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Search results for: METABOLIC DETOXIFICATION
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Ability of Yeast Metabolic Activity to Reduce Sugars and Stabilize Betalains in Red Beet Juice
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Cellular Turnover: A Potential Metabolic Rate–Driven Mechanism to Mitigate Accumulation of DNA Damage
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Metabolic transformations of antitumor imidazoacridinone, C-1311, with microsomal fractions of rat and human liver
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Conducting polymers for biodegradable metallic implants
PublicationNowadays permanent metallic cardiovascular stents are long-term implants. The long-time presence of such an implant in human body can cause overgrowth of tissue within the treated portion of the vessel, blockage of the circulatory system and many other clinical complications, such as thrombosis, prolonged physical irritations or chronic inflammation. Therefore, in recent years, there is an interest to create biodegradable metallic...
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Machining by abrasive-metallic lapping tools.
PublicationPrzedstawiono kontrukcję niekonwencjonalnych narzędzi ścierno-metalowych do docierania. Opracowane narzędzia wykorzystano do badań wydajności i jakości docierania elementów ceramicznych. Określono wpływ podstawowych warunków docierania na efekty obróbki powierzchni płaskich.
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Metabolomic Insight into Polycystic Ovary Syndrome—An Overview
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Synthesis, Molecular Structure, Metabolic Stability and QSAR Studies of a Novel Series of Anticancer N-Acylbenzenesulfonamides
PublicationA series of novel N-acyl-4-chloro-5-methyl-2-(R1-methylthio)benzenesulfonamides 18–47 have been synthesized by the reaction of N-[4-chloro-5-methyl-2-(R1-methylthio) benzenesulfonyl]cyanamide potassium salts with appropriate carboxylic acids. Some of them showed anticancer activity toward the human cancer cell lines MCF-7, HCT-116 and HeLa, with the growth percentages (GPs) in the range from 7% to 46%. Quantitative structure-activity relationship...
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Metabolic responses to a 48-h ultra-marathon run in middle-aged male amateur runners
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Positive Regulation of Macromolecule Metabolic Process Belongs to the Main Mechanisms Crucial for Porcine Oocytes Maturation
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Expression Changes in Fatty acid Metabolic Processrelated Genes in Porcine Oocytes During in Vitro Maturation
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New markers for regulation of transcription and macromolecule metabolic process in porcine oocytes during in vitro maturation
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GC-MS-based untargeted metabolomics of plasma and urine to evaluate metabolic changes in prostate cancer
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Comparison of RP-HPLC columns used for determination of nucleoside metabolic patterns in urine of cancer patients
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Evaluation of early cerebral metabolic, perfusion and microstructural changes in HCV-positive patients: A pilot study
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The studies of imidazoacridinone antitumor agent, C-1311, in the field of metabolic transformations with cytochrome P450 isoenzymes
PublicationPraca zawiera wyniki badań metabolicznej transformacji przeciwnowotworowej pochodnej imidazoakrydonu C-1311 wobec rekombinantowych ludzkich izoenzymów P450. Związek nie ulegał transformacji w badanych warunkach, natomiast wykazano, że ma zdolność hamowania aktywności izoezymów CYP1A2 i CYP3A4.
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Metabolic activation of adriamycin by NADPH-cytochrome P450 reductase; overview of its biological and biochemical effects
PublicationOmówione zostały efekty aktywacji metabolicznej adriamycyny przez NADPH-zależną reduktazę cytochromu P450. Wykazano, że ten rodzaj aktywacji zwiększa aktywność biologiczną tego związku, a przy tym powoduje jego wiązanie się kowalencyjne z ważnymi biologicznie makromolekułami komórkowymi.
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Microbiological corossion of metallic products as a result of biofilm
PublicationWarunkiem do pojawienia się korozji mikrobiologicznej jest utworzenie na powierzchni metalu biofilmu. Zawiera on biologicznie czynne mikroorganizmy wraz z produktami ich przemian metabolicznych. Biofilm ogranicza dyfuzję produktów metabolizmu wytwarzanych przez poszczególne komórki mikrokolonii. Powoduje to, że produkty uboczne tych przemian gromadzą się w bezpośrednim sąsiedztwie metalu. Gdy powierzchnia metalu nie jest odporna...
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Biocompatibility and bioactivity of bearing loaded metallic implants
PublicationPresentation of developed titanium alloy base composite materials possessing better biocompatibility, longer lifetime and bioactivity behavior for bearing loaded implants, e.g. hip joint and knee joint endoproshtesis.
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Biocompatibility and Bioactivity of Load-Bearing Metallic Implants
PublicationThe main objective of here presented research is to develop the titanium (Ti) alloy base composite materials possessing better biocompatibility, longer lifetime and bioactivity behaviour for load-bearing implants, e.g. hip joint and knee joint endoprosthesis. The development of such materials is performed through: modeling the material behaviour in biological environment in long time and developing of new procedures for such evaluation;...
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Biocompatibility and bioactivity of load-bearing metallic implants
PublicationThe main objective of here presented research is to develop the titanium (Ti) alloy base composite materials possessing better biocompatibility, longer lifetime and bioactivity behaviour for load-bearing implants, e.g. hip joint and knee joint endoprosthesis. The development of such materials is performed through: modeling the material behaviour in biological environment in long time and developing of new procedures for such evaluation;...
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Multigap superconducting state in molecular metallic hydrogen
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Nucleate pool boiling on porous metallic coatings
PublicationPrzedstawiono wyniki systematycznych badań eksperymentalnych przejmowania ciepła podczas wrzenia pęcherzykowego wody destylowanej w stanie nasycenia od płaskich i cylindrycznych powierzchni o specjalnie przygotowanej powierzchni: gładkiej, chropowatej oraz pokrytej warstwą porowatą.
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Lapping of flat surfaces with two metallic tools.
PublicationPrzedstawiono opis docierania powierzchni płaskich docierakami aktywizowanymi w sposób swobodny i wymuszony oraz narzędziami dwumetalowymi i ściernometalowymi. Wyznaczono zużycie docieraków stalowo-żeliwnych oraz wydajność obróbki żeliwa sferoidalnego niestopowego i stali NC6.
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Metabolic Profiles of New Unsymmetrical Bisacridine Antitumor Agents in Electrochemical and Enzymatic Noncellular Systems and in Tumor Cells
PublicationNew unsymmetrical bisacridines (UAs) demonstrated high activity not only against a set of tumor cell lines but also against human tumor xenografts in nude mice. Representative UA compounds, named C-2028, C-2045 and C-2053, were characterized in respect to their physicochemical properties and the following studies aimed to elucidate the role of metabolic transformations in UAs action. We demonstrated with phase I and phase II enzymes...
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Chicken feather keratin as a source of bioactive peptides useful in prevention of metabolic disorders – in silico and in vitro hydrolysis
PublicationProtein derived bioactive peptides not only serve as nutrients but can also exert drug-like activity, e.g. antidiabetic, antihypertensive, or antimicrobial, to name a few. Most biopeptides have beneficial effects on health that make them attractive for nutraceutical applications. The majority of bioactive peptides have been obtained from food proteins, but protein-rich by-products generated by agriculture...
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Sustainable nitrogen removal in anammox-mediated systems: Microbial metabolic pathways, operational conditions and mathematical modelling
PublicationAnammox-mediated systems have attracted considerable attention as alternative cost-effective technologies for sustainable nitrogen (N) removal from wastewater. This review comprehensively highlights the importance of understanding microbial metabolism in anammox-mediated systems under crucial operation parameters, indicating the potentially wide applications for the sustainable treatment of N-containing wastewater. The partial...
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The Rate of Improvement in Metabolic Control in Children with Diabetes Mellitus Type 1 on Insulin Glargine Depends on Age
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Metabolic Profiles of New Unsymmetrical Bisacridine Antitumor Agents in Electrochemical and Enzymatic Noncellular Systems and in Tumor Cells
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Cardiovascular, anthropometric, metabolic and hormonal profiling of normotensive women with polycystic ovary syndrome with and without biochemical hyperandrogenism
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29 Metabolic Syndrome and Selected Coronary Heart Disease Risk Factors in the Group of Krakow Adult Residents
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Exposure to non-continuous rotating magnetic field induces metabolic strain-specific response of Komagataeibacter xylinus
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The Co-Culture of Staphylococcal Biofilm and Fibroblast Cell Line: The Correlation of Biological Phenomena with Metabolic NMR1 Footprint
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The Impact of Intraspecies Variability on Growth Rate and Cellular Metabolic Activity of Bacteria Exposed to Rotating Magnetic Field
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Perturbations of the hepatic proteome behind the onset of metabolic disorders in mouse offspring developed following embryo manipulation
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Emerging Role of Adenylate Kinase 4 as a Metabolic Player Regulating Cellular Hypoxic Responses in Pulmonary Cells
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Effects of Low Concentration of Selected Analgesics and Successive Bioaugmentation of the Activated Sludge on Its Activity and Metabolic Diversity
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Primary mediastinal B-cell lymphoma – metabolic and anatomical features in 18FDG-PET/CT and response to therapy
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Peroxidative metabolism of arachidonic acid in the course of Lyme arthritis
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Alternative Lactose Catabolic Pathway in Lactococcus lactis IL1403
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Melatonin: A Cutaneous Perspective on its Production, Metabolism, and Functions
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Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc
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Retained features of embryonic metabolism in the adult MRL mouse
PublicationThe MRL mouse is an inbred laboratory strain that was derived by selective breeding in 1960 from the rapidly growing LG/J (Large) strain. MRL mice grow to nearly twice the size of other commonly used mouse strains, display uncommonly robust healing and regeneration properties, and express later onset autoimmune traits similar to Systemic Lupus Erythematosis. The regeneration trait (heal) in the MRL mouse maps to 14-20 quantitative...
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Vascular Aging and Damage in Patients with Iron Metabolism Disorders
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Metabolomic Signature of Early Vascular Aging (EVA) in Hypertension
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Unbalanced Sphingolipid Metabolism and Its Implications for the Pathogenesis of Psoriasis
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Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects
PublicationSkin diseases such as psoriasis (Ps) and psoriatic arthritis (PsA) are immune-mediated inflammatory diseases. Overlap of autoinflammatory and autoimmune conditions hinders diagnoses and identifying personalized patient treatments due to different psoriasis subtypes and the lack of verified biomarkers. Recently, proteomics and metabolomics have been intensively investigated in a broad range of skin diseases with the main purpose...
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Parametric imaging in dynamic glucose metabolism studies in brain
PublicationArtykuł analizuje badania dynamiczne 18FDG-PET, które służą do estymacji metabolizmu glukozy w mózgu. Zbadano w nim wpływ zakłóceń na wyznaczanie interesującego nas parametru LCMRGlc.
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Metabolism of antitumour agent 1-nitroacridine derivative, C-1748 in pancreatic cancer cell lines
PublicationPancreatic cancer has the highest mortality rate of all major cancers because of limited treatment options. Surgical removal of the tumour is possible only in its early stage, nevertheless the asymptomatic development very often makes unable an accurate diagnose. In the case of metastatic pancreatic cancer only chemotherapy, mainly with gemcitabine, can be offered to patients. However, common resistance towards gemcitabine imposes...
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Electrochemical simulation of metabolic reduction and conjugation reactions of unsymmetrical bisacridine antitumor agents, C-2028 and C-2053
PublicationElectrochemistry (EC) coupled with analysis techniques such as liquid chromatography (LC) and mass spectrometry (MS) has been developed as a powerful tool for drug metabolism simulation. The application of EC in metabolic studies is particularly favourable due to the low matrix contribution compared to in vitro or in vivo biological models. In this paper, the EC(/LC)/MS system was applied to simulate phase I metabolism of the representative...
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Chiral Pyrazolo[4,3-e][1,2,4]triazine Sulfonamides—Their Biological Activity, Lipophilicity, Protein Affinity, and Metabolic Transformations
PublicationReferring to our previous laboratory results related to the tyrosinase and urease inhibition by pyrazolo[4,3-e][1,2,4]triazine sulfonamides, we examined here in silico the mechanism of action at the molecular level of the investigated pyrazolotriazine sulfonamides by the molecular docking method. The studied compounds being evaluated for their cytotoxic effect against cancer cell lines (MCF-7, K-562) and for recombinant Abl and...