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Wyniki wyszukiwania dla: DNA DAMAGE RESPONSE,NON-SMALL-CELL LUNG CANCER, PHARMACEUTICS, TARGET IDENTIFICATION
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A non-quasi-static small-signal model of the four-terminal MOSFET for radio and microwave frequencies.
PublikacjaW pracy zaprezentowano nowy małosygnałowy model tranzystora MOS, w którymuwzględnia się efekt nasycenia prędkości nośników. Model jest spójny fizycznie i może być stosowany w analizie dowolnej konfiguracji włączenia tranzystora.
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Adding Interpretability to Neural Knowledge DNA
PublikacjaThis paper proposes a novel approach that adds the interpretability to Neural Knowledge DNA (NK-DNA) via generating a decision tree. The NK-DNA is a promising knowledge representation approach for acquiring, storing, sharing, and reusing knowledge among machines and computing systems. We introduce the decision tree-based generative method for knowledge extraction and representation to make the NK-DNA more explainable. We examine...
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Non-vitamin K antagonist oral anticoagulants (NOACs) in cancer patients with atrial fibrillation
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Silver nanoparticles induce premutagenic DNA oxidation that can be prevented by phytochemicals from Gentiana asclepiadea
PublikacjaAmong nanomaterials, silver nanoparticles (AgNPs) have the broadest and most commercial applications due to their antibacterial properties, highlighting the need for exploring their potential toxicity and underlying mechanisms of action. Our main aim was to investigate whether AgNPs exert toxicity by inducing oxidative damage to DNA in human kidney HEK 293 cells. In addition, we tested whether this damage could be counteracted...
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Validation of EORTC, CUETO, and EAU risk stratification in prediction of recurrence, progression, and death of patients with initially non–muscle‐invasive bladder cancer (NMIBC): A cohort analysis
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A New Method of Noncausal Identification of Time-varying Systems
PublikacjaThe paper shows that the problem of noncausal identification of a time-varying FIR (finite impulse response) sys- tem can be reformulated, and solved, as a problem of smoothing of the preestimated parameter trajectories. Characteristics of the smoothing filter should be chosen so as to provide the best trade- off between the bias and variance of the resulting estimates. It is shown that optimization of the smoothing operation can...
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Erratum to: Effects of flavonoids on expression of genes involved in cell cycle regulation and DNA replication in human fibroblasts
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The Impact of urban Localizations on the Growth Possibilities for Small Firms
PublikacjaThe purpose of this study was to identify the differences in the profiles of firms and their owners in urban and non-urban locations and also to asses the impact of those differences on the possibilities of growth for firms from both types of locations. Findings: urban entrepreneurs are better educated, more experienced and more positively motivated. Their firms are more innovative, with more qualified employeesadn better access...
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Primary mediastinal B-cell lymphoma – metabolic and anatomical features in 18FDG-PET/CT and response to therapy
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Cytocompatibility of stabilized black phosphorus nanosheets tailored by directly conjugated polymeric micelles for human breast cancer therapy
PublikacjaThe novel procedure of few-layer black phosphorus (FLBP) stabilization and functionalisation was here proposed. The cationic polymer PLL and non-ionic PEG have been involved into encapsulation of FLBP to allow sufficient time for further nanofabrication process and overcome environmental degradation. Two different spacer chemistry was designed to bind polymers to tumor-homing peptides. The efficiency of functionalisation was examined...
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Biochemical, Structural Analysis, and Docking Studies of Spiropyrazoline Derivatives
PublikacjaIn this study, we evaluated the antiproliferative potential, DNA damage, crystal struc‐ tures, and docking calculation of two spiropyrazoline derivatives. The main focus of the research was to evaluate the antiproliferative potential of synthesized compounds towards eight cancer cell lines. Compound I demonstrated promising antiproliferative properties, especially toward the HL60 cell line, for which IC50 was equal to 9.4 μM/L....
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The Effects of Cellular Membrane Damage on the Long-Term Storage and Adhesion of Probiotic Bacteria in Caco-2 Cell Line
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DNA strand breaks induced by nuclear hijacking of neuronal NOS as an anti-cancer effect of 2-methoxyestradiol
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Study of Bioreductive Anticancer Agent RH-1-Induced Signals Leading the Wild-Type p53-Bearing Lung Cancer A549 Cells to Apoptosis
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UNDERWATER NOISE GENERATED BY A SMALL SHIP IN THE SHALLOW SEA
PublikacjaStudy of the sea noise has been a subject of interest for years. The first work of this scope were published at the turn of the twentieth century by Knudsen (KNUDSEN et al., 1948) and G. Wenz (WENZ, 1962). Disturbances called "shipping noise" are one of the important components of the sea noise. In this work the results of an experimental research of underwater noise produced by a small ship of a classic propulsion are...
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Damage Detection Strategies in Structural Health Monitoring of Overhead Power Transmission System
PublikacjaOverhead power transmission lines, their supporting towers, insulators and other elements create a highly distributed system that is vulnerable to damage. Typical damage scenarios cover cracking of foundation, breakage of insulators, loosening of rivets, as well as cracking and breakage of lines. Such scenarios may result from various factors: groundings, lightning strikes, floods, earthquakes, aeolian vibrations, conductors galloping,...
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Genes Involved in the Processes of Cell Proliferation, Migration, Adhesion, and Tissue Development as New Potential Markers of Porcine Granulosa Cellular Processes In Vitro: A Microarray Approach
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The response of human colon cancer cells to C-1748 (4-methyl-1-nitroacridine derivative) treatment
PublikacjaPrzeprowadzone badania miały na celu określenie wpływu pochodnej 4-metylo-1-nitroakrydyny C-1748 na komórki ludzkiego raka okrężnicy HCT8 oraz HT29. Komórki obu linii, traktowane badanym związkiem, ulegały przede wszystkim apoptozie, przy czym liczba komórek apoptotycznych była znacznie większa w przypadku linii HCT8. Ponadto, proliferacja części komórek HCT8, została zahamowana w wyniku uruchomienia procesu starzenia, czego nie...
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Molecular Recognition in Complexes of TRF Proteins with Telomeric DNA
PublikacjaTelomeres are specialized nucleoprotein assemblies that protect the ends of linear chromosomes. In humans and many other species, telomeres consist of tandem TTAGGG repeats bound by a protein complex known as shelterin that remodels telomeric DNA into a protective loop structure and regulates telomere homeostasis. Shelterin recognizes telomeric repeats through its two major components known as Telomere Repeat-Binding Factors, TRF1...
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Dietary intervention with beetroot juice during doxorubicin cancer chemotherapy in vivo reduces markers of oxidative stress
PublikacjaCancer chemotherapy with doxorubicin, despite high antitumor activity and broad spectrum of this drug, is on decline due to toxic side effects. The clinical efficacy of anthracyclines have continuously prompted the search for new adjuvants to alleviate undesirable side toxicity incurred by this group of cytostatics. The recent approaches involve the application of synthetic or purified natural antioxidants in combination with doxorubicin...
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Proteomic profile of melanoma cell‐derived small extracellular vesicles in patients’ plasma: a potential correlate of melanoma progression
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The Role of Matrix Gla Protein (MGP) Expression in Paclitaxel and Topotecan Resistant Ovarian Cancer Cell Lines
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New and Old Genes Associated with Primary and Established Responses to Paclitaxel Treatment in Ovarian Cancer Cell Lines
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Analysis of MDR genes expression and cross-resistance in eight drug resistant ovarian cancer cell lines
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Coordinated reprogramming of renal cancer transcriptome, metabolome and secretome associates with immune tumor infiltration
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On the preestimation technique and its application to identification of nonstationary systems
PublikacjaThe problem of noncausal identification of a nonstationary stochastic FIR (finite impulse response) sys- tem is reformulated, and solved, as a problem of smoothing of preestimated parameter trajectories. Three approaches to preestimation are critically analyzed and compared. It is shown that optimization of the smoothing operation can be performed adaptively using the parallel estimation technique. The new approach is computationally...
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Simple Millimeter Wave Identification System Based on 60 GHz Van Atta Arrays
PublikacjaThe paper presents a proof-of-concept of a millimeter-wave identification system based on Van Atta array tags in the 60 GHz band. For interrogation of the tags, a vector network analyzer and a measurement transceiver were employed in alternative test configurations. The design, fabrication and measurements of co- and cross-polarized Van Atta arrays are presented in the paper. They can be treated as simple chipless RFID tags with...
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Impedance monitoring of fuel cell stacks
PublikacjaThis paper presents an innovative, electrochemical impedance method for monitoring of electrochemical behaviour of a multi-cell, direct methanol fuel cell (DMFC) device. This method not only provides classical voltage changes at successive cells but also allows their detailed impedance behaviour to be presented. Impedance characteristics of individual cells within a fuel cell stack (depending on actual operating conditions) are...
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Characteristics of orthopaedic implants damage and mechanisms of its initiation
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Metals and metal-binding ligands in wine: Analytical challenges in identification.
PublikacjaBackground Due to important role of metals in the vinification process as well as their impact on the human health, their content in this alcoholic beverage has been extensively studied by many researchers. It is already known that speciation of metals determines their toxicity and bioavailability as well as influences their activity. Understanding the chemistry and knowing the structures of metal complexes could have relevant...
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FE-analysis of the beaviour of concrete elements with coupled elasto-plastic-damage models with non-local softening
PublikacjaArtykuł omawia wyniki symulacji zachowania sie elementów betonowych poddanych cyklicznemu obciążeniu. Do symulacji zastosowano połączone modele sprężysto-plastyczne z degradacją sztywności i z nielokalnym osłabieniem. Wyniki symulacji porównano z doswiadczeniami.
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Analysis of concrete behaviour under cycling within coupled elasto-plastic-damage with non-local softening
PublikacjaArtykuł omawia wyniki symulacji zachowania sie elementów betonowych poddanych cyklicznemu obciążeniu. Do symulacji zastosowano 3 połączone modele sprężysto-plastyczne z degradacją sztywności i z nielokalnym osłabieniem. Wyniki symulacji porównano z doświadczeniami laboratoryjnymi..
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Novel molecules containing structural features of NSAIDs and 1,2,3-triazole ring: Design, synthesis and evaluation as potential cytotoxic agents
PublikacjaFor the first time the template containing structural features of more than one NSAIDs and the 1,2,3-triazole ring was explored for the identification of potential cytotoxic agents. These new and complex molecules were predicted to be effective inhibitors of PDE4B by molecular modelling studies in silico. The multi-step synthesis of these compounds were carried out starting from the well-known drug nimesulide and involved the use...
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Regulacja topologii DNA przez topoizomerazę typu II, czyli jak struktura DNA wpływa na funkcjonowanie genów
PublikacjaW wielu ważnych procesach jakie zachodzą w komórce zmienia się topologia DNA i struktura chromatyny. Enzym, topoizomeraza typu II, jest jednym z ważnych czynników, który reguluje zmiany topologiczne i strukturalne w jądrze, przez co ma bezpośredni lub pośredni wpływ na takie procesy jak uporządkowanie struktury chromatyny poprzez wiązanie pętli chromatyny do szkieletu jądrowego, transkrypcję i replikację DNA, reperację uszkodzeń...
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Imaging of Increasing Damage in Steel Plates Using Lamb Waves and Ultrasound Computed Tomography
PublikacjaThis paper concerns inspection of steel plates, with particular emphasis on the assessment of in-creasing damage. Non-destructive tests were performed on four plates, one of which was un-damaged, while the remaining three had a defects in the form of circular holes with a diameter of 2, 5, and 10 cm. Guided Lamb waves were used in the research, and the image reconstruction was performed using ultrasound computed tomography. The...
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Impact damage in SiO2 nanoparticle enhanced epoxy – Carbon fibre composites
PublikacjaLow velocity impact behaviour of nano-SiO2 enhanced carbon fibre/epoxy composites for naval applications is reported. Epoxy resin matrix was enhanced by 1- 8 wt% SiO2 nanoparticles, based on industrial surface-modified nanosilica. Impact parameters: force, deformation, energy, damage size were recorded. The most pronounced effect was damage size decrease; e.g. ∼28% recorded by infrared thermography and X-ray computed radiography...
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Refinement of the Hardening Soil model within the small strain range
PublikacjaThe popularity of the elasto-plastic Hardening Soil (HS) model is based on simple parameter identification from standard testing and empirical formulas. The HS model is implemented in many commercial FE codes designed to analyse geotechnical problems. In its basic version, the stress–strain behaviour within the elastic range is subject to the hypoelastic power law, which assures the barotropy of the elastic stiffness. However,...
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Polymeric Bearings – A New Base Isolation System to Reduce Structural Damage during Earthquakes
PublikacjaBase isolators, like lead rubber bearings, high damping rubber bearings or friction pendulum systems are extensively used in practice in many seismically active regions to protect structures against earthquake forces. The present paper reports the results obtained from the experimental study aimed to determine the effectiveness of the Polymeric Bearings in suppressing structural vibrations during dynamic excitations and therefore...
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Towards Robust Identification of Nonstationary Systems
PublikacjaThe article proposes a fast, two-stage method for the identification of nonstationary systems. The method uses iterative reweighting to robustify the identification process against the outliers in the measurement noise and against the numerical errors that may occur at the first stage of identification. We also propose an adaptive algorithm to optimize the values of the hyperparameters that are crucial for this new method.
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Small city and a bridge. Landscape perspective
PublikacjaThe aim of the paper is to present the problems connected with the location of big infrastructure objects; like bridges; in close neighbourhood to the small cities located in valuable environment and landscape; and the ways to minimize the potential threats. The case study of the small town Wyszogrod in central Poland will be presented to illustrate the values of the environment and landscape; which could have been easily destroyed...
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Effect of osmolytes of different type on DNA behavior in aqueous solution. Experimental and theoretical studies
PublikacjaOsmolytes, the small organic molecules accumulated in cells under environmental stress, can modulate the stability of biopolymers such as proteins and DNA. In spite of many years of research, there is no established molecular mechanism of the influence of osmolytes on DNA structure. Here, we used two model osmolytes that denature (urea) or stabilize (trimethylglycine, TMG) proteins to study their effect on DNA in aqueous solutions...
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Polyethylene as a small vessel's building material
PublikacjaThe most common use of polyethylene we can notice nowadays are areas like water supply systems, gas industry (esp. gas piping), food industry, small-scale, light and consumer goods industries. That material has far more applications. One of them is shipbuilding - especially small inland or offshore vessels.
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Nonlinear Excitation of the Non-Wave Perturbations by the Magnetoacoustic Waves in the Non-Isentropic Plasma
PublikacjaNonlinear excitation of slow modes by the planar magnetosonic perturbations in a plasma is discussed. Plasma is an open system due to radiation and external heating. This may stipulate enhancement of wave perturbations and hence the acoustical activity of plasma. Plasma is assumed to be a homogeneous ideal gas with infinite electrical conductivity. The straight magnetic field is orthogonal to the velocity of fluid’s...
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Proposal of New Tracer Concentration Model in Lung PCT Study Comparison with Commonly Used Gamma-variate Model
PublikacjaPerfusion computed tomography (pCT) is one of the methods that enable non-invasive imaging of the hemodynamics of organs and tissues. On the basis of pCT measurements, perfusion parameters such as blood flow (BF), blood volume (BV), mean transit time (MTT) and permeability surface (PS) are calculated and then used for quantitative evaluation of the tissue condition. To calculate perfusion parameters it is necessary to approximate...
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VARIANT DESIGNING IN the PRELIMINARY SMALL SHIP DESIGN PROCESS
PublikacjaShip designing is a complex process, as the ship itself is a complex, technical multi-level object which operates in the air/water boundary environment and is exposed to the action of many different external and internal factors resulting from the adopted technical solutions, type of operation, and environmental conditions. A traditional ship design process consists of a series of subsequent multistage iterations, which gradually...
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Fine-tuning recA expression in Staphylococcus aureus for antimicrobial photoinactivation: importance of photo-induced DNA damage in the photoinactivation mechanism
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Berry fruit juices protect lymphocytes against DNA damage and ROS formation induced with heterocyclic aromatic amine PhIP
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The development of Decisional DNA digital TV
PublikacjaZaproponowano koncepcje opartej na wiedzy i doswiadczeniu telewizji cyfrowej z wbudowanym decyzyjnym DNA.
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EVALUATION OF EFFECTIVENESS OF WATERJET PROPULSOR FOR A SMALL UNDERWATER VEHICLE
PublikacjaT he goal of the project described is to replace the existing propulsion system of a small underwater vehicle with a solution less prone to mechanical damage and ensuring a lower risk of the entanglement of fibrous objects suspended in the body of water. Four typical marine screws are utilised in the current design of the vehicle. One possible solution of the problem is the application of waterjet propulsors located...
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Damage localisation in a stiffened plate structure using a propagating wave
PublikacjaThe paper presents an application of changes in propagating waves for damage detection in a stiffened aluminium plate. The experimental investigation was conducted on an aluminium plate with riveted two L-shape stiffeners. The wave has been excited with a piezoelectric transducer and measured with the Laser Scanning Doppler Vibrometer. Recorded signals were analysed using the special signal processing techniques developed for damage...