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Search results for: BIOLOGICAL ACTIVE PEPTIDES
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Deep slot effect in the squirrel-cage induction motors with scalar (V/F) control
PublicationQualitative characteristics of the electrical drive considerably depend on identification accuracy of math model parameters. In particular, it is depend on detection accuracy of stator active resistance r1 that is used in calculation of flux linkages, rotary speed in sensorless control systems. Paper provides analysis of influence of stator deep slot effect to stator active resistance value
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Obrony prac doktorskich na Wydziale Chemicznym
EventsDn. 21.01.2022 r. o godz. 10.15 w Audytorium 1.4 Wydziału Chemicznego PG (budynek nr 5) odbędzie się w trybie hybrydowym publiczna obrona pracy doktorskiej mgr inż. Moniki Baranowskiej
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Types of Treatment Wetlands
PublicationThe removal of pollutants in treatment wetland systems is the result of the sorption of biochemical pollutants, redox reactions, and a biological activity of microorganisms as well as hydrophytes plants.
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Methods of ZnO nanoparticles synthesis
PublicationZinc oxide nanostructures are interesting nanomaterials with a wide range of applications. Since the physical and chemical properties of ZnO nanoparticles are influenced both by their shape and size, a control of morphology of ZnO structures is needed for their commercial usage. Different chemical, physical, and biological methods used to produce ZnO nanostructures can be found in the literature. The production of ZnO nanoparticles...
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Rafał Ossowski dr inż.
PeopleRafał Ossowski (born June 8th, 1973 in Chojnice) – expert in soil mechanics and geotechnics, mainly in field of numerical modeling and research on anthropogenic soils. Author and coauthor of publications on numerical modeling in soil mechanics, field soil investigation and application of anthropogenic soils in context of so-called "green geotechnics". In 1992–1997 he studied at the Faculty of Hydrotechnics GUT (renamed: Faculty...
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The characterization of collagen‑based scaffolds modified with phenolic acids for tissue engineering application
PublicationThe aim of the experiment was to study the morphology of collagen-based scaffolds modified by caffeic acid, ferulic acid, and gallic acid, their swelling, and degradation rate, as well as the biological properties of scaffolds, such as antioxidant activity, hemo- and cytocompatibility, histological observation, and antibacterial properties. Scaffolds based on collagen with phenolic acid showed higher swelling rate and enzymatic...
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Prophylaxis of Non-communicable Diseases: Why Fruits and Vegetables may be Better Chemopreventive Agents than Dietary Supplements Based on Isolated Phytochemicals?
PublicationThe World Health Organization (WHO) report from 2014 documented that non-communicable socalled civilization diseases such as cardiovascular disease, chronic respiratory diseases, cancer or type 2 diabetes are responsible for over 50% of all premature deaths in the world. Research carried out over the past 20 years has provided data suggesting that diet is an essential factor influencing the risk of development of these diseases....
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Possibilities of Leachate Co-Treatment Originating from Biogas Production in the Deammonification Process
PublicationIn the methane fermentation process, sewage sludge is the single substrate or serves as a co-substrate with the addition of various waste products. After the treatment stable digestate is obtained, which consists of two phases solid and liquid. Liquid phase, called as a leachate, due to the high content of nutrients must be treated before they are discharged into the final receiver. Physical and chemical methods of leachate treatment...
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In vitro enzyme kinetics and NMR-based product elucidation for glutathione S-conjugation of the anticancer unsymmetrical bisacridine C-2028 in liver microsomes and cytosol: major role of glutathione S-transferase M1-1 isoenzyme
PublicationThis work is the next step in studying the interplay between C-2028 (anticancer-active unsymmetrical bisacridine developed in our group) and the glutathione S-transferase/glutathione (GST/GSH) system. Here, we analyzed the concentration- and pH-dependent GSH conjugation of C-2028 in rat liver microsomes and cytosol. We also applied three recombinant human GST isoenzymes, which altered expression was found in various tumors. The...
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Wear of Electroplated Tools Used for Flat Grinding of Ceramics
PublicationTwo methods for the abrasive properties evaluation, based on the image processing, are presented in the paper. Image processing analysis was developed to evaluate quickly the abrasive properties as the tool wears down. The coefficient based on the image brightness was calculated and additional analysis was based on the number of grains located on the active surface of the tool before and after machining. The active surfaces of...
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Diamond-based protective layer for optical biosensors
PublicationOptical biosensors have become a powerful alternative to the conventional ways of measurement owing to their great properties, such as high sensitivity, high dynamic range, cost effectiveness and small size. Choice of an optical biosensor's materials is an important factor and impacts the quality of the obtained spectra. Examined biological objects are placed on a cover layer which may react with samples in a chemical, biological...
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Biomechanical properties of 3D-printed bone models
PublicationBone lesions resulting from large traumas or cancer resections can be successfully treated by directly using synthetic materials or in combination with tissue engineering methods (hybrid). Synthetic or hybrid materials combined with bone tissue’s natural ability for regeneration and biological adaptation to the directions of loading, allow for full recovery of its biological functions. Increasing interest in new production methods...
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Peptide dendrimers as antifungal agents and carriers for potential antifungal agent—N3‐(4‐methoxyfumaroyl)‐(S)‐2,3‐ diaminopropanoic acid—synthesis and antimicrobial activity
PublicationA series of peptide dendrimers and their conjugates with antimicrobial agent FMDP (N3‐(4‐methoxyfumaroyl)‐(S)‐2,3‐diamino‐propanoic acid) were synthesized. The obtained compounds were tested for the antibacterial and antifungal activity. All novel dendrimers displayed much better activity against the tested strains than FMDP itself. Moreover, their conjugates with FMDP also exhibited antimicrobial activity. The most promising molecules...
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Finite Element Approaches to Model Electromechanical, Periodic Beams
PublicationPeriodic structures have some interesting properties, of which the most evident is the presence of band gaps in their frequency spectra. Nowadays, modern technology allows to design dedicated structures of specific features. From the literature arises that it is possible to construct active periodic structures of desired dynamic properties. It can be considered that this may extend the scope of application of such structures. Therefore,...
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Evidence for solid state electrochemical degradation within a small molecule OLED
PublicationAcridone derivative have been synthesised and used as OLED (Organic Light Emitting Diode) emitters which were found to be electroactive. Electrochemical investigations showed a side reaction takes place inside an active layer which diminished the overall device efficiency. By using a dopant and host active layer architecture, the formation of the by product was removed. The by-product was identified as a σ-dimer formed inside an...
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Therapeutic Potential of Multifunctional Tacrine Analogues
PublicationTacrine is a potent inhibitor of cholinesterases (acetylcholinesterase and butyrylcholinesterase) that shows limiting clinical application by liver toxicity. In spite of this, analogues of tacrine are considered as a model inhibitor of cholinesterases in the therapy of Alzheimer’s disease. The interest in these compounds is mainly related to a high variety of their structure and biological properties. In the present review, we...
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Urban Design Project III 2021/22
e-Learning CoursesNOWY - Nowy Świat 2.0 – BUILDING THE HEART OF AN ACTIVE NEIGHBORHOOD Friday 13.15-16.00 dr hab. inż. arch. J. Martyniuk – Pęczek, prof. uczelni arch. Rana Rizi
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Effects of liquid phase modification on the values of surface tension of trickling liquid
Open Research DataDataset presents the values of surface tension of trickling liquid sampled from three running biotrickling filters.
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Pre-analytical aspects in metabolomics of human biofluids – sample collection, handling, transport, and storage
PublicationMetabolomics is the field of omics research that offers valuable insights into the complex composition of biological samples. It has found wide application in clinical diagnostics, disease investigation, therapy prediction, monitoring of treatment efficiency, drug discovery, or in-depth analysis of sample composition. A suitable study design constitutes the fundamental requirements to ensure robust and reliable results from the...
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A universal NDT method for examination of low energy impact damage in CFRP with the use of TLC film
PublicationThe article presents an attempt to use a sheet of laminated thermochromic liquid crystal film (TLC film) for non-destructive testing of the impact damage (energy values: 1J, 2J, 3J and 4J) in carbon fibre-reinforced polymer (CFRP). This is a new, alternative NDT approach based on the thermo-optical effect. The main advantages of this method are a) the low cost of TLC film, b) the low cost of recording devices due to the usage of...
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A new finite element with variable Young's modulus
PublicationThe Finite Element Method (FEM) is a numerical technique that is well-established in the field of engineering. However, in biological sciences, it is justtaking its first steps. Bone tissue is an example of biological material which isexposed to high loads in its natural environment. Practically every movementof the body results in changing stress levels in the bone. Nature copes with thisvery well but when human intervention is...
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Intelligence Augmentation and Amplification: Approaches, Tools, and Case Studies
PublicationMost experts agree that truly intelligent artificial system is yet to be developed. The main issue that still remains a challenge is imposing trust and explainability into such systems. However, is full replication of human intelligence really desirable key aim in intelligence related technology and research? This is where the concept of augmented intelligence comes into play. It is an alternative conceptualization of artificial...
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Simulation Studies of Control Systems for Doubly Fed Induction Generator Supplied by the Current Source Converter
PublicationThe control system for a Doubly Fed Induction Generator (DFIG) supplied by a grid-connected Current Source Converter (CSC) is presented in this paper. Nonlinear transformation of DFIG model to the multi-scalar form is proposed. The nonlinear control strategy of active and reactive power of DFIG is realized by feedback linearization. In the proposed control scheme, the DFIG model and CSI parameters are included. Two Proportional-Integral...
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Porównanie działania transformatora symetryzującego (zygzak) z aktywnym energoelektronicznym symetryzatorem prądów fazowych linii niskiego napięcia
PublicationNa potrzeby planowania sieci niskiego napięcia operatorzy systemów dystrybucyjnych (OSD) zakładają symetryczne warunki obciążenia linii. Z roku na rok, rośnie liczba rozproszonych systemów fotowoltaicznych (PV) zainstalowanych w sieciach niskiego napięcia, których większość to małe jednofazowe systemy dachowe. Dodatkowo, do niesymetrii obciążenia przyczyniają się instalowane masowo pompy ciepła i ładowane jednofazowo samochody...
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Impact of temperature on optical sensing in biology based on investigation of SARS‐CoV ‐2
PublicationIn this paper, we present an investigation of the influence of the temperature on the sensing of biological samples. We used biofunctionalized microsphere-based fiber-optic sensor to detect immunoglobulin G attached to the sensor head at temperatures relevant in biological research: 5°C, 25°C, and 55°C. The construction of the sensor allowed us to perform measurements in the small amount of solution. The results of our experiment...
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Bioactive quaternary ammonium ionic liquids.
PublicationAn ionic liquid (IL) is an organic compound that contains at least one ionic bond. It consists of an organic cation and an organic or inorganic anion. It is an organic salt having a melting point below 100C. A very interesting group of IL are those with a long chain quaternary ammonium cation. They are formed by direct synthesis or by an anion-exchange reaction in quaternary ammonium halides. Popular and cheap precursors for the...
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Optoelectronic investigation of nanodiamond interactions with human blood
PublicationWe present optoelectronic investigation of in vitro interactions of whole human blood with different nanodiamond biomarkers. Plasmo-chemical modifications of detonation nanodiamond particles gives the possibility for controlling their surface for biological applications. Optical investigations reveal the biological activity of nanodiamonds in blood dependent on its surface termination. We compare different types of nanodiamonds:...
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Effects of the Origin and Deacetylation Degree of Chitosan on Properties of Its Coatings on Titanium
PublicationThe properties of chitosan coatings on titanium surfaces may be influenced by a variety of factors, including their chemical characteristics and the deposition method. The aim of this research was to determine the influence of a chitosan’s origin (a type of shrimp) and deacetylation degree (DD), when deposited on a very smooth titanium surface, on adhesion and biological behavior. The tests were performed using chitosan of a degree...
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The comparison of antioxidant properties and nutrigenomic redox-related activities of vitamin C, C-vitamers, and other common ascorbic acid derivatives
PublicationThe term ‘vitamin C’ describes a group of compounds with antiscorbutic activity of L-ascorbic acid (AA). Despite AA’s omnipresence in plant-derived foods, its derivatives have also been successfully implemented in the food industry as antioxidants, including the D-isomers, which lack vitamin C activity. This study aimed to determine the relationship between redox-related activities for five derivatives of AA using electrochemical,...
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Requirements, modifications and methods of mechanical testing of bone cement – literature review
PublicationThe Aim of the paper is to show the basic requirements for the bone cement, its modifications in terms of physical, mechanical and biological properties and testing methods. This publication is intended to be a source of systematized basic knowledge regarding the modified bone cement.
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Amino Acid and Peptide‐Based Antiviral Agents
PublicationA significant number of antiviral agents used in clinical practice are amino acids, short peptides, or peptidomimetics. Among them, several HIV protease inhibitors (e. g. lopinavir, atazanavir), HCV protease inhibitors (e. g. grazoprevir, glecaprevir), and HCV NS5A protein inhibitors have contributed to a significant decrease in mortality from AIDS and hepatitis. However, there is an ongoing need for the discovery of new antiviral...
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Specific Binding of Cholesterol to the Amyloid Precursor Protein: Structure of the Complex and Driving Forces Characterized in Molecular Detail
PublicationC99 is the C-terminal membrane-bound fragment of the amyloid precursor protein that is cleaved by γ-secretase to release Aβ peptides, the hallmark of Alzheimer’s disease (AD). Specific interactions of C99 with cholesterol have been proposed to underlie the recognized role of cholesterol in promoting amyloidogenesis. By using molecular dynamics simulations, we studied cholesterol binding to C99 in a lipid bilayer. We determined...
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Structural changes of a simple peptide—Trpzip-1—in aqueous solutions and the corresponding hydration phenomena under the influence of temperature
PublicationTrpzip-1, a simple β-hairpin, is a rare example of peptide with stable secondary structure and can be a convenient model to study temperature-related processes that potential prion or amyloid proteins undergo. Although its sequence is simple, the exact processes which the peptide undergoes in aqueous solutions are quite complex and not well understood. The selection of well-established experimental (DSC, FTIR) and theoretical methods...
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Interactions of Nitroaromatic Compounds with the Mammalian Selenoprotein Thioredoxin Reductase and the Relation to Induction of Apoptosis in Human Cancer Cells
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Interactions of Quinones with Thioredoxin Reductase
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The Phytoestrogen Genistein Modulates Lysosomal Metabolism and Transcription Factor EB (TFEB) Activation
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Elucidating of oxidative distress in COVID-19 and methods of its prevention
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Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis
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Cellular uptake of biotransformed graphene oxide into lung cells
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Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases
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New Selective Peptidyl Di(chlorophenyl) Phosphonate Esters for Visualizing and Blocking Neutrophil Proteinase 3 in Human Diseases
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The motif EXEXXXL in the cytosolic tail of the secretory human proprotein convertase PC7 regulates its trafficking and cleavage activity
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Protective effect of Aronia melanocarpa polyphenols against cadmium-induced disorders in bone metabolism: A study in a rat model of lifetime human exposure to this heavy metal
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The LA Loop as an Important Regulatory Element of the HtrA (DegP) Protease from Escherichia coli
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The activity of different extracts from Panax quinquefolium L. cultures against pathogenic Staphylococcus aureus with respect to ginsenoside content
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Antitumor Effects of Photodynamic Therapy Are Potentiated by 2-Methoxyestradiol
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Can chronotype and social jet lag predict burnout among physical therapists?
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Haloperidol, but not olanzapine, may affect expression of PER1 and CRY1 genes in human glioblastoma cell line
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STATISTICAL EVALUATION OF FAMILIAL RISK FACTORS IN TYPE 1 DIABETES
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Molecular basis of lipopolysaccharide heterogeneity in Escherichia coli: envelope stress-responsive regulators control the incorporation of glycoforms with a third 3-deoxy-α-D-manno-oct-2-ulosonic acid and rhamnose.
PublicationMass spectrometric analyses of lipopolysaccharide (LPS) from isogenic Escherichia coli strains with nonpolar mutations in the waa locus or overexpression of their cognate genes revealed that waaZ and waaS are the structural genes required for the incorporation of the third 3-deoxy-α-D-manno-oct-2-ulosonic acid (Kdo) linked to Kdo disaccharide and rhamnose, respectively. The incorporation of rhamnose requires prior sequential incorporation...