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Search results for: DRUM SEPARATION
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NATURE REVIEWS DRUG DISCOVERY
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Current Drug Research Reviews
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Preparation of Internal Standards for 2D-UPLC-MS/MS Quantification of Noncanonical DNA Bases
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A Robust Method for Sample Preparation of Gastrointestinal Stromal Tumour for LC/MS Untargeted Metabolomics
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Preparation and Characterization of Indomethacin Supramolecular Systems with β-Cyclodextrin in Order to Estimate Photostability Improvement
PublicationCyclodextrins have found wide application in contemporary chemistry, pharmacy andmedicine. Because of their unique properties, cyclodextrins are constantly used in research on solubility or stability improvement, as well as other physicochemical properties of medicinal substances. Indomethacin (IND) is a photolabile molecule that also attracts the interest of researchers due to its therapeutic potential and the need to...
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Use of electrochemical methods to examine different surface preparation methods for organic coatings on steel
PublicationObróbka strumieniowo - ścierna jest jedną z powszechnie stosowanych metod przygotowania powierzchni. Wśród nowoczesnych metod coraz większe zainteresowanie wzbudza przygotowanie powierzchni wodą pod wysokim ciśnieniem (z ang. waterjetting). W porównaniu z konwencjonalnymi metodami ''waterjetting'' jest nowoczesną oraz przyjazną środowisku metodą. W literaturze brakuje informacji na temat skuteczności owej metody do zastosowań...
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Preparation of Ag/Cu-doped titanium (IV) oxide nanoparticles in W/O microemulsion
PublicationNanocząstki Cu-TiO2 oraz Ag/Cu-TiO2 otrzymano w mikroemulsji W/O. Właściwości fotokatalityczne zbadano w procesie degradacji fenolu (0,21mM) w zakresie światła widzialnego. Właściwości biobójcze zbadano poprzez wyznaczenie minimalnego stężenia zahamowania wzrostu (MIC) na szczepach bakterii E. coli, St. aureus oraz grzybów S. Cerevisiae i z rodziny Candida. Dla otrzymanych fotokatalizatorów określono wpływ stężenia domieszki metali...
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Preparation and characterization of Langmuir-Blodgett films of 16-membered azobenzocrown ether with naphthalene residue
PublicationOtrzymano i charakteryzowano filmy Langmuira-Blodgett 16-członowej azobenzokorony z resztą naftalenową. Monowarstwy Langmuira były z sukcesem przenoszone na stałe substraty z utworzeniem filmów LB. Filmy osadzone na elektrodach z ITO zostały również użyte jako elektrody w woltametrii cyklicznej i uzyskano rezultaty wskazujące na to, że filmy te wykazują wyraźną odpowiedź na jony metali.
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Preparation, thermal conductivity, and thermal stability of flame retardant polyethylene with exfoliated MoS2/MxOy
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Novel strategy for preparation of highly porous carbon sheets derived from polystyrene for supercapacitors
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Microwave-assisted preparation of Li3V2(PO4)3/C composite with high-rate capacity
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Charakterystyka, przyrządzanie i przechowywanie czynników oddechowych. Characteristics, preparation and storage of breathing mixtures
PublicationOmówiono klasyfikację i metody przygotowania typowych mieszanin gazowych stosowanych podczas nurkowania (tzw. czynniki oddechowe). Obszernie przedstawiono wymagania stawiane czynnikom oddechowym oraz sposoby ich przechowywania.
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New procedure of silica gel surface modification. Preparation of gaseousstandard mixtures for calibration purposes.
PublicationPrzedstawiono nową procedurę modyfikacji powierzchni żelu krzemionkowego z wykorzystaniem trimetyloaminy jako odczynnika. Próbki chemiczne modyfikowanego nośnika zostały wykorzystane do sporządzenia gazowych mieszanin wzorcowych (chlorek metylu jako składnik mierzony) techniką termicznego rozkładu związków powierzchniowych. Głównym celem badań było sprawdzenia przydatności nowej procedury modyfikacji powierzchni żelu do...
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An improved preparation of N2-tert-butoxycarbonyl- and N2-benzyloxycarbonyl-(S)-2,4-diaminobutanoic acids.
PublicationN-Benzyloksykarbonylo i N-tert-butoksykarbonylo-(S)-asparaginę przekształcono do odpowiednio chronionego kwasu (S)-2,4-diaminobutanowego z dobrą wydajnością, w reakcji z octanem jodobenzenu w temp. 0 st.C w mieszaninie tetrahydrofuranu i wody.
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Preparation, characterization and anti-colitis activity of curcumin-asafoetida complex encapsulated in turmeric nanofiber
PublicationUlcerative colitis (UC) is a main form of inflammatory bowel disease (IBD). Asafoetida (ASF) and turmeric have traditionally been used for the treatment of various inflammatory diseases, including UC, because ASF is rich in sulfur compounds and turmeric contains curcumin (CUR). Turmeric nanofiber (TNF), the modified cell wall component of turmeric is considered to play important role in the human diet, health and can be used as...
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Ordered TiO2 nanotubes: the effect of preparation parameters on the photocatalytic activity in air purification process
PublicationVertically ordered TiO2 nanotube arrays were synthesized by anodic oxidation of titanium foil in glycerol, ethylene glycol and water-based electrolytes. The effect of electrolyte composition, anodization voltage, ultrasonic treatment and calcination time on the morphology of the resulting thin films, as well as on their photocatalytic activity in toluene removal, used as a model volatile organic compound, was investigated. Toluene,...
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Preparation of DNA films for studies under vacuum conditions. The influence of cations in buffer solutions
PublicationBadania zostały przeprowadzone w celu określenia optymalnych warunków wymaganych do przygotowania jednolitych filmów superskręconego plazmidowego DNA do wykorzystania w doświadczeniach napromieniowania w warunkach wysokiej próżni. Badania pokazują, że znaczne szkody w DNA powstają w wyniku odpompowywania filmów DNA z roztworów zawierających jedynie czysta wodę.
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Thermal Decomposition of Carbamoyl Meldrum’s Acids: A Starting Point for the Preparation of 1,3-Oxazine Derivatives
PublicationThe ability to undergo [4 + 2] versus [2 + 2] cycloaddition was under investigation for ketenes thermally generated from carbamoyl Meldrum’s acid. Usually, 1,3-oxazino-5-carbamoylo-4,6-diones are formed when carbamoyl Meldrum’s acid reacts with imine. However, in some cases, a reaction takes an unexpected course, leading to the formation of tetraponerines alkaloids derivatives or cyclic iminoethers.
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Softwood-lignin/natural rubber composites containing novel plasticizing agent: Preparation and characterization
PublicationComposite materials based on natural rubber were obtained by using glycerolysate (decomposition prod- uct of polyurethane) as a novel plasticizer. In order to determine the effect of various lignin content, four different filler amounts were used, namely, 5 phr (parts per 100 parts of natural rubber) of lignin (WLI5G), 10 phr (WLI10G), 20 phr (WLI20G), and 40 phr (WLI40G). The reference specimen without lignin (WLI0G) was also...
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Sample preparation procedure for the determination of polycyclic aromatic hydrocarbons in petroleum vacuum residue and bitumen
PublicationThis paper describes a novel method of samplepreparation for the determination of trace concentrations ofpolycyclic aromatic hydrocarbons (PAHs) in high-boilingpetroleum products. Limits of quantitation of the investigatedPAHs in materials of this type range from tens ofnanograms per kilogram to <20 μg/kg. The studies revealedthat in order to separate most of interferences from theanalytes without a significant loss of PAHs, it...
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Simple method for preparation of Dialkyl (2,3-dihydro-1,3-thiazol-2-yl)-phosphonates
PublicationAbstract A simple synthesis of dialkyl (2,3-dihydro-1,3-thiazol-2-yl)-phosphonates from thiazoliumsalts and trialkyl phosphites is described. The series of dialkyl (2,3-dihydro-1,3-thiazol-2-yl)-phosphonates with various substituents in positions 3, 4, and 5 of the thiazole ring wereprepared. However, only phosphonates with an aryl on the nitrogen atom were stable enoughfor chromatographic purification, although all the new phosphonates...
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Determination of volatile organic compounds using solventless sample preparation techniques and gas chromatography
PublicationIn this paper the latest advances in the determination of volatile organic compounds using solvent-free extraction techniques in the sample preparation step are presented. A paper is focus mainly on one of the most popular sample preparation technique: solid-phase microextraction technique (SPME) combined with different detection systems and its applications to sampling of VOCs from the samples with different matrices. This paper...
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Preparation, morphology and properties of natural rubber composites filled with untreated short jute fibres
PublicationGreen composites were obtained by incorporation of short jute fibres in natural rubber matrix using a laboratory two-roll mill. The influence of untreated fibre content (1, 2.5, 5, 7.5 and 10 phr) on the mechanical properties, dynamic mechanical properties, swelling properties was examined. The behaviour of prepared green composites under cyclic compression was also investigated. Fibre dispersion in rubber matrix was studied by...
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The Influence of Different Hydrothermal Processes Used in the Preparation of Brussels Sprouts on the Availability of Glucosinolates to Humans
PublicationCruciferous vegetables represent a valuable source of bioactive compounds. However, there is currently a deficiency of information regarding the extent to which these compounds remain bioaccessible to the body following thermal treatment and digestion processes within the digestive tract. Accordingly, the aim of this study was to evaluate the impact of heat treatment and in vitro digestion on the level of selected bioactive compounds...
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The electrochemical response to glassy carbon electrode modification steps towards viral electrochemical immunosensor preparation
Open Research DataThe dataset contains the electrochemical measurements (CV/EIS) carried out for the consecutive steps of the glassy carbon GC electrode functionalization, in separate subfolders, as described. The cyclic voltammetry (CV) was conducted using a Palmsens 4 potentiostat/galvanostat system (Methrom, Autolab, Netherlands) in the standard three-electrode configuration,...
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Biological effects in photodynamic treatment combined with electropermeabilization in wild and drug resistant breast cancer cells
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Combinatory Treatment with miR-7-5p and Drug-Loaded Cubosomes Effectively Impairs Cancer Cells
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The Correlation between Physical Crosslinking and Water-Soluble Drug Release from Chitosan-Based Microparticles
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Double layer adhesive silicone dressing as a potential dermal drug delivery film in scar treatment
PublicationThe present studies focused on the evaluation of design of an adhesive silicone film intended for scar treatment. Developed silicone double layer film was examined in terms of its future relevance to therapy and applicability on the human skin considering properties which included in vitro permeability of water vapor and oxygen. In order to adapt the patches for medical use in the future there were tested such properties as...
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Tricyclic xanthine derivatives containing a basic substituent: adenosine receptor affinity and drug-related properties
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Increased Expression of Several Collagen Genes is Associated with Drug Resistance in Ovarian Cancer Cell Lines
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New amino acid propyl ester ibuprofenates from synthesis to use in drug delivery systems
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Essentials and Perspectives of Computational Modelling Assistance for CNS-oriented Nanoparticle-based Drug Delivery Systems
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Virulence and Drug-Resistance of Staphylococcus aureus Strains Isolated from Venous Ulcers in Polish Patients
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The bioactivity studies of drug-loaded mesoporous silica-polydimethylsiloxane xerogels using FTIR and SEM/XEDS
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Correlation between physicochemical properties of doxorubicin-loaded silica/polydimethylsiloxane xerogel and in vitro release of drug
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Double layer adhesive silicone dressing as a potential dermal drug delivery film in scar treatment
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Silver Nanoparticles as Chlorhexidine and Metronidazole Drug Delivery Platforms: Their Potential Use in Treating Periodontitis [Corrigendum]
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Novel and effective synthesis protocol of AgNPs functionalized using L-cysteine as a potential drug carrier
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A randomized and controlled study of noninvasive hemodynamic monitoring as a guide to drug treatment of uncontrolled hypertensive patients
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Low-Barrier Hydrogen Bond Determines Target-Binding Affinity and Specificity of the Antitubercular Drug Bedaquiline
PublicationThe role of short strong hydrogen bonds (SSHB) in ligand-target binding remains largely unexplored, thereby hin- dering a potentially important avenue in the rational drug de- sign. Here, we investigate the interaction between bedaquiline (Bq), a potent anti-tuberculosis drug, and the mycobacterial ATP synthase, to unravel the role of a specific hydrogen bond to a conserved acidic residue in the target affinity and specificity....
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Evaluation of multiple genetic markers for typing drug-resistant Mycobacterium tuberculosis strains from Poland
PublicationW publikacji przedstawiono wyniki genotypowania wielolekoopornych szczepów Mycobacterium tuberculosis izolowanych od pacjentów z Polski.
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Molecular modeling and evaluation of novel dibenzopyrrole derivatives as telomerase inhibitors and potential drug for cancer therapy
PublicationDuring previous years, many studies on synthesis, as well as on anti-tumor, anti-inflammatory and anti-bacterial activities of the pyrazole derivatives have been described. Certain pyrazole derivatives exhibit important pharmacological activities and have proved to be useful template in drug research. Considering importance of pyrazole template, in current work the series of novel inhibitors were designed by replacing central...
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Druk 3D części z tworzyw sztucznych na skalę przemysłową w technologii SLS
PublicationFirma EOS, wiodący i światowy dostawca technologii przemysłowego wykorzystania druku 3D dla materiałów metalicznych i polimerowych, zaprezentowała na targach formnext 2017 nowy system EOS P500, przeznaczony do addytywnego wytwarzania modeli. Drukarka 3D adresowana jest dla przedsiębiorstw chcących wytwarzać na skalę przemysłową części i elementy z tworzyw sztucznych o wysokiej jakości.
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Encapsulation of an anticancer drug Isatin inside a host nano-vehicle SWCNT: a molecular dynamics simulation
PublicationThe use of carbon nanotubes as anticancer drug delivery cargo systems is a promising modality as they are able to perforate cellular membranes and transport the carried therapeutic molecules into the cellular components. Our work describes the encapsulation process of a common anticancer drug, Isatin (1H-indole-2,3-dione) as a guest molecule, in a capped single-walled carbon nanotube (SWCNT) host with chirality of (10,10). The...
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pH-Responsive Drug Delivery Nanoplatforms as Smart Carriers of Unsymmetrical Bisacridines for Targeted Cancer Therapy
PublicationSelective therapy and controlled drug release at an intracellular level remain key challenges for effective cancer treatment. Here, we employed folic acid (FA) as a self-navigating molecule in nanoconjugates containing quantum dots (QDs) and β-cyclodextrin (β-CD) for the delivery of antitumor unsymmetrical bisacridine compound (C-2028) to lung and prostate cancers as well as normal cells. The bisacridine derivative can form the...
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Druk 3D części z tworzyw sztucznych na skalę przemysłową w technologii SLS
PublicationFirma EOS, wiodący i światowy dostawca technologii przemysłowego wykorzystania druku 3D dla materiałów metalicznych i polimerowych, zaprezentowała na targach formnext 2017 nowy system EOS P500, przeznaczony do addytywnego wytwarzania modeli. Drukarka 3D adresowana jest dla przedsiębiorstw chcących wytwarzać na skalę przemysłową części i elementy z tworzyw sztucznych o wysokiej jakości.
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From the pills to environment – Prediction and tracking of non-steroidal anti-inflammatory drug concentrations in wastewater
PublicationThe extend of environment pollution by pharmaceuticals is in a stage that required more automatic and integrated solutions. The non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most popular pharmaceutical in the world and emerging pollutants of natural waters. The aim of the paper was to check the correlation of the sales data of selected NSAIDs (ibuprofen, naproxen, diclofenac) and their concentration in the WWTP...
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Optimization of hydrodynamic vortex separator for removal of sand particles from storm water by computational fluid dynamics
PublicationStorm water treatment has been gradually acknowledged for the removal of pollutants from urban areas using the hydro cyclone separation technique. The separation efficiency of the hydrodynamic vortex separator (HDVS) is a complex phenomenon. With the aim enhance the separation potency of HDVS for storm runoff to get rid of sand particles, the HDVS with different structural configurations was studied by computational fluid dynamics....
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Accidents, victims and risk levels on regional roads in pomorskie voivodeship, 2017-2019 - Alcohol and drug accidents
Open Research DataData contain risk classification on regional roads (voivodeship roads) in pomorskie voivodeship in 2017-2019, risk group: Offenders under influence of alcohol or drug - driver or pedestrian. Measures used to assess the level of risk are (5 classes low, low to medium, medium, medium to high, high):