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Search results for: ASSOCIATIONS MINING
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The clamping selection method to reduce the vibration of large-size workpieces during the face milling process
PublicationThe article introduces a method for selecting the best clamping conditions to obtain vibration reduction during milling of large-size workpiece. It is based on experimental modal analysis performed for a set of assumed, fixing conditions of a considered workpiece to identify Frequency Response Functions (FRFs) for each tightening torque of the mounting screws. Simulated plots of periodically changing nominal cutting forces are...
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Low-Barrier Hydrogen Bond Determines Target-Binding Affinity and Specificity of the Antitubercular Drug Bedaquiline
PublicationThe role of short strong hydrogen bonds (SSHB) in ligand-target binding remains largely unexplored, thereby hin- dering a potentially important avenue in the rational drug de- sign. Here, we investigate the interaction between bedaquiline (Bq), a potent anti-tuberculosis drug, and the mycobacterial ATP synthase, to unravel the role of a specific hydrogen bond to a conserved acidic residue in the target affinity and specificity....
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Convenient and efficient N-methylation of secondary amines under solvent-free ball milling conditions
PublicationIn the present work, we report the development of a rapid, efcient, and solvent-free procedure for the N-methylation of secondary amines under mechanochemical conditions. After optimization of the milling parameters, a vibrational ball mill was used to synthesize 26 tertiary N-methylated amine derivatives in a short time of 20 min (30 Hz frequency) and high yields ranging from 78 to 95%. An exception was compounds having a hydroxyl...
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Planning Around Polarisation: Components of Finding Common Ground Based on Regeneration Projects in London and Gdańsk
PublicationVarious forms of public participation in urban design and planning—as presented and discussed in literature—have recently been challenged by the needs and expectations of different stakeholders, including those coming from the private sector. This comes with a redefinition of the public good and the roles and responsibilities of municipal authorities in post‐liberal times. As a result, contemporary participatory processes need...
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RCDs Tripping in the Range from DC to AC 50 kHz for Slowly Rising Residual Current
PublicationThe wide use of power electronic converters means that in many low-voltage systems earth fault currents containing components from DC to AC of various frequencies have to be taken into account. Due to the tendency to increase the modulation frequency in converters, components of higher frequencies may be in the order of several tens of kilohertz. Therefore, it is very important to verify the behavior of devices for protection against...
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Adjusting the Stiffness of Supports during Milling of a Large-Size Workpiece Using the Salp Swarm Algorithm
PublicationThis paper concerns the problem of vibration reduction during milling. For this purpose, it is proposed that the standard supports of the workpiece be replaced with adjustable stiffness supports. This affects the modal parameters of the whole system, i.e., object and its supports, which is essential from the point of view of the relative tool–workpiece vibrations. To reduce the vibration level during milling, it is necessary to...
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Low-Voltage Low-Power Filters with Independent ω0 and Q Tuning for Electronic Cochlea Applications
PublicationAn acoustic second-order low-pass filter is proposed for filter banks emulating the operation of a human cochlea. By using a special filter structure and an innovative quality (Q)-factor tuning technique, an independent change of the cutoff frequency (ω0) and the Q-factor with unchanged gain at low frequencies is achieved in this filter. The techniques applied result in a simple filter design with low Q-factor sensitivity to component...
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Firing map for periodically and almost-periodically driven integrate-and-fire models: a dynamical systems approach
PublicationWe consider the Leaky Integrate-and-Fire and Perfect Integrator models of neuron’s dynamics with the input function being periodic and almost-periodic (in the sense of Stepanov). In particular we analyze properties and dynamics of the so-called firing map, which iterations give timings of consecutive spikes of a neuron. In case of a periodic input function we provide a detailed description of the sequence of interspike-intervals,...
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A 3D-FEM mesh technique for fast analysis of waveguide problems containing rotatable tuning elements
PublicationIn this paper a meshing technique for 3D Finite Element Method is presented. It allows for fast analysis and optimization of the waveguide structures, which contain rotatable tuning elements. In the proposed procedure a thin layer of varying cylindrical mesh buffer is introduced in order to reuse unchanged mesh and FEM matrices in the rest of the domain.
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Numerical Studies on Propellers in Open Water and behind Hulls aiming to support the Evaluation of Propulsion Tests
PublicationA RANS based numerical analysis of propellers can contribute considerably to our understanding of propeller/hull interaction. It may also allow for a review of scaling procedures on results from experimental fluid dynamics (EFD). Using various RANS codes (Fluent, CFX, STAR-CCM+ and FreSCo+) on common test cases the authors first focused on propeller open water (POW) calculations. Next we simulated the propeller hull interaction...
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New Method for Increasing Precision of Position Estimation of a Moving Person in Hybrid Inertial Navigation System
PublicationIn this article a new method for increasing precision of position estimation of inertial navigation in hybrid localization system with reduced number of reference nodes for radio distance measurements is presented. Measuring tests were carried out to verify precision of position estimation of moving person in indoor environment.
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Multi-objective optimization of water quality, pumps operation, and storage sizing of water distribution systems
PublicationA multi-objective methodology utilizing the Strength Pareto Evolutionary Algorithm (SPEA2) linked to EPANET for trading-off pumping costs, water quality, and tanks sizing of water distribution systems is developed and demonstrated. The model integrates variable speed pumps for modeling the pumps operation, two water quality objectives (one based on chlorine disinfectant concentrations and one on water age), and tanks sizing cost...
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The Optimal Spindle Speed Map for Reduction of Chatter Vibration During Milling of Bow Thruster Blade
PublicationW artykule przedstwiono przykład wykorzystania procedury tworzenia mapy optymalnych prędkosci obrotowych w celu ograniczenia drgań samowzbudnych podczas frezowania płata śruby okrętowego steru strumieniowego.
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A Method for The Assessing of Reliability Characteristics Relevant to an Assumed Position-Fixing Accuracy in Navigational Positioning Systems
PublicationThis paper presents a method which makes it possible to determine reliability characteristics of navigational positioning systems, relevant to an assumed value of permissible error in position fixing. The method allows to calculate: availability , reliability as well as operation continuity of position fixing system for an assumed, determined on the basis of formal requirements - both worldwide and national, position-fixing accuracy....
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Ocena wybranych własności materiałowych polimerowej warstwy ślizgowej hydrodynamicznego łożyska wzdłużnego = An estimation of selected material properties of the hydrodynamic thrust bearing polymer lining
PublicationZaprezentowano metody pomiaru najważniejszych własności mechanicznych i cieplnych polimerowego pokrycia segmentowego łożyska wzdłużnego, do których zaliczyć należy moduł sprężystości wzdłużnej oraz współczynnik przewodności cieplnej materiału dodatkowym utrudnieniem planowanego zadania jest fakt, że próbka do badań dostępna będzie jedynie w formie wycinka z segmentu łożyskowego, z tego powodu nie jest możliwe zastosowanie ogólnie...
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Association between plasma proteome profiles analysed by mass spectrometry, a lymphocyte-based DNA-break repair assay and radiotherapy-induced acute mucosal reaction in head and neck cancer patients
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Educational Data Mining
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Marta Kuc-Czarnecka dr
PeopleMarta Kuc-Czarnecka is the deputy head of the Department of Statistics and Economics at the Faculty of Management and Economics of the Gdańsk University of Technology. She also serves as the Dean's proxy for AMBA accreditation. She is a co-founder of Rethinking Economics Gdańsk and a member of the Foundation Edward Lipiński for the promotion of pluralism in economic sciences. In 2018-2022, she was Eurofound’s quality of life and...
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Anna Baj-Rogowska dr
PeopleAnna Baj-Rogowska is employed as an assistant professor at the Department of Informatics in Management at the Faculty of Management and Economics, Gdańsk University of Technology. Her higher education is connected with the University of Gdańsk, where she graduated from a master's degree in business informatics, doctoral studies and then obtained a PhD degree in economics in management science (Department of Business Informatics...
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Rapid Design Tuning of Miniaturized Rat-Race Couplers Using Regression-Based Equivalent Network Surrogates
PublicationA simple technique for fast design tuning of compact rat-race couplers is presented. Our approach involves equivalent circuit representation, corrected by nonlinear functions of frequency with coefficients extracted through nonlinear regression. At the same time, the tuning process connects two levels of coupler representation: EM simulation of the entire circuit and re-optimization of the coupler building blocks (slow-wave cells...
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Influence of rhamnolipids and ionic cross-linking conditions on the mechanical properties of alginate hydrogels as a model bacterial biofilm
PublicationThe literature indicates the existence of a relationship between rhamnolipids and bacterial biofilm, as well as the ability of selected bacteria to produce rhamnolipids and alginate. However, the influence of biosurfactant molecules on the mechanical properties of biofilms are still not fully understood. The aim of this research is to determine the effect of rhamnolipids concentration, CaCl2 concentration, and ionic cross-linking...
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Mapping the Structural and Dynamic Determinants of pH-Sensitive Heparin Binding to Granulocyte Macrophage Colony Stimulating Factor
PublicationGranulocyte macrophage colony stimulating factor (GMCSF) is an immunomodulatory cytokine that is harnessed as a therapeutic. GMCSF is known to interact with other clinically important molecules, such as heparin, suggesting that endogenous and administered GMCSF has the potential to modulate orthogonal treatment outcomes. Thus, molecular level characterization of GMCSF and its interactions with biologically active compounds is critical...
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Highly Conserved Homotrimer Cavity Formed by the SARS-CoV-2 Spike Glycoprotein: A Novel Binding Site
PublicationAn important stage in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) life cycle is the binding of the spike (S) protein to the angiotensin converting enzyme-2 (ACE2) host cell receptor. Therefore, to explore conserved features in spike protein dynamics and to identify potentially novel regions for drugging, we measured spike protein variability derived from 791 viral genomes and studied its properties by molecular...
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The impedance method of monitoring the degradation of rubber linings in applications where progressive deterioration is the predominant failure mechanism
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Linking habitat composition, local population densities and traffic characteristics to spatial patterns of ungulate‐train collisions
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Linking occurrence and changes in local abundance of farmland bird species to landscape composition and land-use changes
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Insights into the Effects of Cancer Associated Mutations at the UPF2 and ATP-Binding Sites of NMD Master Regulator: UPF1
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Interfaces with Structure Dynamics of the Workhorses from Cells Revealed through Cross-Linking Mass Spectrometry (CLMS)
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Highly Conserved Homotrimer Cavity Formed by the SARS-CoV-2 Spike Glycoprotein: A Novel Binding Site
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Synthesis and SAR Studies of Antibacterial Peptidyl Derivatives Based upon the Binding Site of Human Cystatin C
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The meaning of cultural projects in the revitasation of urban Areas / Rola projektów kultury w rewitalizacji obszarów miejskich
PublicationArtykuł przedstawia rolę projektów kultury jako jednego z kluczowych czynników skutecznych działań rewitalizacyjnych.
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Novel single-stranded DNA-binding proteins from extreme psychrophilic bacterium Psychromonas ingrahamii 37
PublicationWe report the identification and characterization of the single-stranded DNA binding protein (SSB) from extreme psychrophilic bacterium Psychromonas ingrahamii 37 (PinSSB) that grows expotentially at -12°C and may well grow at even lower temperatures. PinSSB is one of the largest known bacterial SSB protein consisting 222 amino acid residues with a calculated molecular mass of 25.1 kDa. The analysis by gel filtration chromatography...
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Characterization of exceptionally thermostable single-stranded DNA-binding proteins from Thermotoga maritima and Thermotoga neapolitana
PublicationBACKGROUND: In recent years, there has been an increasing interest in SSBs because they find numerous applications in diverse molecular biology and analytical methods.RESULTS: We report the characterization of single-stranded DNA binding proteins (SSBs) from the thermophilic bacteria Thermotoga maritima (TmaSSB) and Thermotoga neapolitana (TneSSB). They are the smallest known bacterial SSB proteins, consisting of 141 and 142 amino...
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Structure-activity relationship study of tetrapeptide inhibitors of the Vascular Endothelial Growth Factor A binding to Neuropilin-1
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Small-minus-big predicts betting-against-beta: Implications for international equity allocation and market timing
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Molecular dynamics study of a gelsolin-derived peptide binding to a lipid bilayer containing phosphatidylinositol 4,5-bisphosphate
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Control of Luminescence by Tuning of Crystal Symmetry and Local Structure in Mn4+ -Activated Narrow Band Fluoride Phosphors
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Indirect Relationship between Alcoholics Anonymous Spirituality and Their Hopelessness: The Role of Meaning in Life, Hope, and Abstinence Duration
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Correlation between type of alkali rinsing, cytotoxicity of bio-nanocellulose and presence of metabolites within cellulose membranes
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Liver fatty acid-binding protein might be a predictive marker of clinical response to systemic treatment in psoriasis
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Pharmacological characterization and binding modes of novel racemic and optically active phenylalanine-based antagonists of AMPA receptors
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Binding of anionic Pt(ii) complexes in a dedicated organic matrix: towards new binary crystalline composites
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QEEG-based neural correlates of decision making in a well-trained eight-year-old chess player
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Time for a paradigm shift in shared decision-making in trauma and emergency surgery? Results from an international survey
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The estimation of cutting forces and specific force coefficients during finishing ball end milling of inclined surfaces
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Electron Binding Capabilities of Some Silylenes Having Small Singlet−Triplet Splittings or Triplet Ground States
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Strength of the Lewis–Brønsted Superacids Containing In, Sn, and Sb and the Electron Binding Energies of Their Corresponding Superhalogen Anions
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Finding the Right Solvent: A Novel Screening Protocol for Identifying Environmentally Friendly and Cost-Effective Options for Benzenesulfonamide
PublicationThis study investigated the solubility of benzenesulfonamide (BSA) as a model compound using experimental and computational methods. New experimental solubility data were collected in the solvents DMSO, DMF, 4FM, and their binary mixtures with water. The predictive model was constructed based on the best-performing regression models trained on available experimental data, and their hyperparameters were optimized using a newly...
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Fibronectin-, vitronectin- and laminin-binding proteins at the cell walls of Candida parapsilosis and Candida tropicalis pathogenic yeasts
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Molecular simulations study of ligand-release mechanism in an odorant-binding protein from the southern house mosquito
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