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Colorectal neuroendocrine neoplasms — update of the diagnostic and therapeutic guidelines (recommended by the Polish Network of Neuroendocrine Tumours) [Nowotwory neuroendokrynne jelita grubego — uaktualnione zasady diagnostyki i leczenia (rekomendowane przez Polską Sieć Guzów Neuroendokrynych)]
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Procognitive activity of nitric oxide inhibitors and donors in animal models
PublikacjaNitric oxide is a small gaseous molecule that plays important roles in the majority of biological functions. Impairments of NO-related pathways contribute to the majority of neurological disorders, such as Alzheimer’s disease (AD), and mental disorders, such as schizophrenia. Cognitive decline is one of the most serious impairments accompanying both AD and schizophrenia. In the present study, the activities of NO donors, slow (spermine...
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The Impact of Different Drying Methods on the Metabolomic and Lipidomic Profiles of Arthrospira platensis
PublikacjaDrying is an inseparable part of industrial microalgae production. In this work, the impacts of eight different drying methods on the metabolome and lipidome of Arthrospira platensis were investigated. The studied drying methods were freeze drying (FD), sun drying (SD), air drying at 40 and 75 °C (AD′ and AD″), infrared drying at 40 and 75 °C (IRD′ and IRD″), and vacuum drying at 40 and 75 °C (VD′ and VD″). Results gathered by...
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O07 Filaggrin insufficiency renders keratinocyte-derived small extracellular vesicles capable of affecting CD1a-mediated T-cell responses and promoting allergic inflammation
PublikacjaThe association between FLG loss-of-function mutations and the development of atopic dermatitis (AD) indicates that filaggrin is critical to skin barrier function; the mutations are also linked to additional allergic manifestations, but it is unknown how the skin may influence inflammation in distant tissues. Here we investigated the impact of filaggrin insufficiency on keratinocyte-derived exosome-enriched small extracellular...
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Urban scene semantic segmentation using the U-Net model
PublikacjaVision-based semantic segmentation of complex urban street scenes is a very important function during autonomous driving (AD), which will become an important technology in industrialized countries in the near future. Today, advanced driver assistance systems (ADAS) improve traffic safety thanks to the application of solutions that enable detecting objects, recognising road signs, segmenting the road, etc. The basis for these functionalities...
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Gastroduodenal neuroendocrine neoplasms including gastrinoma — update of the diagnostic and therapeutic guidelines (recommended by the Polish Network of Neuroendocrine Tumours) [Nowotwory neuroendokrynne żołądka i dwunastnicy z uwzględnieniem gastrinoma — uaktualnione zasady postępowania (rekomendowane przez Polską Sieć Guzów Neuroendokrynnych)]
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Specific Binding of Cholesterol to the Amyloid Precursor Protein: Structure of the Complex and Driving Forces Characterized in Molecular Detail
PublikacjaC99 is the C-terminal membrane-bound fragment of the amyloid precursor protein that is cleaved by γ-secretase to release Aβ peptides, the hallmark of Alzheimer’s disease (AD). Specific interactions of C99 with cholesterol have been proposed to underlie the recognized role of cholesterol in promoting amyloidogenesis. By using molecular dynamics simulations, we studied cholesterol binding to C99 in a lipid bilayer. We determined...
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Keratinocyte-derived small extracellular vesicles supply antigens for CD1a-resticted T cells and promote their type 2 bias in the context of filaggrin insufficiency
PublikacjaIntroduction: Exosome-enriched small extracellular vesicles (sEVs) are nanosized organelles known to participate in long distance communication between cells, including in the skin. Atopic dermatitis (AD) is a chronic inflammatory skin disease for which filaggrin (FLG) gene mutations are the strongest genetic risk factor. Filaggrin insufficiency affects multiple cellular function, but it is unclear if sEV-mediated cellular communication...
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Neuroendocrine neoplasms of the small intestine and the appendix — update of the diagnostic and therapeutic guidelines (recommended by the Polish Network of Neuroendocrine Tumours) [Nowotwory neuroendokrynne jelita cienkiego i wyrostka robaczkowego — uaktualnione zasady diagnostyki i leczenia (rekomendowane przez Polską Sieć Guzów Neuroendokrynnych)]
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Update of the diagnostic and therapeutic guidelines for gastro-entero-pancreatic neuroendocrine neoplasms (recommended by the Polish Network of Neuroendocrine Tumours) [Aktualizacja zaleceń ogólnych dotyczących postępowania diagnostyczno-terapeutycznego w nowotworach neuroendokrynnych układu pokarmowego (rekomendowane przez Polską Sieć Guzów Neuroendokrynnych)]
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Investigation of the influence of capilary effect on operation of the loop heat pipe
PublikacjaIn the paper presented are studies on the inestigation of the capillary forces effect inducted in the porous structure of a loop heat pipe using water and ethanol ad test fluids. The potential application of such effects is for example in the evaporator of the domestic micro-CHP unit, where the reduction of pumping power could be obtained. Preliminary analysis of the results indicates water as having the best potential for developing...
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AUDITORY DISPLAY FROM THE MUSIC TECHNOLOGY PERSPECTIVE . Obecność wirtualnego środowiska dźwiękowego w technologiach muzycznych
PublikacjaThis paper presents some applications of Auditory Displays (AD) in the domain of music technology. First, the scope of music technology and auditory display areas are shortly outlined. Then, the research trends and system solutions within the fields of music technology, music information retrieval and music recommendation are discussed. Finally, an example of an auditory display that facilities music annotation process based on...
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Development of a new generation of unmanned surface and underwater vehicles using the advanced technologies and achievements towards the application of control systems by the artificial intelligence AI.
PublikacjaThe operation of offshore structures at sea requires implementation of the advanced systems of permanent monitoring of work of such the installations. Novel solutions concerning such the systems should be associated with application of unmanned maritime surface and underwater platforms. The unmanned maritime platforms are and will be based on application of the newest achievements of some important technologies. Between these technologies...
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Marine and Cosmic Inspirations for AI Algorithms
PublikacjaArtificial Intelligence (AI) is a scientific area that currently sees an enormous growth. Various new algorithms and methods are developed and many of them meets practical, successful applications. Authors of new algorithms draw different inspirations. Probably the most common one is the nature. For example, Artificial Neural Networks were inspired by the structure of human brain and nervous system while the classic Genetic Algorithm...
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Challenges associated with development of AUV - unmanned autonomous underwater vehicles to be operated using the AI-based control systems
PublikacjaThe last decade has been devoted towards further development of the UUV unmanned underwater vehicles which may be of two types. There are the USV unmanned surface vehicles and UUV unmanned underwater vehicles. There is a growing interest to work out and implement the fully advanced AUV autonomous underwater vehicles. The main drivers towards development of such the vehicles are the technologies of autonomous systems, sensors and...
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Synthesis and Cholinesterase Inhibitory Activity of N-Phosphorylated /N-Tiophosphorylated Tacrine
PublikacjaNovel phosphorus and thiophosphorus tacrine derivatives were designed, synthesized and their biological activity and molecular modeling was investigated as a new potential anti-Alzheimer's disease (AD) agents. All new synthesized compound exhibited lower toxicity against neuroblastoma cell line (SH-SY5Y) in comparison with tacrine. Two analogues in the series, 7 and 9, demonstrated lack of cytotoxicity against hepatocellular cells...
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Service-based Resilience via Shared Protection in Mission-critical Embedded Networks
PublikacjaMission-critical networks, which for example can be found in autonomous cars and avionics, are complex systems with a multitude of interconnected embedded nodes and various service demands. Their resilience against failures and attacks is a crucial property and has to be already considered in their design phase. In this paper, we introduce a novel approach for optimal joint service allocation and routing, leveraging virtualized...
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THE IPV4 TO IPV6 MIGRATION OF APPLICATIONS AND SERVICE
PublikacjaThis article presents the problems related to IPv4 to IPv6 migration of applications supporting network services. It summarizes the needs of executing such migration. It shows the basic problems of automating the migration process, having defined the basic terms, i.e.: a network service, a network application. It shows a sample implementation of the automation of the migration process between IP technologies for selected network...
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Comparative study of neural networks used in modeling and control of dynamic systems
PublikacjaIn this paper, a diagonal recurrent neural network that contains two recurrent weights in the hidden layer is proposed for the designing of a synchronous generator control system. To demonstrate the superiority of the proposed neural network, a comparative study of performances, with two other neural network (1_DRNN) and the proposed second-order diagonal recurrent neural network (2_DRNN). Moreover, to confirm the superiority...
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TOWARDS EXPLAINABLE CLASSIFIERS USING THE COUNTERFACTUAL APPROACH - GLOBAL EXPLANATIONS FOR DISCOVERING BIAS IN DATA
PublikacjaThe paper proposes summarized attribution-based post-hoc explanations for the detection and identification of bias in data. A global explanation is proposed, and a step-by-step framework on how to detect and test bias is introduced. Since removing unwanted bias is often a complicated and tremendous task, it is automatically inserted, instead. Then, the bias is evaluated with the proposed counterfactual approach. The obtained results...
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International Competitiveness in the Economics Literature: A Bibliometric Study
PublikacjaThis paper has as its main aim to consolidate the state of the art of academic research on international competitiveness, based on a bibliometric study of the economics literature published over the past 70 years. Citation data is collected from the ISI WEB of Science website, Scopus and Google Scholar and is analysed using Histcite and Vosviewer software. The growth pattern of the international competitiveness literature is investigated...
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A Selection of Starting Points for Iterative Position Estimation Algorithms Using Feedforward Neural Networks
PublikacjaThis article proposes the use of a feedforward neural network (FNN) to select the starting point for the first iteration in well-known iterative location estimation algorithms, with the research objective of finding the minimum size of a neural network that allows iterative position estimation algorithms to converge in an example positioning network. The selected algorithms for iterative position estimation, the structure of the...
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Wireless Networks as an Infrastructure for Mission-Critical Business Applications
PublikacjaDespite the dynamic growth of wireless network systems, their pres-ence in business-support infrastructure has been limited. In the article we provide an overview of generic corporate network architecture and examine usefulness of available wireless network solutions in such systems. Following this overview we analyze new wireless network architecture which currently undergoes standardization process - wireless mesh. It can result...
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Tacit Knowledge Sharing and Personal Branding. How to Derive Innovation From Project Teams?
PublikacjaInnovation, relationships, cooperation, and knowledge are key factors which determine a competitive advantage in the networked economy. A network serves as a contemporary form of market process coordination. Network economy, according to the idea of prosumerism, is founded on collaboration of individual creators based on a network of values instead of hierarchical dependencies. Another feature of a network is that it imposes symmetry...
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MARKAL long-term power generation scenarios for Poland: Increasing the share of renewable energy sources by 2040
PublikacjaIn this paper, renewable energy sources (RES) support mechanisms in Poland was presented with perspec-tives of proposed support system modifications, discussed in the project of Renewable Energy Act. In ad-dition, MARKAL model of RES support mechanism was presented, taking into account technology-specific multiplication factors. Two model runs with emission trading system in place and two additional runs without emission trade...
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1D convolutional context-aware architectures for acoustic sensing and recognition of passing vehicle type
PublikacjaA network architecture that may be employed to sensing and recognition of a type of vehicle on the basis of audio recordings made in the proximity of a road is proposed in the paper. The analyzed road traffic consists of both passenger cars and heavier vehicles. Excerpts from recordings that do not contain vehicles passing sounds are also taken into account and marked as ones containing silence....
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Hybrid DUMBRA: an efficient QoS routing algorithm for networks with DiffServ architecture
PublikacjaDynamic routing is very important issue of current packet networks. It may support the QoS and help utilize available network resources. Unfortunately current routing mechanisms are not sufficient to fully support QoS. Although many research has been done in this area no generic QoS routing algorithm has been proposed that could be used across all network structures. Existing QoS routing algorithms are either dedicated to limited...
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A METHOD OF TRUST MANAGEMENT IN WIRELESS SENSOR NETWORKS
PublikacjaThe research problem considered in this paper is how to protect wireless sensor networks (WSN) against cyber-threats by applying trust management and how to strengthen network resilience to attacks targeting the trust management mechanism itself. A new method, called WSN Cooperative Trust Management Method (WCT2M), of distributed trust management in multi-layer wireless sensor networks is proposed and its performance is evaluated....
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QoS Extensions for Flow-Awareness Networks
PublikacjaThe paper contains a description and research results of the proposal for distributed QoS extensions for Flow-Based Networking. These QoS extensions let the network accept or reject flows based on current network load and QoS promises for each of the flows. Proposed solution consists of two distributed components, each of them performing in every node, measurement system and access control. The solution could be applied in any...
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A Novel Multicast Architecture of Programmable Networks
PublikacjaIn the paper a multicast architecture for programmable networks based on separation of group management and network control tasks is proposed. Thanks to this separation, services which want to make use of multicast communications no longer have to implement low-level network functionalities and their operation is greatly simplified. Abstracting service’s view of the network into a fully connected cloud enables us to transparently...
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Distinguishing views in symmetric networks: A tight lower bound
PublikacjaThe view of a node in a port-labeled network is an infinite tree encoding all walks in the network originating from this node. We prove that for any integers n ≥ D ≥ 1, there exists a port-labeled network with at most n nodes and diameter at most D which contains a pair of nodes whose (infinite) views are different, but whose views truncated to depth Omega( D log(n/ D )) are identical.
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Transient detection for speech coding applications
PublikacjaSignal quality in speech codecs may be improved by selecting transients from speech signal and encoding them using a suitable method. This paper presents an algorithm for transient detection in speech signal. This algorithm operates in several frequency bands. Transient detection functions are calculated from energy measured in short frames of the signal. The final selection of transient frames is based on results of detection...
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Mobility Managment Scenarios for IPv6 Networks-Proxy Mobile IP-v6Implementation Issues
PublikacjaManagement of user at the network layer plays an important role in efficient network operation. In the paper, authors' implementation of one of network-based mobility management models, namely Proxy Mobile IPv6, is presented and tested in a number of networking topologies and communication scenarios. The proposed implementation covers PMPIv6 functionality with optional security extensions (use of Diameter protocol) and handover...
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Multi-agent systems registration and maintenance of address mapping without agent self-registation
PublikacjaMonitoring of dynamic multi-agent systems, here agents are allowed to appear and disappear, and can migrate between network nodes is a complex tasks. Applying the traditional monitoring methods is not effective, as little can be assumed in advance about such environments. It is necessary to track changes in addressing and availability of agents to create and maintain mapping between agents and their network addresses. The...
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Towards 5G — Cloud-based Radio Access Networks
PublikacjaIn the paper a general concept of the 5G network architecture is presented as well as system requirements having impact on innovative solutions in the 5G network are highlighted. A major part of the paper is both presentation and discussion of the problem of Cloud Radio Access Network introduction for public networks in which the cell and resource virtualisation will be implemented. On the other hand, the problem of resource virtualization...
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Threshold Attendance under Soft-Crash Model: TAG Protocol and Markovian Analysis
PublikacjaA realistic and systematic network evaluation should subsume an availability model and a failure model. We combine a "hard availability" model we call threshold attendance, whereby a certain minimum number of network elements must be present at any time, with a soft-crash failure model, whereby after experiencing a failure, a network element is still able to function correctly for a while in an emergency mode at a risk of a major...
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A new quantum-inspired approach to reduce the blocking probability of demands in resource-constrained path computation scenarios
PublikacjaThis article presents a new approach related with end-to-end routing, which, owing to quantum-inspired mecha-nisms of prediction of availability of network resources, results in improved blocking probability of incoming requests to establish transmission paths. The proposed scheme has been analyzed for three network topologies and several scenarios of network load. Obtained results show a significant (even twofold) reduction of...
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Active Learning Based on Crowdsourced Data
PublikacjaThe paper proposes a crowdsourcing-based approach for annotated data acquisition and means to support Active Learning training approach. In the proposed solution, aimed at data engineers, the knowledge of the crowd serves as an oracle that is able to judge whether the given sample is informative or not. The proposed solution reduces the amount of work needed to annotate large sets of data. Furthermore, it allows a perpetual increase...
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Introduction to the ONDM 2022 special issue
PublikacjaThis JOCN special issue contains extended versions of selected papers presented at the 26th International Conference on Optical Network Design and Modeling (ONDM 2022), which took place 16–19 May 2022 at Warsaw University of Technology, Warsaw, Poland. The topics covered by the papers represent trends in optical networking research: application of machine learning to network management, cross-layer network performance optimization,...
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Design and implementation of GEPON architecture in laboratory testbed
PublikacjaThis paper presents a proposition of GEPON architecture for the didactic purpose. The GEPON architecture is implemented in access networks laboratory testbed. The paper includes a brief description of GEPON standardization, a description of laboratory GEPON equipment architecture and a short presentation of proposed laboratory exercises. The exemplary performance results are included.The proposition of GEPON architecture testbed...
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On the Disaster Resiliency within the Context of 5G Networks : The RECODIS Experience
PublikacjaNetwork communications and the Internet pervade our daily activities so deeply that we strongly depend on the availability and quality of the services they provide. For this reason, natural and technological disasters, by affecting network and service availability, have a potentially huge impact on our daily lives. Ensuring adequate levels of resiliency is hence a key issue that future network paradigms, such as 5G, need to address. This...
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QoS Resource Reservation Mechanisms for Switched Optical Networks
PublikacjaThe paper regards the problem of resource reservation mechanisms for Quality of Service support in switched optical networks. The authors propose modifications and extensions for resources reservation strategy algorithms with resources pools, link capacity threshold and adaptive advance reservation approach. They examine proposed solutions in Automatically Switched Optical Network with Generalized Multi-Protocol Label Switching...
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Interworking and Cross-layer Service Discovery Extensions for IEEEE802.11s Wireless Mesh Standard
PublikacjaWith the rapid popularization of mobile end-user electronic devices wireless network technologies begin to play a crucial role as networks access technologies. While classic point-to-multipoint wireless access systems, based on fixed infrastructure of base stations providing access to clients, remain the main most popular solution, an increasing attention is devoted to wireless mesh systems, where each connecting client can extend...
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Konzepte zur Energieeffizienzsteigerung bei Internet-Zugangsgeräten
PublikacjaThe key issue of this paper is the power management of Internet access devices. The paper commences with an outline on the energy consumption of today's IT devices. It is followed by a description of options to increase energy efficiency of computers. The paper proves that in practice network cards and other IT network components, such as modems, network access points, switches and routers have the maximum energy consumption -...
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Performance improvement of NN based RTLS by customization of NN structure - heuristic approach
PublikacjaThe purpose of this research is to improve performance of the Hybrid Scene Analysis – Neural Network indoor localization algorithm applied in Real-time Locating System, RTLS. A properly customized structure of Neural Network and training algorithms for specific operating environment will enhance the system’s performance in terms of localization accuracy and precision. Due to nonlinearity and model complexity, a heuristic analysis...
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Ubiquity of client access in heterogeneous access environment
PublikacjaWith popularization of mobile computing and diverse offer of mobile devices providing functionality comparable to stationary computers, the necessity of providing network access for such users cannot be disputed. The requirement is further reinforced by emergence of general purpose mobile operating systems which provide their full functionality only with network connectivity available and popular XaaS (Anything as a Service) approach....
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Influence of Self-Similar Traffic Type on Performance of QoS Routing Algorithms
PublikacjaProviding a Quality of Services (QoS) into current telecommunication networks based on packet technology is a big challenge nowadays. Network operators have to support a number of new services like voice or video which generate new type of traffic. This traffic serviced with QoS in consequence requires access to appropriate network resources. Additionally, new traffic type is mixed with older one, like best-effort. Analysis of...
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Estimation and Prediction of Vertical Deformations of Random Surfaces, Applying the Total Least Squares Collocation Method
PublikacjaThis paper proposes a method for determining the vertical deformations treated as random fields. It is assumed that the monitored surfaces are subject not only to deterministic deformations, but also to random fluctuations. Furthermore, the existence of random noise coming from surface’s vibrations is also assumed. Such noise disturbs the deformation’s functional models. Surface monitoring with the use of the geodetic levelling...
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A MODEL FOR FORECASTING PM10 LEVELS WITH THE USE OF ARTIFICIAL NEURAL NETWORKS
PublikacjaThis work presents a method of forecasting the level of PM10 with the use of artificial neural networks. Current level of particulate matter and meteorological data was taken into account in the construction of the model (checked the correlation of each variable and the future level of PM10), and unidirectional networks were used to implement it due to their ease of learning. Then, the configuration of the network (built on the...
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Direct estimation of linear and nonlinear functionals of quantum state
PublikacjaWe present a simple quantum network, based on the controlled-SWAP gate, that can extract certain properties of quantum states without recourse to quantum tomography. It can be used as a basic building block for direct quantum estimations of both linear and nonlinear functionals of any density operator. The network has many potential applications ranging from purity tests and eigenvalue estimations to direct characterization of...