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Wyniki wyszukiwania dla: biochemical engineering
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BIOCHEMICAL ENGINEERING JOURNAL
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CHEMICAL AND BIOCHEMICAL ENGINEERING QUARTERLY
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Advances in Biochemical Engineering-Biotechnology
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Adaptive stochastic and hybrid nonlinear optimization algorithms for improving the effectiveness of the biological processes at WWTP
PublikacjaWastewater treatment plays an important factor in the modern world. Insufficient treatment may result in environmental pollution which can further lead to disasters and diseases. However, processes that take place inside wastewater treatment plants (WWTP) are highly complex in nature, therefore it is difficult to design an efficient, optimal control system. The problem regarding biochemical reactions inside Sequential Batch Reactor...
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Exposure to non-continuous rotating magnetic field induces metabolic strain-specific response of Komagataeibacter xylinus
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PhageScore: A simple method for comparative evaluation of bacteriophages lytic activity
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Intensification of bacterial cellulose production process with sequential electromagnetic field exposure aided by dynamic modelling
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Treatment of malodorous air in biotrickling filters: A review
PublikacjaOdour nuisance, resulting mainly from the presence of the compounds containing osmophore group and characterized by low olfactory threshold, is associated with danger and may be the cause of negative psychosomatic symptoms. Among different methods of malodorous air treatment, biological methods are of importance, mainly due to reduced operating costs, high purification efficiency of voluminous gas streams characterized by low concentrations...
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Long-term performance and microbial characteristics of the anammox-enriched granular sludge cultivated in a bench-scale sequencing batch reactor
PublikacjaThe anammox-enriched granular sludge was successfully formed during the long-term biogranulation experiment lasting over 330 days. The cultivation was conducted at 30 ◦C in a 10-L sequencing batch reactor (SBR) fed with synthetic medium containing ammonia, nitrite and trace elements. The properties of the developed granules were investigated in terms of the biomass activity (including the growth rate of anammox bacteria), size...
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Kinetic characterization of hydrogen sulfide inhibition of suspended anammox biomass from a membrane bioreactor
PublikacjaThe inhibition effects of hydrogen sulfide (H2S) on anammox-enriched biomass from a laboratory membrane reactor were analyzed in a series of batch respirometric experiments. The determined half maximal inhibitory concentration (IC50) was 4.67 mg H2S-S L−1 at the constant pH = 7.0 and the total sulfide concentration varying between 1 and 15 mg TS-S L−1. In another test, the IC50 was found to be 4.25 mg H2S-S L−1 under a constant...
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BIOCHEMICAL PHARMACOLOGY
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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BIOCHEMICAL GENETICS
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BIOCHEMICAL SYSTEMATICS AND ECOLOGY
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Journal of Biochemical Technology
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BIOCHEMICAL SOCIETY SYMPOSIUM
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Biochemical and Cellular Archives
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Ukrainian biochemical journal
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MOLECULAR AND BIOCHEMICAL PARASITOLOGY
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TRENDS IN BIOCHEMICAL SCIENCES
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Robert Piotrowski dr hab. inż.
OsobyRobert Piotrowski jest absolwentem Wydziału Elektrotechniki i Automatyki (2001r., kierunek: Automatyka i Robotyka) oraz Wydziału Zarządzania i Ekonomii (2002r., kierunek: Organizacja Systemów Produkcyjnych) Politechniki Gdańskiej. Od 2005 roku jest zatrudniony na Wydziale Elektrotechniki i Automatyki, aktualnie w Katedrze Inteligentnych Systemów Sterowania i Wspomagania Decyzji. W 2005 roku obronił rozprawę doktorską (Automatyka...
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Journal of Microbial & Biochemical Technology
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JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
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BIOCHEMICAL JOURNAL
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International Journal of Chemical and Biochemical Sciences
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BIOCHEMICAL SOCIETY TRANSACTIONS
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JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS
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Reactions on the surface of the implant under the influence of biofilm
PublikacjaThe contact of a biomaterial with the biological environment in in vitro and in vivo tests leads to the production of a particular ecosystem in which the active roles perform both, the material surface and the extracellular matrix protein forming a biofilm. Proteins affect cell and bacteria adhesion processes, biological activity of cells and activation of inflammatory response.The knowledge of the reaction mechanisms active on...
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JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTALPHYSIOLOGY
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Robert Bogdanowicz dr hab. inż.
OsobyRobert Bogdanowicz received his Ph.D. degree with honours in Electronics from the Gdansk University of Technology. He worked as a post-doc researcher in Ernst-Moritz-Arndt-Universität Greifswald Institut für Physik. He has initiated optical emission imaging of muti-magnetron pulsed plasma and contributed to the development of antibacterial implant coatings deposited by high-power impulse magnetron sputtering. He moved back to...
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PHYSIOLOGICAL AND BIOCHEMICAL ZOOLOGY
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Establishing the allosteric mechanism in CRISPR‐Cas9
PublikacjaAllostery is a fundamental property of proteins, which regulates biochemical information transfer between spatially distant sites. Here, we report on the critical role of molecular dynamics (MD) simulations in discovering the mechanism of allosteric communication within CRISPR‐Cas9, a leading genome editing machinery with enormous promises for medicine and biotechnology. MD revealed how allostery intervenes during at least three...
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Impact of Extensive Sheep Grazing on the Biochemical Status of Soils of the Grassland Habitat of Natura 2000
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Kinetics of pollutants removal in hybrid treatment wetlands – Case study comparison
PublikacjaRecent years have seen an increasing interest in hybrid constructed wetland (HCW) systems for domestic sewage treatment. This paper is focused on kinetics of removal of the main pollutants occurring in wastewater i.e. organics expressed as chemical oxygen demand, biochemical oxygen demand and total nitrogen. The purpose of the article is to compare different HCW configurations in terms of mass removal rates (MRR) and removal rate...
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Możliwości zastosowań, potencjalne źródła oraz ewolucja technologiczna sposobu otrzymywania trehalozy ze szczególnym uwzględnieniem enzymu syntazy trehalozy [EC 5.4.99.16]
PublikacjaJedna z wiodących gałęzi współczesnej biotechnologii opiera się na produkcji białek – przede wszystkim enzymów. Są one powszechnie wykorzystywane: od przemysłu chemicznego poprzez przemysł spożywczy aż po medycynę i życie codzienne (czy ktoś wyobraża sobie w dzisiejszych czasach proszek do prania „bez enzymu”). Przed rozwojem nowoczesnych metod biologii molekularnej i inżynierii genetycznej pozyskiwano interesujące substancje z...
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Model based evaluation of plant improvement at a large wastewater treatment plant (WWTP)
PublikacjaIn this work, the effect of the improvement carried out at a large-scale wastewater treatment plant (WWTP) was evaluated, by means of modelling works, with the aim to determine the influence of the modernization over the process performance. After modernization, the energy consumption due to the aeration decreased about a 20% maintaining the effluent quality. In order to double-check the good effluent quality, modelling works were...
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Assessment of the usefulness of bacterial cellulose produced by Gluconacetobacter xylinus E25 as a new biological implant
PublikacjaBionanocellulose (BNC) is a clear polymer produced by the bacterium Gluconacetobacter xylinus. In our current study, “Research on the use of bacterial nanocellulose (BNC) in regenerative medicine as a function of the biological implants in cardiac and vascular surgery”, we carried out material analysis, biochemical analysis, in vitro tests and in vivo animal model testing. In stage 1 of the project, we carried out physical and...
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Types of Treatment Wetlands
PublikacjaThe removal of pollutants in treatment wetland systems is the result of the sorption of biochemical pollutants, redox reactions, and a biological activity of microorganisms as well as hydrophytes plants.
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The overexpression of CPR and P450 3A4 in pancreatic cancer cells changes the metabolic profile and increases the cytotoxicity and pro-apoptotic activity of acridine antitumor agent, C-1748
PublikacjaDrug resistance is one of the major cause of pancreatic cancer treatment failure. Thus, it is still imperative to develop new active compounds and novel approach to improve drug efficacy. Here we present 9-amino-1-nitroacridine antitumor agent, C-1748, developed in our laboratory, as a candidate for pancreatic cancer treatment. We examined (i) the cellular response of pancreatic cancer cell lines: Panc-1, MiaPaCa-2, BxPC-3 and...
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Coatings in arthroplasty [online]
PublikacjaThe modern coatings used in arthroplasty for long term implants are reviewed. The phosphate coatingsare the most popular technique to improve the bone-implant interfacial strength and promote theosseointegration. The plasma spraying, electrophoretic precipitation, powder metallurgy, ion beamsputtering, high velocity oxy-fuel (HVOF) combustion spraying, sol-gel technique, biomimeticdeposition are mostly used to obtain the phosphate,...
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An analysis of observability and detectability for different sets of measured outputs - CSTR case study
PublikacjaA problem of proving the observability/detectability at a given measured output for non-linear biochemical systems has been addressed in this paper. A theory of indistinguishable state trajectories has been used to prove the properties of the observability or detectability of this system. It is related to taking system dynamics into consideration depending on initial conditions and the impact of inputs taking into account a given...
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Innovations in Wastewater Treatment: Harnessing Mathematical Modeling and Computer Simulations with Cutting-Edge Technologies and Advanced Control Systems
PublikacjaThe wastewater treatment landscape in Central Europe, particularly in Poland, has undergone a profound transformation due to European Union (EU) integration. Fueled by EU funding and rapid technological advancements, wastewater treatment plants (WWTPs) have adopted cutting-edge control methods to adhere to EU Water Framework Directive mandates. WWTPs contend with complexities such as variable flow rates, temperature fluctuations,...
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Robust asymptotic super twisting sliding mode observer for non-linear uncertain biochemical systems
PublikacjaThe problem of state estimation (reconstruction of the state vector) for a given class of biochemical systems under uncertain system dynamics has been addressed in this paper. In detail, the bioreactor at a water resource recovery facility represents the considered biochemical systems. The biochemical processes taking place in the bioreactor have been modelled using an activated sludge model. Based on this model, an appropriate...
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Recent advances in aqueous virus removal technologies
PublikacjaThe COVID-19 outbreak has triggered a massive research, but still urgent detection and treatment of this virus seems a public concern. The spread of viruses in aqueous environments underlined efficient virus treatment processes as a hot challenge. This review critically and comprehensively enables identifying and classifying advanced biochemical, membrane-based and disinfection processes for effective treatment of virus-contaminated...
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An observability and detectability analysis for non-linear uncertain CSTR model of biochemical processes
PublikacjaThe problem of proving observability/detectability properties for selected non-linear uncertain model of biochemical processes has been addressed in this paper. In particular, the analysis of observability/detectability in the face of parametric and unstructured uncertainty in system dynamics transformed into unknown inputs, and unknown initial conditions has been performed. Various sets of system measured outputs were taken into...
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MGDG, PG and SQDG regulate the activity of light-dependent protochlorophyllide oxidoreductase
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Targeting of FLT3-ITD kinase contributes to high selectivity of imidazoacridinone C-1311 against FLT3-activated leukemia cells
PublikacjaDrugs targeting receptor tyrosine kinase FLT3 are of particular interest since activating FLT3-internal tandem duplication (ITD) mutations abundantly occur in fatal acute myeloid leukemias (AMLs). Imidazoacridinone C-1311, a DNA-reactive inhibitor of topoisomerase II, has been previously shown to be a potent and selective inhibitor of recombinant FLT3. Here, we expand those findings by studying its effect on leukemia cells with...
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PARP inhibition potentiates the cytotoxic activity of C-1305, a selective inhibitor of topoisomerase II, in human BRCA1-positive breast cancer cells
PublikacjaTwo cellular proteins encoded by the breast and ovarian cancer type 1 susceptibility (BRCA1 and BRCA2) tumor suppressor genes are essential for DNA integrity and the maintenance of genomic stability.Approximately 5-10% of breast and ovarian cancers result from inherited alterations or mutations in these genes.Remarkably, BRCA1/BRCA2-deficient cells are hypersensitive to selective inhibition of poly(ADPribose) polymerase 1 (PARP-1),...
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Diminshed toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells
PublikacjaThe narrow "therapeutic window" of anti-tumour therapy may be the result of drug metabolism leading to the activation or detoxification of antitumour agents. The aim of this work is to examine (i) whether the diminished toxicity of a potent antitumour drug, C-1748, 9-(2'-hydroxyethylamino)-4-methyl-1-nitroacridine, compared with its 4-demethyl analogue, C-857, results from the differences between the metabolic pathways for the...
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Increased cytotoxicity of an unusual DNA topoisomerase II inhibitor compound C-1305 toward HeLa cells with downregulated PARP-1 activity results from re-activation of the p53 pathway and modulation of mitotic checkpoints
PublikacjaOur previous studies have shown that murine fibroblast cells, in which PARP-1 gene was inactivated by gene disruption, are extremely sensitive to triazoloacridone compound C-1305, an inhibitor of DNA topoisomerase II with unusual properties. Here, we show that pharmacological inhibition of PARP-1 activity by its inhibitor compound NU1025, sensitizes human cervical carcinoma HeLa cells to compound C-1305 compared to treatment with...