemistry rules. The obtained polymers were fully characterized byelemental analysis, TG/DTG and PXRD,...
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The Product of Matrix Metalloproteinase Cleavage of Doxorubicin Conjugate for Anticancer Drug Delivery: Calorimetric, Spectroscopic, and Molecular Dynamics Studies on Peptide–Doxorubicin Binding to DNA
PublicationMatrix metalloproteinases (MMPs) are extracellular matrix degradation factors, promoting cancer progression. Hence, they could provide an enzyme-assisted delivery of doxorubicin (DOX) in cancer treatment. In the current study, the intercalation process of DOX and tetrapeptide-DOX, the product of the MMPs' cleavage of carrier-linked DOX, into dsDNA was investigated using stationary and time-resolved fluorescence spectroscopy, UV-Vis...
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An insight into the mixed quantum mechanical-molecular dynamics simulation of a ZnII-Curcumin complex with a chosen DNA sequence that supports experimental DNA binding investigations
PublicationAn important aspect of research pertaining to Curcumin (HCur) is the need to arrest its degradation in aqueous solution and in biological milieu. This may be achieved through complex formation with metal ions. For this reason, a complex of HCur was prepared with ZnII, that is not likely to be active in redox pathways, minimizing further complications. The complex is monomeric, tetrahedral, with one HCur, an acetate and a molecule...
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Idea urbanistyczna Juliana Rummla i jej wpływ na międzywojenne plany Gdyni = The Urban Idea of Jukiab Rummel and Its Influence on the Interwar Plans of Gdynia
PublicationJulian Rummel nie był ani architektem ani urbanistą. Był inżynierem budowy okrętów, działaczem gospodarczym, jednym w wielkich orędowników budowy portu i miasta Gdyni oraz współtwórcą polskiej polityki morskiej II Rzeczypospolitej. W połowie 1924 roku, kiedy rozpoczęto w Gdyni przebudowę otwartego zaledwie rok wcześniej Portu Tymczasowego na wielki, uniwersalny port stały, Julian Rummel był pierwszym którzy zwracali uwagę na pilną...
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A multi‐industry and cross‐country comparison of technology contribution to formal and informal knowledge sharing processes for innovativeness
PublicationThe study explores the impact of organizational information technology (IT) competency on knowledge sharing, both explicit and tacit, in the context of innovativeness of products and processes. Knowledge sharing is then assessed in terms of tacit-to-explicit conversion and the impact of both types of knowledge on organizational innovation. Both process (internal) and product/service (external) innovation are included. As an extension,...
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FINANCIAL COMPARISON OF WESTERN BALKAN AND BALTIC SEA STATES USING THE CAMEL APPROACH
Publication• The aim - This article aims to compare the situation in the banking sectors of two regions, which due to their political and economic history have much in common. These are the Western Balkan States of Serbia, Croatia and Macedonia, and the Baltic Sea States of Lithuania, Estonia, and Latvia. • Methods - It presents three approaches to defining banking stability that can be found in the literature and carries out an initial...
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X-Ray Computer Tomography Study of Degradation of the Zircaloy-2 Tubes Oxidized at High Temperatures
PublicationThe investigations of high-temperature oxidation of zirconium alloys, applied for fuel pellets in nuclear power plants, are usually limited to oxidation kinetics, phase transformations and microstructural characterization. The purpose of this research was to characterize the degradation phenomena occurring within oxide layer and at the interface oxide/metal, on internal and external Zircaloy-2 tube...
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Brachytherapy boost improves survival and decreases risk of developing distant metastases compared to external beam radiotherapy alone in intermediate and high risk group prostate cancer patients
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A Cross-Team Collaborative Evaluation of a CRM System
PublicationThis paper presents an analysis of an usability evaluation a CRM (Customer Relationship Management) performed by a team composed of external usability experts jointly with a CRM staff. The evaluation process differed from a classical scheme known from former projects, including some new elements resulting from a specific context of this study. These novel elements resulted in reshaping the role of the CRM system and considering...
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Does the carbon emissions trading system reduce carbon emissions by promoting two-way FDI in developing countries? Evidence from Chinese listed companies and cities
PublicationHow developing countries can effectively promote cities’ carbon emission reduction through the carbon emission trading system (ETS) is a topic worthy of attention in the global carbon reduction campaign. Policy changes in China's ETS provide a unique opportunity to measure whether ETS impacts carbon emissions through two-way FDI. Hence, this paper employs difference-in-differences (DID) method to test the causal impact of ETS...
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Digestive system, femur and tibia bone characteristics of Dworka and Pekin ducks
PublicationThe aim of this study was to determine traits of the digestive system and femur and tibia bone ofDworka and Pekin ducks. A study was conducted on 24 Dworka duck (breeding strain D11) carcassesand 24 Pekin duck (conservative strain P9) carcasses, 12 male carcasses and 12 female carcassesfrom each strain. The lengths of the intestinal segments were tape measured. The diameters of theintestinal segments and leg bone dimensions...
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Digestive system, femur and tibia bone characteristics of Dworka and Pekin ducks
PublicationThe aim of this study was to determine traits of the digestive system and femur and tibia bone ofDworka and Pekin ducks. A study was conducted on 24 Dworka duck (breeding strain D11) carcassesand 24 Pekin duck (conservative strain P9) carcasses, 12 male carcasses and 12 female carcassesfrom each strain. The lengths of the intestinal segments were tape measured. The diameters of theintestinal segments and leg bone dimensions...
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Digestive system, femur and tibia bone characteristics of Dworka and Pekin ducks
PublicationThe aim of this study was to determine traits of the digestive system and femur and tibia bone ofDworka and Pekin ducks. A study was conducted on 24 Dworka duck (breeding strain D11) carcassesand 24 Pekin duck (conservative strain P9) carcasses, 12 male carcasses and 12 female carcassesfrom each strain. The lengths of the intestinal segments were tape measured. The diameters of theintestinal segments and leg bone dimensions...
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Determinants And Barriers In The Development Of The Entrepreneurial Orientation In The Polish Higher Education Institutions
PublicationThe main aim of the paper is to present the results of the research project on the entrepreneurship in the Polish higher education institutions. The project was funded by the Polish National Science Centre and its main aim was to identify the factors that enable, enhance, limit or disable the entrepreneurial potential in higher education institutions. The paper gives an overview of the identified determinants that foster the entrepreneurial...