Filters
total: 12014
displaying 1000 best results Help
Search results for: ANTI-TUMOR ACTIVITY
-
Assay of Cystathionine-γ-synthase (CaStr2p) activity determination.
Open Research DataThe study aimed to obtain conditions optimal for the activity of Candida albicans cystathionine-γ-synthase (CaStr2p) determination. The selection of appropriate reaction conditions included the identification of the reaction buffer and its pH, substrate, and enzyme concentrations. The activity of Str2p was measured by the detection of decrease of the...
-
Voltage fluctuations on the main switchgear of the industrial power system supplying the rolling mill motors
Open Research DataThe dataset presents the voltage waveforms on the bus bars of the main switchgear of the industrial power network for the supply of rolling mills. The data was recorded during an experiment whose purpose was to determine a level of short-term and long-term flicker caused by voltage fluctuations. In the virtual application of flickermeter, a hardware...
-
Antifungal activity of propolis extracts produced with deep eutectic solvents.
Open Research DataThis dataset contains results of our investigation aiming in determination of antimicrobial potential of the propolis extracts produced with deep eutectic solvents. The activity was determined against C. albicans and C. glabarat strains. On the basis of these results MIC values can be calculated. Three samples of propolis were tested.
-
Method for Clustering of Brain Activity Data Derived from EEG Signals
PublicationA method for assessing separability of EEG signals associated with three classes of brain activity is proposed. The EEG signals are acquired from 23 subjects, gathered from a headset consisting of 14 electrodes. Data are processed by applying Discrete Wavelet Transform (DWT) for the signal analysis and an autoencoder neural network for the brain activity separation. Processing involves 74 wavelets from 3 DWT families: Coiflets,...
-
The effect of freeze-drying and storage on lysozyme activity, lactoferrin content, superoxide dismutase activity, total antioxidant capacity and fatty acid profile of freeze-dried human milk
PublicationPooled human milk samples were freeze-dried and stored for 6 weeks at a temperature of 5 C and 25 C. Freeze-drying decreased the water content of milk by 86.5%, and the obtained lyophilizate was readily soluble in water. The freeze-drying process did not affect superoxide dismutase (SOD) activity, fatty acid (FA) profile or lactoferrin (LF) content, but it decreased total antioxidant capacity (TAC) of human milk by 22.1% and induced...
-
Pr-doped TiO2: The effect of metal content on photocatalytic activity
PublicationThe Pr-TiO2 nanoparticles were prepared by using the sol-gel method. As-prepared samples were characterized by BET measurements, X-ray powder diffraction analysis (XRD) and UV-Vis spectra. Visible and ultraviolet light photocatalytic activity of the sample was studied by photodegradation of phenol while considering the influence of the dopant concentration. TiO2 doped with 0.25 mol% of praseodymium showed the highest photocatalytic...
-
Accelerometer signal pre-processing influence on human activity recognition
PublicationA study of data pre-processing influence on accelerometer-based human activity recognition algorithms is presented. The frequency band used to filter-out the accelerometer signals and the number of accelerometers involved were considered in terms of their influence on the recognition accuracy.
-
Influence of the electrosynthesis conditions on the spontaneous release of anti-inflammatory salicylate during degradation of polypyrrole coated iron for biodegradable cardiovascular stent
PublicationIn this work, the spontaneous release of anti-inflammatory salicylate from polypyrrole (PPy) coated iron has been studied during degradation of the material in phosphate buffer saline at 37 C. The sodium salicylate was incorporated into PPy in a one-step electropolymerization process. The influence of the synthesis conditions such as sodium salicylate concentration, pyrrole concentration and deposition charge on drug release profile...
-
European Review of Aging and Physical Activity
Journals -
European Journal of Adapted Physical Activity
Journals -
Women in Sport and Physical Activity Journal
Journals -
Determination of Antioxidant Activity of Vitamin C by Voltammetric Methods
PublicationVoltammetric methods—cyclic (CV) and differential pulse voltammetry (DPV) are considered the most appropriate way to evaluate antioxidant activity of redox active compounds. They provide information about both mechanism and kinetics of electrochemical oxidation of antioxidants as well as their physical and chemical properties such as the redox potential or the number of electrons transferred. These methods are helpful for understanding...
-
The Degree of Global DNA Hypomethylation in Peripheral Blood Correlates with That in Matched Tumor Tissues in Several Neoplasia
Publication -
Increased cytotoxicity of an unusual DNA topoisomerase II inhibitor compound C-1305 toward HeLa cells with downregulated PARP-1 activity results from re-activation of the p53 pathway and modulation of mitotic checkpoints
PublicationOur previous studies have shown that murine fibroblast cells, in which PARP-1 gene was inactivated by gene disruption, are extremely sensitive to triazoloacridone compound C-1305, an inhibitor of DNA topoisomerase II with unusual properties. Here, we show that pharmacological inhibition of PARP-1 activity by its inhibitor compound NU1025, sensitizes human cervical carcinoma HeLa cells to compound C-1305 compared to treatment with...
-
Synthesis and antimicrobial activity of amino acid and peptide derivatives of mycophenolic acid
PublicationThe series of 16 novel amino acid and peptide mycophenolic acid (MPA) derivatives was obtained as potential antibacterial agents. Coupling of MPA with respective amines was optimized with condensing reagents such as EDCI/DMAP and T3P/TEA. Amino acid analogs were received both as methyl esters and also with the free carboxylic group. The biological activity of the products was tested on five references bacterial strains: Klebsiella...
-
Automatic Clustering of EEG-Based Data Associated with Brain Activity
PublicationThe aim of this paper is to present a system for automatic assigning electroencephalographic (EEG) signals to appropriate classes associated with brain activity. The EEG signals are acquired from a headset consisting of 14 electrodes placed on skull. Data gathered are first processed by the Independent Component Analysis algorithm to obtain estimates of signals generated by primary sources reflecting the activity of the brain....
-
Meiothermus ruber cells as β-galactosidase activity biocatalyst
PublicationThe current study allowed to establish the possibility of using whole cells of thermophilic bacteria Meiothermus ruber as a biocatalyst with β-galactosidase activity. β-galactosidases are used for hydrolysis of lactose as well as for oligosaccharides synthesis. The advantages of using whole bacterial cells catalysis is not only elimination of tedious, expensive protein isolation and/or purification but also stabilization of enzymes...
-
Hydrazinolysis Products of Selected Sugar Lactones—Crystal Structure and Microbiological Activity
PublicationCommercially available lactones, as well as those synthesized by us, turned out to be good substrates for the synthesis of sugar hydrazides. The exception was L-ascorbic acid, whose hydrazinolysis led to the formation of a hydrazinium salt, not the hydrazide as expected. The structure of all compounds was confirmed by NMR and X-ray analyses. The lower durability of hydrazinium L-ascorbate was additionally confirmed by thermogravimetric...
-
Influence of the Addition of Selected Spices on Sensory Quality and Biological Activity of Honey
PublicationBee honey is nutritious and has numerous health benefits, but its taste is for many people too bland. Honey with addition of spices could be important to the food industry as a functional product with positive health image and interesting taste. Such product would definitely meet health-driven consumers’ expectations. Therefore, the aim of this study was to evaluate the effect of addition of selected spices on sensory, antimicrobial,...
-
Anti-inflammatory Potential of Flavonoids from the Aerial Parts of Corispermum marschallii
Publication -
Serum Anti-Müllerian Hormone Levels in Patients with Epithelial Ovarian Cancer
Publication -
Assessment of anti‐SARS‐CoV‐2 antibodies level in convalescents plasma
Publication -
Modus operandi of Qatar Resistance Policy against “Anti-Terror Quartet”
Publication -
Investigation of Anti-Lock Braking System failures using wavelet analysis
Publication -
The Anti-Tumoral Potential of Phosphonate Analog of Sulforaphane in Zebrafish Xenograft Model
Publication -
Determination of Flavonoids in Selected Scleranthus Species and Their Anti-Collagenase and Antioxidant Potential
Publication -
Mobile Activity Plan Applications for Behavioral Therapy of Autistic Children
PublicationThis paper concerns technological support for behavioral therapy of autistic children. A family of tools dedicated for mobile devices is presented, that allows to design and perform an activity schedule in behavioral therapy. The paper describes the main challenges, that were encountered, especially in meeting the non-functional requirements of the application: simplicity, repeatability, robustness, personalization, re-usability...
-
Dysfunctional prefrontal cortical network activity and interactions following cannabinoid receptor activation.
PublicationCoordinated activity spanning anatomically distributed neuronal networks underpins cognition and mediates limbic-cortical interactions during learning, memory, and decision-making. We used CP55940, a potent agonist of brain cannabinoid receptors known to disrupt coordinated activity in hippocampus, to investigate the roles of network oscillations during hippocampal and medial prefrontal cortical (mPFC) interactions in rats. During...
-
Physicochemical and Volatile Compounds Analysis of Fruit Wines Fermented with Saccharomyces cerevisiae: FTIR and Microscopy Study with Focus on Anti-Inflammatory Potential
PublicationThe growing trend in fruit wine production reflects consumers’ interest in novel, diverse drinking experiences and the increasing demand for healthier beverage options. Fruit wines made from kiwi, pomegranates, and persimmons fermented using S. bayanus Lalvin strain EC1118 demonstrate the versatility of winemaking techniques. Kiwifruit, persimmon, and pomegranate wines were analyzed using HPLC and GC-TOFMS analyses to determine...
-
Recent Patents on Anti-Infective Drug Discovery
Journals -
Recent Patents on Anti-Cancer Drug Discovery
Journals -
Recent Advances in Anti-Infective Drug Discovery
Journals -
Activity and discrimination against women in the labour market in the countries of Baltic Sea Region
PublicationAn increasing participation of women in the labour market seem to be a key to overcome the problems of the EU labour market and to achieve the objectives of Strategy Europe 2020. Therefore, the objective of this paper is to identify differences in the situation of women in the labour market in selected countries such as those in the Baltic Sea region and to attempt to verify the hypothesis of the existence of discrimination against...
-
Activity assay of O-Acetyl-L-homoserine sulfhydrylase (CaMet15p).
Open Research DataThe study aimed to obtain conditions optimal for the activity of O-acetyl-L-homoserine sulfhydrylase (CaMet15p) and a method suitable for its measurement. The selection of appropriate reaction conditions included the identification of the reaction buffer and its pH, substrate and enzyme concentrations. The activity of CaMet15p was measured by the detection...
-
Sport-related concussion alters cerebral hemodynamic activity during controlled respiration
PublicationThis study investigated cerebral hemodynamic activity following sport-related concussion. Prefrontal cortex oxygenation was assessed by near-infrared spectroscopy (NIRS) during a controlled breathing protocol. Wavelet transformation of the NIRS signals showed significant decreases in HbO2 and HbD amplitude at the respiratory frequency interval (0.10–0.6 HZ) from preseason baseline to acute concussion. These results suggest a decreased...
-
Jaw biomechanics: Estimation of activity of muscles acting at the temporomandibular joint
PublicationThe aim of this study was to elaborate a method of estimation of activity of surface muscles acting at the temporomandibular joint of the healthy subjects by using a surface electromyography (EMG). The scope of this study involved testing chosen jaw motions (open, close, lateral deviation) and process of mastication occurring during eating food with different toughness (chewing gum, cereal and carrot) by using mixed sides, right...
-
The influence of cultivation conditions on the myrosinase activity and glucosinolate content in white cabbage
PublicationIn the process of biofumigation typically natural compounds present in Brassicaceae family are used to combat pests and protect crops. Glucosinolates, sulfur-containing secondary metabolites found in Brassica plants, are hydrolized by the enzyme myrosinase (β-thioglucosidase, EC 3.2.3.1) with the liberation of degradation products such as isothiocyanates, nitriles, thiocyanates and epithionitriles. Isothiocyanates are the most...
-
Electrical Stimulation Modulates High Gamma Activity and Human Memory Performance
PublicationDirect electrical stimulation of the brain has emerged as a powerful treatment for multiple neurological diseases, and as a potential technique to enhance human cognition. Despite its application in a range of brain disorders, it remains unclear how stimulation of discrete brain areas affects memory performance and the underlying electrophysiological activities. Here, we investigated the effect of direct electrical stimulation...
-
Anti-Cancer Agents in Medicinal Chemistry
Journals -
Honey antibacterial activity: A neglected aspect of honey quality assurance as functional food
PublicationBackground Honey is considered as a functional food with health-promoting properties. Its potent antibacterial and antibiofilm effects are the major attributes of so called ‘medical-grade honey’ which is topically used for the treatment of burns, wounds and skin disorders. Nevertheless, the current set of honey quality parameters adopted in the European Union do not include its biological properties. Furthermore, in light of the...
-
The Effect of Conjugation with Octaarginine, a Cell-Penetrating Peptide on Antifungal Activity of Imidazoacridinone Derivative
PublicationAcridine cell-penetrating peptide conjugates are an extremely important family of compounds in antitumor chemotherapy. These conjugates are not so widely analysed in antimicrobial therapy, although bioactive peptides could be used as nanocarriers to smuggle antimicrobial compounds. An octaarginine conjugate of an imidazoacridinone derivative (Compound 1-R8) synthetized by us exhibited high antifungal activity against reference...
-
Investigations on the immunosuppressive activity of derivatives of mycophenolic acid in immature dendritic cell
PublicationThe main activity of mycophenolic acid (MPA) and its analogs is the inhibition of proliferation of T cells. Here, we hypothesized that MPA and its conjugates inhibits also the activity of antigen-presenting cells (APC) including dendritic cells (DCs). We tested the effect of novel amino acid derivatives of MPA and conjugates of MPA with acridines/acridones on DCs by flow cytometry, ELISA and MLR assay. Both acridines/acridone derivatives...
-
Justyna Signerska-Rynkowska dr inż.
PeopleI am currently an assistant professor (adjunct) at Gdansk University of Technology (Department of Differential Equations and Mathematics Applications). My scientific interests include dynamical systems theory, chaos theory and their applications to modeling of biological phenomena, especially to neurosciences. In June 2013 I completed PhD in Mathematics at the Institute of Mathematics of Polish Academy of Sciences (IMPAN) (thesis...
-
Hepatic fibrosis - Female, 52 - Tissue image [5250730010641261]
Open Research DataThis is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
-
Anna Zielińska-Jurek prof. dr hab. inż.
People2018 DSc in technical sciences in the field of chemical technology Chemical Faculty, Gdansk University of Technology, Title: “Functionalized titanium(IV) oxide as a photocatalyst for environmental purification” 2011 Ph. D. in technical sciences in the field of chemical technology Chemical Faculty, Gdansk University of Technology, Title of the dissertation:...
-
Characteristic and specificity of protease activity of thermophilic bacteria Meiothermus ruber
PublicationThe primary purpose of research was to establish the possibility of using thermophilic bacteria Meiothermus ruber as a source of proteolytic enzymes. The main reason of searching new proteases is their commercial value especially in production of detergents, food, pharmaceuticals, leather, diagnostics or waste management. The development of this type processes will be possible by utilization of enzymes which have unique characteristics...
-
Immunoscore, circulating tumor cells and human-derived organoids as potential predictive tools in personalized cancer medicine
Publication -
CGB and GNRH1 expression analysis as a method of tumor cells metastatic spread detection in patients with gynecological malignances
Publication -
Metabolic Profiles of New Unsymmetrical Bisacridine Antitumor Agents in Electrochemical and Enzymatic Noncellular Systems and in Tumor Cells
Publication -
Circulating Tumor Cells as a Marker of Disseminated Disease in Patients with Newly Diagnosed High-Risk Prostate Cancer
Publication