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Search results for: Cell-Penetrating Peptide
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High performance LaNi1-xCoxO3-δ (x = 0.4 to 0.7) infiltrated oxygen electrodes for reversible solid oxide cells
PublicationOxygen electrodes prepared by infiltration of yttria stabilized zirconia backbone with Ce0.8Gd0.2O1.95 barrier layer and LaNi1-xCoxO3-δ (x=0.4 to 0.7) catalyst for application in reversible solid oxide cells have been studied. The effect of temperature and Ni:Co ratio on their phase composition, microstructure and electrochemical properties are discussed. It was shown that oxygen electrodes infiltrated with LaNi0.5Co0.5O3-δ had...
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Synthesis of green benzamide-decorated UiO-66-NH2 for biomedical applications
PublicationMetal-organic frameworks (MOFs) biocompatible systems can host enzymes/bacteria/viruses. Herein we synthesized a series of fatty acid amide hydrolase (FAAH)-decorated UiO-66-NH2 based on Citrus tangerine leaf extract for drug delivery and biosensor applications. Five chemically manipulated FAAH-like benzamides were localized on the UiO-66-NH2 surface with physical interactions. Comprehensive cellular and molecular analyses were...
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Diamond Nanofilm Normalizes Proliferation and Metabolism in Liver Cancer Cells
PublicationPurpose: Surgical resection of hepatocellular carcinoma can be associated with recurrence resulting from the degeneration of residual volume of the liver. The objective was to assess the possibility of using a biocompatible nanofilm, made of a colloid of diamond nanoparticles (nfND), to fill the side after tumour resection and optimize its contact with proliferating liver cells, minimizing their cancerous transformation. Methods:...
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Technologie wytwarzania żywności funkcjonalnej i metodyki badania jej składu.- cz. II
PublicationObserwuje się rozwój technologii produkcji żywności w kierunku wzmocnienia funkcji jej składników. Na podstawie studium literaturowego stwierdzono, że nastąpił coraz bardziej zauważalny postęp w dziedzinie nanotechnologii, której metody są przydatne w procesach produkcji żywności bezpiecznej, o dłuższym terminie przydatności do spożycia, podwyższonych walorach sensorycznych oraz z dodatkiem związków biologicznie aktywnych. Żywność...
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Novel N-(aryl/heteroaryl)-2-chlorobenzenesulfonamide derivatives: synthesis and anticancer activity evaluation
PublicationA new series of N-(aryl/heteroaryl)-2-chlorobenzenesulfonamide derivatives 4-21 have been synthesized, and evaluated at the National Cancer Institute (USA) for their in vitro activities against a panel of 60 different human cancer cell lines. Among them, compounds 16, 20 and 21 exhibited remarkable cytotoxic activity against numerous human cancer cell lines. We found that sulfonamide derivative 21 appeared to be more selective...
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Investigation of catalytic layers on anode for solid oxide fuel cells operating with synthetic biogas
PublicationIn this paper solid oxide fuel cells operating with dry synthetic biogas have been examined. In order to increase their stability the layers of CuO-CeO2, Cu1.3Mn1.7O4 and Y0.08Sr0.92Ti0.8Fe0.2O3 -δ have been deposited on the Ni-YSZ anode site. These layers should catalyze the internal biogas reforming and prevent the carbon deposition on the anode site. It has been found that CuO-CeO2 and Cu1.3Mn1.7O4 catalysts led to an increase...
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Interpolation methods in GPR tomographic imaging of linear and volume anomalies for cultural heritage diagnostics
PublicationThis paper presents results of a ground penetrating radar (GPR) survey conducted in St. Joseph’s Church in Gdańsk, Poland. The aim of the study was to produce tomographic imaging of a renovated floor as well as the objects buried under the floor to detect linear and volume inclusions. The assumed track spacing was meaningfully greater than the single signal spacing in each track, which induced the need for interpolation methods...
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High-performance NdSrCo2O5+δ–Ce0.8Gd0.2O2-δ composite cathodes for electrolyte-supported microtubular solid oxide fuel cells
PublicationNdSrCo2O5+δ (NSCO) is a perovskite with an electrical conductivity of 1551.3 S cm−1 at 500 °C and 921.7 S cm−1 at 800 °C and has a metal-like temperature dependence. This perovskite is used as the cathode material for Ce0.8Gd0.2O2-δ (GDC)-supported microtubular solid oxide fuel cells (MT-SOFCs). The MT-SOFCs fabricated in this study consist of a bilayer anode, comprising a NiO–GDC composite layer and a NiO layer, and a NSCO–GDC...
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Allocation of tools to machines in a flexible machining cell. W: Computerintegrated manufacturing. Advanced design and management. Ed.: B. Skołud, D. Krenczyk. Warszawa: Wydaw. Nauk.-Tech.**2003 s. 486-493, 5 rys. 2 tabl.bibliogr. 10 poz. Przydział narzędzi do obrabiarek w elastycznym gnieździe obróbkowym.
PublicationPrzedstawiono zagadnienia modelowania i analizy przepływu narzędzi w wielo-maszynowym elastycznym gnieździe, zorientowanym na wytwarzanie przedmiotów klasy korpus. Zaproponowano oryginalną metodę i algorytmy współbieżnego sze-regowania zadań produkcyjnych i przydziału narzędzi w warunkach ograniczono-ści zasobów systemu. Wybrane strategie przydziału operacji technologicznych i adekwatnych zestawów narzędziowych poddano analizie...
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Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models
PublicationThe proteasome has key roles in neuronal proteostasis, including the removal of misfolded and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity. Proteasome dysfunction is a prominent feature of Alzheimer’s disease (AD). We show that prevention of proteasome dysfunction by genetic manipulation delays mortality, cell death, and cognitive deficits in fly and cell culture AD models. We developed...
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Tuning Electrochemical Performance by Microstructural Optimization of the Nanocrystalline Functional Oxygen Electrode Layer for Solid Oxide Cells
PublicationFurther development of solid oxide fuel cell (SOFC) oxygen electrodes can be achieved through improvements in oxygen electrode design by microstructure miniaturisation alongside nanomaterials implementation. In this work, improved electrochemical performance of an La0.6Sr0.4Co0.2Fe0.8O3-d (LSCF) cathode was achieved by the controlled modification of the La0.6Sr0.4CoO3-d (LSC) nanocrystalline interlayer introduced between a porous...
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Ocena wpływu pokarmowych kwasów nukleinowych i ich komponentów na replikacyjną i naprawczą syntezę DNA w modelach komórek ludzkiego układu pokarmowego
PublicationKwasy nukleinowe, do których należą DNA i RNA, są podstawowymi elementami każdej komórki niezbędnymi do prawidłowego funkcjonowania organizmu. Pomimo, że cząsteczki te stanowią również nieodłączne składniki produktów żywnościowych spożywanych przez człowieka, to badania na temat ich zawartości w żywności oraz wartości odżywczej są ograniczone. Wyniki uzyskane w niniejszej pracy doktorskiej pokazały istotne różnice w ilości, wielkości...
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A novel in vitro assay for assessing efficacy and toxicity of antifungals using human leukaemic cells infected with Candida albicans
PublicationAims: This study describes a novel in vitro assay that simultaneously determines antifungal efficiency and host cell toxicity using suspensions of human leukaemic cells (HL-60) infected with Candida albicans. Methods and Results: The effect of Candida infection on host cell viability was evaluated by the microscopy of trypan blue-stained cells and lactate dehydrogenase (LDH) activity. The in vitro ‘drug potency assay’ utilized...
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Biochemical, Structural Analysis, and Docking Studies of Spiropyrazoline Derivatives
PublicationIn this study, we evaluated the antiproliferative potential, DNA damage, crystal struc‐ tures, and docking calculation of two spiropyrazoline derivatives. The main focus of the research was to evaluate the antiproliferative potential of synthesized compounds towards eight cancer cell lines. Compound I demonstrated promising antiproliferative properties, especially toward the HL60 cell line, for which IC50 was equal to 9.4 μM/L....
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Koncepcja i modelowanie wysokoobrotowego napędu elektrycznego turbosprężarki. Zastosowanie w ogniwach paliwowych pojazdów samochodowych
PublicationAbstract: Electrical vehicles powered by hydrogen fuel cells become a potential alternative to conventional vehicles. The polymer electrolyte membrane (PEM) are typical fuel cells used in fuel cell vehicle (FCV). The global efficiency of a PEM fuel cell stack is greatly impacted by the use of a motorized compressor for the air supply system. The motor-compressor set-up may consume up to 19 % of the energy supplied by the PEM fuel...
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Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models
PublicationThe proteasome has key roles in neuronal proteostasis, including the removal of misfolded and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity. Proteasome dysfunction is a prominent feature of Alzheimer’s disease (AD). We show that prevention of proteasome dysfunction by genetic manipulation delays mortality, cell death, and cognitive deficits in fly and cell culture AD models. We developed...
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Building a Nest by an Automaton
PublicationA robot modeled as a deterministic finite automaton has to build a structure from material available to it. The robot navigates in the infinite oriented grid $Z x Z$. Some cells of the grid are full (contain a brick) and others are empty. The subgraph of the grid induced by full cells, called the {\em field}, is initially connected. The (Manhattan) distance between the farthest cells of the field is called its {\em span}. The robot...
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Effective Drug Concentration and Selectivity Depends on Fraction of Primitive Cells
PublicationPoor efficiency of chemotherapeutics in the eradication of Cancer Stem Cells (CSCs) has been driving the search for more active and specific compounds. In this work, we show how cell density-dependent stage culture profiles can be used in drug development workflows to achieve more robust drug activity (IC50 and EC50) results. Using flow cytometry and light microscopy, we characterized the cytological stage profiles of the HL-60-,...
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Cytocompatibility of stabilized black phosphorus nanosheets tailored by directly conjugated polymeric micelles for human breast cancer therapy
PublicationThe novel procedure of few-layer black phosphorus (FLBP) stabilization and functionalisation was here proposed. The cationic polymer PLL and non-ionic PEG have been involved into encapsulation of FLBP to allow sufficient time for further nanofabrication process and overcome environmental degradation. Two different spacer chemistry was designed to bind polymers to tumor-homing peptides. The efficiency of functionalisation was examined...
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Alternative Energy: Photovoltaic Solar Cells
PublicationSolar radiation is a fuel for photovoltaic cells and modules, which are a source of electric energy. Viable solar technologies that have been developed in the past are starting to be adopted on a broader and more meaningful global scale across different sectors with ever-increasing market penetration. In this entry, a brief overview of the material properties relevant to solar cell operation, the structure of the solar cell, and electrical...
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Design and synthesis of new analogues of batracylin linked to tuftsin and retro-tuftsin derivatives
PublicationThe synthesis of derivatives of batracylin with several peptides was elaborated followed by their cytotoxic activity investigation.
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In vitro evaluation of novel lipopeptides with potential therapeutic application
PublicationThe synthesis of derivatives of Gly-His-Lys was elaborated followed by their antimicrobial activity investigation.
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Introduction of Pro and Its Analogues in the Conserved P1 Position of Trypsin Inhibitor SFTI-1 Retains Its Inhibitory Activity
PublicationA number of monocyclic SFTI-1 analogues modified in the conserved inhibitor P1 position by Pro, its L-hydroxyproline (Hyp) derivative as well as mimetics with different ring size were synthesized by the solid-phase method. Replacement of Ser6 by Pro, Hyp, and a four-member ring, L-azetidine-2-carboxylic acid (Aze), retained trypsin or chymotrypsin inhibitory activity. The determined association equilibrium constants of these analogues...
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Therapy-Related Changes in the Serum Proteome Patterns of Early Stage Breast Cancer Patients with Different Outcomes
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Lipopeptides - synthesis and their properties
PublicationZaprezentowano syntezę nowych pochodnych tripeptydu Gly-Hyp-Lys o potencjalnie lepszych właściwościach lipofilowych. Modyfikacje polegały na acylowaniu N-końca glicyny kwasami tłuszczowymi (np. palmitynowym i stearynowym). Syntezę lipopeptydów zawierających fragment Gly-X-Y (gdzie: X= Met,Hyp,Hyp-Met,Gly-Hyp; Y=Lys,D-Lys) przeprowadzono na fazie stałej z zastosowaniem procedury Fmoc. Do wydłużanie łańcucha peptydowego zastosowano...
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Biological activity of conjugates of muramyl dipeptides with batracylin derivatives
PublicationZaprezentowano immunomodulacyjne właściwości nowych koniugatów batracyliny (BAT) z pochodnymi muramylodipeptydów wobec subpopulacji leukocytów krwi obwodowej hodowanych w obecności komórek linii nowotworowych. Leukocyty izolowane były z krwi obwodowej uzyskanej od zdrowych ochotników. Zbadane koniugaty MDP lub nor-MDP z batracyliną wykazały silniejsze własności hamujące proliferację komórek wybranych linii nowotworowych (K562,...
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Synthesis of conjugates of muramyl dipeptide and nor-muramyl dipeptide derivatives with adenosine as potential immunosuppressant
PublicationZaprezentowano syntezę koniugatów adenozyny z pochodnymi muramylo- i nor-muramylodipeptydów zawierających w części peptydowej D-aminokwasy (D-Ala, D-Val, D-Ser, D-Pro, D-2-ABA). Jako substrat zastosowano rybozyd 6-chloropuryny, który łączono poprzez 1,2-diaminoetan z odpowiednimi pochodnymi MDP lub nor-MDP w obecności EDCI i HOBt. Struktury otrzymanych związków zostały potwierdzone widmami 1H i 13C NMR (500 MHz), widmami MS oraz...
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Synthesis and SAR Studies of Antibacterial Peptidyl Derivatives Based upon the Binding Site of Human Cystatin C
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Novel analogues of bradykinin conformationally restricted in the C-terminal part of the molecule
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Analogues of Trypsin Inhibitor SFTI-1 with Disulfide Bridge Substituted by Various Length of Carbonyl Bridges
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Synthesis of conjugates of MDP and nor-MDP linked to tuftsin derivatives as potential immunomodulators
PublicationZsyntetyzowano nowe koniugaty muramylodipeptydu (MDP) i nor-muramylo-dipeptydu (nor-MDP) z pochodnymi tuftsyny zawierającymi wiązanie izopeptydowe na epsilon-aminowej grupie lizyny jako potencjalne immunomodulatory. Do syntezy wykorzystano metodę mieszanych bezwodników z chloromrówczanem izobutylu i N-metylomorfoliną w bezwodnym DMF. Końcowe produkty charakteryzowno za pomocą NMR, analizy elementarnej i analizy aminokwasowej na...
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Solid phase synthesis and biological activity of linear tuftsin and retro-tuftsin derivatives
PublicationPrzedstawiono syntezę na fazie stałej nowych pochodnych tuftsyny i retro-tuftsyny i ich mikrobiologiczne właściwości. Otrzymane pochodne zawierały wiązanie izopeptydowe między epsilon-aminową grupą lizyny a takimi aminokwasami jak: Ala, beta-Ala, Val, Ile, Gly.
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Solid phase synthesis of conjugates of tuftsin analogues with 1-nitro-acridine derivatives
PublicationZsyntetyzowano na fazie stałej koniugaty 1-nitro-akrydyny z pochodnymi tuftsyny modyfikowanymi na grupie epsilon-aminowej lizyny prostymi aminokwasami, np. alaniną, valiną, beta-alaniną. Końcowe produkty były charakteryzowane za pomocą MS, NMR, analizy elementarnej i przekazane do badań ich aktywności przeciwnowotworowej.
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Solid phase synthesis of 4,5,8-trihydroxy-9,10-anthraquinone-1-yl-(tuftsin or retro-tuftsin) derivatives
PublicationPrzedstawiono syntezę na fazie stałej połączeń leuko-1,4,5,8-tetra-hydroksyantrachinonów z pochodnymi tuftsyny i retro-tuftsyny zawierającymi wiązanie izopeptydowe. Do syntezy wykorzystano standardową metodę Fmoc i DIC jako odczynnik aktywujący.
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Molecular dynamics study of amyloid formation of two Abl-SH3 domain peptides
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Synthesis, activity on NK-3 tachykinin receptor and conformational solution studies of scyliorhinin II analogs modified at position 16
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Conformational studies of vasopressin and mesotocin using NMR spectroscopy and molecular modelling methods. Part II: studies in the SDS micelle
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Vasopressin V2 receptor/bioligand interactions
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Conformation-activity relationships ofcyclo-constrained µ/δ opioid agonists derived from theN-terminal tetrapeptide segment of dermorphin/deltorphin
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Solution conformational study of Scyliorhinin I analogues with conformational constraints by two-dimensional NMR and theoretical conformational analysis
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Computer modeling of the solution conformation of cyclic enkephalins
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Molecular Simulations of Rhodopsin Tetrameter
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Deltorphin analogs restricted via a urea bridge: structure and opioid activity
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Conformational studies of neurohypophyseal hormones analogues with glycoconjugates by NMR spectroscopy
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Synthesis, biological activity and conformational analysis of head-to-tail cyclic analogues of LL37 and histatin 5
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Solution conformations of bradykinin antagonists modified with CαCα cyclized nonaromatic residues
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Interactions of vasopressin and oxytocin receptors with vasopressin analogues substituted in position 2 with 3,3′-diphenylalanine - a molecular docking study
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Conformational studies of highly potent 1-aminocyclohexane-1-carboxylic acid substituted V2 vasopressin agonists
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Effect of head-to-tail cyclization on conformation of histatin-5
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Conformational studies of vasopressin and mesotocin using NMR spectroscopy and molecular modelling methods. Part I: studies in water
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