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Search results for: MPA ANALOGUES
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Performance and Power-Aware Modeling of MPI Applications for Cluster Computing
PublicationThe paper presents modeling of performance and power consumption when running parallel applications on modern cluster-based systems. The model includes basic so-called blocks representing either computations or communication. The latter includes both point-to-point and collective communication. Real measurements were performed using MPI applications and routines run on three different clusters with both Infiniband and Gigabit Ethernet...
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The neuroprotective activity of new phenylalanine-based AMPA receptor antagonists
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Self-normalized density map (SNDM) for counting microbiological objects
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3-Substituted phenylalanines as selective AMPA- and kainate receptor ligands
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Efektywność studiów Master of Business Administration (MBA) w Polsce
PublicationW artykule oszacowano efektywność 28 programów studiów MBA w Polsce za pomocą „alokacyjnego” modelu New Cost (Tone 2002) należącego do nieparametrycznej metody DEA. Za nakłady przyjęto liczbę godzin programu MBA oraz jego koszt, zaś za wynik ogólny wskaźnik rankingowy studiów MBA w 2018 roku opracowany przez Perspektywy. Uzyskane wyniki świadczą o przeciętnej efektywności studiów MBA wynoszącej 68%, tylko sześć programów było...
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Study of the High-Pressure Superconducting State in H3Se at 300 GPa
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GBTX Emulation for BM@N/MPD Data Acquisition Systems
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Conceptual design report of the MPD Cosmic Ray Detector (MCORD)
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Comparison of Indian and Nepalese media on “Nepal's New Political Map”
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Fashion Games, Fashion in Games and Gamification in Fashion. A First Map
PublicationFashion companies have been using different forms of entertainment such as film and television, sport, music, museums, and photography as inspiration sources and as communication and marketing channels for decades. However, in recent years, they have also started to consider the gaming world. While gaming offers a potential revenue stream from sales of physical and digital clothing, change in it is also the gateway to access new...
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Performance of Noise Map Service Working in Cloud Computing Environment
PublicationIn the paper a noise map service designated for the user interested in environmental noise subject is presented. It is based on cloud computing. Noise prediction algorithm and source model, developed for creating acoustic maps, are working in cloud computing environment. In the study issues related to noise modeling of sound propagation in urban spaces are discussed with a special focus on road noise. Examples of results obtained...
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Self–Organizing Map representation for clustering Wikipedia search results
PublicationThe article presents an approach to automated organization of textual data. The experiments have been performed on selected sub-set of Wikipedia. The Vector Space Model representation based on terms has been used to build groups of similar articles extracted from Kohonen Self-Organizing Maps with DBSCAN clustering. To warrant efficiency of the data processing, we performed linear dimensionality reduction of raw data using Principal...
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Implementacja algorytmu regulacji predykcyjnej MPC w sterownikach programowalnych
PublicationSterowniki programowalne PLC (ang. Programmable Logic Controllers) są główną przemysłową platformą implementacji algorytmów sterowania bezpośredniego. Standardowo producenci PLC udostępniają programistom jedynie podstawowe algorytmy sterowania. W niniejszym artykule rozważana jest implementacja w PLC zaawansowanej metody sterowania – algorytmu MAC/MPC (ang. Model Algorithmic Control/Model Predictive Control) ze względu na jego...
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Self-Organizing Map representation for clustering Wikipedia search results
PublicationThe article presents an approach to automated organization of textual data. The experiments have been performed on selected sub-set of Wikipedia. The Vector Space Model representation based on terms has been used to build groups of similar articles extracted from Kohonen Self-Organizing Maps with DBSCAN clustering. To warrant efficiency of the data processing, we performed linear dimensionality reduction of raw data using Principal...
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Statistical properties of a modified standard map in quantum and classical regimes
PublicationWe present a model—a modified standard map. This model has interesting properties that allow quantum–classical correspondences to be studied. For some range of parameters in the classical phase space of this model, there exist large accelerator modes. We can create a family of maps that have large accelerator modes.
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Towards Easy-to-Use Checkpointing of MPI Applications within CLUSTERIX.
PublicationW literaturze wymienia się wiele bibliotek/systemów zarówno poziomu jądra jak i użytkownika, które wspomagają zapisywanie i odtwarzanie stanu procesów. W odniesieniu do aplikacji równoległych, jest to jednak zadanie cały czas trudne. Praca prezentuje nasze podejście do zapisywania/odtwarzania stanu aplikacji MPI wspomagane przez programistę, które wykorzystane będzie w środowisku projektu CLUSTERIX tj. zintegrowanej grupie klastrów...
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Effect of resveratrol analogue, DMU-212, on antioxidant status and apoptosis-related genes in rat model of hepatocarcinogenesis
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Molecular Modeling of Interaction of the Vasopressin Analogs with Vasopressin and Oxytocin Receptors
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Vitamin D and its analogs as anticancer and anti-inflammatory agents
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Steroid Sulfatase Inhibitors Based on Phosphate and Thiophosphate Flavone Analogs
PublicationA series of phosphate and thiophosphate flavone derivatives were synthesized and biologically evaluated in vitro for inhibition of steroid sulfatase (STS) activity. The described synthesis includes the straightforward preparation of 7-hydroxy-2-phenyl-4H-chromen-4-one 3a, 2-(4-fluorophenyl)-7-hydroxy-4H-chromen-4-one 3b, 7-hydroxy-2-(4-(trifluoromethyl)phenyl)-4H-chromen-4-one 3c, 7-hydroxy-2-(p-tolyl)-4H-chromen-4-one 3d modified...
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Fabrication and photoactivity of organic-inorganic systems based on titania nanotubes and PEDOT containing redox centres formed by different Prussian Blue analogues
PublicationHerein, the heterojunction composed of an inorganic substrate: ordered hydrogenated titania nanotubes (H-TiO2NTs) and a deposited organic film: poly(3,4-ethylenedioxythiophene) (PEDOT) is reported. The conducting polymer is modified with different transition metal haxacyanoferrates (Mehcf), wherein as metal: copper, iron, cobalt and nickel are introduced. The presence of various metal centres provides characteristic redox activity...
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Synthesis and Fluorescent Properties of 6-(4-Biphenylyl)-3,9-dihydro-9-oxo-5H-imidazo[1,2-A]purine Analogues of Acyclovir and Ganciclovir
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Analogues of trypsin inhibitor SFTI-1 modified in the conserved P1′ position by synthetic or non-proteinogenic amino acids retain their inhibitory activity
PublicationA series of linear and monocyclic (with a disulfide bridge only) analogues of trypsin inhibitor SFTI-1 modified in the P-1 and/or P-1' positions were synthesized by the solid-phase method. In the substrate specificity P-1 position, Phe or N-benzylglycine (Nphe) were introduced, whereas the conserved Ser6 in Bownam-Birk (BBI) inhibitors was replaced by Hse (L-homoserine), Nhse [N-(2-hydroxyethyl)glycine], Sar, and Ala. Kinetic studies...
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Synthesis and biological activity of ester derivatives of mycophenolic acid and acridines/acridones as potential immunosuppressive agents
PublicationImproved derivatives of mycophenolic acid (MPA) are necessary to reduce the frequency of adverse effects, this drug exerts in treated patients. In this study, MPA was coupled with N-(x-hydroxyalkyl)-9-acridone-4-carboxamides or N-(x-hydroxyalkyl)acridine-4-carboxamides to give respective ester conjugates upon Yamaguchi protocol. This esterification required protection of phenol group in MPA. Designed conjugates revealed higher...
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Ambisoniczna mapa wybranych miejsc w Trójmieście z obrazem 360°
PublicationW projekcie, który zostanie opisany w niniejszym rozdziale, założonym celem było stworzenie ambisonicznej mapy Trójmiasta w formie aplikacji internetowej. Materiały wideo w technologii 360° z dźwiękiem w postaci sygnału ambisonicznego zostały zarejestrowane w wybranych lokalizacjach uznanych za charakterystyczne dla tej aglomeracji. Celem badawczym projektu było porównanie dostępnych algorytmów miksowania sygnałów ambisonicznych...
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Deep Features Class Activation Map for Thermal Face Detection and Tracking
PublicationRecently, capabilities of many computer vision tasks have significantly improved due to advances in Convolutional Neural Networks. In our research, we demonstrate that it can be also used for face detection from low resolution thermal images, acquired with a portable camera. The physical size of the camera used in our research allows for embedding it in a wearable device or indoor remote monitoring solution for elderly and disabled...
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Tworzenie map konceptów dla ontologii opartych na logice opisowej
PublicationW poprzednich pracach przedstawiono nową metodę reprezentacji wiedzy nazwaną metodą kartograficzną. Metoda ta pozwala na uchwycenie zależności pomiędzy pojęciami wyznaczonymi w ramach terminologii, jak również na stopniowe (w miarę zwiększania się naszej wiedzy) przyporządkowywanie indywidualnych obiektów tym pojęciom. Zależności te reprezentowane są w postaci tzw. mapy konceptów. Efektywność budowy mapy konceptów stanowi zagadnienie...
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BALCONY: an R package for MSA and functional compartments of protein variability analysis
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Prediction of CO2 emissions of a car using the discrete map of the operating conditions
PublicationW pracy przedstawiono propozycję opisu warunków eksploatacji pojazdów w wybranej aglomeracji miejskiej z użyciem dyskretnej mapy warunków eksploatacji. Mapa taka umożliwia prognozowanie wybranych parametrów eksploatacyjnych pojazdów dla przyjętych dróg przejazdu oraz różnych jednostek napędowych. Głównymi parametrami wyznaczanymi z użyciem dyskretnej mapy warunków eksploatacji są: całkowita energia przeznaczana do napędu wybranego...
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Object serialization and remote exception pattern for distributed C++/MPI application
PublicationMPI is commonly used standard in development of scientific applications. It focuses on interlanguage operability and is not very well object oriented. The paper proposes a general pattern enabling design of distributed and object oriented applications. It also presents its sample implementations and performance tests.
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TWORZENIE MAP SIECI KOMPUTEROWYCH Z WYKORZYSTANIEM PROTOKOŁÓW TYPU LLDP
PublicationDla administratorów systemów sieciowych niezwykle istot-nym jest posiadanie narzędzia tworzącego dynamicznie mapę sieci do celów zarządzania, diagnostyki, zapobiegania awariom i włamaniom. Artykuł prezentuje protokoły wspierające tworzenie map sieci a także własne badania nad usprawnieniem istniejących algorytmów. Proponowane rozwiązania to: budowa map z użyciem protokołu LLDP i SNMP, odkrywanie wąskich gardeł w sieciach dzięki...
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MMA fighters's technical-tacticak preparation-fight analysis: a case study
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Analysis of dynamics of a map-based neuron model via Lorenz maps
PublicationModeling nerve cells can facilitate formulating hypotheses about their real behavior and improve understanding of their functioning. In this paper, we study a discrete neuron model introduced by Courbage et al. [Chaos 17, 043109 (2007)], where the originally piecewise linear function defining voltage dynamics is replaced by a cubic polynomial, with an additional parameter responsible for varying the slope. Showing that on a large...
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Conformational latitude – activity relationship of KPPR tetrapeptide analogues toward their ability to inhibit binding of vascular endothelial growth factor 165 to neuropilin‐1
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Peptide splicing in a double‐sequence analogue of trypsin inhibitor SFTI‐1 substituted in the P1 positions by peptoid monomers
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Molecular modelling of transition state analogue inhibitors of glucosamine-6-P synthase and glucose-6-P isomerase.
PublicationStruktura kompleksu 2-amino-2-deoksy-D-glucitolo-6-P (ADGP) z centrum aktywnym syntazy GlcN-6-P z E. coli została wykorzystAna jako punkt wyjścia do modelowania molekularnego analogów ADGP. Używając programu GROMOS96 wygenerowano konformacje analogów o najniższych energiach wewnętrznych, które następnie ''dokowano'' w centrum aktywnym enzymu. Dokonano syntezy wybranych związków i określono parametry kinetyczne i termodynamiczne...
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Interaction of antitumor triazoloacridone C-1305 and its analogs with telomeric DNA
PublicationBadaliśmy oddziaływanie pochodnej triazoloakrydonu C-1305 i jego bliskich analogów strukturalnych z oligonukleotydami zawierającycmi sekwencje telomerowe TTAGGG oraz oligonukleotydami sfałdowanymi w strukturę G-kwadrupleksu. Wykazaliśmy, że spośród badanych związków pochodna C-1305 wykazała największą specyficzność w stosunku do telomerowego DNA. Związek ten stabilizował także strukturę G-kwadrupleksu, podczas gdy jego analogi...
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Deltorphin analogs restricted via a urea bridge: structure and opioid activity
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Deltorphin analogs restricted via a urea bridge: structure and opioid activity
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Novel approaches in the synthesis of batracylin and its analogs: rebirth of an old player?
PublicationW pracy opisano batracylinę (BAT), jej syntezę i aktywność biologiczną oraz otrzymane analogi. BAT została wyselekcjonowana przez NCI (Bethesda, USA) w programie poszukiwań nowych potencjalnych leków przeciwnowotworowych. Związek ten w badaniach in vivo na myszach okazał się bardzo aktywny przeciw nowotworowi okrężnicy 38 (Colon 38), trudnemu do wyleczenia przez dotychczas znane leki przeciwnowotworowe. Jest ona skuteczna również...
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Synthesis and Biological Evaluation of Acridine/Acridone Analogs as Potential Anticancer Agents
PublicationAcridine and acridone analogues were prepared by Ullmann condensation and then cyclization reaction. As a result of nucleophilic substitution reaction 1-nitro-9-phenoxyacridine or 1-chloro-4-nitro-9(10H)-acridone with the corresponding peptides, the planned acridine derivatives (10a-c, 12, 17-a-d, 19) have been obtained. The cytotoxic activity of the newly obtained analogs were evaluated against melanotic (Ma) and amelanotic (Ab)...
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Metallochromic crown ether analogs bearing aromatic residues and azo groupings
PublicationPraca zawiera przegląd syntezowanych, różnych chromogenicznych związków koronowych, zawierających oprócz dwóch grup azowych i łańcucha polieterowego fragmenty heterocykliczne. Porównano właściwości otrzymanych związków w zależności od obecności heteroatomów w pierścieniu makrocyklicznym oraz różnego podstawienia cząsteczki heterocykliczej.
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Anticancer Properties of Amino Acid and Peptide Derivatives of Mycophenolic Acid
PublicationBackground: Although Mycophenolic Acid (MPA) is applied as prodrugs in clinic as an immunosuppressant, it also possesses anticancer activity. MPA acts as Inosine-5’-Monophosphate Dehydrogenase (IMPDH) inhibitor, where the carboxylic group at the end of the side chain interacts with Ser 276 of the enzyme via hydrogen bonds. Therefore, MPA derivatives with other polar groups indicated high inhibition too. On the other hand, potent...
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Synthesis and antimicrobial activity of amino acid and peptide derivatives of mycophenolic acid
PublicationThe series of 16 novel amino acid and peptide mycophenolic acid (MPA) derivatives was obtained as potential antibacterial agents. Coupling of MPA with respective amines was optimized with condensing reagents such as EDCI/DMAP and T3P/TEA. Amino acid analogs were received both as methyl esters and also with the free carboxylic group. The biological activity of the products was tested on five references bacterial strains: Klebsiella...
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Power System Stabilizer as a Part of a Generator MPC Adaptive Predictive Control System
PublicationIn this paper, a model predictive controller based on a generator model for prediction purposes is proposed to replace a standard generator controller with a stabilizer of a power system. Such a local controller utilizes an input-output model of the system taking into consideration not only a generator voltage Ug but also an additional, auxiliary signal (e.g., α, Pg, or ωg). This additional piece of information allows for taking...
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New approach for determining the QoS of MP3-coded voice signals in IP networks
PublicationPresent-day IP transport platforms being what they are, it will never be possible to rule out conflicts between the available services. The logical consequence of this assertion is the inevitable conclusion that the quality of service (QoS) must always be quantifiable no matter what. This paper focuses on one method to determine QoS. It defines an innovative, simple model that can evaluate the QoS of MP3-coded voice data transported...
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Application of cross-priming amplification (CPA) for detection of fowl adenovirus (FAdV) strains
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Structural and Pharmacological Characterization of Phenylalanine-Based AMPA Receptor Antagonists at Kainate Receptors
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A Solution to Image Processing with Parallel MPI I/O and Distributed NVRAM Cache
PublicationThe paper presents a new approach to parallel image processing using byte addressable, non-volatile memory (NVRAM). We show that our custom built MPI I/O implementation of selected functions that use a distributed cache that incorporates NVRAMs located in cluster nodes can be used for efficient processing of large images. We demonstrate performance benefits of such a solution compared to a traditional implementation without NVRAM...
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Direct algorithm for optimizing robust MPC of drinking water distribution systems hydraulics
PublicationModel-based predictive control is an effective method for control the large scale systems [1]–[6], [8], [16], [17]. Method is based on on-line solution of the control task over the control horizon using current and past measurements, as well as the system model. Only a first element of calculated control sequence is applied to the plant. At the next sampling instant, based on new process output measurements, control procedure is...