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Search results for: reductive metabolism
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Synergistic effects in micellization and surface tension reduction in nonionic gemini S-10 and cationic RTAB surfactants mixtures
PublicationMixtures of nonionic gemini surfactant S-10 (α,α′-[2,4,7,9-tetrametyl-5-decyne-4,7-diyl]bis[ω-hydroxy -polioxyetylene] with cationic alkyltrimethylammonium bromides of different alkyl chain length (RTAB) were investigated. Basing on surface tension measurements the cmc values and other adsorption parameters were found. The Clint, Rubing’s and Rosen theories were applied for evaluation of the synergistic effects in mixed films and...
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Stathmin reduction and cytoskeleton rearrangement in rat nucleus accumbens in response to clozapine and risperidone treatment – Comparative proteomic study
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Selective Photocatalytic Reduction of 3‐Nitrophenol to 3‐Aminophenol by Anatase and Rutile TiO2 – What Stands Behind the Photoactivity?
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Quantitative Structure–Activity Relationships in Two-Electron Reduction of Nitroaromatic Compounds by Enterobacter cloacae NAD(P)H:Nitroreductase
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The Study of NADPH-Dependent Flavoenzyme-Catalyzed Reduction of Benzo[1,2-c]1,2,5-oxadiazole N-Oxides (Benzofuroxans)
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Naphtho[1′,2′:4,5]imidazo[1,2-a]pyridine-5,6-diones: Synthesis, enzymatic reduction and cytotoxic activity
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Two-electron reduction of quinones by rat liver NAD(P)H:quinone oxidoreductase: quantitative structure–activity relationships
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The influence of a strong external magnetic field from a permanent magnet on a measurement accuracy of an inductive watt-hour meter
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The hybrid estimation algorithm for wastewater treatment plant robust model predictive control purposes at medium time scale
PublicationThe paper proposes an approach to designing the hybrid estimation algorithm/module (HEA) with moving measurements window for Wastewater Treatment Plant (WWTP) Robust Model Predictive Control (RMPC) purposes at medium time scale. The RMPC uses a dedicated grey-box model of biological reactor for the system outputs prediction purposes. The grey-box model parameters are dependant on the plant operating point. Hence, these parameters...
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Analysis of Cogging Torque Reduction Method Effectiveness on the Example of a Surface Mounted Permanent Magnet Synchronous Motor Model
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Estimation of wastewater treatment plant state for model predictive control of N-P remowal at medium time scale.
PublicationPrzy ograniczonych możliwościach pomiarowych estymaty stanu są potrzebne w sterowaniu optymalizującym, opartym na sterowaniu predykcyjnym, sterującym usuwaniem azotu i fosforu, w biologicznej oczyszczalni ścieków. Optymalizator MPC do implementacji sprzężenia zwrotnego z obiektu potrzebuje tych estymat. Dodatkowo aktualizowane muszą być parametry modelu Gray-Box wykorzystywanego w module MPC. Wtedy estymaty stanu są używane przez...
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Weighted least squares parameter estimation for model predictive control of integrated wastewater systems at medium time scale.
PublicationW artykule przedstawione zostało sformułowanie i implementacja algorytmu ważonej sumy najmniejszych kwadratów na przesuwnym oknie pomiarowym dla celów estymacji parametrów modelu typu szara skrzynka. Model typu szara skrzynka dynamiki reaktora biologicznego jest wykorzystywany przez moduł sterowania predykcyjnego sterujący zintegrowanym systemem ściekowym w średniej skali czasu. Algorytm estymacji parametrów był walidowany na symulatorze...
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Event-Triggered Communication in Cooperative, Adaptive Model Predictive Control of a Nuclear Power Plant’s Turbo–Generator Set
PublicationThis paper discusses the issue of optimizing the communication between the components of a cooperating control system formed by a pair of MPC controllers of a nuclear power plant turbine set using online recursive least squares identification. It is proposed to use event-triggered communication, i.e., sending information only at selected time instants, as opposed to the standard approach where communication is triggered by time...
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Study of the Effectiveness of Model Order Reduction Algorithms in the Finite Element Method Analysis of Multi-port Microwave Structures
PublicationThe purpose of this paper is to investigate the effectiveness of model order reduction algorithms in finite element method analysis of multi-port microwave structures. Consideration is given to state of the art algorithms, i.e. compact reduced-basis method (CRBM), second-order Arnoldi method for passive-order reduction (SAPOR), reduced-basis methods (RBM) and subspace-splitting moment-matching MOR (SSMM-MOR)
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A Subspace-Splitting Moment-Matching Model-Order Reduction Technique for Fast Wideband FEM Simulations of Microwave Structures
PublicationThis article describes a novel model-order reduction (MOR) approach for efficient wide frequency band finite-element method (FEM) simulations of microwave components. It relies on the splitting of the system transfer function into two components: a singular one that accounts for the in-band system poles and a regular part that has no in-band poles. In order to perform this splitting during the reduction process, the projection...
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Low-cost multi-criterial design optimization of compact microwave passives using constrained surrogates and dimensionality reduction
PublicationDesign of contemporary microwave circuits is a challenging task. Typically, it has to take into account several performance requirements and constraints. The design objectives are often conflicting and their simultaneous improvement may not be possible; instead, compromise solutions are to be sought. Representative examples are miniaturized microwave passives where reduction of the circuit size has a detrimental effect on its electrical...
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Towards Promotion of Graphene/Titania‐Based Electrode via Ultrafast and Self‐Expansion Reduction for Li‐ion Battery
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Improving SBR Performance Alongside with Cost Reduction through Optimizing Biological Processes and Dissolved Oxygen Concentration Trajectory
PublicationAuthors of this paper take under investigation the optimization of biological processes during the wastewater treatment in sequencing batch reactor (SBR) plant. A designed optimizing supervisory controller generates the dissolved oxygen (DO) trajectory for the lower level parts of the hierarchical control system. Proper adjustment of this element has an essential impact on the efficiency of the wastewater treatment process as well...
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Low-cost data-driven modelling of microwave components using domain confinement and PCA-based dimensionality reduction
PublicationFast data-driven surrogate models can be employed as replacements of computationally demanding full-wave electromagnetic simulations to facilitate the microwave design procedures. Unfortunately, practical application of surrogate modelling is often hindered by the curse of dimensionality and/or considerable nonlinearity of the component characteristics. This paper proposes a simple yet reliable approach to cost-efficient modelling...
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Circular polarization diversity implementation for correlation reduction in wideband low-cost multiple-input-multiple-output antenna
PublicationIn this paper, a multiple-input-multiple-output (MIMO) antenna featuring circular polarization diversity, and designed on a common coplanar ground is presented. The proposed antenna design utilizes a coplanar waveguide (CPW) feeding technique with three parallel coplanar ground planes, and two feedlines in-between. For circular polarization (CP), quasi-loops are created by etching slots on the outermost ground planes. With this...
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Effect of nitrogen doping on TiOxNy thin film formation at reactive high-power pulsed magnetron sputtering
PublicationThe paper is focused on a study of formation of TiOxNy thin films prepared by pulsed magnetron sputtering of metallic Ti target. Oxygen and nitrogen were delivered into the discharge in the form of reactive gases O2 and N2. The films were deposited by high-power impulse magnetron sputtering working with discharge repetition frequency f = 250 Hz at low (p = 0.75 Pa) and high (p = 10 Pa) pressure. The substrates were on floating...
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Experimental and theoretical studies on the photodegradation of 2-ethylhexyl 4-methoxycinnamate in the presence of reactive oxygen and chlorine species
Publication2-Ethylhexyl 4-methoxycinnamate (EHMC) is one of the most commonly used sunscreen ingredient. In this study we investigated photodegradation of EHMC in the presence of such common oxidizing and chlorinating systems as H2O2, H2O2/HCl, H2O2/UV, and H2O2/HCl/UV. Reaction products were detected by gas chromatography with a mass spectrometric detector (GC-MS). As a result of experimental studies chloro-substituted 4-methoxycinnamic...
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Photodynamic Inactivation of Candida albicans with Imidazoacridinones: Influence of Irradiance, Photosensitizer Uptake and Reactive Oxygen Species Generation
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Occlusion phenomenon of redox probe by protein as a way of voltammetric detection of non-electroactive C-reactive protein
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Cast polyurethanes obtained from reactive recovered polyol intermediates via crude glycerine decomposition process
PublicationIn this work, the possibility of applying intermediates from polyurethane waste recycling in polyurethane synthesis was presented. Polyurethanes were synthesised in a two-step method using a mixture of petrochemical polyol and glycerolysate, used as a reactive component, 4,4-diphenylmethane diisocyanate (MDI) and 1,4-buthanediol (BD). Glycerolysates were produced during decomposition of polyurethane elastomer by crude glycerine...
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Reclaimed rubber in-situ grafted with soybean oil as a novel green reactive plasticizer in SBR/silica compounds
PublicationPolymer recycling and biodegradable polymeric materials are two major routes towards the sustainable development of polymer materials which contributes to the management of waste. In this regard, an eco-friendly approach is presented wherein high reclaiming degree of ground tire rubber (GTR) was achieved by low-temperature oxidation under swollen action of soybean oil. In-situ reclaimed GTR with soybean oil was cured into reactive...
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A reactive algorithm for deducing nodal forwarding behavior in a multihop ad-hoc wireless network in the presence of errors
PublicationA novel algorithm is presented to deduce individual nodal forwarding behavior from standard end-to-end acknowledgments. The algorithm is based on a well-established mathematical method and is robust to network related errors and nodal behavior changes. The proposed solution was verified in a network simulation, during which it achieved sound results in a challenging multihop ad-hoc network environment.
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Drug-drug interaction potential of antitumor acridine agent C-1748: The substrate of UDP-glucuronosyltransferases 2B7, 2B17 and the inhibitor of 1A9 and 2B7
PublicationBackground The compound 9-(2′-hydroxyethylamino)-4-methyl-1-nitroacridine (C-1748), the promising antitumor agent developed in our laboratory was determined to undergo phase I metabolic pathways. The present studies aimed to know its biotransformation with phase II enzymes – UDP-glucuronosyltransferases (UGTs) and its potential to be engaged in drug-drug interactions arising from the modulation of UGT activity. Methods UGT-mediated...
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Bioactivities of Phenolic Compounds from Kiwifruit and Persimmon
PublicationFruit used in the common human diet in general, and kiwifruit and persimmon particularly, displays health properties in the prevention of heart disease. This study describes a combination of bioactivity, multivariate data analyses and fluorescence measurements for the differentiating of kiwifruit and persimmon, their quenching and antioxidant properties. The metabolic differences are shown, as well in the results of bioactivities...
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The overexpression of CPR and P450 3A4 in pancreatic cancer cells changes the metabolic profile and increases the cytotoxicity and pro-apoptotic activity of acridine antitumor agent, C-1748
PublicationDrug resistance is one of the major cause of pancreatic cancer treatment failure. Thus, it is still imperative to develop new active compounds and novel approach to improve drug efficacy. Here we present 9-amino-1-nitroacridine antitumor agent, C-1748, developed in our laboratory, as a candidate for pancreatic cancer treatment. We examined (i) the cellular response of pancreatic cancer cell lines: Panc-1, MiaPaCa-2, BxPC-3 and...
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Novel 2-(2-alkylthiobenzenesulfonyl)-3-(phenylprop-2-ynylideneamino)guanidine derivatives as potent anticancer agents – Synthesis, molecular structure, QSAR studies and metabolic stability
PublicationA series of new 2-(2-alkylthiobenzenesulfonyl)-3-(phenylprop-2-ynylideneamino)guanidine derivatives have been synthesized and evaluated in vitro by MTT assays for their antiproliferative activity against cell lines of colon cancer HCT-116, cervical cancer HeLa and breast cancer MCF-7. The obtained results indicated that these compounds display prominent cytotoxic effect. The best anticancer properties have been observed for derivatives...
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Adenylate Kinase 4—A Key Regulator of Proliferation and Metabolic Shift in Human Pulmonary Arterial Smooth Muscle Cells via Akt and HIF-1α Signaling Pathways
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MRI assessment of ectopic fat accumulation in pancreas, liver and skeletal muscle in patients with obesity, overweight and normal BMI in correlation with the presence of central obesity and metabolic syndrome
PublicationPurpose: Obesity, defined as a body mass index (BMI) exceeding 30 kg/m2, is a serious health problem, which can be called an epidemic on a global scale and is one of the most important causes of preventable death. The aim of this study was to assess ectopic fat accumulation in pancreas, liver and skeletal muscle in patients with obesity, overweight and normal BMI in correlation with metabolic syndrome (MetS). Patients and methods:...
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Izoenzymy cytochromu P450 w metabolizmie związków endo- i egzogennych.
PublicationCytochromy P450 (CYP) należą do enzymatycznych białek hemowych występujących we wszystkich organizmach żywych. W komórkach eukariotycznych katalizują biosyntezę związków endogennych, głównie lipidów i ich pochodnych, ale także metabolizm ksenobiotyków, w tym leków. W reakcjach tych substraty ulegają C-oksydacji (hydroksylacja, epoksydacja, peroksydacja), N-oksydacji, S-oksydacji oraz oksydacyjnej O-, S-, i N-dealkilacji. W konsekwencji...
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Recent Patents on Endocrine Metabolic & Immune Drug Discovery
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Morphology and structure of V2O5 nanorods deposited on the silicon substrate after reduction
Open Research DataThe DataSet contains the XRD patterns and SEM micrographs of V2O5 nanorods on the silicon substrate after thermal treatment under a reducing atmosphere. Thin films were annealed at 500C for 40 under a reducing atmosphere (94% Ar, 6% H2).
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The TPR reduction profile of CeO2/10wt.%Cu with BCD - 2 cycles
Open Research DataThe dataset includes the TPR reduction profiles of CeO2/10wt.%Cu. The samples of nanoCeO2 impregnated with BCD-assisted precursor solution (betacyclodextrin). The dataset includes two cycles of reduction (samples oxidized in between)
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The TPR reduction profile of CeO2/10wt.%Mn with BCD - 2 cycles
Open Research DataThe dataset includes the TPR reduction profiles of CeO2/10wt.%Mn. The samples of nanoCeO2 impregnated with BCD-assisted precursor solution (betacyclodextrin). The dataset includes two cycles of reduction (samples oxidized in between)
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The TPR reduction profile of CeO2/10wt.%Co with BCD - 2 cycles
Open Research DataThe dataset includes the TPR reduction profiles of CeO2/10wt.%Co. The samples of nanoCeO2 impregnated with BCD-assisted precursor solution (betacyclodextrin). The dataset includes two cycles of reduction (samples oxidized in between)
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The TPR reduction profile of CeO2/10wt.%Ni with BCD - 2 cycles
Open Research DataThe dataset includes the TPR reduction profiles of CeO2/10wt.%Ni. The samples of nanoCeO2 impregnated with BCD-assisted precursor solution (betacyclodextrin). The dataset includes two cycles of reduction (samples oxidized in between)
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The TPR reduction profile of CeO2/10wt.%Fe with BCD - 2 cycles
Open Research DataThe dataset includes the TPR reduction profiles of CeO2/10wt.%Fe. The samples of nanoCeO2 impregnated with BCD-assisted precursor solution (betacyclodextrin). The dataset includes two cycles of reduction (samples oxidized in between)
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Strategies to improve the nutritional value of meat products: incorporation of bioactive compounds, reduction or elimination of harmful components and alternative technologies
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Potential Predictive Value of Serum Pentraxin 3 and Paraoxonase 1 for Cardiometabolic Disorders Development in Patients with Psoriasis—Preliminary Data
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Reduction of human chorionic gonadotropin beta subunit expression by modified U1 snRNA caused apoptosis in cervical cancer cells
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N-doped mesoporous carbon nanosheets obtained by pyrolysis of a chitosan–melamine mixture for the oxygen reduction reaction in alkaline media
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An insertion/deletion polymorphism of the dihydrofolate reductase (DHFR) gene is associated with serum and red blood cell folate concentrations in women
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N-doped mesoporous carbon nanosheets obtained by pyrolysis of a chitosan–melamine mixture for the oxygen reduction reaction in alkaline media.
PublicationBy simple thermal decomposition of low-cost precursors (chitosan, melamine) in an inert atmosphere, nitrogen-doped porous carbonaceous materials were prepared. The samples pyrolyzed at 700 C are composed of mainly mesoporous nitrogen-doped carbon nanosheets and partially graphitized carbon. The nanosheets contain a disordered area due to the strain imposed by the presence of nitrogen and/or oxygen groups in their structure. Some...
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A study on the protection of methionine and the reduction of methionine sulfoxide in methionine-containing analogues of the growth-modeling factor Gly-His-Lys
PublicationThe protection of methionine and the reduction of methionine sulfoxide in methionine-containing analogues of Gly-His-Lys are described. The peptides were synthesized by a solid-phase method using the standard Fmoc procedure. Simultaneous deprotection of the peptide side chain and liberation from the resin were achieved using an appropriate TFA cocktail. The TFA cocktail was selected to minimize oxidation of the methionine residue....
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Discussion on 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors reduce human pancreatic cancer cell invasion and metastasis
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Morphology and dispersion of nanostructured manganese–cobalt spinel on various carbon supports: the effect on the oxygen reduction reaction in alkaline media
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