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Search results for: BŁEDY NAMIARU CELU NIERUCHOMEGO
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Discussion on 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors reduce human pancreatic cancer cell invasion and metastasis
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The Effects of Rotating Magnetic Field on Growth Rate, Cell Metabolic Activity and Biofilm Formation by Staphylococcus Aureus and Escherichia Coli
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Vanadium toxicity in chickpea (Cicer arietinum L.) grown in red soil: Effects on cell death, ROS and antioxidative systems
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Calculation of silicon cell temperature of loaded photovoltaic module based on thermal coefficients for different weather conditions of Northern Poland
PublicationWydajność obciążonego modułu fotowoltaicznego zależy silnie od natężenia promieniowania słonecznego, temperatury otoczenia, prędkości wiatru i temperatury wewnętrznej składowych ogniw fotowoltaicznych. Sprawność konwersji fotowoltaicznej spada istotnie wraz z e wzrostem temperatury złącza p-n. Pomiar tej temperatury jest niemożliwy i oblicza się ją w oparciu o mierzoną wartość temperatury przedniej lub tylnej powierzchni modułu...
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Low temperature processed MnCo2O4 and MnCo1.8Fe0.2O4 as effective protective coatings for solid oxide fuel cell interconnects at 750 °C
PublicationIn this study two materials, MnCo2O4 and MnCo1.8Fe0.2O4 are studied as potential protective coatings for Solid Oxide Fuel Cell interconnects working at 750 °C. First powder fabrication by a modified Pechini method is described followed by a description of the coating procedure. The protective action of the coating applied on Crofer 22 APU is evaluated by following the area specific resistance (ASR) of the scale/coating for 5500...
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Novel Nystatin A1 derivatives exhibiting low host cell toxicity and antifungal activity in an in vitro model of oral candidosis
PublicationOpportunistic oral infections caused by Candida albicans are frequent problems in immunocompromised patients. Management of such infections is limited due to the low number of antifungal drugs available, their relatively high toxicity and the emergence of antifungal resistance. Given these issues, our investigations have focused on novel derivatives of the antifungal antibiotic Nystatin A1, generated by modifications at the amino...
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T cell Activation Is Driven by an ADP-Dependent Glukosinase Linking Enhanced Glycolysis with Mitochondrial Reactive Oxygen Species Generation
PublicationMitochondria-originating reactive oxygen species control T cell receptor (TCR)-induced gene expression. Here, we show that TCR-triggered activation of ADP-dependent glucokinase (ADPGK), an alternative, glycolytic enzyme typical for Archaea, mediates generation of the oxidative signal. We also show that ADPGK is localized in the endoplasmic reticulum and suggest that its active site protrudes toward the cytosol. The ADPGK-driven...
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Expression of Osteoblast-Specific Factor 2 (OSF-2, Periostin) Is Associated with Drug Resistance in Ovarian Cancer Cell Lines
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PTPRK Expression Is Downregulated in Drug Resistant Ovarian Cancer Cell Lines, and Especially in ALDH1A1 Positive CSCs-Like Populations
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Potent antidiuretic agonists, deamino-vasopressin and desmopressin, and theirinversoanalogs: NMR structure and interactions with micellar and liposomic models of cell membrane
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Monitoring T-Cell Responses in Translational Studies: Optimization of Dye-Based Proliferation Assay for Evaluation of Antigen-Specific Responses
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Stromal-Epithelial Cross-Talk in the Intestinal Stem Cell Niche is Mediated by a Regulatory Network that Involves TGF-Beta and CTGF
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Induced Pluripotent Stem Cell (iPSC)–Derived Extracellular Vesicles Are Safer and More Effective for Cardiac Repair Than iPSCs
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Characterization of the interactions between human high-molecular-mass kininogen and cell wall proteins of pathogenic yeasts, Candida tropicalis
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Changes in subcellular localization of visfatin in human colorectal HCT-116 carcinoma cell line after cytochalasin B treatment
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Antiproliferative Activity of Double Point Modified Analogs of 1,25-Dihydroxyvitamin D2 Against Human Malignant Melanoma Cell Lines
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Geldanamycin-Induced Osteosarcoma Cell Death Is Associated with Hyperacetylation and Loss of Mitochondrial Pool of Heat Shock Protein 60 (Hsp60)
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Expression of stem cell and mesenchymal markers in circulating tumor cells is associated with poor prognosis of early breast cancer patients
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An insertion/deletion polymorphism of the dihydrofolate reductase (DHFR) gene is associated with serum and red blood cell folate concentrations in women
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Tumor infiltrating lymphocyte signature is associated with single nucleotide polymorphisms and predicts survival in esophageal squamous cell carcinoma patients
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Artificial Intelligence-Based Weighting Factor Autotuning for Model Predictive Control of Grid-Tied Packed U-Cell Inverter
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The influence of a ferrofluid in the presence of an external rotating magnetic field on the growth rate and cell metabolic activity of a wine yeast strain
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Update on the molecular pathogenesis and clinical treatment of Mantle Cell Lymphoma (MCL): minutes of the 9th European MCL Network conference
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Acalabrutinib in relapsed or refractory mantle cell lymphoma (ACE-LY-004): a single-arm, multicentre, phase 2 trial
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Azithromycin Clears Bordetella pertussis Infection in Mice but Also Modulates Innate and Adaptive Immune Responses and T Cell Memory
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LC-PDA-MS and GC-MS Analysis of Scorzonera hispanica Seeds and Their Effects on Human Breast Cancer Cell Lines
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Antitumor DNA-Damaging C-1748 is a New Inhibitor of Autophagy that Triggers Apoptosis in Human Pancreatic Cancer Cell Lines
PublicationDespite the enormous progress that has been made over the past decades in diagnosis, treatment and prevention of many types of tumors, survival rates in pancreatic cancer still remain poor. Pancreatic cancer is one of the most malignant and chemoresistant tumors and the profound mechanism supporting these phenomena is the constitutively activated prosurvival autophagy. The antitumor 1-nitroacridine derivative C-1748 belongs to...
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Result of the 6-min walk test is an independent prognostic factor of surgically treated non-small-cell lung cancer
PublicationPathological tumour, node and metastasis (TNM) stage remains the most significant prognostic factor of non-small-cell lung cancer (NSCLC). Meanwhile, age, gender, pulmonary function tests, the extent of surgical resection and the presence of concomitant diseases are commonly used to complete the prognostic profile of the patient with early stage of NSCLC. The aim of this study is to assess how the result of a 6-min walk test (6MWT)...
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Genotoxicity of selected pharmaceuticals, their binary mixtures, and varying environmental conditions – study with human adenocarcinoma cancer HT29 cell line
PublicationPharmaceutical residues are present in the environment in mixtures and their adverse effects may also result from interactions that occur between compounds. Studies presented in this work focus on genotoxicity of pharmaceuticals from different therapeutic groups in mixtures and in individual solutions impacted with different environmental conditions assessed using comet assay (alkaline approach). Binary mixtures of pharmaceuticals...
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Mission impossible for cellular internalization: When porphyrin alliance with UiO-66-NH2 MOF gives the cell lines a ride
PublicationIs it possible to accelerate cell internalization by hybridization of nanomaterials? Herein we support the realization of using metal-organic frameworks (MOFs) with the assistance of rigid porphyrin structure (H2TMP) aimed at drug loading, drug release, relative cell viability, and targeted in vitro drug delivery. There are several MOFs, i.e., UiO-66-NH2 (125 ± 12.5 nm), UiO-66-NH2 @H2TMP (160 ± 14 nm), UiO-66-NH2 @H2TMP@DOX, and...
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9,10-Dioxoanthracenyldithiocarbamates effectively inhibit the proliferation of non-small cell lung cancer by targeting multiple protein tyrosine kinases
PublicationAnthraquinones have attracted considerable interest in the realm of cancer treatment owing to their potent anticancer properties. This study evaluates the potential of a series of new anthraquinone derivatives as anticancer agents for non-small-cell lung cancer (NSCLC). The compounds were subjected to a range of tests to assess their cytotoxic and apoptotic properties, ability to inhibit colony formation, pro-DNA damage functions,...
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Dehydrogenaza sacharopiny (NADP+, tworząca L-glutaminian) z Candida albicans jako cel molekularny
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alfa-Aminotransferaza kwasu L-alfa-aminoadypinowego z Candida albicans jako cel molekularny
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CEL FUNKCJONOWANIA, ZADANIA I OBSZARY BADAWCZE CENTRUM MORSKIEJ ENERGETYKI WIATROWEJ POLITECHNIKI GDAŃSKIEJ
PublicationW artykule przybliżono wybrane aspekty funkcjonowania Centrum Morskiej Energetyki Wiatrowej w Politechnice Gdańskiej. Scharakteryzowano główne zadania Centrum oraz wstępnie zdefiniowane obszary badawcze, w których specjalizują się naukowcy reprezentujący niemal wszystkie wydziały akademickie Uczelni (oprócz Wydziału Architektury). Przedstawiono kierunki działania Centrum w perspektywie kilku najbliższych lat, w wyniku których nastąpi...
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Przenośny analizator impedancji z detektorem fazoczułym
PublicationW artykule przedstawiono prototyp analizatora impedancji, w którym zastosowano dwa mikrosystemy AD5933 do wydzielania składowych ortogonalnych sygnałów pomiarowych w zakresie częstotliwości od 0,01 Hz do 1 kHz i detektory fazoczułe dla częstotliwości z przedziału 1 kHz ÷ 100 kHz. Przyjęte rozwiązanie pozwoliło wyeliminować błędy pomiaru argumentu impedancji wprowadzane przez AD5933 w górnym zakresie częstotliwości. Uzyskany błąd...
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Nowa metoda wyznaczenia pola powierzchni skóry przedramienia i dłoni wykorzystująca sztuczną sieć neuronową
PublicationW artykule przedstawiono rozbieżności pomiędzy wartościami pola powierzchni skóry obliczonymi za pomocą znanych metod a ich rzeczywistymi wartościami. Wykorzystując skaner 3D o wysokiej dokładności, zmierzono pole powierzchni skóry przedramienia i dłoni. Zaobserwowano, że błędy obliczeń są w wysokim stopniu skorelowane z wartościami BMI badanych osób. W grupie osób o BMI poniżej 20 stwierdzono maksymalny błąd względny wynoszący...
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Wykorzystanie lokalnych współczynników wariancji w ocenie istotności przemieszczeń obiektów inżynierskich
PublicationW monografii przedstawiono wykorzystanie lokalnych współczynników wariancji do oceny istotności przemieszczeń. Lokalne współczynniki wariancji i obliczone na ich podstawie macierze kowariancji pozwalają określić prawidłowość przejętych a priori błędów średnich każdej z grup obserwacji, jak również oszacować wartości średnich błędów pomiaru a posteriori w bardziej wiarygodny sposób niż ich szacowanie na podstawie jednego globalnego...
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Zastosowanie techniki dozymetrii pasywnej do pomiaru wielkości strumienia emisji różnego typu składników z materiałów sezonowanych w miniaturowych komorach emisyjnych
PublicationWyniki badań prowadzonych w różnych ośrodkach wskazują jednoznacznie, że w wielu przypadkach jakość powietrza w pomieszczeniach zamkniętych jest znacznie gorsza od jakości powietrza atmosferycznego (zewnętrznego). Niebezpieczne związki chemiczne występujące w powietrzu wewnętrznym mogą negatywnie wpływać na funkcjonowanie ludzkiego organizmu i być przyczyną wielu chorób układu oddechowego i krwionośnego. Obecność szkodliwych związków...
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Biochar-mediated transformation of titanium dioxide nanoparticles concerning TiO2NPs-biochar interactions, plant traits and tissue accumulation to cell translocation
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Bioactive Compounds in Aegopodium podagraria Leaf Extracts and Their Effects against Fluoride-Modulated Oxidative Stress in the THP-1 Cell Line
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Electrochemical performance of Co3O4/CeO2 electrodes in H2S/H2O atmospheres in a proton-conducting ceramic symmetrical cell with BaZr0.7Ce0.2Y0.1O3 solid electrolyte
PublicationThe electrochemical performance of Co3O4/CeO2 mixed oxide materials as electrodes, when exposed to H2S/H2O atmospheres, was examined employing a proton conducting symmetrical cell, with BaZr0.7Ce0.2Y0.1O3 (BZCY72) as the solid electrolyte. The impact of temperature (700–850 °C) and H2S concentration (0–1 v/v%) in steam-rich atmospheres (90 v/v% H2O) on the overall cell performance was thoroughly assessed by means of electrochemical...
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Cell Density-Dependent Cytological Stage Profile and Its Application for a Screen of Cytostatic Agents Active Toward Leukemic Stem Cells
PublicationProliferation and expansion of leukemia is driven by leukemic stem cells (LSCs). Multidrug resistance (MDR) of LSCs is one of the main reasons of failure and relapses in acute myeloid leukemia (AML) treatment. In this study, we show that maintaining HL-60 at low cell culture density or applying a 240-day treatment with anthrapyridazone (BS-121) increased the percentage of primitive cells, which include LSCs determining the overall...
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The extended version of restriction analysis approach for the examination of the ability of low-molecular-weight compounds to modify DNA in a cell-free system
PublicationOne of the primary requirements in toxicology is the assessment of ability of chemicals to induce DNA covalent modification. There are several well-established methods used for this purpose such as 32P-Postlabeling or HPLC-MS. However, all of these approaches have difficult to overcome limitations, which prevents their use in genotoxin screening. Here, we describe the simple protocol exploiting specificity of restriction enzymes...
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Assessment of immunomodulation and regulation of cell cycle in epithelium and stroma after Cidofovir injection in patients with recurrent respiratory papillomatosis—Pilot study
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Zinc Oxide Nanoparticles Impair the Integrity of Human Umbilical Vein Endothelial Cell Monolayer <I>In</I> <I>Vitro</I>
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Muscle Cell Morphogenesis, Structure, Development and Differentiation Processes Are Significantly Regulated during Human Ovarian Granulosa Cells In Vitro Cultivation
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Piperine Targets Different Drug Resistance Mechanisms in Human Ovarian Cancer Cell Lines Leading to Increased Sensitivity to Cytotoxic Drugs
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The Significance of MicroRNAs Expression in Regulation of Extracellular Matrix and Other Drug Resistant Genes in Drug Resistant Ovarian Cancer Cell Lines
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Arginine-, d-arginine-vasopressin, and their inverso analogues in micellar and liposomic models of cell membrane: CD, NMR, and molecular dynamics studies
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Novel Cell Permeable Polymers of N-Substituted L-2,3-Diaminopropionic Acid (DAPEGs) and Cellular Consequences of Their Interactions with Nucleic Acids
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