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Wyniki wyszukiwania dla: drug delivery systems
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Measurements and Measurement Systems [2021/22]
Kursy OnlineThe aim of the course is to introduce theoretical and practical students with basic and advanced methods of measurement of various measured quantity and the design and function of the measurement systems.
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Glutathione-mediated conjugation of anticancer drugs: an overview of reaction mechanisms and biological significance for drug detoxification and bioactivation.
PublikacjaThe effectiveness of many anticancer drugs depends on the creation of specific metabolites that may alter their therapeutic or toxic properties. One significant route of biotransformation is a conjugation of electrophilic compounds with reduced glutathione, which can be non-enzymatic and/or catalyzed by glutathione-dependent enzymes. Glutathione usually combines with anticancer drugs and/or their metabolites to form more polar...
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Systems of boundary value problems of advanced differential equations
PublikacjaThis paper considers the existence of extremal solutions to systems of advanced differential equations with corresponding nonlinear boundary conditions. The monotone iterative method is applied to obtain the existence results. An example is provided for illustration.
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IEEE TRANSACTIONS ON POWER DELIVERY
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Stream Reasoning to Improve Decision-Making in Cognitive Systems
PublikacjaABSTRACT Cognitive Vision Systems have gained a lot of interest from industry and academia recently, due to their potential to revolutionize human life as they are designed to work under complex scenes, adapting to a range of unforeseen situations, changing accordingly to new scenarios and exhibiting prospective behavior. The combination of these properties aims to mimic the human capabilities and create more intelligent and efficient...
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Thin layer chromatography in drug discovery process
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Drug Research
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DRUG SAFETY
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Drug Topics
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The Interaction of Heptakis (2,6-di-O-Methyl)-β-Cyclodextrin with Mianserin Hydrochloride and Its Influence on the Drug Toxicity
PublikacjaOne tetracyclic antidepressant, mianserin hydrochloride (MIA), has quite significant side effects on a patients’ health. Cyclodextrins, which are most commonly used to reduce the undesirable features of contained drugs within their hydrophobic interior, also have the potential to alter the toxic behavior of the drug. The present paper contains investigations and the characteristics of interaction mechanisms for MIA and the heptakis...
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Computational collective intelligence for enterprise information systems
PublikacjaCollective intelligence is most often understood as a kind of intelligence which arises on the basis of a group (collective) of autonomous unites (people, systems) which is taskoriented. There are two important aspects of an intelligent collective: The cooperation aspect and the competition aspect (Levy 1997). The first of them means the possibility for integrating the decisions made by the collective members for creating the decision of...
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Annual Review of Control Robotics and Autonomous Systems
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Rule-Based Model for Selecting Integration Technologies for Smart Cities Systems
PublikacjaThe aim of this article is to present the stages of development for an information technology integration model for the design of systems for smart cities. The Introduction explains the need for integration technologies and presents a model for selecting integration technologies and the conditions for its use in designing smart cities systems. Then two verification stages of the presented model are discussed. In the first stage,...
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Using anticipatory and drug-evoked appetitive ultrasonic vocalization for monitoring the rewarding effect of amphetamine in a rat model of drug self-administration
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The Significance of MicroRNAs Expression in Regulation of Extracellular Matrix and Other Drug Resistant Genes in Drug Resistant Ovarian Cancer Cell Lines
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Potential Application of Solar Energy Systems for Electrified Urban Transportation Systems
PublikacjaThe paper presents a novel approach toward the use of solar energy systems in public transportation. The concept of energy generation in PV systems for supplying a trolleybus transportation system is proposed for the city of Gdynia (Poland). The suggested way of energy production allows reducing the environmental harm impact of the municipal transportation system. Moreover, the proposed way of green energy use can be a more profitable...
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Andrzej Czyżewski prof. dr hab. inż.
OsobyProf. zw. dr hab. inż. Andrzej Czyżewski jest absolwentem Wydziału Elektroniki PG (studia magisterskie ukończył w 1982 r.). Pracę doktorską na temat związany z dźwiękiem cyfrowym obronił z wyróżnieniem na Wydziale Elektroniki PG w roku 1987. W 1992 r. przedstawił rozprawę habilitacyjną pt.: „Cyfrowe operacje na sygnałach fonicznych”. Jego kolokwium habilitacyjne zostało przyjęte jednomyślnie w czerwcu 1992 r. w Akademii Górniczo-Hutniczej...
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Real-time Operating Systems - Seminar 2023/4
Kursy OnlinePage to support seminar clases of Real-time Operating Systems
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Solubility advantage of sulfanilamide and sulfacetamide in natural deep eutectic systems: experimental and theoretical investigations
PublikacjaObjective: The aim of this study was to explore the possibility of using natural deep eutectic solvents (NADES) as solvation media for enhancement of solubility of sulfonamides, as well as gaining some thermodynamic characteristics of the analyzed systems. Significance: Low solubility of many active pharmaceutical ingredients is a well-recognized difficulty in pharmaceutical industry, hence the need for different strategies addressing...
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Molecular modeling and evaluation of novel dibenzopyrrole derivatives as telomerase inhibitors and potential drug for cancer therapy
PublikacjaDuring previous years, many studies on synthesis, as well as on anti-tumor, anti-inflammatory and anti-bacterial activities of the pyrazole derivatives have been described. Certain pyrazole derivatives exhibit important pharmacological activities and have proved to be useful template in drug research. Considering importance of pyrazole template, in current work the series of novel inhibitors were designed by replacing central...
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A CONTEXT IN RECOMMENDER SYSTEMS
PublikacjaRecommender systems aim to propose potentially interesting items to a user based on his preferences or previous interaction with the system. In the last decade, researcher found out that known recommendation techniques are not sufficient to predict user decisions. It has been noticed that user preferences strongly depend on the context in which he currently is. This raises new challenges for the researchers such as how to obtain...
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Periodic Solutions of Generalized Lagrangian Systems with Small Perturbations
PublikacjaIn this paper we study the generalized Lagrangian system with a small perturbation. We assume the main term in the system to have a maximum, but do not suppose any condition for perturbation term. Then we prove the existence of a periodic solution via Ekeland’s principle. Moreover, we prove a convergence theorem for periodic solutions of perturbed systems.
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From Knowledge based Vision Systems to Cognitive Vision Systems: A Review
PublikacjaComputer vision research and applications have their origins in 1960s. Limitations in computational resources inherent of that time, among other reasons, caused research to move away from artificial intelligence and generic recognition goals to accomplish simple tasks for constrained scenarios. In the past decades, the development in machine learning techniques has contributed to noteworthy progress in vision systems. However,...
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Context-Aware Indexing and Retrieval for Cognitive Systems Using SOEKS and DDNA
PublikacjaVisual content searching, browsing and retrieval tools have been a focus area of interest as they are required by systems from many different domains. Context-based, Content-Based, and Semantic-based are different approaches utilized for indexing/retrieving, but have their drawbacks when applied to systems that aim to mimic the human capabilities. Such systems, also known as Cognitive Systems, are still limited in terms of processing...
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Perspectives of Transport Systems Development in the Light of Radio Communication Systems Evolution Towards 5G
PublikacjaIn the paper conditions of development and implementation of transport systems with reference to the development of radio communication networks towards 5G are presented. First, general properties of next generation systems are mentioned and their architecture. Moreover, planned characteristics of B4G and 5G systems are depicted which can significantly contribute to the promotion and development of transport systems. In particular...
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Editorial: Applied intelligence and knowledge based systems: approaches and case studies - part 2
PublikacjaWydanie Cybernetics and Systems poswiecone zagadnieniom zarzadzania wiedza.
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Cognitive memory for intelligent systems of decision-making, based on human psychology
PublikacjaA model of memory, which allows to expand the functionality of autonomous decision-making systems for robotic and human-system-interface purposes, is discussed. The model provides functions and features which make the prospective robotic and interfacing systems more human-like as well as more efficient in solving interactive issues.
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Does Obesity Influence Women’s Decision Making about the Mode of Delivery?
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Survey of Radio Navigation Systems
PublikacjaAt present, there is a growing demand for radio navigation systems, ranging from pedestrian navigation to consumer behavior analysis. These systems have been successfully used in many applications and have become very popular in recent years. In this paper we present a review of selected wireless positioning solutions operating in both indoor and outdoor environments. We describe different positioning techniques, methods, systems,...
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Introduction to the special issue on intelligent systems to aid the handicapped.
PublikacjaWśród wielu zastosowań sztucznej inteligencji i technologii bazodanowych pojawiają się zastosowania wspierające osoby niepełnosprawne. Z chwilą pojawienia są każdej nowej technologii komputerowej świat naukowy proponuje zastosowania tej technologii do celu poprawy komunikacji z osobami niepełnosprawnymi bądź technologie wspierające te osoby bezpośrednio. Niniejsze wydanie specjalne czasopisma Journal of Intelligent Information...
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Feasibility study of a Raman spectroscopic route to drug detection
PublikacjaWe present an surface-enhanced Raman spectroscopy (SERS) approach for detection of drugs of abuse in whole human blood. We utilize a near infrared laser with 830 nm excitation wavelength in order to reduce the influence of fluorescence on the spectra of blood. However, regular plasmon resonance peak of plasmonic nanoparticles, such as silver or gold fall in a much lower wavelength regime about 400 nm. Therefore, we have shifted...
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Dynamic Execution of Engineering Processes in Cyber-Physical Systems of Systems Toolchains
PublikacjaEngineering tools support the process of creating, operating, maintaining, and evolving systems throughout their lifecycle. Toolchains are sequences of tools that build on each others' output during this procedure. The complete chain of tools itself may not even be recognized by the humans who utilize them, people may just recognize the right tool being used at the right place in time. Modern engineering processes, however, do...
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Geometric methods in dynamical systems modelling: electrical, mechanical and control systems
PublikacjaRozważono zagadnienia modelowania systemów dynamicznych z zastosowaniem metod geometrii różniczkowej. Równania dynamiczne otrzymano w postaci inkluzji różniczkowych. Przestrzenie konstytucyjne przyjęto w postaci subwiązek włóknistych. Rozważono przestrzenie konstytucyjne układów elektrycznych, układów mechanicznych i układów sterowania. Podstawowe wyniki pracy dotyczą struktury przestrzeni rozwiązań rozważanych systemów.
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Multi agent grid systems
PublikacjaThis chapter presents an idea of merging grid and volunteer systemswith multi agent systems. It gives some basics concerning multi agentsystem and the most followed standard. Some deliberations concerningsuch an existing systems were made in order to finally present possibilities of introducing agents into the Comcute system.
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Developing Methods for Building Intelligent Systems of Information Resources Processing Using an Ontological Approach
PublikacjaThe problem of developing methods of information resource processing is investigated. A formal procedure description of processing text content is developed. A new ontological approach to the implementation of business processes is proposed. Consider that the aim of our work is to develop methods and tools for building intelligent systems of information resource processing, the core of knowledge bases of which are ontology’s, and...
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Security and Anonymity in Agent Systems
PublikacjaMany agent systems have been developed and suggested for commercial application. However, in spite of the significant potential offered by the agent paradigm, the lack of such important properties as security, anonymity and untracebility especially in open dynamical environment, such as the Internet, has blocked the active implementation of agent technologies. Protecting agent systems poses a more demanding challenge comparing...
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Microbial Drug Resistance
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Prediction of Overall In Vitro Microsomal Stability of Drug Candidates Based on Molecular Modeling and Support Vector Machines. Case Study of Novel Arylpiperazines Derivatives
PublikacjaOther than efficacy of interaction with the molecular target, metabolic stability is the primary factor responsible for the failure or success of a compound in the drug development pipeline. The ideal drug candidate should be stable enough to reach its therapeutic site of action. Despite many recent excellent achievements in the field of computational methods supporting drug metabolism studies, a well-recognized procedure to model...
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Development of a Peptide Derived from Platelet-Derived Growth Factor (PDGF-BB) into a Potential Drug Candidate for the Treatment of Wounds
PublikacjaObjective: This study evaluated the use of novel peptides derived from platelet-derived growth factor (PDGF-BB) as potential wound healing stimulants. One of the compounds (named PDGF2) was subjected for further research after cytotoxicity and proliferation assays on human skin cells. Further investigation included evaluation of: migration and chemotaxis of skin cells, immunological and allergic safety, the transcriptional analyses...
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Combined Heat & Power Generating Systems
PublikacjaSteam cycles in combined heat and power plants. Efficiency of combined heat and power systems. Characteristics of steam-turbine CHP plants. Choice of equipment in CHP generating systems. Economic effects of combined heat and power production. Costs and energy produced CHP generating systems. Future development trends in CHP generating systems.
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Cancer stem cells in drug resistance and drug screening: can we exploit the cancer stem cell paradigm in search for new antitumor agents?
PublikacjaPraca przedstawia przegląd literatury dotyczącej hipotezy komórek pierwotnych nowotworu, w szczególności w ich oporności na istniejące terapie. Dyskutowane jest także zagadnienie możliwości wykorzystania wiedzy o tych komórkach do konstrukcji nowych testów do badań przesiewowych in vitro w celu poszukiwania nowych leków przeciwnowotworowych.
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CaZnO-based nanoghosts for the detection of ssDNA, pCRISPR and recombinant SARS-CoV-2 spike antigen and targeted delivery of doxorubicin
PublikacjaOverexpression of proteins/antigens and other gene-related sequences in the bodies could lead to significant mutations and refractory diseases. Detection and identification of assorted trace concentrations of such proteins/antigens and/or gene-related sequences remain challenging, affecting different pathogens and making viruses stronger. Correspondingly, coronavirus (SARS-CoV-2) mutations/alterations and spread could lead to overexpression...
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Geographical Information Systems GIS (project) [2022/23]
Kursy OnlineSubject: Geographical Information Systems GIS, Inter-faculty (field of study: Energy Technologies), undergraduate studies, full-time studies (semester 6) Teacher: dr inż. Andrzej Augusiak, doc. PG Abstract: The course aims to teach the practical implementation of a simple project in the field of GIS geographical information systems. As part of the project, the course participant will learn how to use the basic methods and tools...
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Identification of Continuous Systems - Practical Issues of Insensitivity to Perturbations
PublikacjaIn this paper the issue of continuous systems estimation, insensitive to certain perturbations, is discussed. Such an approach has rational advantages, especially when robust schemes are used to assist a target system responsible for industrial diagnostics. This requires that estimated model parameters are generated on-line, and their values are reliable and to a great extent accurate. Practical hints are suggested to challenge...
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A system automating repairs of IT systems
PublikacjaThis paper presents two problems that are important nowadays: the problem of IT systems monitoring and the problem of repairing them. It shows the developed solution, aimed to automate the existing industrial repair process and to integrate it with the existing monitoring solutions and mechanisms. Described solution is a part of a bigger whole, called the Repair Management Framework (RMF). This paper presents also briefly a case...
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Investigation on domestic fruits seed oils in personal care emulsion systems
PublikacjaThe use of fruit seed oils in personal care products is of significance to both their function and image. Poland is an important processor of fruit products within the EU, and thus has a large availability of seeds from domestic fruits, which are normally considered to be a waste material. Unfortunately, current literature is scarce of the suitability of these oils for topical use in the form of cosmetic emulsions. Published data...
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Investigation of tracking systems properties in CAVE-type virtual reality systems
PublikacjaIn recent years, many scientific and industrial centers in the world developed a virtual reality systems or laboratories. One of the most advanced solutions are Immersive 3D Visualization Lab (I3DVL), a CAVE-type (Cave Automatic Virtual Environment) laboratory. It contains two CAVE-type installations: six-screen installation arranged in a form of a cube, and four-screen installation, a simplified version of the previous one. The...
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2022/2023_zima SCADA Systems in Automatic Control
Kursy OnlineSCADA Systems in Automatic Control - project materials
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2021/2022_zima SCADA Systems in Automatic Control
Kursy OnlineSCADA Systems in Automatic Control - project materials
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Non-regular, incomplete and singular dynamical systems: impasse points indynamical systems
PublikacjaRozważono nieregularne, niezupełne i osobliwe różniczkowe systemy dynamicznez zastosowaniem metod geometrii różniczkowej.