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Search results for: database, mirna, sirna, snorna, rna interference
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BASECOL2023 scientific content
PublicationContext. The global context of making numerous data produced by researchers available requires collecting and organising the data, assigning meaningful metadata, and presenting the data in a meaningful and homogeneous way. The BASECOL database, which collects inelastic rate coefficients for application to the interstellar medium and to circumstellar and cometary atmospheres, meets those requirements. Aims. We aim to present the...
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A vector-enzymatic DNA fragment amplification-expression technology for construction of artificial, concatemeric DNA, RNA and proteins for novel biomaterials, biomedical and industrial applications
PublicationA DNA fragment amplification/expression technology for the production of new generation biomaterials for scientific, industrial and biomedical applications is described. The technology enables the formation of artificial Open Reading Frames (ORFs) encoding concatemeric RNAs and proteins. It recruits the Type IIS SapI restriction endonuclease (REase) for an assembling of DNA fragments in an ordered head-to-tail-orientation. The...
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Levels of hemoglobin and lipid peroxidation metabolites in blood, catalase activity in erythrocytes and peak expiratory flow rate in subjects with passive exposure to tobacco smoke
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Structural characterization of plasmenylcholine photooxidation products.
PublicationZbadano fotoutlenianie PPlsC w obecności rozpuszczalnego w wodzie sensybilizatora (uczulacza) jakim jest tetrasulfonian ftalocyjaniny zawierający aluminium(III). Stosując metody chromatograficzne (HPLC) wyizolowano, zidentyfikowano oraz scharakteryzowano zasadnicze produkty powstające w obecności tlenu podczas ciągłego naświetlania światłem widzialnym o długości fali 610nm.
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Z informacji naukowej – rossica i sovietica w bibliografii piśmiennictwa polskiego. Bibliograficzna baza danych za lata 1862–2015 [On scholarly information – Rossica and Sovietica in the bibliography of Polish writings. Bibliographical database fo the years 1862–2015]
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An integrated DNA and RNA variant detector identifies a highly conserved three base exon in the MAP4K5 kinase locus
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A digital implementation of the PSK transmitter and receiver as multirate algorithms of the digital signal processing
PublicationIn this paper designs of the transmitter and the receiver of PSK signals as three-rate algorithms of the digital signal processing are described. Additionally we show the examples of the transmitter and the receiver of the following signals: BPSK, QPSK. We discussed also an influence of the cascade of the shaping filter and the receiving filter on the intersymbol interference in the received complex envelope.W pracy opisano projektowanie...
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Acquisition and indexing of RGB-D recordings for facial expressions and emotion recognition
PublicationIn this paper KinectRecorder comprehensive tool is described which provides for convenient and fast acquisition, indexing and storing of RGB-D video streams from Microsoft Kinect sensor. The application is especially useful as a supporting tool for creation of fully indexed databases of facial expressions and emotions that can be further used for learning and testing of emotion recognition algorithms for affect-aware applications....
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GIS three-dimensional Modelling with geo-informatics techniques
PublicationThe integration issue of virtual models and geo-referenced database have a very broad spectrum of potential applications. Before the integration issue was on the cusp, it was quite problematic to combine three-dimensional models with the geo-referenced database. An integrated database contains a variety of data including such as object orientated data model and raster data. Within this paper, authors present an integration process...
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Aims of protective areas and conditions of use of water in a catchment area in shaping the water quality of the water reservoirs
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The antitumor compound triazoloacridinone C-1305 inhibits FLT3 kinase activity and potentiates apoptosis in mutant FLT3-ITD leukemia cells.
PublicationAim: FMS-like receptor tyrosine kinase (FLT3) is expressed in some normal hematopoietic cell types and plays an important role in the pathogenesis of acute myeloid leukemia (AML). In this study, we examined the effects of triazoloacridinone C-1305, an antitumor compound, on AML cells with different FLT3 status in vitro. Methods: A panel of human leukemic cell lines with different FLT3 status was used, including FLT3 internal tandem...
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Detection and Direction-of-Arrival Estimation of Weak Spread Spectrum Signals Received with Antenna Array
PublicationThis paper presents a method for the joint detection and direction of arrival (DOA) estimation of low probability of detection (LPD) signals. The proposed approach is based on using the antenna array to receive spread-spectrum signals hidden below the noise floor. Array processing exploits the spatial correlation between phase-delayed copies of the signal and allows us to evaluate the parameter used to make the decision about the...
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Mechanism of reaction of RNA-dependent RNA polymerase from SARS-CoV-2
PublicationWe combine molecular dynamics, statistical mechanics, and hybrid quantum mechanics/molecular mechanics simulations to describe mechanistically the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (RdRp). Our study analyzes the binding mode of both natural triphosphate substrates as well as remdesivir triphosphate (the active form of drug), which is bound preferentially over ATP by RdRp while...
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DUABI - Business Intelligence Architecture for Dual Perspective Analytics
PublicationA significant expansion of Big Data and NoSQL databases made it necessary to develop new architectures for Business Intelligence systems based on data organized in a non-relational way. There are many novel solutions combining Big Data technologies with Data Warehousing. However, the proposed solutions are often not sufficient enough to meet the increasing business demands, such as low data latency while still maintaining high...
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Musical Instrument Separation Applied to Music Genre Classification . Separacja instrumentów muzycznych w zastosowaniu do rozpoznawania gatunków muzycznych
PublicationThis paper outlines first issues related to music genre classification and a short description of algorithms used for musical instrument separation. Also, the paper presents proposed optimization of the feature vectors used for music genre recognition. Then, the ability of decision algorithms to properly recognize music genres is discussed based on two databases. In addition, results are cited for another database with regard to...
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Latest Insights on Novel Deep Eutectic Solvents (DES) for Sustainable Extraction of Phenolic Compounds from Natural Sources
PublicationPhenolic compounds have long been of great importance in the pharmaceutical, food, and cosmetic industries. Unfortunately, conventional extraction procedures have a high cost and are time consuming, and the solvents used can represent a safety risk for operators, consumers, and the environment. Deep eutectic solvents (DESs) are green alternatives for extraction processes, given their low or non-toxicity, biodegradability, and reusability....
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La vera vedova die vivare a Dio, e morire al mondo”. Le aspettative di Bernardino da Siena e Gilberto di Tournai riguardo al comportamento e ai doveri delle vedove,
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Raman Spectra Measurements for Chemical Identifications - Aspect of Uncertainty Sources and Reduction of Their Effects
PublicationRaman spectrometers enable fast and non-contact identification of examined chemicals. These devices measure Raman spectra and compare with the spectra database to identify unknown and often illicit chemicals (e.g. drugs, explosives) usually without any sample preparation. Raman spectra measurements are a challenge due to noise and interferences present outside the laboratories (field applications). The design of a portable Raman...
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EvOLAP Graph – Evolution and OLAP-Aware Graph Data Model
PublicationThe objective of this paper is to propose a graph model that would be suitable for providing OLAP features on graph databases. The included features allow for a multidimensional and multilevel view on data and support analytical queries on operational and historical graph data. In contrast to many existing approaches tailored for static graphs, the paper addresses the issue for the changing graph schema. The model, named Evolution...
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NASBA – IZOTERMICZNA AMPLIFIKACJA RNA
PublicationNASBA (ang. Nucleic Acid Sequence-Based Amplification) jest skuteczną i czułą techniką izotermicznej amplifikacji opartej na transkrypcji, służąca głównie do detekcji cząsteczek RNA. Znalazła ona zastosowanie do wykrywania RNA wirusowego, bakteryjnego i grzybiczego w próbkach klinicznych oraz żywości.
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Regulated assembly of lipopolysaccharide and sensing of its alterations in Escherichia coli
PublicationThis thesis describes mechanism of the regulation of the transcription of the rpoE gene encoding an essential RNA polymerase subunit in Escherichia coli. The RpoE regulates extracytoplasmic stress response regulon and is required to initiate transcription of genes, whose products are involvedin the folding of periplasmic proteins and synthesis and transport of outer membrane components. The transcriptional regulation of the rpoE...
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Data regarding a new, vector-enzymatic DNA fragment amplification-expression technology for the construction of artificial, concatemeric DNA, RNA and proteins, as well as biological effects of selected polypeptides obtained using this method
PublicationApplications of bioactive peptides and polypeptides are emerging in areas such as drug development and drug delivery systems. These compounds are bioactive, biocompatible and represent a wide range of chemical properties, enabling further adjustments of obtained biomaterials. However, delivering large quantities of peptide derivatives is still challenging. Several methods have been developed for the production of concatemers –...
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Semantic technologies based method of collection, processing and sharing information along food chain
PublicationIn the paper the method of collecting, processing and sharing information along food chain is presented. Innovative features of that method result from advantages of data engineering based on semantic technologies. The source to build ontology are standards and regulations related to food production, and data collected in databases owned by food chain participants. It allows food chain information resources can be represented in...
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Effect of Simultaneous Valve Closures in Hydraulic Piping Systems
PublicationThe paper investigates wave interference (between pressure waves) occurring in simple hydraulic systems. Water hammer was induced by simultaneous closure of three valves located at the reservoirs of a “Y” type hydraulic system. Numerical simulations were carried out with the help of the freeware computer package Allievi enabling the reader to replicate results in a direct manner. The influence of the following quantities has been...
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A Multi-Antenna Scheme for Early Detection and Mitigation of Intermediate GNSS Spoofing
PublicationThis article presents a method for detecting and mitigating intermediate GNSS spoofing. In this type of attack, at its early stage, a spoofer transmits counterfeit signals which have slight time offsets compared to true signals arriving from satellites. The anti-spoofing method proposed in this article fuses antenna array processing techniques with a multipath detection algorithm. The latter is necessary to separate highly correlated...
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Photodynamic Inactivation of Candida albicans with Imidazoacridinones: Influence of Irradiance, Photosensitizer Uptake and Reactive Oxygen Species Generation
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The effects of RNA editing in cancer tissue at different stages in carcinogenesis
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Regulacja topologii DNA przez topoizomerazę typu II, czyli jak struktura DNA wpływa na funkcjonowanie genów
PublicationW wielu ważnych procesach jakie zachodzą w komórce zmienia się topologia DNA i struktura chromatyny. Enzym, topoizomeraza typu II, jest jednym z ważnych czynników, który reguluje zmiany topologiczne i strukturalne w jądrze, przez co ma bezpośredni lub pośredni wpływ na takie procesy jak uporządkowanie struktury chromatyny poprzez wiązanie pętli chromatyny do szkieletu jądrowego, transkrypcję i replikację DNA, reperację uszkodzeń...
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Obliczenia numeryczne konstrukcji dna jachtu podczas wejścia na mieliznę
PublicationPozytywne zmiany w dostępie do żeglarstwa, które dokonały się w ostatnim dziesięcioleciu spowodowały wzrost liczby osób uprawiających ten sport. Przepisy, wg których projektowane są jachty nie stawiają żadnych wymagań wytrzymałości konstrukcji na wypadek kolizji jednostki z dnem. Z doświadczenia wiadomo, że wejście jachtu na piaszczystą mieliznę nie musi powodować uszkodzeń, jednak kolizja z podwodną skałą w szkierach szwedzkich...
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Zaopatrzenie w wodę. Wymagania dotyczące systemów zewnętrznych i ich części składowych. Norma PN-EN 805 jako charakterystyczny przykład uwzględnienia specyfiki współczesnych warunków projektowania rurociągu ciśnieniowego
PublicationCharakterystyczne problemy projektowania współczesnego rurociągu ciśnieniowego. Problemy bezpieczeństwa technicznego i sanitarnego. Zróżnicowania materiałowe, strategia normalizacji europejskiej.
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The control software of the portable raman spectrometer
PublicationThe paper contains a description of the control software of a portable Raman spectrometer which was built in the Department of Optoelectronics and Electronic Systems Faculty of Electronics, Telecommunications and Informatics Gdansk University of Technology. The software has modular structure, which includes the laser control module and the spectrum acquisition module (laser power selection, working mode and data acquisition time)...
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The conducted EMI in DC-DC converters
PublicationThis book presents the phenomena of conducted electromagnetic interference (EMI) generation in DC-DC converters. The measurement and simulation are used to analyze the impact of the most important parameters on the character, level and propagation path of interference. In this book, the analysis of the interference generation and propagation is presented on the example of three basic converters. The wide banded behavior of all...
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Wpływ dodatku kwasu deoksyrybonukleinowego (DNA) na właściwości mechaniczne żeli żelatynowych
PublicationKwasy nukleinowe cieszą się coraz większym zainteresowaniem pod względem zastosowania ich w przemyśle farmaceutycznym, kosmetycznym oraz żywnościowym. Określono wpływ dodatku długo- i krótkołańcuchowych kwasów nukleinowych na właściwości mechaniczne żeli żelatynowych. Badania wykazały występowanie specyficznych interakcji pomiędzy żelatyną a kwasami nukleinowymi oraz pozwoliły na ocenę wpływu tych oddziaływań na twardość, kohezyjność,...
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Modeling the Structure, Dynamics, and Transformations of Proteins with the UNRES Force Field
PublicationThe physics-based united-residue (UNRES) model of proteins ( www.unres.pl ) has been designed to carry out large-scale simulations of protein folding. The force field has been derived and parameterized based on the principles of statistical-mechanics, which makes it independent of structural databases and applicable to treat nonstandard situations such as, proteins that contain D-amino-acid residues. Powered by Langevin dynamics...
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A Salp-Swarm Optimization based MPPT technique for harvesting maximum energy from PV systems under partial shading conditions
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The structure and role of mammalian sperm RNA: a review
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SERRATE: a key factor in coordinated RNA processing in plants
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Early Stages of RNA-Mediated Conversion of Human Prions
PublicationPrion diseases are characterized by the conversion of prion proteins from a PrPC fold into a disease-causing PrPSC form that is self-replicating. A possible agent to trigger this conversion is polyadenosine RNA, but both mechanism and pathways of the conversion are poorly understood. Using coarse-grained molecular dynamic simulations we study the time evolution of PrPC over 600 μs. We find that both the D178N mutation and interacting...
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Swapping Space for Time: An Alternative to Time-Domain Interferometry
PublicationYoung's double-slit experiment [1] requires two waves produced simultaneously at two different points in space. In quantum mechanics the waves correspond to a single quantum object, even as complex as a big molecule. An interference is present as long as one cannot tell for sure which slit is chosen by the object. The more we know about the path, the worse the interference. In the paper we show that quantum mechanics allows for...
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Numeryczna analiza wpływu budowy podpory mostu na rzece Wiśle na przepływ i rozmycie dna koryta rzeki
PublicationW artykule opisano wyniki hydraulicznej analizy wpływu jednego z filarów mostu w Kwidzynie na zmianę pola prędkości przepływu i warunków transportu rumowiska w rzece Wiśle, powodujących lokalne rozmywanie dna koryta rzeki w rejonie filara zlokalizowanego w nurcie rzeki. Bezpośrednią przyczyną podjęcia badań były zaobserwowane podczas budowy mostu lokalne rozmycia dna w sąsiedztwie podpory nr 24.
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The determination and identification of stray current source influences on buried pipelines using time/frequency analysis
PublicationZaprezentowano metodę detekcji źródła interferencji prądów błądzących na rurociągach podziemnych w aglomeracjach miejskich z wykorzystaniem łącznej analizy czasowo-częstotliwościowej mierzonych sygnałów. Badania przeprowadzono na rurociągu podziemnym zlokalizowanym w sąsiedztwie dwóch trakcji elektrycznych: tramwajowej i kolejowej. Wyniki analiz zaprezentowano w formie spektrogramów, które ilustrują zmiany spektralnej gęstości...
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THE 3D MODEL OF WATER SUPPLY NETWORK WITH APPLICATION OF THE ELEVATION DATA
Publication3D visualization is a key element of research and analysis and as the source used by experts in various fields e.g.: experts from water and sewage systems. The aim of this study was to visualize in three-dimensional space model of water supply network with relief. The path of technological development of GESUT data (Geodezyjna Ewidencja Sieci Uzbrojenia Terenu – geodetic records of public utilities) for water supply and measurement...
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Real and Virtual Instruments in Machine Learning – Training and Comparison of Classification Results
PublicationThe continuous growth of the computing power of processors, as well as the fact that computational clusters can be created from combined machines, allows for increasing the complexity of algorithms that can be trained. The process, however, requires expanding the basis of the training sets. One of the main obstacles in music classification is the lack of high-quality, real-life recording database for every instrument with a variety...
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Wystawa zbiorowa "Póki my żyjemy" na 9. Triennale Młodych w Orońsku
PublicationPóki my żyjemy Jesteśmy świadomi zmiany na naszej planecie i czujemy się za nią odpowiedzialni. Dopóki tu jesteśmy mamy głos i możemy zmieniać rzeczywistość. Mamy prawo poruszać wszystkie ważne tematy dotyczące tego kim jesteśmy i jak będzie wyglądać nasza przyszłość. Wraz z artystami i artystkami tworzymy wystawę opierająca się na sztuce, która jest zarówno reakcją jak i działaniem wobec tego zwrotu. Nasz świat będzie istniał...
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Prezentacja działa "Największe słońce widziane z ziemi, dotyka naszej relacji" na 9. Triennale Młodych w Orońsku "Póki my żyjemy"
PublicationPóki my żyjemy Jesteśmy świadomi zmiany na naszej planecie i czujemy się za nią odpowiedzialni. Dopóki tu jesteśmy mamy głos i możemy zmieniać rzeczywistość. Mamy prawo poruszać wszystkie ważne tematy dotyczące tego kim jesteśmy i jak będzie wyglądać nasza przyszłość. Wraz z artystami i artystkami tworzymy wystawę opierająca się na sztuce, która jest zarówno reakcją jak i działaniem wobec tego zwrotu. Nasz świat będzie istniał...
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Gender Disparity in the FinTech Sector: Systematic Literature Review
PublicationThe main objective of this chapter is to identify research areas of FinTech activity in which gender disparity has been observed. In addition, we shall identify how the development of FinTech reduces the gender gap. A systematic literature review using the PRISMA concept is the preferred research method. Publications were searched in the following databases: Web of Science, Scopus and Google Scholar using the formula “FinTech AND...
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Platelet RNA Sequencing Data Through the Lens of Machine Learning
PublicationLiquid biopsies offer minimally invasive diagnosis and monitoring of cancer disease. This biosource is often analyzed using sequencing, which generates highly complex data that can be used using machine learning tools. Nevertheless, validating the clinical applications of such methods is challenging. It requires: (a) using data from many patients; (b) verifying potential bias concerning sample collection; and (c) adding interpretability...
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Selective jamming of OFDM transmission in NB-IoT radio interface
PublicationThe paper presents the concept of smart jamming, which involves selective interference aimed at critical components of the OFDM signal. Research verifying the feasibility of this type of electronic attack are described. A realized testbed for jamming real NB-IoT signals in a downlink is presented. The test results demonstrate the feasibility of realizing selective jamming and its greater effectiveness compared to barrage interference.
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Modelling gene expression of a self-regulating protein
PublicationWe analyze a model of gene transcription and protein synthesis. We take into account the number of sites on the protein’s promoter at which the protein’s dimers can bind blocking transcription of protein mRNA.
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Klasyfikacja dna morskiego na podstawie kątowej zależności cech echa z sonaru wielowiązkowego
PublicationPrzedstawiono metodę rozpoznawania i klasyfikacji rodzaju dna morskiego opartą na przetwarzaniu echa z sonaru wielowiązkowego. Metoda ta polega na obliczaniu zbioru parametrów obwiedni ech dla poszczególnych wiązek, podobnie jak w metodach wykorzystujących echosondy jednowiązkowe. Następnie estymowana jest zależność wartości poszczególnych parametrów od kąta wiązki oraz badane jest powiązanie otrzymanej zależności z rodzajem dna...