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Wyniki wyszukiwania dla: human topoisomerase 2
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Cellular localization and putative role of aquaporin-2 Ser-261 in the bovine kidney
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Rewitalizacja posadzek betonowych typu lastrico w obiektach zabytkowych. Część 2
PublikacjaW artykule przedstawiono zagadnienia materiałowe i technologiczne dotyczące posadzek typu lastrico w aspekcie oceny ich stanu technicznego oraz sposobów naprawy i rewitalizacji. Tekst stanowi kontynuacje artykułu zamieszczonego w Builder Science3 nr 9/2021
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Three-dimensional geographically weighted inverse regression (3GWR) model for satellite derived bathymetry using Sentinel-2 observations
PublikacjaCurrent trends of development of satellite derived bathymetry (SDB) models rely on applying calibration techniques including analytical approaches, neuro-fuzzy systems, regression optimization and others. In most of the cases, the SDB models are calibrated and verified for test sites, that provide favourable conditions for the remote derivation of bathymetry such as high water clarity, homogenous bottom type, low amount of sediment...
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Problemy otoczenia konkurencyjnego i globalnego sektora bioetanolu w Polsce. Cz. 2. Potencjał produkcyjny i perspektywy jego rozwoju
PublikacjaW artykule przedstawiono problematykę otoczenia konkurencyjnego i globalnego sektora bioetanolu w Polsce, w okresie ostatnich lat. Opisano wstępne przewidywania ekspertów - w myśl których Polska miała stać się potentatem w zakresie produkcji i eksportu bioetanolu oraz sytuację obecną - w której stosowanie bioetanolu (Dyrektywa 2003/30/EC i 2009/28/EC) bazuje głównie na biokomponentach zagranicznych. Opisano także sytuację w sektorze...
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Tweet you right back: Follower anxiety predicts leader anxiety in social media interactions during the SARS-CoV-2 pandemic
PublikacjaRecent research has shown that organizational leaders’ tweets can influence employee anxiety. In this study, we turn the table and examine whether the same can be said about followers’ tweets. Based on emotional contagion and a dataset of 108 leaders and 178 followers across 50 organizations, we infer and track state- and trait-anxiety scores of participants over 316 days, including pre- and post the onset of the SARS-CoV-2 pandemic...
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New potent steroid sulphatase inhibitors based on 6-(1-phenyl-1H-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate derivatives
PublikacjaIn the present work, we report a new class of potent steroid sulphatase (STS) inhibitors based on 6-(1-phenyl-1H-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate derivatives. Within the set of new STS inhibitors, 6-(1-(1,2,3-trifluorophenyl)-1H-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate 3L demonstrated the highest activity in the enzymatic assay inhibiting the STS activity to 7.98% at 0.5 µM concentration. Furthermore, to verify...
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Intercalation complex of imidazoacridinone C-1311, a potential anticancer drug, with DNA helix d(CGATCG)2: stereostructural studies by 2D NMR spectroscopy.
PublikacjaImidazoacridinone C-1311 (Symadex®) is a powerful antitumor agent, which successfully made its way through the Phase I clinical trials and has been recommended for Phase II few a years ago. It has been shown experimentally that during the initial stage of its action C-1311 forms a relatively stable intercalation complex with DNA, yet it has shown no base-sequence specificity while binding to DNA. In this paper, the d(CGATCG)2:C-1311...
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Beyond the helium buffer: 12C−2 rotational cooling in cold traps with H2 as a partner gas: interaction forces and quantum dynamics
Publikacjaabstract = { The scattering cross-sections and corresponding rate coefficients for rotationally inelastic collisions of $^{12}$C$_2$^-$ ($^2 \Sigma_g^+$) with H$_2$ ($^1 \Sigma_g^+$) are presented over a broad range of cold-trap temperatures. They have been calculated using quantum scattering theory that employs a new ab initio potential energy surface. The rate coefficients for the inelastic processes in the anionic partner are...
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Diiodo-BODIPY Sensitizing of the [Mo3S13]2– Cluster for Noble-Metal-Free Visible-Light-Driven Hydrogen Evolution within a Polyampholytic Matrix
PublikacjaWe report on a photocatalytic setup that utilizes the organic photosensitizer (PS) diiodo-BODIPY and the non-precious-metal-based hydrogen evolution reaction (HER) catalyst (NH4)2[Mo3S13] together with a polyampholytic unimolecular matrix poly(dehydroalanine)-graft-poly(ethyleneglycol) (PDha-g-PEG) in aqueous media. The system shows exceptionally high performance with turnover numbers (TON > 7300) and turnover frequencies (TOF...
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Reactions of Lithium Salts of Triphosphanes tBu2P-PLi-PtBu2 and tBu2P-PLi-P(NEt2)2 with Metal Complexes [(R3P)2MCl2] (M = Ni, Pd, Pt, R3P = Et3P, pTol3P, Ph2EtP, iPr3P)
PublikacjatBu2P-PLi-PtBu2·2THF reacts with [(R3P)2MCl2] (M = Pt, Pd, Ni; R3P = Et3P, pTol3P, Ph2EtP, iPr3P) to yield isomers of [(1,2-η-tBu2P=P-PtBu2)M(PR3)Cl], in which the tBu2P-P-PtBu2 ligand adopts the arrangement of a side-on bonded 1,1-di-tert-butyl-2-(di-tert-butylphosphanyl)diphosphenium cation. tBu2P-PLi-P(NEt2)2·2THF reacts with [(R3P)2MCl2] but does not form complexes with a tBu2P-P-P(NEt2)2 moiety, however, splitting...
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Expression of metalloproteinase 2 (MMP-2) and metalloproteinase 9 (MMP-9) in THP-1 macrophages cultured with three-dimensional titanium mini-plate systems used for surgical treatment of condylar fractures
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Dicyclohexylammonium benzenethiolate. Acta Cryst. Sect. E Struct. Rep. [on-line]**2003 vol. 59 s. o765-o766, 2 rys. 2 tab. bibliogr. 11 poz. tiofenolan dicykloheksyloamoniowy.
PublikacjaZwiązek o wzorze C12H24N+ x C6H5S- został otrzymany poprzez reakcję tiofeno-lu z dicykloheksyloaminą. Oba fragmenty jonowe powiązane są w długie łańcu-chy poprzez wiązania N-H...S. Strukturę cząsteczkową i krystaliczną wyzna-czono posługując się rentgenowską analizą strukturalną.
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The Efficacious Benefit of 25-Hydroxy Vitamin D to Prevent COVID-19: An In-Silico Study Targeting SARS-CoV-2 Spike Protein
PublikacjaThe environment has rapidly looked at proven specialist task forces in the aftermath of the COVID-19 pandemic to build public health policies and measures to mitigate the effects of emerging coronaviruses. According to the researchers, taking 10 μg of 25-hydroxy vitamin D daily is recommended to keep us safe. There have been several studies recently indicating that there is a reduced risk of contracting Coronavirus by 25-hydroxy...
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Antitumor DNA-Damaging C-1748 is a New Inhibitor of Autophagy that Triggers Apoptosis in Human Pancreatic Cancer Cell Lines
PublikacjaDespite the enormous progress that has been made over the past decades in diagnosis, treatment and prevention of many types of tumors, survival rates in pancreatic cancer still remain poor. Pancreatic cancer is one of the most malignant and chemoresistant tumors and the profound mechanism supporting these phenomena is the constitutively activated prosurvival autophagy. The antitumor 1-nitroacridine derivative C-1748 belongs to...
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A new dilution-enrichment sample preparation strategy for expanded metabolome monitoring of human breast milk that overcomes the simultaneous presence of low- and high-abundance lipid species
PublikacjaThe complex nature of human breast milk (HBM) makes samples difficult to analyze, requiring several extraction techniques and analytical platforms to obtain high metabolome coverage. In this work, we combined liquid-liquid extraction (LLE) and solid-phase extraction (SPE) techniques to prepare HBM samples to overcome the challenge of low- and high-abundance lipid species, enabling the semiquantitative analysis of total HBM lipids...
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An unusual four-nuclear Pb(II)-pyrrole-2-carboxylato polymer: The effect of the lone pair and non-covalent interactions on the supramolecular assembly and fluorescence properties
PublikacjaThe reaction of Pb(NO3)2 with 1H-pyrrole-2-carboxylic acid (2prCOOH) leads to the formation of a new four-nuclear Pb(II) polymer, [Pb4(2prCOO)8(H2O)]n, which has been characterized by CHN, FT-IR, TG, PL and single-crystal X-ray diffraction methods. In view of the primary Pb–O bonds, Pb1 and Pb3 show hemidirected pentagonal pyramidal geometries, while Pb2 and Pb4 display hemidirected octahedral geometries. The topology of the strongest...
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The Metal-Free Regioselective Deuteration of 2-Methylquinolin-8-ol and 2,5-Dimethylquinolin-8-ol, Spectroscopic and Computational Studies
PublikacjaAbstract: Aim and Background: Introducing deuterium to a molecule is of interest to a wide variety of research, including investigation of reaction mechanisms or kinetics, analysis of drug metabolism, structural elucidation of molecules, and syntheses of isotopically labeled materials used for NMR spectroscopy and medicinal research. Objective: The transition-metal-free regioselective deuteration of 2-methylquinolin-8-ol...
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Magnetic anisotropy and structural flexibility in the f ield-induced single ion magnets [Co{(OPPh2) (EPPh2)N}2], E = S, Se, explored by experimental and computational methods
PublikacjaDuring the last few years, a large number of mononuclear Co(II) complexes of various coordination geometries have been explored as potential single ion magnets (SIMs). In the work presented herein, the Co(II) S = 3/2 tetrahedral [Co{(OPPh2)(EPPh2)N}2], E = S, Se, complexes (abbreviated as CoO2E2), bearing chalcogenated mixed donor-atom imidodiphosphinato ligands, were studied by both experimental and computational techniques. Specifically,...
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Depreciation - underestimated tax optimization tool
PublikacjaOptymalizacja podatkowa zmierza i pozwala na zmniejszenie obciążeń podatkowych a tym samym na zwiększenie zysku podmiotu gospodarczego. Prowadzenie działalności gospodarczej zazwyczaj wymaga zaangażowania odpowiednio dużych środków finansowych w zakupy składników majątkowych zaliczanych do środków trwałych. Te odnoszone są w koszty działalności poprzez odpisy amortyzacyjne, które stanowią istotny element całości kosztów prowadzonej...
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The analysis of human leukocyte antigen‐G level in patients with endometrial cancer by Western blot technique
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Aqueous Extracts of Selected Potentilla Species Modulate Biological Activity of Human Normal Colon Cells
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The influence of extracts from Rubus caesius leaves on human colon carcinoma cells cultured in vitro
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Imidazoacridinone C-1311 induces both autophagy and senescence in human lung cancer A549 cells
PublikacjaNiedrobnokomórkowy rak płuc (ang. NSCLC, non-small cell lung cancer), stanowiący blisko 80-87% wszystkich przypadków, jest najczęściej występującą formą raka płuc. Skuteczność dotychczas stosowanych chemoterapeutyków w stosunku do tej formy raka jest bardzo ograniczona dlatego poszukuje się nowych związków o lepszych właściwościach leczniczych. Imidazoakrydon C-1311 wykazuje wysoką aktywność cytotoksyczną wobec komórek niedrobnokomórkowego...
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The effect of 7-ketocholesterol and 25-hydroxycholesterol on the integrity of the human aortic endothelial and intestinal epithelial barriers
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An inter-laboratory validation of methods of lipid peroxidation measurement in UVA-treated human plasma samples
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Haloperidol, but not olanzapine, may affect expression of PER1 and CRY1 genes in human glioblastoma cell line
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Sulforaphane, a cruciferous vegetable-derived isothiocyanate, inhibits protein synthesis in human prostate cancer cells
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Nonlinear dynamic analysis of the pure “buckling” mechanism during blow-out trauma of the human orbit
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Bulky DNA adducts in human sperm: relationship with fertility, semen quality, smoking, and environmental factors
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Podstawowe sposoby zwiększania wiarygodności wykonania przebiegów wymagających udziału człowieka w human workflow
PublikacjaOpisano pojęcie procesu biznesowego oraz przepływu pracy w kontekście automatyzacji mającej na celu optymalizację działań i podniesienie jakości usługi. Przedstawiono charakterystykę procesów pracy angażujących człowieka oraz wykorzystujących dedykowane wzorce przepływów tego typu. Zaproponowano zwiększenie stopnia automatyzacji wykonania procesu wraz z metodami zwiększania wiarygodności wykonania przebiegów pracy przez kontrolę...
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Establishing the background level of base oxidation in human lymphocyte DNA: results of an interlaboratory validation study
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Human bone marrow as a tissue in post-mortem identification and determination of psychoactive Substances—Screening methodology
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Missing the sweet spot: one of the two N-glycans on human Gb3/CD77 synthase is expendable
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Experimental immunology First report of cylindrospermopsin effect on human peripheral blood lymphocytes proliferation in vitro
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<p>Nanomechanics and Histopathology as Diagnostic Tools to Characterize Freshly Removed Human Brain Tumors</p>
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Novel markers of human ovarian granulosa cell differentiation toward osteoblast lineage: A microarray approach
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Comparison of Fluoride Ion-Selective Electrode Based Potentiometric Methods of Fluoride Determination in Human Urine
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Human Health Risk Assessment on the Consumption of Apples Growing in Urbanized Areas: Case of Kharkiv, Ukraine
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Inhibition of HIV‐1 or bacterial activation of macrophages by products of HIV‐1‐resistant human cells
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Carboxymethylated starch and cellulose derivatives-based film as human skin equivalent for adhesive properties testing
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Environmental Phage-Based Cocktail and Antibiotic Combination Effects onAcinetobacter baumanniiBiofilm in a Human Urine Model
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Irreversible alterations in the hemoglobin structure affect oxygen binding in human packed red blood cells
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Temporal sequence of the human RBCs' vesiculation observed in nano-scale with application of AFM and complementary techniques
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Similarities and differences in affinity and binding modes of tricyclic pyrimido- and pyrazinoxanthines at human and rat adenosine receptors
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Effects of flavonoids on expression of genes involved in cell cycle regulation and DNA replication in human fibroblasts
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Molecular dynamics simulation of human neurohypophyseal hormone receptors complexed with oxytocin—modeling of an activated state
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Prevalence of human pathogens of the clade Nakaseomyces in a culture collection—the first report on Candida bracarensis in Poland
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Artificial intelligence support for disease detection in wireless capsule endoscopy images of human large bowel
PublikacjaIn the work the chosen algorithms of disease recognition in endoscopy images were described and compared for theirs efficiency. The algorithms were estimated with regard to utility for application in computer system's support for digestive system's diagnostics. Estimations were achieved in an advanced testing environment, which was built with use of the large collection of endoscopy movies received from Medical University in Gdańsk....
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Modulation of CYP1A1, CYP1A2 and CYP1B1 expression by cabbage juices and indoles in human breast cell lines
PublikacjaEpidemiological studies have shown that consumption of cab- bage and sauerkraut is connected with significant reduction of breast cancer incidences. Estrogens are considered a major breast cancer risk factor and their metabolism by P450 enzymes substan- tially contributes to carcinogenic activity. The aim of this study was to investigate the effect of cabbage and sauerkraut juices of differ- ent origin on the expression profile...
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Biochemical properties of thyroid peroxidase (TPO) expressed in human breast and mammary-derived cell lines
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