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Wyniki wyszukiwania dla: drug
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Weakly-Supervised Word-Level Pronunciation Error Detection in Non-Native English Speech
PublikacjaWe propose a weakly-supervised model for word-level mispronunciation detection in non-native (L2) English speech. To train this model, phonetically transcribed L2 speech is not required and we only need to mark mispronounced words. The lack of phonetic transcriptions for L2 speech means that the model has to learn only from a weak signal of word-level mispronunciations. Because of that and due to the limited amount of mispronounced...
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Acetaminophen in Friction Ridge Skin Raman Spectra - acetaminophen (paracetamol) Reference and from drugs 2023
Dane BadawczeRaman spectra for acetaminophen (paracetamol) from different drugs and paracetamol reference.
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Existence of solutions for second order impulsive differential equations with deviating arguments
PublikacjaPraca dotyczy równań różniczkowych z impulsami i odchylonymi argumentami. Badano problem istnienia rozwiązań stosując metodę iteracji monotonicznych opartą na dolnych i górnych rozwiązaniach. Praca uogólnia szereg znanych wyników.
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Nonlinear boundary value problems for second order differential equations with causal operators
PublikacjaW pracy rozważane są równania różniczkowe rzędu drugiego z nielinowymi warunkami brzegowymi. Prawa strona takich zagadnień zawiera operatory typu ''causal''. Podane zostały warunki dostateczne na istnienie rozwiązań tego typu problemów. Badano też nierówności różniczkowe związane z w/w równaniami różniczkowymi. Podano przykład ilustrujący otrzymane wyniki teoretyczne.
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The use of HPLC-Q-TOF-MS for comprehensive screening of drugs and psychoactive substances in hair samples and several “legal highs” products
PublikacjaNon-targeted screening of drugs present in herbal products, known as “legal high” drugs and in hair as a biological matrix commonly used in toxicological investigations was accomplished with the use of high pressure liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF-MS). In total, 25 and 14 therapeutical drugs and psychoactive substances/metabolites were detected in investigated hair samples...
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Is sequential batch reactor an efficient technology to protect recipient against non-steroidal anti-inflammatory drugs and paracetamol in treated wastewater?
PublikacjaThe tested facility was a wastewater treatment plant (WWTP) in Swarzewo, where the wastewater treatment takes place in aeration chambers with activated sludge using sequential batch reactors (SBRs). The concentration of the following pharmaceuticals: ibuprofen, paracetamol, flurbiprofen, naproxen, diclofenac, and its metabolites 5OH-diclofenac and 4OH-diclofenac was tested in influents and effluents. Simultaneously, the conventional...
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Iso-Partricin, an Aromatic Analogue of Amphotericin B: How Shining Light on Old Drugs Might Help Create New Ones
PublikacjaPartricin is a heptaene macrolide antibiotic complex that exhibits exceptional antifungal activity, yet poor selective toxicity, in the pathogen/host system. It consists of two compounds, namely partricin A and B, and both of these molecules incorporate two cis-type bonds within their heptaenic chromophores: 28Z and 30Z. In this contribution, we have proven that partricins are susceptible to a chromophore-straightening photoisomerization...
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Design, synthesis and biological evaluation of novel N-phosphorylated and O-phosphorylated tacrine derivatives as potential drugs against Alzheimer’s disease
PublikacjaIn this work, we designed, synthesised and biologically investigated a novel series of 14N- and O-phosphorylated tacrine derivatives as potential anti-Alzheimer’s disease agents. In the reaction of 9-chlorotacrine and corresponding diamines/aminoalkylalcohol we obtained diamino and aminoalkylhydroxy tacrine derivatives. Next, the compounds were acid to give final products 6–13 and 16–21 that were characterised by 1H, 13 C, 31P...
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Letter to the editor on the article “Alteration of redox status by commonly used antimalarial drugs in the north-western region of Nigeria” by Muhammad A et al.
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A new pH/organic modifier gradient RP HPLC method for convenient determination of lipophilicity and acidity of drugs as applied to established imidazoline agents
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Positive solutions to second order four-point boundary value problems for impulsive differential equations
PublikacjaPraca dotyczy problemów brzegowych dla równań różniczkowych drugiego rzędu z impulsami. Podane zostały warunki dostateczne na istnienie trzech dodatnich rozwiązań takich problemów z czteropunktowymi warunkami brzegowymi. W badaniach korzystano z twierdzenia Leggetta-Williamsa.
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Mispronunciation Detection in Non-Native (L2) English with Uncertainty Modeling
PublikacjaA common approach to the automatic detection of mispronunciation in language learning is to recognize the phonemes produced by a student and compare it to the expected pronunciation of a native speaker. This approach makes two simplifying assumptions: a) phonemes can be recognized from speech with high accuracy, b) there is a single correct way for a sentence to be pronounced. These assumptions do not always hold, which can result...
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Determination of non-steroidal anti-inflammatory drugs in natural waters using off-line and on-line SPE followed by LC coupled with DAD-MS
PublikacjaOpisano dwie metody pozwalające na jednoczesne oznaczanie zawartości niesterydowych leków przeciwzapalnych (difluisal, diklofenak, naproksen, tolmetin, fenoprofen, ibuprofen) w próbkach wodnych. Próbki przygotowywano do analizy z użyciem techniki ekstrakcji do fazy stałej (off-line i on-line). Natomiast oznaczeń końcowych dokonano z użyciem LC-DAD-MS. Sprawdzono kilka różnych kolumienek ekstrakcyjnych i wybrano RP-18 jako najlepsze...
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New examples of N^(+)-H···^(-)S hydrogen bonds: Synthesis and X-ray study of selected secondary ammonium tri-tert-butoxysilanethiolates
PublikacjaTri-tert-butoksysilanotiol reagując z aminami drugorzędowymi: Et2NH, morfoliną, dicykloheksyloaminą i 2,2,4,4-tetrametylopiperydyną daje odpowiednie sole amoniowe. Jak wykazują rentgenowskie badania strukturalne wszystkie te związki tworzą w ciele stałym jednostki dimeryczne {RS(-), R'NH2(+)}2, powiązane wiązaniami wodorowymi typu: N(+)-H···(-)S.
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DRUGRES Nowe potencjalne leki przeciwgrzybowe aktywne wobec wielolekoopornych drożdżaków z rodzaju Candida
ProjektyProjekt realizowany w Katedra Technologii Leków i Biochemii
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A new silylating reagent – dimethyl(3,3,3-trifluoropropyl)silyldiethylamine – for the derivatisation of non-steroidal anti-inflammatory drugs prior to gas chromatography–mass spectrometry analysis
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Discovery of small-molecule regenerative drugs using a model of complex tissue injury in mice. Transcriptomic responses of neurodevelopmental genes during pharmacologically induced regeneration
PublikacjaDespite significant development in regenerative medicine, there is a deficit of effective therapies for wound healing and tissue regeneration. Research performed using animal wound models allows for a better understanding of this complex process, searching for compounds with pro-regenerative properties, and assessing their efficacy and safety. Unfortunately, the lack of adequate preclinical models proves to be an issue as no animal...
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Enhanced Activity of P4503A4 and UGT1A10 Induced by Acridinone Derivatives C-1305 and C-1311 in MCF-7 and HCT116 Cancer Cells: Consequences for the Drugs’ Cytotoxicity, Metabolism and Cellular Response
PublikacjaActivity modulation of drug metabolism enzymes can change the biotransformation of chemotherapeutics and cellular responses induced by them. As a result, drug-drug interactions can be modified. Acridinone derivatives, represented here by C-1305 and C-1311, are potent anticancer drugs. Previous studies in non-cellular systems showed that they are mechanism-based inhibitors of cytochrome P4503A4 and undergo glucuronidation via UDP-glucuronosyltranspherase...
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Positive solutions of three-point boundary value problems for second order impulsive differential equations with advanced arguments
PublikacjaW pracy dyskutowano problem istnienia dodatnich rozwiązań dla równań różniczkowych z impulsami rzędu drugiego i z argumentami typu wyprzedzonego. Podano warunki dostateczne na istnienie jednego lub dwóch rozwiązań dodatnich takich zagadnień.
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Rapid and simple multi-analyte LC–MS/MS method for the determination of benzodiazepines and Z-hypnotic drugs in blood samples: Development, validation and application based on three years of toxicological analyses
PublikacjaBenzodiazepines (BZDs) and Z-drugs have been particularly important treatments for sleeping and anxiety disorders for many years. However, recently, a number of new benzodiazepines (named designer benzodiazepines, DBZDs) were synthesised, but some of them have never been used in the clinic; they reached the black drug market as new psychoactive substances and are used for recreational purposes. The abuse of these substances has...
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Simultaneous analysis of non-steroidal anti-inflammatory drugs and estrogenic hormones in water and wastewater samples using gas chromatography–mass spectrometry and gas chromatography with electron capture detection
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Rosja mentalna Miłosza [C. Miłosz’s Russia as a Mental Concept]
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Detection of Lexical Stress Errors in Non-Native (L2) English with Data Augmentation and Attention
PublikacjaThis paper describes two novel complementary techniques that improve the detection of lexical stress errors in non-native (L2) English speech: attention-based feature extraction and data augmentation based on Neural Text-To-Speech (TTS). In a classical approach, audio features are usually extracted from fixed regions of speech such as the syllable nucleus. We propose an attention-based deep learning model that automatically de...
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Comprehensive Evaluation of Statistical Speech Waveform Synthesis
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Influenza vaccination: key facts for general practitioners in Europe—a synthesis by European experts based on national guidelines and best practices in the United Kingdom and the Netherlands
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Chemical and Genetic Diversity of Nodularia spumigena from the Baltic Sea
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Specific Chemical and Genetic Markers Revealed a Thousands-Year Presence of Toxic Nodularia spumigena in the Baltic Sea
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Unique Aggregation of Sterigmatocystin in Water Yields Strong and Specific Circular Dichroism Response Allowing Highly Sensitive and Selective Monitoring of Bio-Relevant Interactions
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N-acylpeptides with glucosamine-6-phosphate synthase inhibitors - synthesisand antifungal activity
PublikacjaOpracowano syntezę kilku peptydów (di i tripeptydów) zawierających inhibitory syntazy glukozamino-6-fosforanu oraz przeprowadzono je w N-acylopochodne (acetylowe, heksanoilowe, dekanoilowe) oraz zbadano ich aktywność przeciwgrzybową w stosunku do szczepów Candida albicans z opornością wielolekową. Stwierdzono, że N-acylopeptydy wykazują aktywność przeciwgrzybową oraz określono wartości MIC.
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The Combination of Beta-Blockers and ACE Inhibitors Across the Spectrum of Cardiovascular Diseases
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Two novel nucleoside ester derivatives of chlorambucil as potential antileukemic prodrugs: a preliminary study
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Fatal iatrogenic vinorelbine poisoning
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Preclinical toxicological examination of a putative prostate cancer-specific 4-methyl-1-nitroacridine derivative in rodents
PublikacjaW pracy przedstawiono wyniki przedklinicznych badań toksykologicznych zwiazków C-1748 i C-857 na szczurach Copenhagen i myszach BALB/c, po podaniu dootrzewnowym lub dożylnym. U myszy dawki letalne (LD50) dla C-1748 wynosiły odpowiednio 9 i 13,4 mg/kg w porównaniu z 2,2 i 3 mg/kg dla C-857. U szczurów po podaniu dootrzewnowym lub dożylnym dla C-1748 dawki LD50 wynosiły odpowiednio 4 i 1,3 mg/kg. Nie stwierdzono zmian w liczbie komórek...
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Protective Effect of Black Tea Against Ethanol-Induced Oxidative Modifications of Liver Proteins and Lipids
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Pregabalin for the treatment of social anxiety disorder
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Space BriGade Utworzenie i prowadzenie wspólnych studiów drugiego stopnia w zakresie Technologii Kosmicznych w Gdańsku i Bremie
ProjektyProjekt realizowany w Katedra Mechaniki i Mechatroniki
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Katedra Inżynierii Sanitarnej
Zespoły BadawczeKatedra realizuje swoje zadania badawcze w takim zakresie jak opracowywanie metody podczyszczania lub oczyszczania ścieków przemysłowych oraz ich pomiary. Drugą gałęzią zainteresowań są modele matematyczne i symulacje procesów oczyszczania ścieków i zagospodarowania osadów, opracowywanie symulacji strategii eksploatacyjnych i działań modernizacyjnych.
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Zespół Katedry Analizy Nieliniowej i Statystyki
Zespoły BadawczeW Katedrze prowadzone są badania w trzech wiodących kierunkach. Pierwszy dotyczy zastosowania metod topologicznych i wariacyjnych w układach dynamicznych, w teorii równań różniczkowych zwyczajnych i cząstkowych oraz w teorii bifurkacji. Drugim kierunkiem badań Katedry jest zastosowanie rachunku prawdopodobieństwa i teorii aproksymacji. Ostatnią specjalizacją jest Geometria i Grafika Komputerowa, która istnieje od 2014 roku. Wybór...
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Ahmer Bin Hafeez
OsobyI have experience in Computational Biology, particularly bioinformatics, homology modeling, phylogenetics, structural biology, and drug discovery. Furthermore, I have hands-on experience with Bioinformatics software. Currently, my interest lies in translatable omics studies and drug discovery against novel protein targets involved in cancer and infectious diseases and Host-Pathogen PPIs. My aim involves the use of computational...
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Dr.shazia Farheen Qureshi
OsobyI am Psychiatrist wants to heal and inspire the minds. I did post grdauation from College of Physicians and Surgeons of Bombay, Mumbai, India. I am having 10 years experience in field of Psychiatry in variety of Clinical settings that have included Child, Adolesecent, Geriatric and Forensic Psychiatry and drug deaddiction services also clinical research work.
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Javed Ather Siddiqui DR.
OsobyI AM PSYCHATRIST,WANTS TO BRING SMILE ON THE FACES OF MENTALLY ILL PATIENTS. I LOVE MY PROFESSION AND WANT TO FACE CHALLENGES FOR SAKE OF THE PATIENTS. I EARNED POST GRADUATE DEGREE FROM MUMBAI UNIVERSITY AT G S SRTH MEDICAL COLLEGE AND KEM HOSPITAL, MUMBAI, INDIA. I HAVE OVER 20 YEARS OF MENTAL HEALTH EXPERIENCE. I HAVE WORKED IN VARIETY OF CLINICAL SETTINGS THAT HAVE INCLUDED DRUG DEADDICTION, CHILD, ADOLESCENT, GERIATRIC AND...
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The II phase metabolism of endogenous and exogenous compounds, including antitumor chemotherapeutics
PublikacjaThe II phase metabolism, it is a set of metabolism and excretion pathways of endogenous as well as exogenous compounds including xenobiotics. UDP-glucuronyltransferases (UGTs; EC 2.4.1.17) are the most crucial representatives of II phase enzymes, which are responsible for the transformation of bilirubine and bile acids, steroids and thyroid hormones and lipids. Exogenous compounds, including drugs, carcinogens, environmental pollutants...
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Biopsy needles coated with the antimicrobial coatings
PublikacjaDrug delivery systems are used to achieve higher therapeutic effects of medicaments in a specific diseased site with minimal toxicological effect. The used of biopolymers in drug delivery systems ensure the biocompatibility, biodegradability and low immunogenicity. Drug delivery systems enhance the drug delivery actively and can be used in different diseases. In this study, two types of polymer coatings were prepared and were...
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Pregnane X receptor dependent up-regulation of CYP2C9 and CYP3A4 in tumor cells by antitumor acridine agents, C-1748 and C-1305, selectively diminished under hypoxia
PublikacjaInduction of proteins involved in drug metabolism and in drug delivery has a significant impact on drug-drug interactions and on the final therapeutic effects. Two antitumor acridine derivatives selected for present studies, C-1748 (9-(2’-hydroxyethylamino)-4-methyl-1-nitroacridine) and C-1305 (5-dimethylaminopropylamino-8-hydroxy-triazoloacridinone), expressed high and low susceptibility to metabolic transformations with liver...
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Screening of predicted synergistic multi-target therapies in glioblastoma identifies new treatment strategies
PublikacjaAbstract Background IDH-wildtype glioblastoma (GBM) is a highly malignant primary brain tumor with a median survival of 15 months after standard of care, which highlights the need for improved therapy. Personalized combination therapy has shown to be successful in many other tumor types and could be beneficial for GBM patients. Methods We performed the largest drug combination screen to date in GBM, using a high-throughput effort...
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Pemphigoid - Female, 86 - Tissue image [6160730013048041]
Dane BadawczeThis is the histopathological image of SKIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Poloxamer: A versatile tri-block copolymer for biomedical applications
PublikacjaPoloxamers, also called Pluronic, belong to a unique class of synthetic tri-block copolymers containing central hydrophobic chains of poly(propylene oxide) sandwiched between two hydrophilic chains of poly(ethylene oxide). Some chemical characteristics of poloxamers such as temperature-dependent self-assembly and thermo-reversible behavior along with biocompatibility and physiochemical properties make poloxamer-based biomaterials...
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Mission impossible for cellular internalization: When porphyrin alliance with UiO-66-NH2 MOF gives the cell lines a ride
PublikacjaIs it possible to accelerate cell internalization by hybridization of nanomaterials? Herein we support the realization of using metal-organic frameworks (MOFs) with the assistance of rigid porphyrin structure (H2TMP) aimed at drug loading, drug release, relative cell viability, and targeted in vitro drug delivery. There are several MOFs, i.e., UiO-66-NH2 (125 ± 12.5 nm), UiO-66-NH2 @H2TMP (160 ± 14 nm), UiO-66-NH2 @H2TMP@DOX, and...
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Damian Rosiak dr inż.
OsobyWykształcenie Studia I stopnia - inżynierskie, kierunek BIOTECHNOLOGIATytuł pracy inżynierskiej: "Reakcja halogenków rtęci(II) z wybranymi N-benzoilotiomocznikami i charakterystyka strukturalna jej produktów"Promotor: prof. dr hab. inż. Barbara Becker, prof. zw. PG Studia II stopnia - magisterskie, kierunek BIOTECHNOLOGIATytuł pracy magisterskiej: "Reakcje halogenków rtęci(II) z wybranymi tiomocznikami i charakterystyka produktów"Praca...
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Voltammetric and biological studies of folate-targeted non-lamellar lipid mesophases
PublikacjaFolate-targeted lipid nanostructures are promising strategies for the development of biocompatible drug delivery systems. The objective of this study was to evaluate the efficacy of drug delivery to cancer cells by folate-targeted lipid mesophases, cubosomes (CUB) and hexosomes (HEX), loaded with doxorubicin (DOX). Three cancer-derived cell lines (KB, HeLa, T98G) exhibiting different expressional levels of folate receptor protein...