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Search results for: PHOSPHAMANNOSE ISOMERASE (PMI)
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Crystal structures of the DsbG disulfide isomerase reveal an unstable disulfide
PublicationDsb proteins control the formation and rearrangement of disulfide bonds during the folding of secreted and membrane proteins in bacteria. DsbG, a member of this family, has disulfide bond isomerase and chaperone activity. Here, we present two crystal structures of DsbG at 1.7- and 2.0-Angstrom resolution that are meant to represent the reduced and oxidized forms, respectively. The oxidized structure, however, reveals a mixture...
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Distant Non-Obvious Mutations Influence the Activity of a Hyperthermophilic Pyrococcus furiosus Phosphoglucose Isomerase
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Structural analogues of reactive intermediates as inhibitors of glucosamine-6-phosphate synthase and phosphoglucose isomerase
PublicationCentra aktywne izomerazy fosfoglukozowej (PGI) oraz domeny izomerazowej (HPI) syntazy glukozamino-6-fosforanu (GlcN-6-P), wykazują podobieństwo ułożenia przestrzennego kluczowych reszt aminokwasowych, z wyjątkiem reszty Arg272 PGI i reszt Lys603 i Lys485 HPI. Dziesięć pochodnych D-heksitolo-6-P, kwasu 5-fosfoarabonowego i kwasu 6-fosfoglukonowego, strukturalnych analogów cis-enolaminy lub cis-enolanu, przypuszczalnych stanów przejściowych...
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Electron scattering on C3H6 isomers
PublicationZmierzono całkowity przekrój czynny na rozproszenie elektronów na dwóch izomerach strukturalnych węglowodoru C3H6 dla energii 0.5-370 eV. Wykorzystano spektometr pracujący w oparciu o liniową metodę transmisyjną. Zaobserwowano wyraźny efekt izomeryczny. Uzyskane wyniki porównano z wcześniejszymi danymi eksperymentalnymi oraz obliczeniami.
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Synthesis of phosphono and phosphate derivatives of hydroxyimino-D-alditols as new potential antifungal agents
PublicationIn search for new effective we antyfungals we focus on two enzymes involved in biosynthesis of the fungal cell wall. The first enzyme is glucosamine-6-phosphate (GlmS), which catalyzes transformation of D-fructose-6-phosphate (Fru-6P) to D-glucosamine-6-phodphate (GlcN-6P) in the chitin biosynthesis pathway. The second enzyme is phosphomannose isomerase (PMI) repored to play a crucial role in biosynthesis of many mannosylated structures,...
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PCI JOURNAL
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Crystallization and preliminary X-ray analysis of the isomerase domain of glucosamine-6-phosphate synthase from Candida albicans
PublicationSyntaza glukozamino-6-fosforanu (EC 2.6.1.16) katalizuje pierwszy, praktycznie nieodwracalny etap w szlaku biosyntezy heksozoamin, którego produktem końcowym jest UDP-GlcNAc, kluczowy substrat dla tworzenia ściany komórkowej drobnoustrojów. Otrzymano kryształy domeny izomerazowej syntazy GlcN-6-P z Candida albicans, składającej się z reszt 346-712 (42 kDa). Analiza rentgenograficzna kryształu wykazała, że należy on do grupy przestrzennej...
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Molecular modelling of transition state analogue inhibitors of glucosamine-6-P synthase and glucose-6-P isomerase.
PublicationStruktura kompleksu 2-amino-2-deoksy-D-glucitolo-6-P (ADGP) z centrum aktywnym syntazy GlcN-6-P z E. coli została wykorzystAna jako punkt wyjścia do modelowania molekularnego analogów ADGP. Używając programu GROMOS96 wygenerowano konformacje analogów o najniższych energiach wewnętrznych, które następnie ''dokowano'' w centrum aktywnym enzymu. Dokonano syntezy wybranych związków i określono parametry kinetyczne i termodynamiczne...
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BC-MPI: running an mpi application on multiple clusters with beesycluster connectivity
PublicationW artykule zaproponowano nowy pakiet BC-MPI, który umożliwiauruchomienie aplikacji MPI na wielu klastrach z różnymi implementacjami MPI. Wykorzystuje dedykowane implementacje MPIdo komunikacji wewnątrz klastrów oraz tryb MPI THREAD MULTIPLE dokomunikacji pomiędzy klastrami w dodatkowych wątkach aplikacji MPI. Ponadto, aplikacja BC-MPI może być automatycznie skompilowanai uruchomiona przez warstwę pośrednią BeesyCluster. BeesyClusterumożliwia...
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Identification of Substrates of Cytoplasmic Peptidyl-Prolyl Cis/Trans Isomerases and Their Collective Essentiality in Escherichia Coli
PublicationProtein folding often requires molecular chaperones and folding catalysts, such as peptidyl-prolyl cis/trans isomerases (PPIs). The Escherichia coli cytoplasm contains six well-known PPIs, although a requirement of their PPIase activity, the identity of their substrates and relative enzymatic contribution is unknown. Thus, strains lacking all periplasmic and one of the cytoplasmic PPIs were constructed. Measurement of their PPIase...
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QSRR Evaluation of the New Anticancer Sulfonamides in View of the cis-trans Isomerism
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Revue Internationale PME
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PHI DELTA KAPPAN
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Negatively Charged Xanthine. I. Anions Formed by Canonical Isomers
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Zeszyty Naukowe PIM MSWiA Zeszyty Naukowe PIM MSWiA
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The conducted EMI in DC-DC converters
PublicationThis book presents the phenomena of conducted electromagnetic interference (EMI) generation in DC-DC converters. The measurement and simulation are used to analyze the impact of the most important parameters on the character, level and propagation path of interference. In this book, the analysis of the interference generation and propagation is presented on the example of three basic converters. The wide banded behavior of all...
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The Wiener filter applied to EMI decomposition
PublicationArtykuł przestawia zastosowanie metody filtracji Wienera do dekompozycji zaburzeń elektromagnetycznych z różnych źródeł. Zaburzenia generowane w trójfazowym rezonansowym falowniku napięcia typy PQRDCLI oraz w przekształtniku napięcia stałego zasilającego obwód sterowania falownika zostały zmierzone z zastosowaniem sieci sztucznej (LISN). W oparciu o transmitancje częstotliwościowe pomiędzy źródłami zaburzeń i zaburzeniami zmierzonymi...
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XRD (X-ray Diffraction) patterns of PMH, PMD and simulated MIL-53(Al)
Open Research DataThese data contain XRD (X-ray Diffraction) patterns of PMH, PMD and simulated MIL-53(Al). The results were recorded by a Philipsdiffractometer using Cu Ka radiation. Sample abbreviations (PMH, PMD, MIL-53(Al)) are in agreement with the markings used in the linked publication.
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SEM (scanning electron microscopy) and TEM (transmission electron microscopy) images of PMD and PMH
Open Research DataThese data contains SEM (scanning electron microscopy) and TEM (transmission electron microscopy) images of PMD and PMH. TEM was performed on a FEI Tecnai F30 transmission electron microscope operating at an acceleration voltage of 200 kV. SEM was done with a SEM, XL30ESEM-FEG with an acceleration voltage of 20 KV. Sample abbreviations (PMH, PMD) are...
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Impact of selected amino acids of HP0377 (Helicobacter pylori thiol oxidoreductase) on its functioning as a CcmG (cytochrome c maturation) protein and Dsb (disulfide bond) isomerase
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Checkpointing of Parallel MPI Applications using MPI One-sided API with Support for Byte-addressable Non-volatile RAM
PublicationThe increasing size of computational clusters results in an increasing probability of failures, which in turn requires application checkpointing in order to survive those failures. Traditional checkpointing requires data to be copied from application memory into persistent storage medium, which increases application execution time as it is usually done in a separate step. In this paper we propose to use emerging byte-addressable...
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Conducted emi propagation modelling in the wound components.
PublicationThe modelling of EMC behaviour of power electronics converters require specific models of devices which are adequate in a wide frequency range. A novel equivalent-circuit model of the inductor, suitable for EMC applications, has been developed and validated. The model can be used for the analyses of wounded components' behaviour in the conducted-EMI frequency range. The parameters of the proposed model can be evaluated based on...
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Better understanding EMI generation of power converters
PublicationPrzedstawiono metodę przewidywania poziomu zaburzeń w układzie podwyższającym napięcie w oparciu o metodę filtracji Wienera. Pozwoliło to na określenie odpowiedzi impulsowej pomiędzy przyczyną zaburzenia (zmianą napięcia na elementach półprzewdonikowych) a zaburzeniem. Metodę zwerifikowano przy użyciu danych z symulacji oraz pomiarów w rzeczywistym obiekcie
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Modelling EMI choke for the power electronics application
PublicationPrzedstawiono wyniki przeprowadzonych badań symulacyjnych i eksperymentalnych dotyczących propagacji zakłóceń elektromagnetycznych przewodzonych w dławikach przeciwzakłóceniowych stosowanych w przekształtnikach energoelektronicznych. Zaproponowany model obwodowy dławika pozwala na analizę symulacyjną właściwości w zakresie częstotliwości zaburzeń elektromagnetycznych przewodzonych. Model uwzględnia zjawiska związane z pojemnościami...
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PM&R
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Conducted emi identification in power electronic converters : modeling of EMI generation and propagation using circuit simulation and wiener filtering methods.
PublicationThis work presents the circuit simulations and the conventional signal processing technique (Wiener filtering) in order to reconstruct conducted ElectroMagnetic Interferences (EMI), generated and propagated in power electronics converters. In the simulation study, the most accurate presently available models of components of circuit have been used and improved. The proposed Wiener filtering method allows to identifying the transfer...
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EMI Matrix for Naval Systems. [Wykorzystanie macierzy EMI do projektowania systemów hydro- i radiolokacyjnych na statkach wojennych]
PublicationPrzedstawiono problemy związane z badaniami zakóceń e-m występujacych na okrętach wojennych, zwłaszcza w odniesieniu do systemów hydro- i radiolokacyjnych. Omówiono wymagania standaryzacyjne odnoszące sie do metod pomiarowych i stanu poprawności kompatybilnościowej. Przeanalizowane wybrane wyniki pomiarowe.
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Unexpected Z/E isomerism of N-methyl-O-phosphothioyl benzohydroxamic acids, their oxyphilic reactivity and inertness to amines
PublicationThiophosphinoylation of N-methyl p-substituted benzohydroxamic acids using disulfanes (method A) or diphenylphosphinothioyl chloride (method B) provides only one conformer of the respective O-phosphothioyl derivative (Xray and NMR analysis). Undergoing the P-transamidoxylation reaction is an evidence of the reversibility of thiophosphinoylation. Only those products containing strong EWG substituents in the aroyl residue or bulky...
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Induction machine behavioral modeling for prediction of EMI propagation.
PublicationThis paper presents the results of wideband behavioral modeling of an induction machine (IM). The proposed solution enables modeling the IM differential- and common-mode impedance for a frequency range from 1 kHz to 10 MHz. Methods of parameter extraction are derived from the measured IM impedances. The developed models of 1.5 kW and 7.5 kW induction machines are designed using the Saber Sketch scheme editor and simulated in the...
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A spectroscopic study of the cis/trans-isomers of penta-2,4-dienoic acid attached to gold nanoclusters
PublicationIn this theoretical work, we present a spectroscopic analysis of the cis/trans-isomers of a molecular switch, penta-2,4-dienoic acid, attached to gold clusters of different size (1, 2 and 20 gold atoms). We have simulated 4 different spectroscopic techniques: Infrared spectroscopy, normal Raman scattering, absorption spectra and resonance Raman scattering. We discuss how the position and the conformation of the molecule determine...
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Elevated Levels of Renalase, the β-NAD(P)H Isomerase, Can Be Used as Risk Factors of Major Adverse Cardiovascular Events and All-Cause Death in Patients with Chronic Kidney Disease
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Antiproliferative activity of side-chain truncated vitamin D analogs (PRI-1203 and PRI-1204) against human malignant melanoma cell lines
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Pi of the Sky
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Corrosion Inhibition Mechanism and Efficiency Differentiation of Dihydroxybenzene Isomers Towards Aluminum Alloy 5754 in Alkaline Media
PublicationThe selection of efficient corrosion inhibitors requires detailed knowledge regarding the interaction mechanism, which depends on the type and amount of functional groups within the inhibitor molecule. The position of functional groups between different isomers is often overlooked, but is no less important, since factors like steric hinderance may significantly affect the adsorption mechanism. In this study, we have presented how...
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A method for the production of D-tagatose using a recombinant Pichia pastoris strain secreting beta-D-galactosidase from Arthrobacter chlorophenolicus and a recombinant L-arabinose isomerase from Arthrobacter sp. 22c
PublicationD-Tagatose is a natural monosaccharide which can be used as a low-calorie sugar substitute in food, beverages and pharmaceutical products. It is also currently being tested as an anti-diabetic and obesity control drug. D-Tagatose is a rare sugar, but it can be manufactured by the chemical or enzymatic isomerization of D-galactose obtained by a beta-D-galactosidase-catalyzed hydrolysis of milk sugar lactose and the separation of...
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Investigation of hyperfine structure of several major lines in PbI and PbII
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Revisions of the SMS maintenance procedures based on computerized PMS data
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Towards Easy-to-Use Checkpointing of MPI Applications within CLUSTERIX.
PublicationW literaturze wymienia się wiele bibliotek/systemów zarówno poziomu jądra jak i użytkownika, które wspomagają zapisywanie i odtwarzanie stanu procesów. W odniesieniu do aplikacji równoległych, jest to jednak zadanie cały czas trudne. Praca prezentuje nasze podejście do zapisywania/odtwarzania stanu aplikacji MPI wspomagane przez programistę, które wykorzystane będzie w środowisku projektu CLUSTERIX tj. zintegrowanej grupie klastrów...
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Temperature-induced changes of HtrA2(Omi) protease activity and structure
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Management of MV/LV Transformer Replacement Based on AMI Platform
PublicationThe paper presents the extended possibilities of managing the selection and replacement of MV/LV transformers using the measurement data from the Advanced Metering Infrastructure (AMI) system. The analysis was conducted on samples of over 1900 transformers that operate in two different types of MV grids: rural and urban. The analysis has shown that there is a great potential in the field of optimizing the rated power of the transformers.
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Performance and Power-Aware Modeling of MPI Applications for Cluster Computing
PublicationThe paper presents modeling of performance and power consumption when running parallel applications on modern cluster-based systems. The model includes basic so-called blocks representing either computations or communication. The latter includes both point-to-point and collective communication. Real measurements were performed using MPI applications and routines run on three different clusters with both Infiniband and Gigabit Ethernet...
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Use of AMI Meters in the Process of Low Voltage Grid Optimization
PublicationThis is a report of a project involving, inter alia, low voltage grid performance optimization with data from AMI meters . The study was supported with a European UPGRID grant, and executed by a consortium of companies from seven European countries, including Poland .
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Quest for the Molecular Basis of Improved Selective Toxicity of All-Trans Isomers of Aromatic Heptaene Macrolide Antifungal Antibiotics
PublicationThree aromatic heptaene macrolide antifungal antibiotics, Candicidin D, Partricin A (Gedamycin) and Partricin B (Vacidin) were subjected to controlled cis-trans to all trans photochemical isomerization. The obtained all-trans isomers demonstrated substantially improved in vitro selective toxicity in the Candida albicans cells: human erythrocytes model. This effect was mainly due to the diminished hemotoxicity. The molecular modeling...
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Gracjana Klein-Raina dr hab.
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EMI attenuation in a DC-DC buck converter using GaN HEMT
PublicationA dc-dc buck converter using gallium nitride (GaN) high electron mobility transistors (HEMT) is experimentally investigated at the discontinuous current mode (DCM) and at the triangular current mode (TCM) operation. The paper objective is to specify the power conversion efficiency and attenuation of common mode (CM) and differential mode (DM) noise voltage, measured at the line impedance stabilization network (LISN) for compared...
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Wiener Filtering Applied to Conducted EMI Estimation in Soft Switching Inverter
PublicationW artykule tym przedstawiono metodę szacowania poziomu zaburzeń elektromagnetycznych przewodzonych generowanych w miekko-przełączalnym falowniku napięcia. Wykorzystano metodę filtracji Wienera, gdzie wykorzystano skończoną liczbę filtrów Wienera jako odzwierciedlenie wszystkich warunków generacji i propagacji zaburzeń. Do określenia transmitancji filtrów wykorzystano przebiegi napięć na zaciskach łączników energoelektronicznych...
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<title>Data acquisition module implemented on PCI mezzanine card</title>
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<title>FPGA based PCI mezzanine card with digital interfaces</title>
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Modern Platform for Parallel Algorithms Testing: Java on Intel Xeon Phi
PublicationParallel algorithms are popular method of increasing system performance. Apart from showing their properties using asymptotic analysis, proof-of-concept implementation and practical experiments are often required. In order to speed up the development and provide simple and easily accessible testing environment that enables execution of reliable experiments, the paper proposes a platform with multi-core computational accelerator:...
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EMI mitigation of GaN power inverter leg by local shielding techniques
PublicationThis paper presents local shielding techniques applied to a half-bridge inverter leg with the aim to reduce the common mode (CM) current noise at converter’s DC input. The research study is conducted for 650V Enhancement mode Gallium Nitride (GaN) power transistor switches. Main contributors of parasitic capacitances referred to the inverter-leg middle point node are identified. Then, shielding solutions are proposed to reduce...