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Integrating Statistical and Machine‐Learning Approach for Meta‐Analysis of Bisphenol A‐Exposure Datasets Reveals Effects on Mouse Gene Expression within Pathways of Apoptosis and Cell Survival
PublicationBisphenols are important environmental pollutants that are extensively studied due to different detrimental effects, while the molecular mechanisms behind these effects are less well understood. Like other environmental pollutants, bisphenols are being tested in various experimental models, creating large expression datasets found in open access storage. The meta‐analysis of such datasets is, however, very complicated for various...
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Genetic Variability of Hepatitis B Virus Isolates in Poland
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Dissection of σE‐dependent cell lysis in Escherichia coli: roles of RpoE regulators RseA, RseB and periplasmic folding catalyst PpiD
PublicationTo understand the mechanism of sigma(E)-dependent cell lysis, we examined the consequences of deletion derivatives of rpoE regulators rseA, rseB and rseC on sigma(E) transcription, on levels of free versus membrane-bound sigma(E) and on OMP-biogenesis limiting factor(s) that could impact cell lysis. RT-PCR showed that individual nonpolar DeltarseA and DeltarseB increased the rpoE expression to varying extents, with pronounced induction...
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Evolving gene regulatory networks controlling foraging strategies of prey and predators in an artificial ecosystem
PublicationCo-evolution of predators and prey is an example of an evolutionary arms race, leading in nature to selective pressures in positive feedback. We introduce here an artificial life ecosystem in which such positive feedback can emerge. This ecosystem consists of a 2-dimensional liquid environment and animats controlled by evolving artificial gene regulatory networks encoded in linear genomes. The genes in the genome encode chemical...
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Man in Early Islamic Philosophy: Al-Kindi and Al-Farabi
PublicationMan was, neither for Al-Kindi, nor for Al-Farabi, a clearly isolated object of philosophical reflection. This does not mean, however, that both Islamic philosophers were not at all concerned with the uniqueness of man, his nature or the purpose of his existence. In order to understand and analyze in depth the philosophies of man voiced by Al-Kindi and Al-Farabi, one must focus primarily on their epistemologies, on their philosophical...
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Influence of grain shape on the mechanical behaviour of granular materials
PublicationWe performed series of numerical vertical compression tests on assemblies of 2D granular material using a Discrete Element code and studied the results in regard to the grain shape. The samples consist of 5000 grains made either of 3 overlapping discs (clump - grain with concavities) or of six-edged polygons (convex grain). These two types of grains have a similar external envelope, ruled with a geometrical parameter α. In the...
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Electronic Noses and Electronic Tongues
PublicationChapter 7 reports the achievements on the field of artificial senses, such as electronic nose and electronic tongue. It examines multivariate data processing methods and demonstrates a promising potential for rapid routine analysis. Main attention is focused on detailed description of sensor used, construction and principle of operation of these systems. A brief review about the progress in the field of artificial senses and future trends...
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Antitumor Activity of Triazine Mimic Antibiotics for DNA-binding Implications (Impressive Activity in Vitro Against a Variety of Tumor Types in the NCI-60 Screen): NSC 710607 To Fight HCT-116 Human Colon Carcinoma Cell Lines in Vivo Using the Hollow Fiber Assay and Xenograft Mouse Models
PublicationPurpose Successful clinical applications of DNA-directed selective cytotoxic agents disrupt the vital replication/transcription processes and ultimately lead to cancer cell death. This study aimed to examine the growth screen of two lead triazine compounds in a number of cell lines and xenografts and to develop anticancer agents with noncovalent binding affinity bringing fewer side effects. Methods The NCI initial hollow...
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Antimicrobial peptides (AMPs) as drug candidates: a patent review (2003–2015)
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Inhibitors of cathepsin G: a patent review (2005 to present)
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Future of Protease Activity Assays
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Adrenal Secretory Protease
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Novel N-(aryl/heteroaryl)-2-chlorobenzenesulfonamide derivatives: synthesis and anticancer activity evaluation
PublicationA new series of N-(aryl/heteroaryl)-2-chlorobenzenesulfonamide derivatives 4-21 have been synthesized, and evaluated at the National Cancer Institute (USA) for their in vitro activities against a panel of 60 different human cancer cell lines. Among them, compounds 16, 20 and 21 exhibited remarkable cytotoxic activity against numerous human cancer cell lines. We found that sulfonamide derivative 21 appeared to be more selective...
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A Simulation Model for Risk and Pricing Competition in the Retail Lending Market
PublicationWe propose a simulation model of the retail lending market with two types of agents: borrowers searching for low interest rates and lenders competing through risk-based pricing. We show that individual banks observe adverse selection, even if every lender applies the same pricing strategy and a credit scoring model of comparable discrimination power. Additionally, the model justifies the reverse-S shape of the response rate curve....
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Sektor usług wiedzochłonnych oraz jego dynamika i struktura zatrudnienia w krajach Unii Europejskiej
PublicationNiniejszy artykuł dotyczy sektora usług wiedzochłonnych oraz jego dynamiki i struktury zatrudnienia. W części teoretycznej opracowania przedstawiono zagadnienia definicyjne oraz klasyfikacyjne związane z sektorem usług wiedzochłonnych, a także omówiono kwestie wiedzochłonności tego sektora. W części badawczej zaprezentowano analizę dynamiki i struktury zatrudnienia w sektorach usług wiedzochłonnych krajów należących do Unii Europejskiej....
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Inhomogeneity of low-noise wearing courses evaluated by tire/road noise measurements using the close-proximity method
PublicationPerforming numerous analyses of tire/road noise measurements on low-noise pavements during the last several years, the authors observed significant inhomogeneity of the wearing course in numerous cases, while similar problems were almost non-existent when dense pavements were measured. Three main causes of low-noise pavement inhomogeneity can be defined. The first one is imperfections in the technology used for asphalt mix production...
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A new proteinase 3 substrate with improved selectivity over human neutrophil elastase
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Arterial cannula shape optimization by means of the rotational firefly algorithm
PublicationThe article presents global optimization results of arterial cannula shapes by means of the newly modified firefly algorithm. The search for the optimal arterial cannula shape is necessary in order to minimize losses and prepare the flow that leaves the circulatory support system of a ventricle (i.e. blood pump) before it reaches the heart. A modification of the standard firefly algorithm, the so-called rotational firefly algorithm,...
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CYP3A4-dependent cellular response does not relate to CYP3A4-catalysed metabolites of C-1748 and C-1305 acridine antitumor agents in HepG2 cells
PublicationHigh CYP3A4 expression sensitizes tumor cells to certain antitumor agents while for others it can lower their therapeutic ef fi cacy. We have elucidated the in fl uence of CYP3A4 overexpression on the cellular response induced by antitumor acridine derivatives, C-1305 and C-1748, in two hepatocellular carcinoma (HepG2) cell lines, Hep3A4 stably transfected with CYP3A4 isoenzyme, and HepC34 expressing empty vector. The compounds...
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High resolution X-ray diffractometry and reflectometry of semiconductor nano- and micro- structures based on X-ray refractive optics
PublicationIn this thesis proposed, discussed and studied novel synchrotron X-ray diffractometry and reflectometry methods based on a refractive optics. The experimental results obtained from the ID06 beamline at ESRF, Grenoble, France are presented and analyzed in this work to demonstrate a high angular and space resolution in addition to the opportunity to manage in situ and on operando experiments with the help of proposed X-ray optical...
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Evaluation Of Single Pole Auto-Reclosing Effectiveness With Nonlinear Secondary Arc Model
PublicationThe paper discusses two evaluation methods of single pole auto-reclosing process effectiveness in HV transmission lines. Secondary arc current and recovery voltage results obtained by load flow calculation are compared to the results obtained by the time domain simulations. Moreover, a non-linear secondary arc implementation is presented. The authors indicate, that precise representation of secondary electric arc leads to more...
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Role of Sports Facilities in the Process of Revitalization of Brownfields
PublicationThe paper gives an evidence that building a large sports facility can generate beneficial urban space transformation and a significant improvement in the dilapidated urban areas. On the basis of theoretical investigations and case studies it can be proved that sports facilities introduced to urban brownfields could be considered one of the best known large scale revitalization methods. Large urban spaces surrounding sport facilities...
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Interpolation methods in GPR tomographic imaging of linear and volume anomalies for cultural heritage diagnostics
PublicationThis paper presents results of a ground penetrating radar (GPR) survey conducted in St. Joseph’s Church in Gdańsk, Poland. The aim of the study was to produce tomographic imaging of a renovated floor as well as the objects buried under the floor to detect linear and volume inclusions. The assumed track spacing was meaningfully greater than the single signal spacing in each track, which induced the need for interpolation methods...
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PHASE OBJECT OBSERVATION SYSTEM BASED ON DIFFRACTION PHASE MICROSCOPY
PublicationIn the paper authors present a special measurement system for observing phase objects. The diffraction phas microscopy makes it possible to measure the dimensions of a tested object with a nanometre resolution. To meet this requirement, it is proposed to apply a spatial transform. The proposed setup can be based either on a two lenses system (called 4 f ) or a Wollaston prism. Both solutions with all construction aspects are described...
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Multiscaled Hybrid Features Generation for AdaBoost Object Detection
PublicationThis work presents the multiscaled version of modified census features in graphical objects detection with AdaBoost cascade training algorithm. Several experiments with face detector training process demonstrate better performance of such features over ordinal census and Haar-like approaches. The possibilities to join multiscaled census and Haar features in single hybrid cascade of strong classifiers are also elaborated and tested....
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Novel TG‐FGFR1 and TRIM33‐NTRK1 transcript fusions in papillary thyroid carcinoma
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Substrate specificity and inhibitory study of human airway trypsin-like protease
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Imunofan—RDKVYR Peptide—Stimulates Skin Cell Proliferation and Promotes Tissue Repair
PublicationRegeneration and wound healing are vital to tissue homeostasis and organism survival. One of the biggest challenges of today’s science and medicine is finding methods and factors to stimulate these processes in the human body. Effective solutions to promote regenerative responses will accelerate advances in tissue engineering, regenerative medicine, transplantology, and a number of other clinical specialties. In this study, we...
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Analysis of positioning error and its impact on high frequency properties of differential signal coupler
PublicationThis paper presents the analysis of the effect of differential signal coupler positioning accuracy on its high frequency performance parameters for contact-less high speed chip-to-chip data transmission on PCB application. Our considerations are continuation of the previous works on differential signal coupler concept, design methodology and analysis for high speed data transmission monitoring. The theoretical analysis of possible...
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Protect our right to light
Publication“The struggle for light” is how the Swiss architect Le Corbusier described the history of architecture in 1935. Today, with the skies crowded out by buildings in modern cities, those words should ring in the ears of policymakers and planners. Skyscraper construction is booming. China is the leader, last year completing 88 of the 143 buildings around the world that are taller than 200 metres (see ‘Vertical growth’). As the nation’s...
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Design of a compact planar transmission line for miniaturized rat-race coupler with harmonics suppression
PublicationThis paper presents an elegant yet straightforward design procedure for a compact rat-race coupler (RRC) with an extended harmonic suppression. The coupler’s conventional λ/4 transmission lines (TLs) are replaced by a specialized TL that offers significant size reduction and harmonic elimination capabilities in the proposed approach. The design procedure is verified through the theoretical, circuit, and electromagnetic (EM) analyses,...
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Energy Loss Coefficients ki in a Displacement Pump and Hydraulic Motor used in Hydrostatic Drives
PublicationThe article aims at defining and analysing the energy loss coefficients in design solutions of rotating displacement machines, with a piston machine as an example. The energy losses observed in these machines include mechanical loss, volumetric loss, and pressure loss. The scale and relations between these losses in different machines depend on machine design and manufacturing quality, and on operating parameters. The operating...
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Core loss resistance impact on sensorless speed control of an induction motor using hybrid adaptive sliding mode observer
PublicationInduction motors (IMs) experience power losses when a portion of the input power is converted to heat instead of driving the load. The combined effect of copper losses, core losses, and mechanical losses results in IM power losses. Unfortunately, the core losses in the motor, which have a considerable impact on its energy efficiency, are not taken into account by the generally employed dynamic model in the majority of the studies. Due...
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Sens egzystencji Wiktora z „Panien z Wilka” Jarosława Iwaszkiewicza w ujęciu stadiów egzystencji Sørena Kierkegaarda. Studium przypadku
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Impact of surface skin temperature change on blood flow characteristics in palm
PublicationHeating a human palm during 3 minutes period causes changes in superficial skin temperature and leads to thermoregulation system response. The response time and level of flow characteristics change depend on the subject hand size and health of his vascular tree. A solution of Pennes bioheat propagation model was analyzed in order to see how much heat has to be transferred into the tissue to extort the observable reaction. The reflective...
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Non‐Proteasomal Urine Activity in Bladder Cancer
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Elastolytic activity is associated with inflammation in bladder cancer
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Chromogenic Substrates of Bovine β-Trypsin: The Influence of an Amino Acid Residue in P1 Position on Their Interaction with the Enzyme
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Microarrays and Dynamics of Fluorescent Dyes
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Synthesis and Biological Evaluation of Acridine/Acridone Analogs as Potential Anticancer Agents
PublicationAcridine and acridone analogues were prepared by Ullmann condensation and then cyclization reaction. As a result of nucleophilic substitution reaction 1-nitro-9-phenoxyacridine or 1-chloro-4-nitro-9(10H)-acridone with the corresponding peptides, the planned acridine derivatives (10a-c, 12, 17-a-d, 19) have been obtained. The cytotoxic activity of the newly obtained analogs were evaluated against melanotic (Ma) and amelanotic (Ab)...
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Resistance of Escherichia coli and Enterococcus spp. to selected antimicrobial agents present in municipal
PublicationIn this study, the susceptibility to erythromycin (E) and to trimethoprim/sulfamethoxazole (SXT) among isolates of Enterococcus spp. and Escherichia coli was tested, respectively. Both fecal indicators were detected and isolated from raw(RW) and treated wastewater (TW) as well as from samples of activated sludge (AS) collected in a local wastewater treatment plant (WWTP). Biodiversity of bacterial community in AS was also monitored...
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Model matematyczny strat objętościowych ściskania oleju hydraulicznego w pompie wyporowej o zmiennej wydajności
PublicationCelem pracy było stworzenie możliwości oceny strat objętościowych wynikających ze ściskania oleju hydraulicznego w komorach roboczych wysokociśnieniowej pompy wyporowej o zmiennej wydajności na obrót wału. Straty objętościowe ściskania oleju muszą być określone jako funkcje tych samych parametrów, w zależności od których ocenione są straty objętościowe przecieków oleju w komorach, wynikające z jakości rozwiązania konstrukcyjnego...
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Porównanie mocy strat energetycznych w pompie wyporowej o zmiennej wydajności określonych bez uwzględnienia bądź z uwzględnieniem mocy ściskania oleju hydraulicznego
PublicationPorównano moce strat energetycznych w pompie wyporowej o zmiennej wydajności, określone bez uwzględnienia bądź z uwzględnieniem mocy ściskania oleju hydraulicznego. Ocena mocy ściskania cieczy w pompie stała się możliwa dzięki zastosowaniu, zaproponowanej przez autora, metody określenia stopnia zapowietrzenia cieczy w pompie. W metodzie określenia stopnia zapowietrzenia cieczy w pompie oraz w ocenie mocy strat objętościowych ściskania...
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Flavones in cocoa defence against Phytophthora megakarya
PublicationCross-pollination of suitable genotypes and earlier selection of elite offspring using adequate plants-associated defence markers in plantlets leaves are decisive for development of T. cacao genotypes tolerant to black pods disease (BPD). T. cacao plantlets from manual cross-pollination of ♀SNK64 × ♂UPA143 were analyzed for their susceptibility to BPD using leaf disc test. Subsequently, leaves (healthy, wounded and wound+infected)...
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Polyurethanes as a carrier of drugs for gentamicin
PublicationGentamicin is one of the most popular drug and is widely used due to its antibiotic properties. 3% of world production of polyurethanes (PU) is dedicated to biomedical applications, where they can serve are parts of orthopedic prosthesis or artificial organs, disposable medical devices, wound and burn dressing, contact lenses among others. In the study, to obtain drug carriers, a combination of these two materials were prepared...
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Analysis of Positioning Error and Its Impact on High Frequency Performance Parameters of Differential Signal Coupler of Differential Signal Coupler
PublicationThis paper presents the analysis of the effect of differential signal coupler positioning accuracy on its high frequency performance parameters for contact-less high speed chip-to-chip data transmission on PCB application. Our considerations are continuation of the previous works on differential signal coupler concept, design methodology and analysis for high speed data transmission monitoring presented in [1, 2]. The theoretical...
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The Belt and Road Initiative and export variety: 1996–2019
PublicationThis study examines the association between the Belt and Road Initiative (BRI) and export variety (EV). We propose three hypotheses on how BRI may foster export markets (destinations) or export product lines. The estimates are based on a dataset constructed specifically for this analysis, covering 183 countries and linked with trade data from 1996 to 2019. We apply the instrumental variable (IV) approach in regressions for covering the...
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Synthesis, structural characterization, and thermal properties of Ca‐ and La‐doped soda‐lime glasses by laser melting
PublicationLaser melting techniques have been used in the preparation of unconventional glass compositions with high melting temperatures. Thus, we wanted to test the feasibility of using a CO2 laser in the preparation of nitrogen-rich oxynitride glasses and nitride silicate glasses. Melting from oxides and metallic raw materials, we wanted to study first glass formation and possible evaporation losses of the glass components. Two glass series...
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Imunofan - RDKVYR peptide - stimulates skin cell proliferation and promotes tissue repair
PublicationRegeneration and wound healing are vital to tissue homeostasis and organism survival. One of the biggest challenges of today's science and medicine is finding methods and factors to stimulate these processes in the human body. Effective solutions to promote regenerative responses will accelerate advances in tissue engineering, regenerative medicine, transplantology, and a number of other clinical...
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DNA-damaging imidazoacridinone C-1311 induces autophagy followed by irreversible growth arrest and senescence in human lung cancer cells
PublicationImidazoacridinone 5-diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) is an antitumor inhibitor of topoisomerase II and FMS-like tyrosine kinase 3 receptor. In this study, we describe the unique sequence of cellular responses to C-1311 in human non-small cell lung cancer (NSCLC) cell lines, A549 and H460. In A549 cells, C-1311 (IC80 = 0.08 µM) induced G1 and G2/M arrests, whereas H460 cells (IC80 = 0.051 µM) accumulated...