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N-(1-Piperidinepropionyl)amphotericin B methyl ester (PAME) - a new derivative of the antifungal antibiotic amphotericin B: Searching for the mechanism of its reduced
PublicationZ zastosowaniem techniki monowarstw Langmuira zbadano naturę oddziaływań pochodnej antybiotyku przeciwgrzybowego amfoterycyny B o obniżonej toksyczności tj. estru metylowego N-(1-piperydynopropionylo)amfoterycyny B (PAME) z komponentami błon biologicznych takich jak: ergosterol, cholesterol i modelowy fosfolipid DPPC i stwierdzono, że zróżnicowanie tych oddziaływań jest podstawą obniżonej toksyczności związku.
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Effect of the ex situ physical and in situ chemical modification of bacterial nanocellulose on mechanical properties in the context of its potential applications in heart valve design
PublicationBacterial nanocellulose (BNC) is a promising material for heart valve prostheses. However, its low strength properties limit its applicability in cardiovascular surgery. To overcome these limitations, the mechanical properties of BNC can be improved through modifications. The aim of the research was to investigate the extent to which the mechanical properties of BNC can be altered by modifying its structure during its production...
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The forecasted values of cutting power for sawing on band sawing machines for Polish Scots pine wood (Pinus sylvestris L.) in a function of its provenance.
PublicationIn this paper the predicted values of cutting power for band sawing machine (EB 1800, f. EWD), which is used in the Polish sawmills, were showed. The values of cutting power were forecasted for Scots pine (Pinus sylvestris L.) wood of five provenances from Poland. These values were determined using an innovative method of predicting the cutting power, which takes into account of elements of fracture mechanics. The resulting predictions...
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A new Toxoplasma gondii chimeric antigen containing fragments of SAG2, GRA1, and ROP1 proteins—impact of immunodominant sequences size on its diagnostic usefulness
PublicationThis study presents the first evaluation of new Toxoplasma gondii recombinant chimeric antigens containing three immunodominant regions of SAG2, GRA1, and one of two ROP1 fragments differing in length for the serodiagnosis of human toxoplasmosis. The recombinant chimeric antigens SAG2-GRA1-ROP1L (with large fragment of ROP1, 85-396 amino acid residues) and SAG2-GRA1-ROP1S (with a small fragment of ROP1, 85-250 amino acid residues)...
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A method for evaluating the performance of a marine piston internal combustion engine used as the main engine on a ship during its voyage in different sailing conditions
PublicationPrzedstawiono metodę oceny działania tłokowych silników spalinowych napędu głównego staków morskich, nazywanych silnikami głównymi, działających w typowych warunkach ich eksploatacji. Warunki te zostały opisane z uwzględnieniem pola osiągów tego rodzaju silników. Metoda ta umożliwia obliczenie wartości działania w wyniku zastosowania rachunku całkowego. Znamienne jest to, że działanie wspomnianych silników spalinowych zostało przyrównane...
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Architektura współczesnego muzeum i jej znaczenie dla tożsamości krajobrazu miasta = The Architecture of Contemporary Museum and its Significance for the Identity of the Urban Landscape
PublicationArtykuł dotyczy architektury współczesnych muzeów, które pod koniec XX w. przeszły znaczący rozwój jako instytucje publiczne. Oprócz specyficznych wymagań technicznych, funkcjonalnych, estetycznych i kulturowych, ich charakterystyczną cechą jest wzrastające zapotrzebowanie na przestrzeń dodatkową służącą edukacji, odpoczynkowi, rozrywce i strefie komercyjnej (handlu i usług). Atrakcyjna przestrzeń publiczna zapewnia dostęp do wszystkich...
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High-temperature oxidation of the Crofer 22 H ferritic steel with Mn1.45Co1.45Fe0.1O4 and Mn1.5Co1.5O4 spinel coatings under thermal cycling conditions and its properties
PublicationThe aim of the presented study was to deposit protective-conducting Mn1.45Co1.45Fe0.1O4 and Mn1.5Co1.5O4 spinel coatings on the Crofer 22 H ferritic steel by means of electrophoresis and to evaluate their physicochemical properties after high-temperature oxidation under thermal cycling conditions. When the Crofer 22 H steel – whether uncoated or coated with the two spinels – was oxidized in 48-h cycles involving a temperature of...
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The semi-Markov model of energy state changes of the main marine internal combustion engine and method for evaluating its operation during ships voyage
PublicationPrzedstawiono metodę oceny działania tłokowych silników spalinowych napędu głównego statków morskich, nazywanych silnikami głównymi, działających w różnych warunkach ich eksploatacji. Metoda ta umożliwia obliczenie wartości działania w wyniku zastosowania teorii procesów semimarkowskich i statystyki matematycznej. Znamienne jest to, że działanie wspomnianych silników spalinowych zostało przyrównane do wielkości fizycznej, którą...
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Improved cytotoxicity and preserved level of cell death induced in colon cancer cells by doxorubicin after its conjugation with iron-oxide magnetic nanoparticles
PublicationA promising strategy for overcoming the problem of limited efficacy in antitumor drug delivery and in drug release is the use of a nanoparticle-conjugated drug. Doxorubicin (Dox) anticancer chemotherapeutics has been widely studied in this respect, because of severe cardiotoxic side effects. Here, we investigated the cytotoxic effects, the uptake process, the changes in cell cycle progression and the cell death processes in the...
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Discussion on “Dynamic soil-structure interaction: A three-dimensional numerical approach and its application to the Lotung case study”. Poor performance of the HSS model
PublicationThe Hardening Soil Small (HSS) is a constitutive model being extension to the well established Hardening Soil Model (HS) accounting for the nonlinearity of small strain stiffness. It is implemented in commercial finite element computer codes for geotechnical analyses and used widely in research and design. The article deals with a problem known as overshooting after very small load reversals. It induces much higher stiffness than...
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The influence of the type of halogen substituent and its position on the molecular conformation, intermolecular interactions and crystal packing for a series of 1-benzoyl-3-(halogenophenyl)thioureas
PublicationBy the reaction of benzoyl chloride, potassium isothiocyanate and the appropriate halogenoaniline, i.e. 2/3/4-(bromo/iodo)aniline, we have obtained five new 1-benzoyl-3-(halogenophenyl)thioureas, namely, 1-benzoyl-3-(2-bromophenyl)- thiourea and 1-benzoyl-3-(3-bromophenyl)thiourea, C14H11BrN2OS, and 1-benzoyl-3-(2-iodophenyl)thiourea, 1-benzoyl-3-(3-iodophenyl)thiourea and 1-benzoyl-3-(4-iodophenyl)thiourea, C14H11IN2OS. Structural...
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Rediscovering Automatic Detection of Stuttering and Its Subclasses through Machine Learning—The Impact of Changing Deep Model Architecture and Amount of Data in the Training Set
PublicationThis work deals with automatically detecting stuttering and its subclasses. An effective classification of stuttering along with its subclasses could find wide application in determining the severity of stuttering by speech therapists, preliminary patient diagnosis, and enabling communication with the previously mentioned voice assistants. The first part of this work provides an overview of examples of classical and deep learning...
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Detoxification of the tricyclic antidepressant opipramol and its analog – IS-noh by UGT enzymes before and after activation by phase I enzymes in rat liver microsomes
PublicationThe present studies were carried out to evaluate the simultaneous one-pot metabolism of opipramol (IS-opi) and analog (IS-noh) by phase I and phase II enzymes present in rat liver microsomes (RLM) as an alternative to separate testing with recombinant enzymes. This approach allows for more time-saving and cost-effective screening of the metabolism of newly discovered drugs. We also considered that the lack of results for phase...
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Synthesis of UiO-66-OH zirconium metal-organic framework and its application for selective extraction and trace determination of thorium in water samples by spectrophotometry
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Highly Sensitive Determination of Bisphenol A in Bottled Water Samples by HPLC after Its Extraction by a Novel Th-MOF Pipette-Tip Micro-SPE
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Deformation of the Titanium Plate Stabilizing the Lateral Ankle Fracture Due to Its Overloading in Case of the Young, Obese Patient: Case Report Including the Biomechanical Analysis
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Molecular Characterization of a Novel Lytic Enzyme LysC from Clostridium intestinale URNW and Its Antibacterial Activity Mediated by Positively Charged N-Terminal Extension
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Advanced oxidation (H2O2 and/or UV) of functionalized carbon nanotubes (CNT-OH and CNT-COOH) and its influence on the stabilization of CNTs in water and tannic acid solution
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Comparative in vitro studies on liposomal formulations of amphotericin Band its derivative, N-methyl-N-D-fructosyl amphotericin B methyl ester (MFAME)
PublicationMFAME, ester metylowy N-metylo-N-D-fruktozylo amfoterycyny B jest półsyntetyczną pochodną antybiotyku przeciwgrzybowego amfoterycyny B (AMB). W przeciwieństwie do wyjściowego antybiotyku pochodna ta jest nietoksyczna dla komórek zwierzęcych oraz tworzy rozpuszczalne sole rozpuszczalne w wodzie. Przeprowadzono badania porównawcze aktywności biologicznej wolnego antybiotyku i wolnej pochodnej oraz ich preparatów liposomalnych. Stosowano...
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Urban city lights. Light pollution as one of the effects of incorrectly designed external illumination. How can a successful lighting masterplan diminish its impact?
PublicationIn the modern world, artificial lighting brings many tangible benefits such as the ability to extend working hours and so increase production, recreational use of the city after dark, or the possibility to travel regardless of the time of day. However, this flexibility comes at a price and negatively impacts on the environment. One such negative phenomenon is Light Pollution ‐ a term used to describe excessive nighttime artificial...
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Determination of free tyrosine in equestrian supplements by LC–MS/MS and comparison of its quantity with total free amino acids content in view of doping control
PublicationThe reports on the probable beneficial impact of tyrosine (TYR) supplementation on performance enhancement have contributed to the growth of interest in TYR in equestrian sports field and related industries, such as the manufacture of dietary and nutritional supplements. In this study, the first attempt to the assessment of horses exposure to TYR during nutritional supplementation was demonstrated by quantification of unbound TYR...
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Cellulose and its derivatives, coffee grounds, and cross-linked, β-cyclodextrin in the race for the highest sorption capacity of cationic dyes in accordance with the principles of sustainable development
PublicationIn this study, seven different materials were analyzed and includes coffee grounds (CG), two types of cellulose (CGC and CC), two types of modified cellulose (CT and CTCD), and cross-linked β-cyclodextrin (CD-1 and CD-2) were tested as adsorbents for the removal of dyes from the wastewater. The composition, morphology, and presence of functional groups in the obtained sorption materials were characterized by elemental analysis,...
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Limiting distribution of the three-state semi-Markov model of technical state transitions of ship power plant machines and its applicability in operational decision-making.
PublicationThe article presents the three-state semi-Markov model of the process {W(t): t 0} of state transitions of a ship power plant machine, with the following interpretation of these states: s1 – state of full serviceability, s2 – state of partial serviceability, and s3 – state of unserviceability. These states are precisely defined for the ship main engine (ME). A hypothesis is proposed which explains the possibility of application...
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Determination of bromhexine and its metabolites in equine serum samples by liquid chromatography – Tandem mass spectrometry: Applicability to the elimination study after single oral dose
PublicationBromhexine (BH), expectorant used in the treatment of respiratory disorders associated with viscid or excessive mucus, is not permitted for use in the competing horse by many authorities in horseracing and Olympic disciplines. Metabolic studies are of the great importance in anti-doping field because they allow for updating the selection of the most appropriate markers for prohibited substances, such as metabolites present at higher...
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Fabrication of a Molecularly Imprinted Polymer Adsorbent for Pipette Tip Micro Solid-phase Extraction of Levofloxacin from Aqueous Samples Prior to its Spectrophotometric Determination
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Co-microprecipitation/flotation of trace amounts of cadmium from environmental samples through its complexation with iodide and neutralization with cetyltrimethylammonium bromide in the presence of perchlorate ions
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Prevalence of food neophobia in pre-school children from southern Poland and its association with eating habits, dietary intake and anthropometric parameters: a cross-sectional study
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Świadomość posiadania nadwagi pierwszym krokiem w zapobieganiu otyłości i jej powikłaniom = Awaraness of being overweight is the first step to avoid obesity and its complications
Publicationw ostatnim dwudziestoleciu obserwuje się niepokojący wzrost występowania nadwagi i otyłości na całym świecie. Istotnym elementem profilaktyki zapobiegajacej dalszemu nadmiernemu rozpowszechnieniu nadwagi i otyłości jest uświadomienie osobom najbardziej zagrożonym posiadania tych zaburzeń. Niniejsza praca ma na celu ocenę świadomości mieszkańców wsi na temat nadwagi
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Modification of Rapana thomasiana hemocyanin with choline amino acid salts significantly enhances its antiproliferative activity against MCF-7 human breast cancer cells
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Impact of selected amino acids of HP0377 (Helicobacter pylori thiol oxidoreductase) on its functioning as a CcmG (cytochrome c maturation) protein and Dsb (disulfide bond) isomerase
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The effect of thermal modification of ash wood on granularity and homogeneity of sawdust in the sawing process on a sash gang saw PRW 15-M in view of its technological usefulness
PublicationPrzedstawiono wyniki analiz granulometrycznych trocin, drewna jesionowego niemodyfikowanego (Fraxinus exelsior L.) i modyfikowanego termicznie, otrzymanych w procesie przecinania drewna na pilarce ramowej wielopiłowej PRW15-M. Przecinanie drewna prowadzono dla dwu prędkości posuwu 0,36 m·min-1 oraz 1,67 m·min-1. Ziarnistośćpowstających trocin dla drewna jesionowego modyfikowanego termicznie zawierała się w przedziale od 33,5 μm...
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A New Expression System Based on Psychrotolerant Debaryomyces macquariensis Yeast and Its Application to the Production of Cold-Active β-D-Galactosidase from Paracoccus sp. 32d
PublicationYeasts provide attractive host/vector systems for heterologous gene expression. The currently used yeast-based expression platforms include mesophilic and thermotolerant species. A eukaryotic expression system working at low temperatures could be particularly useful for the production of thermolabile proteins and proteins that tend to form insoluble aggregates. For this purpose, an expression system based on an Antarctic psychrotolerant...
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Idea urbanistyczna Juliana Rummla i jej wpływ na międzywojenne plany Gdyni = The Urban Idea of Jukiab Rummel and Its Influence on the Interwar Plans of Gdynia
PublicationJulian Rummel nie był ani architektem ani urbanistą. Był inżynierem budowy okrętów, działaczem gospodarczym, jednym w wielkich orędowników budowy portu i miasta Gdyni oraz współtwórcą polskiej polityki morskiej II Rzeczypospolitej. W połowie 1924 roku, kiedy rozpoczęto w Gdyni przebudowę otwartego zaledwie rok wcześniej Portu Tymczasowego na wielki, uniwersalny port stały, Julian Rummel był pierwszym którzy zwracali uwagę na pilną...
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Determination of profenofos in seawater and foodstuff samples after its molecularly imprinted polymer pipette-tip micro solid phase extraction optimized by response surface methodology
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Facile synthesis of accordion-like porous carbon from waste PET bottles-based MIL-53(Al) and its application for high-performance Zn-ion capacitor
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On the derivative of associated Le.gendre function of the first kind of integer degree with respect to its order (with applications to the construction of the associated Legendre function of the second kind of integer degree and order)
PublicationW pracy podano szereg zamkniętych wyrażeń dla pochodnej stowarzyszonej funkcji Legendre'a o stopniu (dolnym indeksie) całkowitym względem jej rzędu (górnego indeksu). Wyniki zastosowano do wyprowadzenia kilku nowych reprezentacji, w tym typu Rodriguesa, stowarzyszonych funkcji Legendre'a drugiego rodzaju z całkowityni indeksani.
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Charakterystyka, procesy chemicznej modyfikacji oraz zastosowanie krzemionki i jej zmodyfikowanych postaci = Characteristics, processes of chemical modification as ell as the application of silica and its modified forms
PublicationRóżnorodność chemicznych modyfikacji krzemionki i jej zmodyfikowanych postaci powodują, iż materiały te znajdują coraz szerszy zakres wykorzystania. W artykule przedstawiono charakterystykę krzemionki, żelu krzemionkowego, aerożelu oraz kserożelu. Omówiono otrzymywanie, zastosowanie, a także właściwości tych materiałów. Przedstawiono sposoby chemicznej modyfikacji struktur powierzchniowych z użyciem różnych związków chemicznych....
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Implementation of Molecular Dynamics and Its Extensions with the Coarse-Grained UNRES Force Field on Massively Parallel Systems: Toward Millisecond-Scale Simulations of Protein Structure, Dynamics, and Thermodynamics
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Targeting Spike‐ACE2 Interface of SARS‐CoV‐2 and its Omicron Variant: A Comparative Screening of Potential Inhibitors for Existing and Anticipating Variants Using Molecular Modelling Approach
PublicationThe recent COVID pandemic has shown major impact on public health and economic crisis. Despite the development of many vaccines and drugs against the severe acute respiratory syndrome (SARS) coronavirus 2, the pandemic still persists. The continued spread of the virus is largely driven by the emergence of viral variants such as α, β, γ, delta, epsilon spike, omicron and its subvariants (BA.1,2,3) which can evade the current vaccines...
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On the derivative of the associated Legendre function of the first kind of integer order with respect to its degree (with applications to the construction of the associated Legendre function of the second kind of integer degree and order).
PublicationWyprowadzono szereg zamkniętych wyrażeń dla pochodnych stowarzyszonej funkcji Legendre'a pierwszego rodzaju względem jej dolnego indeksu w przypadku, gdy górny indeks jest liczbą całkowitą. Wyniki zastosowano do znalezienia pewnych nowych reprezentacji (w tym typu Rodriguesa) stowarzyszonych funkcji Legendre'a drugiego rodzaju o indeksach całkowitych.
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Effect of Thermal Treatment of Birch Wood by Saturated Water Vapor on Granulometric Composition of Chips from Sawing and Milling Processes from the Point of View of Its Processing to Composites
PublicationThe goal of this work is to investigate the impact of thermal modification of birch wood with saturated steam on the particle size distribution of the sawing and milling process. Birch wood (Betula pendula Roth) is an excellent source to produce plywood boards. Wastes from mechanical processing of birch wood are suitable to produce composite materials. Granulometric analyses of chips from sawing processes on the PRW 15M frame saw,...
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PCN-222 metal–organic framework: a selective and highly efficient sorbent for the extraction of aspartame from gum, juice, and diet soft drink before its spectrophotometric determination
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Cross-Sectoral Inter-Country Linkages under the Belt and Road Initiative: Chinese ICT Services Value Added Inflows to Manufacturing Exports in the New Eurasian Land Bridge Economies
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Does China use its trade potential in the Belt and Road Initiative properly? The relations between Chinese value added and trade potential in the European countries: bottom-up analysis
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Effect of poplar (Populus sp.) biomass pretreatment on the yield of its enzymatic hydrolysis Wpływ obróbki wstępnej biomasy z topoli (Populus sp.) na wydajność hydrolizy enzymatycznej
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Effect of the production method on the properties of RS3/RS4 type resistant starch. Part 1: Properties of retrograded starch (RS3) produced under various conditions and its susceptibility to acetylation
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Application of Box-Behnken design in response surface methodology for the molecularly imprinted polymer pipette-tip solid phase extraction of methyl red from seawater samples and its determination by spectrophotometery
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Synthesis, characterization and application of a zirconium-based MOF-808 functionalized with isonicotinic acid for fast and efficient solid phase extraction of uranium(VI) from wastewater prior to its spectrophotometric determination
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Separation and determination of ciprofloxacin in seawater, human blood plasma and tablet samples using molecularly imprinted polymer pipette‐tip solid phase extraction and its optimization by response surface methodology
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Lower rim substituted p-tert-butyl-calix[4]arene. Part 16. Synthesis of 25,26,27,28-tetrakis(piperidinylthiocarbonylmethylene)-p-tert-butylcalix[4]arene and its interaction with metal ions
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