Wyniki wyszukiwania dla: METABOLOME
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New plasma preparation approach to enrich metabolome coverage in untargeted metabolomics: plasma protein bound hydrophobic metabolite release with proteinase K
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Non-Targeted Metabolite Profiling Reveals Host Metabolomic Reprogramming during the Interaction of Black Pepper with Phytophthora capsici
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Coordinated reprogramming of renal cancer transcriptome, metabolome and secretome associates with immune tumor infiltration
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Metabolomic Insight into Polycystic Ovary Syndrome—An Overview
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Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects
PublikacjaSkin diseases such as psoriasis (Ps) and psoriatic arthritis (PsA) are immune-mediated inflammatory diseases. Overlap of autoinflammatory and autoimmune conditions hinders diagnoses and identifying personalized patient treatments due to different psoriasis subtypes and the lack of verified biomarkers. Recently, proteomics and metabolomics have been intensively investigated in a broad range of skin diseases with the main purpose...
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Metabolomic Signature of Early Vascular Aging (EVA) in Hypertension
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International Journal of Secondary Metabolite
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Nutrition Clinique et Metabolisme
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Metabolomic and antioxidant properties of different varieties and origins of Dragon fruit
PublikacjaDragon fruit has appealed much concern from consumers as a novelty fruit with potent nutritional and medicinal benefits. Dragon fruit quality warrants comprehensive evaluation, based on the contents of pigments and health- promoting natural compounds in different varieties. This study was aimed to evaluate the differences among dragon fruit varieties extracted with methanol–water (CD3OD-D2O) and methanol (CD3OD) by proton nuclear magnetic...
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Spektrometria mas jako narzędzie umożliwiające poznanie metabolomu-główne strategie i wyzwania
PublikacjaBadania z zakresu metabolomiki ukierunkowane są na wykrywanie i oznaczanie endogennych związków małocząsteczkowych o masie <1000 Da (np. aminokwasy, cukry, lipidy) w próbkach biologicznych takich jak płyny biologiczne (głównie krew i mocz) oraz kondensaty wydychanego powietrza. Ze względu na szerokie spektrum występowania i niskie poziomy stężeń metabolitów w próbkach, analizy metabolomiczne wymagają stosowania technik o wysokiej...
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Systemic Effects of Radiotherapy and Concurrent Chemo-Radiotherapy in Head and Neck Cancer Patients—Comparison of Serum Metabolome Profiles
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Completing Autophagy: Formation and Degradation of the Autophagic Body and Metabolite Salvage in Plants
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Urinary metabolomic signature of muscle-invasive bladder cancer: A multiplatform approach
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The Impact of Different Drying Methods on the Metabolomic and Lipidomic Profiles of Arthrospira platensis
PublikacjaDrying is an inseparable part of industrial microalgae production. In this work, the impacts of eight different drying methods on the metabolome and lipidome of Arthrospira platensis were investigated. The studied drying methods were freeze drying (FD), sun drying (SD), air drying at 40 and 75 °C (AD′ and AD″), infrared drying at 40 and 75 °C (IRD′ and IRD″), and vacuum drying at 40 and 75 °C (VD′ and VD″). Results gathered by...
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New supervised alignment method as a preprocessing tool for chromatographic data in metabolomic studies
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The Influence of Hydrodynamic Conditions in a Laboratory-Scale Bioreactor on Pseudomonas aeruginosa Metabolite Production
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Human red blood cells targeted metabolome analysis of glycolysis cycle metabolites by capillary electrophoresis using an indirect photometric detection method
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Paraffin-Embedded Tissue as a Novel Matrix in Metabolomics Study: Optimization of Metabolite Extraction Method
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Metabolomic approach for determination of urinary nucleosides as potential tumor markers using electromigration techniques
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Altered levels of nucleoside metabolite profiles in urogenital tract cancer measured by capillary electrophoresis
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Strategia analizy niecelowanej w metabolomice i lipidomice – aspekty praktyczne cz.2
PublikacjaStrategia analizy niecelowanej jest powszechnie wykorzystywana do analizy różnego rodzaju próbek biologicznych, takich jak tkanki czy płyny ustrojowe, w celu otrzymania „odcisku palca” oraz określenia różnic w składzie jakościowym oraz ilościowym pomiędzy badanymi próbkami. Wskazanie różnic w zawartości różnych biocząsteczek (peptydów, metabolitów, lipidów) pozwala na uzyskanie informacji na temat powiązania składu biochemicznego...
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Strategia analizy niecelowanej w metabolomice i lipidomice. Cz. 1. Aspekty praktyczne
PublikacjaStrategia analizy niecelowanej jest powszechnie wykorzystywana do analizy różnego rodzaju próbek biologicznych, takich jak tkanki czy płyny ustrojowe, w celu otrzymania „odcisku palca” oraz określenia różnic w składzie jakościowym oraz ilościowym pomiędzy badanymi próbkami. Wskazanie różnic w zawartości różnych biocząsteczek (peptydy, metabolity, lipidy) pozwala na uzyskanie informacji na temat powiązania składu biochemicznego...
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Metabolomic Heterogeneity of Urogenital Tract Cancers Analyzed by Complementary Chromatographic Techniques Coupled with Mass Spectrometry
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Seasonal pattern of vitamin D hydroxyl metabolite concentrations and their association with cardiac medications – An observational study
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Serum Metabolite Profiles in Participants of Lung Cancer Screening Study; Comparison of Two Independent Cohorts
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A targeted metabolomic protocol for quantitative analysis of volatile organic compounds in urine of children with celiac disease
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Selective determination of cocaine and its metabolite benzoylecgonine in environmental samples by newly developed sorbent materials
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Antifungal Activity of Capridine β as a Consequence of Its Biotransformation into Metabolite Affecting Yeast Topoisomerase II Activity
PublikacjaIn the last few years,increasing importance is attached to problems caused by fungal pathogens. Current methods of preventing fungal infections remain unsatisfactory. There are several antifungal compounds whichare highly effective in some cases, however, they have limitations in usage: Nephrotoxicity and other adverse effects. In addition, the frequent use of available fungistatic drugs promotes drug resistance....
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A new dilution-enrichment sample preparation strategy for expanded metabolome monitoring of human breast milk that overcomes the simultaneous presence of low- and high-abundance lipid species
PublikacjaThe complex nature of human breast milk (HBM) makes samples difficult to analyze, requiring several extraction techniques and analytical platforms to obtain high metabolome coverage. In this work, we combined liquid-liquid extraction (LLE) and solid-phase extraction (SPE) techniques to prepare HBM samples to overcome the challenge of low- and high-abundance lipid species, enabling the semiquantitative analysis of total HBM lipids...
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Induction of secondary metabolite production in transformated callus of Ammi majus L. grown after electromagnetic treatment of culture medium
PublikacjaW pracy przedstawiono wyniki badań, których celem było zbadanie wpływu elicytacji przy użyciu ADR-4, na produkcję metabolitów wtórnych. Elicytacja ADR-4 zwiększyła 2-krotnie zawartość bergaptenu. Porównano również efektywność 3 technik ekstrakcyjnych stosowanych do izolacji feuranokumaryn, kumaryn i ich glikozydów z kalusa A.majus. Ekstrakcja przy użyciu techniki ASE okazała się najbardziej efektywna.
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Urine metabolic fingerprinting using LC–MS and GC–MS reveals metabolite changes in prostate cancer: A pilot study
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Plasma free amino acid profiling as metabolomic diagnostic and prognostic biomarker in paediatric cancer patients: a follow‑up study
PublikacjaAmino acids (AAs) play a crucial role in cancer cell metabolism. Levels of 22 plasma AAs at the time of diagnosis and after treatment were established among 39 pediatric cancer patients and 33 healthy children. Glutamic acid levels decreased and tryptophan levels increased during treatment. Cancer patients presented significantly lower levels of glutamine and leucine post-treatment while levels of 12 other AAs were higher comparing...
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Correction to: Plasma free amino acid profiling as metabolomic diagnostic and prognostic biomarker in paediatric cancer patients: a follow-up study
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Toxic potencies of metabolite(s) of non-cylindrospermopsin producing Cylindrospermopsis raciborskii isolated from temperate zone in human white cells
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Dodecanol, metabolite of entomopathogenic fungus Conidiobolus coronatus, affects fatty acid composition and cellular immunity of Galleria mellonella and Calliphora vicina
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State of the art in sample preparation for human breast milk metabolomics—merits and limitations
PublikacjaHuman breast milk (HBM) contains metabolites that are diverse in chemical structure and concentration. These metabolites range from high-abundance to low-abundance compounds and from polar to nonpolar. This complex nature of HBM makes HBM samples difficult to analyze, especially in global metabolomic studies for the determination and characterization of complete sets of metabolites. In this review, the state of the art in sample...
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Octanoic Acid—An Insecticidal Metabolite of Conidiobolus coronatus (Entomopthorales) That Affects Two Majors Antifungal Protection Systems in Galleria mellonella (Lepidoptera): Cuticular Lipids and Hemocytes
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Applied Physiology Nutrition and Metabolism-Physiologie appliquee nutrition et metabolisme
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3-Methoxytyramine Is the Major Metabolite of Released Dopamine in the Rat Frontal Cortex: Reassessment of the Effects of Antipsychotics on the Dynamics of Dopamine Release and Metabolism in the Frontal Cortex, Nucleus Accumbens, and Striatum by a Simple T
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Silicon’s Influence on Polyphenol and Flavonoid Profiles in Pea (Pisum sativum L.) under Cadmium Exposure in Hydroponics: A Study of Metabolomics, Extraction Efficacy, and Antimicrobial Properties of Extracts
PublikacjaThe current study aimed to investigate the impact of silicon (Si) supplementation in the form of Na2SiO3 on the metabolome of peas under normal conditions and following exposure to cadmium (Cd) stress. Si is known for its ability to enhance stress tolerance in various plant species, including the mitigation of heavy metal toxicity. Cd, a significant contaminant, poses risks to...
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Agata Kot-Wasik prof. dr hab. inż.
OsobyAgata Kot-Wasik, urodzona w 1964 r. w Siedlcach (woj. mazowieckie), ukończyła studia magisterskie w 1988 r. na Wydziale Chemicznym Politechniki Gdańskiej, w specjalności Analityka Techniczna i Przemysłowa. W latach 1988–1992 była zatrudniona w Katedrze Chemii Organicznej na macierzystym wydziale na stanowisku naukowo-technicznym. W 1990 r. ukończyła na PG studia podyplomowe „Techniki Instrumentalne w Analizie Śladów i Ochronie...
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Budesonide treatment of professional athletes and anti-doping testing- case studies
PublikacjaAccording to the World Anti-Doping Agency (WADA) Prohibited List, glucocorticosteroids are prohibited in competition and only when administered by oral, intravenous, intramuscular or rectal routes. Up to now, in order to differentiate whether glucocorticosteroids were administered by one of the prohibited routes or not, a specific reporting limit for urinary concentrations of parent compounds and their metabolites was established...
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Phase I and phase II metabolism simulation of antitumor-active 2-hydroxyacridinone with electrochemistry coupled on-line with mass spectrometry.
PublikacjaHere, we report the metabolic profile and the results of associated metabolic studies of 2-hydroxyacridinone (2-OH-AC), the reference compound for antitumor-active imidazo- and triazoloacridinones. Electrochemistry coupled with mass spectrometry was applied to simulate the general oxidative metabolism of 2-OH-AC for the first time. The reactivity of 2-OH-AC products to biomolecules was also examined. The usefulness of the electrochemistry...
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Histaminol and Its Complexes with Copper(II) - Studies in Solid State and Solution
PublikacjaHistaminol [4(5)-(B-hydroxyethyl)imidazole, 4-(1H-imidazol-2-yl)ethanol, L] is an analogue of histamine and its minor metabolite. So far its properties have not been studied in detail due to the synthetic difficulties. Here, the structure and acid-base properties of histaminol, as well as the results of studies on its copper(II) complexes in solid state and aqueous solution are reported. Stability constants of the histaminol–CuII...
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Diminshed toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells
PublikacjaThe narrow "therapeutic window" of anti-tumour therapy may be the result of drug metabolism leading to the activation or detoxification of antitumour agents. The aim of this work is to examine (i) whether the diminished toxicity of a potent antitumour drug, C-1748, 9-(2'-hydroxyethylamino)-4-methyl-1-nitroacridine, compared with its 4-demethyl analogue, C-857, results from the differences between the metabolic pathways for the...
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Determination of bromhexine and its metabolites in equine serum samples by liquid chromatography – Tandem mass spectrometry: Applicability to the elimination study after single oral dose
PublikacjaBromhexine (BH), expectorant used in the treatment of respiratory disorders associated with viscid or excessive mucus, is not permitted for use in the competing horse by many authorities in horseracing and Olympic disciplines. Metabolic studies are of the great importance in anti-doping field because they allow for updating the selection of the most appropriate markers for prohibited substances, such as metabolites present at higher...
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The study of the influence of ZnO nanoparticles on pyocyanin production - the optimization of production and the study of the physiological response of the cells
Dane BadawczeThis dataset presents the in-depth analysis of the influence of zinc oxide nanoparticles on pyocyanin production.
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Main strategies, analytical trends and challenges in LC-MS and ambient mass spectrometry-based metabolomics
PublikacjaA plethora of analytical LC-MS-based methods have been successfully applied to analyses of complex samples of various origin for metabolomics investigations. Over the last ten years, the substantial evolution of ambient mass spectrometry (AMS) techniques has highlighted their tremendous potential in metabolomic studies due to the minimal sample pretreatment requirement and the ability to analyse samples in their native state. This...
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Glutathione conjugation of the antitumor-active 1-nitroacridine derivatives compounds C-857 and C-1748 – the major role of glutathione S-transferase M1-1
Dane BadawczeObjectives: C-857 and C-1748 are antitumor-active agents, monomers of unsymmetrical bisacridine derivatives. The aim of this study was to analyze their glutathione (GSH) conjugation in vitro in the presence of glutathione S-transferase (GST) M1-1.
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Mitochondrial DNA copy number and trimethylamine levels in the blood: New insights on cardiovascular disease biomarkers
PublikacjaAmong cardiovascular disease (CVD) biomarkers, the mitochondrial DNA copy number (mtDNAcn) is a promising candidate. A growing attention has been also dedicated to trimethylamine-N-oxide (TMAO), an oxidative derivative of the gut metabolite trimethylamine (TMA). With the aim to identify biomarkers predictive of CVD, we investigated TMA, TMAO, and mtDNAcn in a population of 389 coronary artery disease...