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Search results for: DRUG REPOSITIONING
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Current Drug Research Reviews
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Molecular modeling and evaluation of novel dibenzopyrrole derivatives as telomerase inhibitors and potential drug for cancer therapy
PublicationDuring previous years, many studies on synthesis, as well as on anti-tumor, anti-inflammatory and anti-bacterial activities of the pyrazole derivatives have been described. Certain pyrazole derivatives exhibit important pharmacological activities and have proved to be useful template in drug research. Considering importance of pyrazole template, in current work the series of novel inhibitors were designed by replacing central...
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The bioactivity studies of drug-loaded mesoporous silica-polydimethylsiloxane xerogels using FTIR and SEM/XEDS
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Correlation between physicochemical properties of doxorubicin-loaded silica/polydimethylsiloxane xerogel and in vitro release of drug
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Biological effects in photodynamic treatment combined with electropermeabilization in wild and drug resistant breast cancer cells
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Increased Expression of Several Collagen Genes is Associated with Drug Resistance in Ovarian Cancer Cell Lines
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Double layer adhesive silicone dressing as a potential dermal drug delivery film in scar treatment
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Silver Nanoparticles as Chlorhexidine and Metronidazole Drug Delivery Platforms: Their Potential Use in Treating Periodontitis [Corrigendum]
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Novel and effective synthesis protocol of AgNPs functionalized using L-cysteine as a potential drug carrier
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A randomized and controlled study of noninvasive hemodynamic monitoring as a guide to drug treatment of uncontrolled hypertensive patients
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Essentials and Perspectives of Computational Modelling Assistance for CNS-oriented Nanoparticle-based Drug Delivery Systems
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Virulence and Drug-Resistance of Staphylococcus aureus Strains Isolated from Venous Ulcers in Polish Patients
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The Correlation between Physical Crosslinking and Water-Soluble Drug Release from Chitosan-Based Microparticles
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Double layer adhesive silicone dressing as a potential dermal drug delivery film in scar treatment
PublicationThe present studies focused on the evaluation of design of an adhesive silicone film intended for scar treatment. Developed silicone double layer film was examined in terms of its future relevance to therapy and applicability on the human skin considering properties which included in vitro permeability of water vapor and oxygen. In order to adapt the patches for medical use in the future there were tested such properties as...
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Tricyclic xanthine derivatives containing a basic substituent: adenosine receptor affinity and drug-related properties
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Combinatory Treatment with miR-7-5p and Drug-Loaded Cubosomes Effectively Impairs Cancer Cells
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New amino acid propyl ester ibuprofenates from synthesis to use in drug delivery systems
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pH-Responsive Drug Delivery Nanoplatforms as Smart Carriers of Unsymmetrical Bisacridines for Targeted Cancer Therapy
PublicationSelective therapy and controlled drug release at an intracellular level remain key challenges for effective cancer treatment. Here, we employed folic acid (FA) as a self-navigating molecule in nanoconjugates containing quantum dots (QDs) and β-cyclodextrin (β-CD) for the delivery of antitumor unsymmetrical bisacridine compound (C-2028) to lung and prostate cancers as well as normal cells. The bisacridine derivative can form the...
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From the pills to environment – Prediction and tracking of non-steroidal anti-inflammatory drug concentrations in wastewater
PublicationThe extend of environment pollution by pharmaceuticals is in a stage that required more automatic and integrated solutions. The non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most popular pharmaceutical in the world and emerging pollutants of natural waters. The aim of the paper was to check the correlation of the sales data of selected NSAIDs (ibuprofen, naproxen, diclofenac) and their concentration in the WWTP...
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Encapsulation of an anticancer drug Isatin inside a host nano-vehicle SWCNT: a molecular dynamics simulation
PublicationThe use of carbon nanotubes as anticancer drug delivery cargo systems is a promising modality as they are able to perforate cellular membranes and transport the carried therapeutic molecules into the cellular components. Our work describes the encapsulation process of a common anticancer drug, Isatin (1H-indole-2,3-dione) as a guest molecule, in a capped single-walled carbon nanotube (SWCNT) host with chirality of (10,10). The...
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Low-Barrier Hydrogen Bond Determines Target-Binding Affinity and Specificity of the Antitubercular Drug Bedaquiline
PublicationThe role of short strong hydrogen bonds (SSHB) in ligand-target binding remains largely unexplored, thereby hin- dering a potentially important avenue in the rational drug de- sign. Here, we investigate the interaction between bedaquiline (Bq), a potent anti-tuberculosis drug, and the mycobacterial ATP synthase, to unravel the role of a specific hydrogen bond to a conserved acidic residue in the target affinity and specificity....
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Evaluation of multiple genetic markers for typing drug-resistant Mycobacterium tuberculosis strains from Poland
PublicationW publikacji przedstawiono wyniki genotypowania wielolekoopornych szczepów Mycobacterium tuberculosis izolowanych od pacjentów z Polski.
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Enhanced switched parasitic antenna with switched active monopoles for indoor positioning systems
PublicationThis paper presents the concept of enhanced reduced-size steerable antenna array with two rows of switched active and passive elements. Designed array is similar to ESPAR antenna but it has a set of switched monopoles instead of central one. It is intended for 2.4 GHz ISM applications with emphasis on indoor positioning systems (IPS). Proposed antenna provides improved radiation parameters and reduced dimensions in comparison to...
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Tracking body movement for radio channel measurements in BAN with indoor positioning system
PublicationThis paper presents indoor positioning system based on inertial navigation with additional distance measurements using UWB modems and map matching to increase accuracy and eliminate position drift. Such system may be used to track position of human body during radio channel measurements for body area networks. Performance of proposed system and limitations caused by inertial navigation are briefly described.
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An Intergrated Model of Motion, Steering, Positioning and Stabilization of an Unmanned Autonomous Maritime Vehicle
PublicationIn the paper the aim of an interdisciplinary research is presented. The research method is introduced. An object the unmanned autonomous maritime vehicle is briefly described. The key research problem concerns a combined model of the vehicle motion including the loads of lift and hydrodynamic nature. The model takes into account the gravity and displacement forces, resistance and thrust forces, lift and other hydrodynamic forces....
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Miniaturization-Oriented Design of Spline-Parameterized UWB Antenna for In-Door Positioning Applications
PublicationDesign of ultra-wideband antennas for in-door localization applications is a challenging task. It involves development of geometry that maintains appropriate balance between the size and performance. In this work, a topologically-flexible monopole has been generated using a stratified framework which embeds a gradient-based trust-region (TR) optimization algorithm in a meta-loop that gradually increases the structure dimensionality....
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Shading, Dusting and Incorrect Positioning of Photovoltaic Modules as Important Factors in Performance Reduction
PublicationThe amount of solar radiation reaching the front cover of a photovoltaic module is crucial for its performance. A number of factors must be taken into account at the design stage of the solar installation, which will ensure maximum utilization of the potential arising from the location. During the operation of a photovoltaic installation, it is necessary to limit the shading of the modules caused by both dust and shadowing by trees...
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Sensing of anesthetic drugs in blood with Raman spectroscopy
PublicationA proof-of-concept study of a Raman spectroscopy-based approach for measuring the content of anesthesia drugs in blood is presented. Spectra of spiked blood from several patients exhibit prominent changes in regions associated with the drug.
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Analiza zagrożeń na jednorodnych odcinkach dróg
PublicationPrzedstawiono założenia do oceny zagrożeń w ruchu drogowym z wykorzystaniem inspekcji bezpieczeństwa ruchu drogowego. Opisano modele wpływu wybranych czynników na gęstość ofiar śmiertelnych i liczbę ofiar śmiertelnych na drogach krajowych
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Druga edycja Konferencji Inżynierii Oprogramowania beIT
PublicationW dniach 18–20 marca 2016 roku na Wydziale Elektroniki, Telekomunikacji i Informatyki odbyła się II Konferencja Inżynierii Oprogramowania beIT. Podobnie jak pierwszą edycję Konferencji beIT, tegoroczne spotkanie zorganizowało Koło Naukowe Zarządzanie IT przy wsparciu Katedry Inżynierii Oprogramowania, WETI oraz JM Rektora PG. Do przeprowadzenia 15 warsztatów, 4 sesji dyskusyjnych round tables oraz 5 wykładów organizatorzy zaprosili...
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Obciążenia finansowe gmin kosztami realizacji dróg
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Parametryczna krzywa przejściowa dla dróg kolejowych
PublicationZakres stosowania krzywych przejściowych o nieliniowej zmianie krzywizny na drogach kolejowych jest, jak dotąd, bardzo ograniczony. W pracy (przeprowadzając stosowną analizę) wskazano na główną przyczynę takiego stanu rzeczy - bardzo małe wartości rzędnych poziomych w rejonie początkowym, w praktyce często wręcz niemożliwe do realizacji. Postanowiono więc poszukać nowej postaci krzywej przejściowej, rezygnując z warunku zerowania...
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Metody zarządzania ryzykiem na sieci dróg
PublicationMetoda zarządzania ryzykiem w inżynierii drogowej. Przykłady zarządzania ryzykiem w inżynierii drogowej. Koncepcja metody zarządzania ryzykiem na drogach krajowych w Polsce.
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Wygładzona krzywa przejściowa dla dróg kolejowych
PublicationW pracy zwrócono uwagę na problemy występujące w eksploatacji krzywych przejściowych stosowanych w układach geometrycznych toru kolejowego. Wskazano na trudności w praktycznej realizacji i utrzymaniu bardzo małych rzędnych poziomych krzywej przejściowej i rzędnych rampy przechyłkowej w rejonie początkowym, występujących na gładkich krzywych przejściowych. Jako podstawową przyczynę takiej sytuacji uznano nadmierne wyłagodzenie...
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AutoCAD Civil3D w projektowaniu dróg szynowych
PublicationNa Wydziale Inżynierii Lądowej i Środowiska Politechniki Gdańskiej od kilku lat głównym programem typu CAD wykorzystywanym w procesie kształcenia jest AutoCAD Civil 3D. Sposób rozwiązywania przez program niektórych zagadnień z dziedziny projektowania dróg szynowych jest odmienny od obowiązujących w Polsce przepisów. Należy to uwzględnić w programie nauczania przedmiotów ''Drogi Szynowe'', ''Projektowanie dróg szynowych'' oraz ''Projektowanie...
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Samorządowy dług publiczny i jego konsekwencje.
PublicationArtykuł odnosi się do samorządowego długu publicznego na tle długu państwa.Ukazuje konsekwencje i zagrożenia dla inwestycji komunalnych. Autor omawia w nim również kwestię apsorbcji polskich funduszy unijnych
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Katedra Inżynierii Drogowej. Zakład Budowy Dróg.
PublicationDepartment of Highway Engineering is divided into two divisions: Road Construction Division and Traffic Engineering Division. The head of Road Construction Division is Prof. J. Judycki. There are nine members of division: professor, three PhD, two MSc, two technicians and secretary. The main areas of research activities are: analysis of flexible, semi-rigid and rigid pavements, resistance of asphalt pavement to permanent deformation,...
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CNS DRUGS
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DRUGS & AGING
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PEDIATRIC DRUGS
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DRUGS OF TODAY
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Drugs in Context
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Indian Drugs
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Drugs and Clinic
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Poor sensitization of 50-kHz vocalization response to amphetamine predicts rat susceptibility to self-administration of the drug
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Targeted Nano-Drug Delivery of Colchicine against Colon Cancer Cells by Means of Mesoporous Silica Nanoparticles
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<p>Nanoparticles And Human Saliva: A Step Towards Drug Delivery Systems For Dental And Craniofacial Biomaterials</p>
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Analysis of MDR genes expression and cross-resistance in eight drug resistant ovarian cancer cell lines
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Thromboelastometric Analysis of Anticancer Cerrena unicolor Subfractions Reveal Their Potential as Fibrin Glue Drug Carrier Enhancers
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Controlled Drug Release and Cytotoxicity Studies of Beta-Lapachone and Doxorubicin Loaded into Cyclodextrins Attached to a Polyethyleneimine Matrix
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