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Induction of immune responses in sheep by vaccination with liposome-entrapped DNA complexes encoding Toxoplasma gondii MIC3 gene
PublikacjaToxoplasma gondii is a parasite that has been extensively studied due to its medical and veterinary importance in terminating pregnancies. Consequently, a satisfactory vaccine is required to control itsadverse effects on pregnant animals. The microneme protein, MIC3, is a major adhesion protein that binds to the surface of host cells and parasites, and is therefore a potential vaccine against T. gondii.The viability of MIC3 as...
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Unknown Enemy and Psychopathological Responses: A Cross-Sectional Nationwide Study Assessing the Knowledge About COVID-19
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Coping Strategies and Psychopathological Responses Among Medical and Non-medical Professionals – a Cross-Sectional Online Survey
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Psychopathological responses and face mask restrictions during the COVID-19 outbreak: Results from a nationwide survey
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Age-dependent sympathetic neural responses to ß1 selective beta-blockade in untreated hypertension-related tachycardia
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High-normal blood pressure is associated with increased resting sympathetic activity but normal responses to stress tests
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New and Old Genes Associated with Primary and Established Responses to Paclitaxel Treatment in Ovarian Cancer Cell Lines
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Emerging Role of Adenylate Kinase 4 as a Metabolic Player Regulating Cellular Hypoxic Responses in Pulmonary Cells
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Self-testing of analog parts of mixed-signal electronic microsystems based on multiple sampling of time responses
PublikacjaW artykule przedstawiono nowe podejście samo-testowania toru analogowego zakończonego przetwornikiem A/C w mieszanych sygnałowo elektronicznych systemach wbudowanych sterowanych mikrokontrolerami. Bazuje ono na nowej metodzie diagnostycznej opartej na przekształceniu transformującym zbiór próbek odpowiedzi czasowej układu badanego na pobudzenie impulsem prostokątnym na rodzinę krzywych identyfikacyjnych umieszczonych w przestrzeni...
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Biological responses to environmental contamination. How can metal pollution impact signal honesty in avian species?
PublikacjaEnvironmental pollution, for example with metals, can significantly affect the ecosystem balance leading to severe changes. Biologically active pigments are relevant for the appearance and condition of birds. Melanin and carotenoid particles are the most frequently deposited pigments in avian integument. They are responsible for the majority of colors of bird plumage. The phenotypic expression can be affected by metal contamination....
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Detection of Delamination in Laminate Wind Turbine Blades Using One-Dimensional Wavelet Analysis of Modal Responses
PublikacjaThis paper demonstrates the effectiveness of a nondestructive diagnostic technique used to determine the location and size of delamination in laminated coatings of wind turbine blades. This is realized based on results of numerical and experimental investigations obtained by the use of the finite element method (FEM) and laser scanning vibrometry (LSV). The proposed method is based on the one-dimensional continuous wavelet transform...
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Bystander Effects Induced by Medium From Irradiated Cells: Similar Transcriptome Responses in Irradiated and Bystander K562 Cells
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New and Old Genes Associated with Primary and Established Responses to Cisplatin and Topotecan Treatment in Ovarian Cancer Cell Lines
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An investigation of structural responses of inverted pavements by numerical approaches considering nonlinear stress-dependent properties of unbound aggregate layer
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Methadone is substantially less effective than morphine in modifying locomotor and brain Fos responses to subsequent methadone challenge in rats
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Recombinant Human Plasma Gelsolin Stimulates Phagocytosis while Diminishing Excessive Inflammatory Responses in Mice with Pseudomonas aeruginosa Sepsis
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Role of melatonin seed priming on antioxidant enzymes and biochemical responses of Carthamus tinctorius L. under drought stress conditions
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Cross-linking of sodium caseinate-structured emulsion with transglutaminase alters postprandial metabolic and appetite responses in healthy young individuals
PublikacjaThe physico-chemical and interfacial properties of fat emulsions influence lipid digestion and may affect postprandial responses. The aim of the present study was to determine the effects of the modification of the interfacial layer of a fat emulsion by cross-linking on postprandial metabolic and appetite responses. A total of fifteen healthy individuals (26·5 (sem 6·9) years and BMI 21·9 (sem 2·0) kg/m2) participated in a cross-over...
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Evaluation and cellular responses of modulators of TRF1/TRF2 protein’s function as potential anticancer drugs interfering with telomeric shelterin’s function
PublikacjaA number of proteins that interact with telomeres have been identified in human cells, indicating the high plasticity of human nucleoprotein complex organization. The most important complex is the "shelterin" complex, which consists of six proteins: TRF1, TRF2, TIN2, POT1, TPP1. The TRF1 and TRF2 directly bind to telomeric double-stranded DNA and the TIN2 protein. The TIN2 protein also binds to the TPP1 protein, stabilizing the...
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Konfrontowanie reprezentatywnych struktur spektralnych odpowiedzi impulsowej kanału głosowego [Confronting representative spectral structures of vocal tract pulse responses]
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Diverse behavioral, monoaminergic and Fos protein responses to opioids in Warsaw high-alcohol preferring and Warsaw low-alcohol preferring rats
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Neonatal ventral hippocampal damage modifies serum corticosterone and dopamine release responses to acute footshock in adult Sprague-Dawley rats
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The immune responses of sheep after DNA immunization with, Toxoplasma gondii MAG1 antigen—with and without co-expression of ovine interleukin 6
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The immune responses of sheep after DNA immunization with Toxoplasma gondii MAG1 antigen - with and without co-expression of ovine interleukin 6
PublikacjaW niniejszej pracy porównano odpowiedź immunologiczną owiec, którym podano domięśniowo plazmid DNA zawierający gen kodujący białko macierzy cyst tkankowych (MAG1) Toxoplasma gondii - pojedynczo bądź z DNA plazmidu kodującego owczą interleukinę 6 (IL-6). Dzięki wykorzystaniu plazmidu zawierającego gen mag1 odnotowano podwyższony poziom przeciwciał IgG1 oraz IgG2 w surowicach szczepionych zwierząt.
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Evaluation of immune responses in sheep induced by DNA immunization with genes encoding GRA1, GRA4, GRA6 and GRA7 antigens of Toxoplasma gondii
PublikacjaW niniejszej pracy oszacowano odpowiedź immunologiczną owiec szczepionych domięśniowo szczepionkami DNA zawierającymi geny kodujące cztery antygeny granul o dużej gęstości (GAR1, GRA4, GRA6 oraz GRA7) Toxoplasma gondii. Wykazano, iż wykorzystanie DNA plazmidu pGRA7 indukuje znaczący poziom przeciwciał IgG-2 anty-GRA7 oraz IFN-gammma, podczas gdy iniekcja pGRA1, pGRA4 oraz pGRA6 stymuluje odpowiedź przeciwciał IgG1 z ograniczoną...
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Morphine and methadone pre-exposures differently modify brain regional Fos protein expression and locomotor activity responses to morphine challenge in the rat
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O07 Filaggrin insufficiency renders keratinocyte-derived small extracellular vesicles capable of affecting CD1a-mediated T-cell responses and promoting allergic inflammation
PublikacjaThe association between FLG loss-of-function mutations and the development of atopic dermatitis (AD) indicates that filaggrin is critical to skin barrier function; the mutations are also linked to additional allergic manifestations, but it is unknown how the skin may influence inflammation in distant tissues. Here we investigated the impact of filaggrin insufficiency on keratinocyte-derived exosome-enriched small extracellular...
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Cardiovascular and Perceptual Responses to Resistance Training with Practical Blood Flow Restriction Induced by a Non-Elastic Band vs. Pneumatic Cuff: A Crossover Randomized Study
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Discovery of small-molecule regenerative drugs using a model of complex tissue injury in mice. Transcriptomic responses of neurodevelopmental genes during pharmacologically induced regeneration
PublikacjaDespite significant development in regenerative medicine, there is a deficit of effective therapies for wound healing and tissue regeneration. Research performed using animal wound models allows for a better understanding of this complex process, searching for compounds with pro-regenerative properties, and assessing their efficacy and safety. Unfortunately, the lack of adequate preclinical models proves to be an issue as no animal...
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Differing responses of the estuarine bivalve Limecola balthica to lowered water pH caused by potential CO2 leaks from a sub-seabed storage site in the Baltic Sea: An experimental study
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Analog fault signature based on sigma-delta modulation and oscillation-test methodology.
PublikacjaW artykule dokonano przeglądu prac z zakresu testowania układów elektronicznych metodą oscylacyjną. Wskazując na niedostatki aktualnie stosowanej techniki testowania oscylacyjnego zaproponowano nową sygnaturę uszkodzeń dla układów analogowych. Proponowany parametr diagnostyczny jest wydobywany z odpowiedzi czasowej oscylatora testującego, w układzie złożonym z detektora szczytowego, modulatora sigma-delta oraz licznika rewersyjnego....
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Nickel Oxide Thin Film Sensor for Fluctuation-Enhanced Gas Sensing of Formaldehyde
PublikacjaNanocrystalline nickel-oxide-based thin films were prepared by advanced reactive gas deposition, and the response of these films to formaldehyde was studied by fluctuationenhanced sensing. Morphological and structural analyses showed porous deposits of nickel oxide particles with face-centered cubic structure. Resistance fluctuations were measured upon exposure to ethanol, formaldehyde and methane at 200 °C. Power density spectra...
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Influence of Escherichia coli on Expression of Selected Human Drug Addiction Genes
PublikacjaThe impact of enteric microflora on the expression of genes associated with cocaine and amphetamine addiction was described. Human genome-wide experiments on RNA transcripts expressed in response to three selected Escherichia coli strains allowed for significant alteration (p > 0.05) of the linear regression model between HT-29 RNA transcripts associated with the KEGG pathway:hsa05030:Cocaine addiction after 3 h stimulation with...
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Multi-Objective Design Optimization of Compact Quasi-Isotropic Dielectric Resonator Antenna
PublikacjaMulti-objective optimization of a quasi-isotropic dielectric resonator antenna (DRA) is presented. Utilization of variable-fidelity electromagnetic (EM) DRA models, response surface approximations, and response correction techniques, allows us to obtain—at a low computational cost—a set of alternative antenna designs representing the best possible trade-offs between three conflicting objectives: antenna size, its reflection response,...
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Gas sensors based on conducting polymers-recent developments
PublikacjaThis work discusses sensing performance dependence of PEDOT polymer and its composites on the counter ions used in the polymerization process. The sensors based on PEDOT-RGO composite show reversible response to NO2, while on PEDOT/LiClO4 irreversible. As a result, PEDOT-RGO could be used as a typical gas sensor, while sensor based PEDOT/LiClO4 could be used as an integrating gas sensor, also known as an accumulating gas sensor....
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Improving web user experience with caching user interface
PublikacjaOften, Web technologies are used to operate or to configure network-enabled equipment, to configure and administer modular applications, or as teaching environments. The comfort of human work requires a similar response time in these applications as in the Internet. To improve response time, various forms of caching at different levels are employed. To improve the user experience in regard to response time when performing specific...
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Improving web user experience with caching user interface
PublikacjaIn human-computer interaction, response time is assumed generally not to exceed significantly 1-2 seconds. While the natural competition in the Internet public Web serving ensures adhering widely to such limits, some Web environments are less competitive and offer much worse user experience in terms of response time. This paper describes a solution to significantly improve user experience in terms of response time with only modification...
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Generalization of Kramers-Krönig relations for evaluation of causality in power-law media
PublikacjaClassical Kramers-Krönig (K–K) relations connect real and imaginary parts of the frequency-domain response of a system. The K–K relations also hold between the logarithm of modulus and the argument of the response, e.g. between the attenuation and the phase shift of a solution to a wave-propagation problem. For square-integrable functions of frequency, the satisfaction of classical K–K relations implies causality in the time domain....
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Numeryczna analiza dynamiczna wieszaków w łukowym wiadukcie kolejowym. Analiza przypadku
PublikacjaW artykule przedstawiono analizę dynamiczną wiaduktu kolejowego w ciągu Centralnej Magistrali Kolejowej zlokalizowanego koło Huty Zawadzkiej. W analizie zwrócono szczególną uwagę na lokalną odpowiedź wieszaków na obciążenie przejeżdżającym pociągiem oraz wiatrem. Obliczenia przeprowadzono na podstawie wykonanego modelu MES. Zweryfikowano poprawność modelu poprzez porównanie uzyskanych wyników z wartościami pomierzonymi. Przeprowadzono...
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Shaking table experimental study on pounding between adjacent structures founded on different soil types
PublikacjaThe aim of this study is to extensively investigate the effect of the soil type on the response of colliding structures based on shaking table experimental tests. Two single-storey models of steel buildings with different dynamic parameters were considered in this study. Three pounding scenarios were taken into account by applying different seismic gaps (0.5 cm, 1 cm and 1.5 cm as well as the no pounding case). First, the effect...
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Dynamic modeling of non-cylindrical curved viscoelastic single-walled carbon nanotubes based on the second gradient theory
PublikacjaThis paper is devoted to the theoretical study of the dynamic response of non-cylindrical curved viscoelastic single-walled carbon nanotubes (SWCNTs). The curved nanotubes are largely used in many engineering applications, but it is challenging in understanding mechanically the dynamic response of these curved SWCNTs when considering the influences of the material viscosity. The viscoelastic damping effect on the dynamic response...
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A Systematic Search for New Coupling Schemes of Cross-Coupled Resonator Bandpass Filters
PublikacjaIn this paper, a systematic approach to an extensive search for topologies of cross-coupled filters with generalized Chebyshev response is presented. The technique applies graph theory to find unique, nonisomorphic filter configurations, and tests whether a specific frequency response can be realized in a given set of topologies. The results of the search are then stored in a database of possible filter configurations.
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Shaking table experimental study on the effectiveness of polymer bearings for seismic isolation of structures
PublikacjaSeismic isolation has been recognised to be a very effective way of protecting structures from damage during earthquakes. It allows us to extend the natural period of the structure and therefore avoid resonance with the ground motion. Moreover, by increasing damping in the isolation devices, more energy can be dissipated and thus the structural response can be further reduced. The aim of this paper is to show the results of the...
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Fast Multi-Objective Optimization of Narrow-Band Antennas Using RSA Models and Design Space Reduction
PublikacjaComputationally efficient technique for multi-objective design optimization of narrow-band antennas is presented. In our approach, the corrected low-fidelity antenna model (obtained through coarse-discretization EM simulations) is enhanced using frequency scaling and response correction, sampled, and utilized to obtain a fast response surface approximation (RSA) antenna surrogate. The RSA model is constructed in the reduced design space....
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Rapid Yield Estimation and Optimization of Microwave Structures Exploiting Feature-Based Statistical Analysis
PublikacjaIn this paper, we propose a simple, yet reliable methodology to expediteyield estimation and optimization of microwave structures. In our approach,the analysis of the entire response of the structure at hand (e.g., $S$-parameters asa function of frequency) is replaced by response surface modeling of suitablyselected feature points. On the one hand, this is sufficient to determinewhether a design satisfies given performance specifications....
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Modelling of dielectric properties of BiNbO4-based microwave ceramics
PublikacjaIn the present paper results of the studies devoted to computer simulations of dielectric response of electroceramics in a frequency domain as well as analysis of the experimental data are given. As an object of investigations BiNbO4-based microwave ceramics was taken. Simulations of the hypothetical impedance response of the ceramic system were performed under assumption of the brick-layer model. A strategy for analysis and modelling...
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Nonlinear numerical simulation of earthquake-induced pounding between timber frame buildings
PublikacjaEarthquakes may induce serious dynamic loads acting on buildings, which can lead to damage or even destruction of the whole structure. In densely populated areas, it is quite common that buildings are located very close one to another which can result in pounding between them during ground motions. Due to the environmental awareness, multi-story timber frame buildings are gaining popularity and therefore there is a need to investigate...
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Two-Rate Based Low-Complexity Variable Fractional-Delay FIR Filter Structures
PublikacjaThis paper considers two-rate based structures for variable fractional-delay (VFD) finite-length impulse response (FIR) filters. They are single-rate structures but derived through a two-rate approach. The basic structure considered hitherto utilizes a regular half-band (HB) linear-phase filter and the Farrow structure with linear-phase subfilters. Especially for wide-band specifications, this structure is computationally efficient...
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Charakterystyka procesu ciągłej dewulkanizacji termomechanicznej z zastosowaniem metod doświadczalnych
PublikacjaBadano proces termomechanicznej dewulkanizacji rozdrobnionych odpadów gumowych prowadzono przy użyciu wytłaczarki dwuślimakowej współbieżnej o specjalnej konfiguracji układu uplastyczniającej, umożliwiającego wywieranie znacznych sił ścinających na miał gumowy. W badaniach doświadczalnych zastosowano metodę powierzchni odpowiedzi RSM (response surface methodology). Wyznaczono modele matematyczne wyrażające zmienność właściwości...
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Fast bubble dynamics and sizing
PublikacjaSingle bubble sizing is usually performed by measuring the resonant bubble response using the Dual Frequency Ultrasound Method. However, in practice, the use of millisecond-duration chirp-like waves yields nonlinear distortions of the bubble oscillations. In comparison with the resonant curve obtained under harmonic excitation, it was observed that the bubble dynamic response shifted by up to 20 percent of the resonant frequency...