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Wyniki wyszukiwania dla: RATIONAL DRUG DESIGN
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Study of rotational separators operation and design
PublikacjaOmówiono zasadę działania i podstawy projektowania separatorów cyrkulacyjnych, wyrózniając separatory wirowe oraz cyklony.Przeanalizowano bilans sił, działających na cząstkę usuwanej zawiesiny. Na przykładzie obliczeniowym wykazano wady istniejących metod projektowych. Przedstawiono ogólną koncepcję nowej metody.
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Selected aspects of system design theory.
PublikacjaPrzedstawiono wybrane zagadnienia z teorii projektowania systemów. Szczgólną uwagę zwrócono na problemy występujące w systemach o dużej złożoności, które charakteryzują się skomplikowaną funkcją globalną, jak również dużą ilością elementów należących do takich systemów. Omówiono także niektóre cechy elementów wynikające z różnych procesów wytwarzania oraz ich wpływ na funkcję, strukturę i eksploatację systemu, powstałego ze skojarzenia...
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The methods of design reliable distributed networks
PublikacjaOpisano dwie metody projektowania niezawodnych sieci rozległych. W pierwszej metodzie przyjęto, że koszt konstrukcji każdego połączenia jest jednakowy, w drugiej koszty opisuje zadana macierz kosztów. Jako parametr niezawodnościowy przyjęto liczbę niezależnych dróg pomiędzy węzłami sieci. Pierwsza z metod jest metodą dokładną, druga heurystyczną. Zdefiniowano i oceniono błąd metody heurystycznej. Opublikowano wyniki otrzymane...
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Multicriteria optymization method for yacht design
PublikacjaArtykuł dotyczy optymalizacji wielokryterialnej projektowania innowacyjnego systemu jachtowego w taki sposób by osiągnąć polepszone zachowanie dynamiczne w dowolnych warunkach nawigacji morskiej. W artykule skoncentrowano się na komputerowej symulacji, modelowaniu i optymalizacji matematycznego modelu jachtu w różnych warunkach żeglowania w celu poprawy zdolności manewrowania i zwiększenia szybkości. Przeprowadza się symulację...
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Selected aspects of system design theory.
PublikacjaPrzedstawiono wybrane fragmenty z teorii i techniki projektowania złożonych systemów technicznych. Zwrócono szczególną uwagę na tworzenie schematów strukturalnych i funkcjonalnych systemów, a także występujących tam relacji między elementami takiego systemu. Opisano kolejne kroki postępowania dla doboru cech elementów systemu wg macierzy ich przewidywanych właściwości oraz przykłady podziału dla istniejących składników systemów...
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Problems of ship system design for safety.
PublikacjaSystem bezpieczny to taki, który nie stwarza ryzyka większego niż przyjęte w odpowiednich kryteriach. Kryteria te mogą być wyrażone jakościowo oraz ilościowo. Bezpieczeństwo jako atrybut systemu może być przedmiotem projektowania. Rozróżniono tutaj dwa przypadki: A - dotyczące systemu dla którego właściwe są kryteria jakościowe i B - dotyczące systemu dla którego zastosowano kryteria ilościowe. W uwagach końcowych przedyskutowano...
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A new approach to the prosthetic finger design
PublikacjaW pracy zaprezentowano nowy sposób projektowania protez ręki przy użyciu aplikacji CAD. Uzyskano projekt palca wskazującego, w którym zaproponowano napęd poszczególnych członów w oparciu o stopy z pamięcią kształtu.
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Microstructural Design of Ba0.5La0.5Co0.5Fe0.5O3 Perovskite Ceramics
PublikacjaBa0.5La0.5Co0.5Fe0.5O3 was synthesized in the solid-state reaction route. The influence of ball milling parameters (such as milling media size, angular velocity, and time), pelletizing pressure, and annealing parameters on the microstructure was studied. The grain size distribution and density or specific surface area changes were investigated in each approach while the individual parameters were changed. The evaluation of BLCF...
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Slurry Erosion -Design of Test Devices
PublikacjaDegradation of material caused by impacts of a solid particle (erodent) suspended in a liquid is called slurry erosion and is a major problem in the hydropower and maritime industry. Slurry erosion depends on many factors, e.g. liquid and erodent velocity, size, shape, angle of impact, hardness and number of erodents, and strength of a target material. The various types of test devices have been designed to investigate an effect...
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[AiU] Sustainable design and environmental changes
Kursy Online{mlang pl} Dyscyplina: Architektura i Urbanistyka Zajęcia obowiązkowe dla doktorantów I roku Prowadzący: prof. Giovanna Acampa Liczba godzin: 15 h Forma zajęć: warsztaty {mlang} {mlang en} Discipline: Architecture and Urbanism Obligatory course for 1st year PhD students Academic teacher: prof. Giovanna Acampa Total hours of training: 15 teaching hours Course type: workshops {mlang}
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Modelling methods in design (CAD, FEM)
Kursy Online -
[AiU] Sustainable Design and Environmental Changes
Kursy OnlineThis course is compulsory for PhD students assigned to Architecture and Urbanism tracks at Doctoral School at Gdańsk University of Technology. The course is conducted by prof. Giovanna Acampa, Kore University of Enna Course type: workshops Total hours of training: 15 teaching hours
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[AiU] 20232024_Sustainable Design and Environmental Changes
Kursy OnlineThis course is compulsory for PhD students assigned to Architecture and Urbanism tracks at Doctoral School at Gdańsk University of Technology. The course is conducted by Prof. Marichela Sepe, DICEA / Sapienza University Rome Course type: workshops Total hours of training: 15 teaching hours Classes in online mode (classes conducted online)
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[AiU] Sustainable design and environmental changes
Kursy Online{mlang pl} Dyscyplina: Architektura i Urbanistyka Zajęcia obowiązkowe dla doktorantów I roku Prowadzący: prof. Giovanna Acampa Liczba godzin: 15 h Forma zajęć: warsztaty {mlang} {mlang en} Discipline: Architecture and Urbanism Obligatory course for 1st year PhD students Academic teacher: prof. Giovanna Acampa Total hours of training: 15 teaching hours Course type: workshops {mlang}
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Technology-Enhanced Environmental Learning: Co-design of Educational Mobile Application Case
PublikacjaThe process of co-creating an educational mobile application to support environmentally friendly behavior is presented in this paper. The research material consisted of quantitative data collected on the application during the first testing phase by early adopters. The results suggest that the most frequently used features of the app were related to transport and educational activities. While women tended to split their time between...
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Rapid design of miniaturised branch-line couplers through concurrent cell optimisation and surrogate-assisted fine-tuning
PublikacjaIn this study, the authors introduce a methodology for low-cost simulation-driven design optimisation of highly miniaturised branch-line couplers (BLCs). The first stage of their design approach exploits fast concurrent optimisation of geometrically dependent, but electromagnetically isolated cells that constitute a BLC. The cross-coupling effects between the cells are taken into account in the second stage, where a surrogate-assisted...
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A biochemical multi-species quality model of a drinking water distribution system for simulation and design
PublikacjaDrinking Water Distribution Systems (DWDSs) play a key role in sustainable development of modern society. They are classified as critical infrastructure systems. This imposes a large set of highly demanding requirements on the DWDS operation and requires dedicated algorithms for on-line monitoring and control to tackle related problems. Requirements on DWDS availability restrict the usability of the real plant in the design phase....
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On Reduced-Cost Design-Oriented Constrained Surrogate Modeling of Antenna Structures
PublikacjaDesign of contemporary antenna structures heavily relies on full-wave electromagnetic (EM) simulation models. Such models are essential to ensure reliability of evaluating antenna characteristics, yet, they are computationally expensive and therefore unsuitable for handling tasks that require multiple analyses, e.g., parametric optimization. The cost issue can be alleviated by using fast surrogate models. Conventional data-driven...
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Expedited EM-Driven Design of Miniaturized Microwave Hybrid Couplers Using Surrogate-Based Optimization
PublikacjaMiniaturization of microwave hybrid couplers is important for contemporary wireless communication engineering. Using standard computer-aided design methods for development of compact structures is extremely challenging due to a general lack of computationally efficient and accurate simulation models. Poor accuracy of available equivalent circuits results from neglecting parasitic cross-couplings that greatly affect the performance...
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On deterministic procedures for low-cost multi-objective design optimization of miniaturized impedance matching transformers
PublikacjaPurpose This paper aims to investigate deterministic strategies for low-cost multi-objective design optimization of compact microwave structures, specifically, impedance matching transformers. The considered methods involve surrogate modeling techniques and variable-fidelity electromagnetic (EM) simulations. In contrary to majority of conventional approaches, they do not rely on population-based metaheuristics, which permit lowering...
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The significance of the underground experience: Selection of reference design cases from the underground public transport stations and interchanges of the European Union
PublikacjaAbstract Background Recent research into the way public transport users appreciate stations and interchanges has highlighted several key aspects. Importantly, the optimization of these facilities should not simply aim to resolve dissatisfiers, but should also focus on addressing satisfiers, through the incorporation of factors such as comfort and experience. ‘Soft requirements,’ which have emerged in architecture and urban design,...
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Inverse modeling for fast design optimization of small-size rat-race couplers incorporating compact cells
PublikacjaIn the paper, a framework for computationally-efficient design optimization of compact rat-race couplers (RRCs) is discussed. A class of hybrid RRCs with variable operating conditions is investigated, whose size reduction is obtained by replacing ordinary transmission lines with compact microstrip resonant cells (CMRCs). Our approach employs a bottom-up design strategy leading to the development of compact RRCs through rapid design...
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State of the Art in Open Platforms for Collaborative Urban Design and Sharing of Resources in Districts and Cities
PublikacjaThis work discusses recent developments in sharing economy concepts and collaborative co-design technology platforms applied in districts and cities. These developments are being driven both by new technological advances and by increased environmental awareness. The paper begins by outlining the state of the art in smart technology platforms for collaborative urban design, highlighting a number of recent examples. The case of peer-to-peer...
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Low-cost EM-Simulation-based Multi-objective Design Optimization of Miniaturized Microwave Structures
PublikacjaIn this work, a simple yet reliable technique for fast multi-objective design optimization of miniaturized microwave structures is discussed. The proposed methodology is based on point-by-point identification of a Pareto-optimal set of designs representing the best possible trade-offs between conflicting objectives such as electrical performance parameters as well as the size of the structure of interest. For the sake of computational...
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Computer-Aided Greenery Design—Prototype Green Structure Improving Human Health in Urban Ecosystem
PublikacjaIncreasing population and urbanization, with climate change consequences, such as rising temperatures, influence public health and well-being. The search to improve the quality of life in cities becomes one of the priority objectives. A solution can be found in the role of greenery in an urban environment and its impact on human health. This opens a path toward experimentation on microclimate green structures that can be inserted...
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Design of synchronous generator two inputs regulator based on hinf control theory.
PublikacjaThe power system is highly nonlinear system, its dynamics depends on system network configuration, system loading… etc. To overcome the above mentioned difficulties and fulfill the performance requirements the different control methods are considered and tested for design of synchronous generator control system. Application of the H optimization method to synchronous generator regulator based on measurement of generator voltage...
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Healthier and Environmentally Responsible Sustainable Cities and Communities. A New Design Framework and Planning Approach for Urban Illumination
PublikacjaAlthough sustainability and sustainable development are both considered necessary practices in various fields today, a recent analysis showed that the Sustainable Development Goal SDG11: Sustainable Cities and Communities established by the United Nations does not address urban illumination and its impact. This oversight is of concern because research carried out in the last 20+ years indicates artificial light at night (ALAN)...
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A design framework and a digital toolset supporting the early-stage explorations of responsive kinetic building skin concepts
PublikacjaIn this paper we present the first phase of our research on the development of a framework for early-stage responsive kinetic building skin design. The aims of this study were: to formulate a methodological and instrumental basis for the construction of the framework, to conduct an initial pre-assessment of its features, and finally to provide the first example of how the framework could be applied in practice. Importantly, at...
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Knowledge-Based Expedited Parameter Tuning of Microwave Passives by Means of Design Requirement Management and Variable-Resolution EM Simulations
PublikacjaThe importance of numerical optimization techniques has been continually growing in the design of microwave components over the recent years. Although reasonable initial designs can be obtained using circuit theory tools, precise parameter tuning is still necessary to account for effects such as electromagnetic (EM) cross coupling or radiation losses. EM-driven design closure is most often realized using gradient-based procedures,...
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Accelerated multi-objective design of miniaturized microwave components by means of nested kriging surrogates
PublikacjaDesign of microwave components is an inherently multiobjective task. Often, the objectives are at least partially conflicting and the designer has to work out a suitable compromise. In practice, generating the best possible trade‐off designs requires multiobjective optimization, which is a computationally demanding task. If the structure of interest is evaluated through full‐wave electromagnetic (EM) analysis, the employment of...
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Adaptabilność obiektów architektonicznych we współczesnym projektowaniu / The adaptability of architectural objects in contemporary design
PublikacjaThe article discusses the issue of adaptability - the ability to modify modern architectural objects to a changing context - as an important element of contemporary design. Adaptability can take on different forms. It is most commonly understood as a change in the architectural form in reaction to various stimuli from the environment through transformative structures, or as an object's ability to adapt to climatic conditions, providing...
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Design-oriented modeling of antenna structures by means of two-level kriging with explicit dimensionality reduction
PublikacjaThe employment of full-wave electromagnetic (EM) analysis is a practical necessity in the design of contemporary antenna structures. This is because simpler models are generally not available or of limited accuracy. At the same time, EM-based design is computationally expensive. Consequently, the ways of accelerating tasks such as parametric optimization or uncertainty quantification have to be sought. A possible workaround that...
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Constrained multi-objective optimization of compact microwave circuits by design triangulation and pareto front interpolation
PublikacjaDevelopment of microwave components is an inherently multi-objective task. This is especially pertinent to the design closure stage, i.e., final adjustment of geometry and/or material parameters carried out to improve the electrical performance of the system. The design goals are often conflicting so that the improvement of one normally leads to a degradation of others. Compact microwave passives constitute a representative case:...
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Accelerated Re-Design of Antenna Structures Using Sensitivity-Based Inverse Surrogates
PublikacjaThe paper proposes a novel framework for accelerated re-design (dimension scaling) of antenna structures using inverse surrogates. The major contribution of the work is a sensitivity-based model identification procedure, which permits a significant reduction of the number of reference designs required to render the surrogate. Rigorous formulation of the approach is supplemented by its comprehensive numerical validation using a...
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Accelerated simulation-driven design optimisation of compact couplers by means of two-level space mapping
PublikacjaIn this study, the authors discuss a robust and efficient technique for rapid design of compact couplers. The approach exploits two-level space mapping (SM) correction of an equivalent circuit model of the coupler structure under design. The first SM layer (local correction) is utilised to ensure good matching between the equivalent circuit and the electromagnetic model at the component level. Subsequent global correction allows...
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Model Correction and Optimization Framework for Expedited EM-Driven Surrogate-Assisted Design of Compact Antennas
PublikacjaDesign of compact antennas is a numerically challenging process that heavily relies on electromagnetic (EM) simulations and numerical optimization algorithms. For reliability of simulation results, EM models of small radiators often include connectors which—despite being components with fixed dimensions—significantly contribute to evaluation cost. In this letter, a response correction method for antenna models without connector,...
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Design of a test bench for determining the general characteristics of an internal combustion engine using a hydraulic power take-off system
PublikacjaThe paper presents a design of an engine test bench, which is used to determine the general characteristics of a truck engine using a power take-off (PTO). PTO drives a hydraulic system that generates a load on the engine at various points in its operation in the power range specified by the hydraulic system. The design allows for stationary and mobile tests with the test bench mounted on the truck, without any modification of...
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High mortality explained by mildly elevated blood pressure in Scandinavian adolescent conscripts – A plea for early drug treatment?
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Impact of orthostatic hypotension and antihypertensive drug treatment on total and cardiovascular mortality in a very elderly community-dwelling population
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Semi-continuous production of the anticancer drug taxol by Aspergillus fumigatus and Alternaria tenuissima immobilized in calcium alginate beads
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Electroporation and lipid nanoparticles with cyanine IR-780 and flavonoids as efficient vectors to enhanced drug delivery in colon cancer
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New diamidequat-type surfactants in fabrication of long-sustained theranostic nanocapsules: Colloidal stability, drug delivery and bioimaging
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Inhibition of ALDH1A1 activity decreases expression of drug transporters and reduces chemotherapy resistance in ovarian cancer cell lines
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Microarray-based detection and expression analysis of new genes associated with drug resistance in ovarian cancer cell lines
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Enzymatic Polymerization of Cyclic Monomers in Ionic Liquids as a Prospective Synthesis Method for Polyesters Used in Drug Delivery Systems
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Novel 2019 coronavirus structure, mechanism of action, antiviral drug promises and rule out against its treatment
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DNA structure and integrity checkpoints in the cell cycle and their role in drug targeting and resistance of tumor cells to anticancer treatment
PublikacjaW artykule dokonaliśmy przeglądu literatury dotyczącej różnych typów uszkodzeń DNA indukowanych przez różne czynniki terapeutyczne w komórkach nowotworowych. Omówiliśmy także w jaki sposób aktywują różne typy punktów kontrolnych w cyklu komórkowym i w jaki sposób punkty te są regulowane przez inne szlaki sygnalizacji wewnątrzkomórkowej takie jak szlaki naprawy uszkodzeń DNA, stresu komórkowego i śmierci-przeżycia. W szczególności...
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The antitumor derivative, C-1748, affects CYP3A4: crosstalk between drug metabolism, CYP3A4 expression and enzymatic activity
PublikacjaJedną z głównych przeszkód w przewidywaniu wyników terapii u pacjentów z nowotworem jest indywidualny przebieg metabolizmu stosowanych leków wynikający z polimorfizmu genów enzymów metabolizujących, jak również duża zmienność farmakokinetyki leków obserwowana u różnych pacjentów podczas trwania chemioterapii. Z powodu tzw. ''wąskiego okna terapeutycznego'' występującego w przypadku terapii lekami przeciwnowotworowymi, małe zmiany...
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Techno‐economic evaluation of a natural deep eutectic solvent‐based biorefinery: Exploring different design scenarios
PublikacjaThis paper presents a comprehensive techno‐economic evaluation of an integrated natural deep eutectic solvent (NADES)‐based biorefinery – a 1 ton day−1 capacity design plant. The key parameters include payback period, net present value (NPV), and internal rate of return (IRR). These were compared with the parameters of conventional biorefineries. The ‘n th plant’ results clearly revealed that the single product‐based biorefinery...
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Kriging-assisted hybrid reliability design and optimization of offshore wind turbine support structure based on a portfolio allocation strategy
PublikacjaIn recent years, offshore wind power generation technology has developed rapidly around the world, making important contributions to the further development of renewable energy. When designing an Offshore Wind Turbine (OWT) system, the uncertainties in parameters and different types of constraints need to be considered to find the optimal design of these systems. Therefore, the Reliability-Based Design Optimization (RBDO) method...