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Wyniki wyszukiwania dla: CRYPTOCURRENCY MINING
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Highly Conserved Homotrimer Cavity Formed by the SARS-CoV-2 Spike Glycoprotein: A Novel Binding Site
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Synthesis and SAR Studies of Antibacterial Peptidyl Derivatives Based upon the Binding Site of Human Cystatin C
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Molecular dynamics study of a gelsolin-derived peptide binding to a lipid bilayer containing phosphatidylinositol 4,5-bisphosphate
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Specific Binding of Cholesterol to the Amyloid Precursor Protein: Structure of the Complex and Driving Forces Characterized in Molecular Detail
PublikacjaC99 is the C-terminal membrane-bound fragment of the amyloid precursor protein that is cleaved by γ-secretase to release Aβ peptides, the hallmark of Alzheimer’s disease (AD). Specific interactions of C99 with cholesterol have been proposed to underlie the recognized role of cholesterol in promoting amyloidogenesis. By using molecular dynamics simulations, we studied cholesterol binding to C99 in a lipid bilayer. We determined...
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Taq DNA polymerase fused with DNA binding protein with increased resistance to inhibitors from clinical samples
PublikacjaNowadays PCR method is commonly used in molecular diagnostic. However, in many cases PCR is limited, by the presence of inhibitory substances in biological, soil or food samples Efficiency and fidelity of amplification is strongly connected with DNA polymerase and reaction conditions. To meet the requirements of modern diagnostic methods it is essential to seeking for new DNA polymerases with better properties useful in these field....
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Identification and characterization of single-stranded DNA-binding protein from the facultative psychrophilic bacteria Pseudoalteromonas haloplanktis
PublikacjaSingle-stranded DNA-binding protein (SSB) plays an important role in DNA metabolism such as DNAreplication, repair, and recombination, and is essential for cell survival. This study reports on the ssb-likegene cloning, gene expression and characterization of a single-stranded DNA-binding protein of Pseudoal-teromonas haloplanktis (PhaSSB) and is the first report of such a protein from psychrophilic microorganism.PhaSSB possesses...
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In Vitro Studies on the Relationship Between the Antioxidant Activities of Some Berry Extracts and Their Binding Properties to Serum Albumin
PublikacjaThe aim of this study was to investigate the possibility to use the bioactive components from cape gooseberry (Physalis peruviana), blueberry (Vaccinium corymbosum), and cranberry (Vaccinium macrocarpon) extracts as a novel source against oxidation in food supplementation. The quantitative analysis of bioactive compounds (polyphenols, flavonoids, flavanols, carotenoids, and chlorophyll) was based on radical scavenging spectrophometric assays...
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Mapping the Structural and Dynamic Determinants of pH-Sensitive Heparin Binding to Granulocyte Macrophage Colony Stimulating Factor
PublikacjaGranulocyte macrophage colony stimulating factor (GMCSF) is an immunomodulatory cytokine that is harnessed as a therapeutic. GMCSF is known to interact with other clinically important molecules, such as heparin, suggesting that endogenous and administered GMCSF has the potential to modulate orthogonal treatment outcomes. Thus, molecular level characterization of GMCSF and its interactions with biologically active compounds is critical...
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Membrane Sterols Modulate the Binding Mode of Amphotericin B without Affecting Its Affinity for a Lipid Bilayer
PublikacjaMembrane-active antibiotics are known to selectively target certain pathogens based on cell membrane properties, such as fluidity, lipid ordering, and phase behavior. These are in turn modulated by the composition of a lipid bilayer and in particular by the presence and type of membrane sterols. Amphotericin B (AmB), the golden standard of antifungal treatment, exhibits higher activity toward ergosterol-rich fungal membranes, which...
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Highly Conserved Homotrimer Cavity Formed by the SARS-CoV-2 Spike Glycoprotein: A Novel Binding Site
PublikacjaAn important stage in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) life cycle is the binding of the spike (S) protein to the angiotensin converting enzyme-2 (ACE2) host cell receptor. Therefore, to explore conserved features in spike protein dynamics and to identify potentially novel regions for drugging, we measured spike protein variability derived from 791 viral genomes and studied its properties by molecular...
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Structure-activity relationship study of tetrapeptide inhibitors of the Vascular Endothelial Growth Factor A binding to Neuropilin-1
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Small-minus-big predicts betting-against-beta: Implications for international equity allocation and market timing
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Pharmacological characterization and binding modes of novel racemic and optically active phenylalanine-based antagonists of AMPA receptors
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Binding of anionic Pt(ii) complexes in a dedicated organic matrix: towards new binary crystalline composites
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QEEG-based neural correlates of decision making in a well-trained eight-year-old chess player
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Electron Binding Capabilities of Some Silylenes Having Small Singlet−Triplet Splittings or Triplet Ground States
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Strength of the Lewis–Brønsted Superacids Containing In, Sn, and Sb and the Electron Binding Energies of Their Corresponding Superhalogen Anions
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Finding the Right Solvent: A Novel Screening Protocol for Identifying Environmentally Friendly and Cost-Effective Options for Benzenesulfonamide
PublikacjaThis study investigated the solubility of benzenesulfonamide (BSA) as a model compound using experimental and computational methods. New experimental solubility data were collected in the solvents DMSO, DMF, 4FM, and their binary mixtures with water. The predictive model was constructed based on the best-performing regression models trained on available experimental data, and their hyperparameters were optimized using a newly...
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Fibronectin-, vitronectin- and laminin-binding proteins at the cell walls of Candida parapsilosis and Candida tropicalis pathogenic yeasts
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Molecular simulations study of ligand-release mechanism in an odorant-binding protein from the southern house mosquito
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Control of Luminescence by Tuning of Crystal Symmetry and Local Structure in Mn4+ -Activated Narrow Band Fluoride Phosphors
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Indirect Relationship between Alcoholics Anonymous Spirituality and Their Hopelessness: The Role of Meaning in Life, Hope, and Abstinence Duration
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Correlation between type of alkali rinsing, cytotoxicity of bio-nanocellulose and presence of metabolites within cellulose membranes
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Liver fatty acid-binding protein might be a predictive marker of clinical response to systemic treatment in psoriasis
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The meaning of cultural projects in the revitasation of urban Areas / Rola projektów kultury w rewitalizacji obszarów miejskich
PublikacjaArtykuł przedstawia rolę projektów kultury jako jednego z kluczowych czynników skutecznych działań rewitalizacyjnych.
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Novel single-stranded DNA-binding proteins from extreme psychrophilic bacterium Psychromonas ingrahamii 37
PublikacjaWe report the identification and characterization of the single-stranded DNA binding protein (SSB) from extreme psychrophilic bacterium Psychromonas ingrahamii 37 (PinSSB) that grows expotentially at -12°C and may well grow at even lower temperatures. PinSSB is one of the largest known bacterial SSB protein consisting 222 amino acid residues with a calculated molecular mass of 25.1 kDa. The analysis by gel filtration chromatography...
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A qualitative 5-country comparison of the perceived impacts of COVID-19 on people living with dementia and unpaid carers
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Met and unmet care needs of older people with dementia living at home: Personal and informal carers’ perspectives
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On making operational decisions with taking into account value of operation applied to ship main propulsion engine as an example
PublikacjaObiektywizm i racjonalność w podejmowaniu decyzji eksploatacyjnych, są podstawowymi warunkami umożliwiającymi ich optymalny wybór. Zmusza to, do stosowania ocen ilościowych rozpatrywanych kryteriów, a tym samym do poszukiwania takich wskaźników, które w danej sytuacji pozwolą uznać jedną z wielu rozpatrywanych decyzji za najbardziej odpowiednią.Dokładne określenie zadania dla systemu energetycznego (np. zadania transportowego dla...
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Time for a paradigm shift in shared decision-making in trauma and emergency surgery? Results from an international survey
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The estimation of cutting forces and specific force coefficients during finishing ball end milling of inclined surfaces
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Characterization of exceptionally thermostable single-stranded DNA-binding proteins from Thermotoga maritima and Thermotoga neapolitana
PublikacjaBACKGROUND: In recent years, there has been an increasing interest in SSBs because they find numerous applications in diverse molecular biology and analytical methods.RESULTS: We report the characterization of single-stranded DNA binding proteins (SSBs) from the thermophilic bacteria Thermotoga maritima (TmaSSB) and Thermotoga neapolitana (TneSSB). They are the smallest known bacterial SSB proteins, consisting of 141 and 142 amino...
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A Mechatronic System for Building the Map of Optimal Spindle Speeds During High Speed Milling of Flexible Details
PublikacjaW pracy przedstawiono mechatroniczny system tworzenia mapy optymalnych prędkości obrotowych wrzeciona w celu nadzorowania drgań typu chatter podczas frezowania szybkościowego przedmiotów podatnych. System ten składa się z części pomiarowej oraz części obliczeniowej, w której wykorzystuje się oprogramowanie autorskie i komercyjne. Na bazie uogólnionego warunku Liao-Younga utworzono mapy optymalnych prędkości obrotowych wrzeciona,...
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A decision-making system supporting selection of commanded outputs for a ship's propulsion system with a controllable pitch propeller
PublikacjaThe ship's operators have to make decisions regarding the values of commanded outputs (commanded engine speed and pitch ratio) which ensure maximum vessel speed and minimum fuel consumption. Obviously, the presented decision problems are opposed. Therefore, there is a need for a compromise solution that enables more flexible vessel voyage planning. This paper deals with development of a computer-aided system supporting selection...
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Rapid Design Tuning of Miniaturized Rat-Race Couplers Using Regression-Based Equivalent Network Surrogates
PublikacjaA simple technique for fast design tuning of compact rat-race couplers is presented. Our approach involves equivalent circuit representation, corrected by nonlinear functions of frequency with coefficients extracted through nonlinear regression. At the same time, the tuning process connects two levels of coupler representation: EM simulation of the entire circuit and re-optimization of the coupler building blocks (slow-wave cells...
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Combinatorial scheme of finding minimal number of periodic points for smooth self-maps of simply connected manifolds
PublikacjaLet M be a closed smooth connected and simply connected manifold of dimension m at least 3, and let r be a fixed natural number. The topological invariant D^m_r [f], defined by the authors in [Forum Math. 21 (2009), 491-509], is equal to the minimal number of r-periodic points in the smooth homotopy class of f, a given self-map of M. In this paper, we present a general combinatorial scheme of computing D^m_r [f] for arbitrary dimension...
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Fast EM-Driven Parameter Tuning of Microwave Circuits with Sparse Sensitivity Updates via Principal Directions
PublikacjaNumerical optimization has become more important than ever in the design of microwave components and systems, primarily as a consequence of increasing performance demands and growing complexity of the circuits. As the parameter tuning is more and more often executed using full-wave electromagnetic (EM) models, the CPU cost of the overall process tends to be excessive even for local optimization. Some ways of alleviating these issues...
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A Time Delay Controller Included Terminal Sliding Mode and Fuzzy Gain Tuning for Underwater Vehicle-Manipulator Systems
PublikacjaAn improved Time Delay Control (TDC) method for an Underwater Vehicle-Manipulator System (UVMS) is proposed. The proposed controller consists of three terms: a time-delay-estimation term that cancels nonlinearities of the UVMS dynamics, a Terminal Sliding Mode (TSM) term that provides a fast response and a PID term that reduces the tracking error. In addition the proposed controller uses fuzzy rules to adaptively tune the gains...
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Predicting Value of Binding Constants of Organic Ligands to Beta-Cyclodextrin: Application of MARSplines and Descriptors Encoded in SMILES String
PublikacjaThe quantitative structure–activity relationship (QSPR) model was formulated to quantify values of the binding constant (lnK) of a series of ligands to beta–cyclodextrin (β-CD). For this purpose, the multivariate adaptive regression splines (MARSplines) methodology was adopted with molecular descriptors derived from the simplified molecular input line entry specification (SMILES) strings. This approach allows discovery of regression...
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The Application of a Multi-Criteria Decision-Making for Indication of Directions of the Development of Renewable Energy Sources in the Context of Energy Policy
PublikacjaThis paper presents the application of multi-criteria decision-making (MCDM) for evaluating what technologies using renewable energy sources (RES) for electricity production have the chance to develop in Poland under the current socio-economic conditions. First, the Analytical Hierarchy Process (AHP) method was used to determine the weights of the optimization criteria. Five main criteria and 30 sub-criteria were identified. Next,...
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Tuning the Laser-Induced Processing of 3D Porous Graphenic Nanostructures by Boron-Doped Diamond Particles for Flexible Microsupercapacitors
PublikacjaCarbon (sp3)-on-carbon (sp2) materials have the potential to revolutionize fields such as energy storage and microelectronics. However, the rational engineering and printing of carbon-on-carbon materials on flexible substrates remains a challenge in wearable electronics technology. This study demon-strates the scalable fabrication of flexible laser-induced graphene (LIG)-boron doped diamond nanowall (BDNW) hybrid nanostructures...
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Study of a Multicriterion Decision-Making Approach to the MQL Turning of AISI 304 Steel Using Hybrid Nanocutting Fluid
PublikacjaThe enormous use of cutting fluid in machining leads to an increase in machining costs, along with different health hazards. Cutting fluid can be used efficiently using the MQL (minimum quantity lubrication) method, which aids in improving the machining performance. This paper contains multiple responses, namely, force, surface roughness, and temperature, so there arises a need for a multicriteria optimization technique. Therefore,...
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Tuning of the plasmon resonance location in Au nanostructures coated with a ultrathin film of Al2O3 – Optical measurements and FDTD simulations
PublikacjaThe Au nanostructures have been coated with an ultra-thin films of amorphous aluminium oxide. Optical absorption spectra show the influence of the thickness of Al2O3 on plasmon resonance wavelength. The observed red-shift of the resonance location with the increase of the thickness of the Al2O3 film, can be explained by the change in the dielectric function of this film. It allows control of the optical spectra of the coated particles....
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Molecular mechanism and energetics of coupling between substrate binding and product release in the F 1 -ATPase catalytic cycle
PublikacjaF1-ATPase is a motor protein that couples the rotation of its rotary γ subunit with ATP synthesis or hydrolysis. Single-molecule experiments indicate that nucleotide binding and release events occur almost simultaneously during the synthesis cycle, allowing the energy gain due to spontaneous binding of ADP to one catalytic β subunit to be directly harnessed for driving the release of ATP from another rather than being dissipated...
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Tuning Optical and Granulometric Properties of Gold Nanostructures Synthesized with the Aid of Different Types of Honeys for Microwave-Induced Hyperthermia
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Study of the influence of high-energy milling time on the Cu–13Al–4Ni alloy manufactured by powder metallurgy process
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Auto-tuning methodology for configuration and application parameters of hybrid CPU + GPU parallel systems based on expert knowledge
PublikacjaAuto-tuning of configuration and application param- eters allows to achieve significant performance gains in many contemporary compute-intensive applications. Feasible search spaces of parameters tend to become too big to allow for exhaustive search in the auto-tuning process. Expert knowledge about the utilized computing systems becomes useful to prune the search space and new methodologies are needed in the face of emerging heterogeneous...
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NUMERICAL SIMULATIONS OF HONING PROCESS OF THIN WALL CYLINDER LINERS, WITH CONSTANT AND WITH VARIABLE THICKNESS OF WALL OF HONED PARTS
PublikacjaNumerical simulations of honing process of thin-wall cylinder liners, with constant and with variable thickness of the wall of honed workpieces can improve and can help to conduct the experimental research of honing process and can improve the honing process. A very valuable research assumption, before performing the numerical analysis of computer simulation of honing process, is the measurement of the real geometry of the honing...
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Experimentally Aided Operational Virtual Prototyping to Predict Best Clamping Conditions for Face Milling of Large-Size Structures
PublikacjaVibrations occurring during milling operations are one of the main issues disturbing the pursuit of better efficiency of milling operations and product quality. Even in the case of a stable cutting process, vibration reduction is still an important goal. One of the possible solutions to obtain it is selection of the favorable conditions for clamping the workpiece to the machine table. In this paper, a method for predicting and...
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Rapid design of miniaturised branch-line couplers through concurrent cell optimisation and surrogate-assisted fine-tuning
PublikacjaIn this study, the authors introduce a methodology for low-cost simulation-driven design optimisation of highly miniaturised branch-line couplers (BLCs). The first stage of their design approach exploits fast concurrent optimisation of geometrically dependent, but electromagnetically isolated cells that constitute a BLC. The cross-coupling effects between the cells are taken into account in the second stage, where a surrogate-assisted...