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The cellular response of human colon carcinoma HCT116 cells to 4-methyl-1-nitroacridine derivative C-1748 treatment depending on p53 status
PublikacjaWykazano, że pochodna C-1748 indukuje apoptozę w komórkach linii ludzkich raków jelita grubego HCT116 p53+/+ i p53-/- w sposób zależny od czasu inkubacji i stężenia związku. Wskazują na to: pojawienie się frakcji komórek sub-G1, charakterystyczne zmiany w morfologii jąder komórkowych, zmiany w strukturze błony plazmatycznej. Ponadto, pod wpływem badanego związku komórki HCT116 p53+/+ wykazują większą podatność do ulegania apoptozie...
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Successful Treatment of Persistent SARS-CoV-2 Infection in a B-Cell Depleted Patient with Activated Cytotoxic T and NK Cells: A Case Report
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The role of anthranilic acid in the increase of depressive symptoms and major depressive disorder during treatment for hepatitis C with pegylated interferon-α2a and oral ribavirin
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Strategy towards the use of ultrafiltration and reverse osmosis for industrial water recovery and reuse as part of the Green Deal Implementation
PublikacjaIn line with the European Parliament’s Resolution of February 10th, 2021 on the new action plan for a closed economy, most of the activities undertaken in the wastewater treatment process should focus on the search for new technologies that use wastewater as a source of water and nutrients. The paper reviews the concept of water reuse in industrial installations, with special emphasis on the use of membrane technologies for this...
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Efficacy and safety of the obinutuzumab-chlorambucil combination in the frontline treatment of elderly CLL patients with comorbidities – Polish Adult Leukemia Group (PALG) real-life analysis
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High-dose chemotherapy with autologous stem cell transplantation is an effective treatment of primary refractory Hodgkin's disease. Retrospective study of the Polish Lymphoma Research Group
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Radioimmunotherapy with 90Y-ibritumomab tiuxetan is a safe and efficient treatment for patients with B-cell lymphoma relapsed after auto-SCT: an analysis of the international RIT-Network
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Actual problems of dyslipidaemia treatment in Poland — 2nd Declaration of Sopot. Experts’ Group Consensus endorsed by the Polish Cardiac Society Working Group on Cardiovascular Pharmacotherapy
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Influence of Sulfation Treatment on Photocatalytic Performance of Mesoporous Bi<SUB>2</SUB>O<SUB>3</SUB>–TiO<SUB>2</SUB> Composites
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Diverging changes in rat striatal extracellular dopamine and DOPAC levels and in frequency-modulated 50-kHz ultrasonic vocalizations rate during repeated amphetamine treatment
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In Vitro Effect of 3D Plates Used for Surgical Treatment of Condylar Fractures on Prostaglandin E2 (PGE2) and Thromboxane B2 (TXB2) Concentration in THP-1 Macrophages
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Immediate and late benefits of treating very elderly people with hypertension: results from active treatment extension to Hypertension in the Very Elderly randomised controlled trial
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Determination of the minimum inhibitory concentration of new bisacridines IKE15-19 and IKE21, against yeast strains
Dane BadawczeThe datasets contain the results of determining the minimum inhibitory concentration of new bisacridines against C. albicans ATCC 10231, C. glabrata ATCC 90030, C. krusei ATCC 6258 and C. parapsilosis ATCC 22019, S. cerevisiae ATCC 9763 and fluconazole resistant C. albicans strains by the modified M27-A3 specified by the CLSI.
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Persulfates to degrade a mixture of dyes (rhodamine B, methylene blue) in the presence of glucose and visible light
PublikacjaA treatment process utilizing visible-light-activated (Vis) persulfates (PS) in the presence of an organic promoter (glucose) was developed for the simultaneous decolorization of a rhodamine B (RhB) and methylene blue (MB) mixture. Various doses of glucose, PS concentrations, pH values, initial dye concentrations and process time were tested to find out the most appropriate parameters for degrading the RhB/MB mixture in the...
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Influence of process of straightening ship hull structure made of 316L stainless steel on corrosion resistance and mechanical properties
PublikacjaThe AISI 316L type steel belongs to the group of chromium-nickel stainless steels. They are determined according to European standards as X2CrNiMo17-12-2 and belong to the group of austenitic stainless steels. Steels of this group are used for elements working in seawater environments, for installations in the chemical, paper, and food, industries, for architectural elements, and many others. The chemical composition of corrosion-resistant...
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Mahaveer Mahaveer
OsobyI am a PhD candidate in Civil Engineering, Geodesy, and Transport at the Department of Geotechnical and Hydraulic Engineering, Faculty of Civil and Environmental Engineering, Gdańsk University of Technology (Gdańsk University of Technology), Poland. My research is focused on optimizing hydrodynamic vortex separators for enhanced separation. My current research builds on my experiences from my Master of Engineering research in...
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Practical guidelines for the supplementation of vitamin D and the treatment of deficits in Central Europe — recommended vitamin D intakes in the general population and groups at risk of vitamin D deficiency
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A comparison of the effects of monotherapy with rosuvastatin, atorvastatin or ezetimibe versus combination treatment with rosuvastatin-ezetimibe and atorvastatin-ezetimibe on the integrity of vascular endothelial cells damaged by oxidized cholesterol
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Alkali-activated slag (AAS) and OPC-based composites containing crumb rubber aggregate: Physico-mechanical properties, durability and oxidation of rubber upon NaOH treatment
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Mitotic catastrophe followed by necrosis versus pro-survival autophagy - two opposite cellular effects triggered upon C-1311 treatment in MCF-7 cells
PublikacjaPrzeprowadzone badania miały na celu określenie zdolności imidazoakrydonu C-1311 do indukcji katastrofy mitotycznej, nekrozy i autofagii w komórkach ludzkiego raka piersi MCF-7. Wszystkie eksperymenty przeprowadzone zostały przy stężeniu hamującym proliferację komórek nowotworowych w 80%. Wykazano, że pochodna C-1311 powoduje przejściową akumulację komórek MCF-7 w fazie G2 cyklu życiowego (59% po 48 godz. inkubacji) z równoczesnym...
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Heavy metals removal in the mechanical - biological wastewater treatment plant ''Wschod'' in Gdańsk. Usuwanie metali ciężkich w mechaniczno-biologicznej oczyszczalni ścieków Gdańsk ''Wschód''.
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Toxicity of ionic liquid cations and anions towards activated sewage sludge organisms from different sources – Consequences for biodegradation testing and wastewater treatment plant operation
PublikacjaIonic liquids (ILs) have attracted great interest in academia and industry during the last decade. So far, several ILs have been used in technological processes, from small scale to industrial applications, which makes it more and more likely that they will be released into the environment. Researches have been actively studying the environmental and toxicological bevaviour of ILs, but their influence on the activated sewage sludge...
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Marcin Andrzej Madziała dr n. o zdr.
OsobyResearch and teaching activities Emergency Medicine;Resuscitation; Cardiopulmonary Resuscitation; CPR; Airway Management; Emergency Management; Emergency Medical Services; Intubation; Trauma; Emergency Treatment; EMS; Prehospital Medicine; Mechanical Ventilation; Ventilation; Medical Simulation; Wounds; Disaster Management; Disaster Planning; Disaster Preparedness; Disaster Safety and Management; Sociology of Medicine
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Low frequency of itraconazole resistance found among avian Aspergillus fumigatus isolates
PublikacjaAspergillus fumigatus is the most frequent etiological factor of invasive aspergillosis in human as well as animals, including birds. Aspergillosis caused by drug-resistant strains poses a significant therapeutic issue, especially if resistance pattern includes insensitivity to triazoles, i.e. drugs recommended for the primary therapy purposes. Majority of resistant isolates hold the TR34/L98H...
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Urinary Tract Infections Caused by K. pneumoniae in Kidney Transplant Recipients – Epidemiology, Virulence and Antibiotic Resistance
PublikacjaUrinary tract infections are the most common complication in kidney transplant recipients, possibly resulting in the deterioration of a long-term kidney allograft function and an increased risk of recipient’s death. K. pneumoniae has emerged as one of the most prevalent etiologic agents in the context of recurrent urinary tract infections, especially with multidrug resistant strains. This paper discusses the epidemiology and risk...
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Human-associated bacteria and their mobile genetic elements - important minority in wastewater and wastewater impacted ecosystems
PublikacjaSince human-associated bacteria have been recognized as vectors in two - way gene transmission between the pathogenic and environmental populations, health hazard connected with wastewater discharge requires reevaluation. In this paper the particular attention was given to antimicrobial-resistance of Escherichia coli and enterococci isolated from wastewater and wastewater impacted environments. The obtained results showed that...
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Guidelines of the Polish Psychiatric Association – Wroclaw Division, the Polish Society of Family Medicine and the College of Family Physicians in Poland for diagnosis and treatment of depressive disorders in primary health care
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Single-pill combinations (SPCs) and treatment of arterial hypertension in Poland. Expert consensus statement of the Polish Society of Hypertension and Polish Cardiac Society Working Group on Cardiovascular Pharmacotherapy
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Solar light driven degradation of textile dye contaminants for wastewater treatment – studies of novel polycationic selenide photocatalyst and process optimization by response surface methodology desirability factor
PublikacjaThe unplanned anthropogenic activities and raced industrial revolution detrimentally causes serious threat to terrestrial and aquatic life. A high discharge of wastewater from industries using dyes affects living organisms and the environment. This paper presents studies on polycationic selenides (PCS) synthesized by hydrothermal methods for photocatalytic degradation of dyes. The synthesized PCS were confirmed by various characterization...
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Tomasz Dziubich dr inż.
OsobyWykonane projekty badawcze i celowe Internetowa platforma integracji danych i współpracy medycznych zespołów badawczych dla potrzeb ośrodków udarowych 2013 - 2016 MAYDAY EURO 2012 Superkomputerowa platforma kontekstowej analizy strumieni danych multimedialnych do identyfikacji wyspecyfikowanych obiektów lub niebezpiecznych zdarzeń – zadanie (Rozwój algorytmów i budowa aplikacji wspomagających badania medyczne), 2008-2012 Rozwój...
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Treated wasetewater as a source of humic substances in surface waters
PublikacjaHumic substances impose substantial effect on the aquatic environment as well as the water organisms and human health. Among other features, the humic acids determine organoleptic properties of surface waters. Therefore explanation of the origin and properties of humic acids in surface waters is one of the priorities of water technology.Recently it was pointed out that in the wastewater treatment process organic compounds characterized...
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Tuning of the Electrochemical Properties of Transparent Fluorine-doped Tin Oxide Electrodes by Microwave Pulsed-plasma Polymerized Allylamine
PublikacjaWe report here the dry, one-step, and low-temperature modification of FTO surfaces using pulsed plasma polymerization of allylamine (PPAAm). PPAAm/FTO surfaces were characterized by X-ray photoelectron spectroscopy, spectroscopic ellipsometry, and contact angles to understand the morphological, structural, and optical properties. FTO were coated with a very thin layer of adherent cross-linked, pinhole-, and additive-free allylamine...
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Influence of controlled crystallization and SrF2 content on the structure and properties of Eu3+ doped phosphate glasses
PublikacjaNew phosphate glasses and glass-ceramics P2O5–Bi2O3–K2O–Nb2O5-SrF2 doped with Eu were synthesized and studied in this work. The influence of the SrF2 content (0–15 mol%) and the parameters of the heat treatment on their structural and optical properties were investigated. For the above purpose, the structural characterization by FTIR spectroscopy and XRD measurements was carried out, which showed a significant effect of SrF2 on...
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Jacek Mąkinia prof. dr hab. inż.
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Cladribine Combined with Low-Dose Cytarabine as Frontline Treatment for Unfit Elderly Acute Myeloid Leukemia Patients: Results from a Prospective Multicenter Study of Polish Adult Leukemia Group (PALG)
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Chemical treatment of crystalline silicon solar cells as a main stage of pv modules recycling = Obróbka chemiczna krzemowych ogniw słonecznych jako najważniejszy etap w recyklingu modułów fotowoltaicznych
PublikacjaIn recent years, photovoltaic systems have gained worldwide recognition and popularity as a environmentally friendly way of solving energetic problems. However, a problem of utilizing worn out photovoltaic systems, amount of which will rapidly increase in the future, is yet to be solved. Establishing a technology of recycling and reusing obsolete photovoltaic panels is a necessity.Photovoltaic modules in crystalline silicon solar...
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Obróbka chemiczna krzemowych ogniw słonecznych jako najważniejszy etap w recyklingu modułów fotowoltaicznych = Chemical treatment of the crystalline silicon solar cells as the main stage of PV modules recycling
PublikacjaZaproponowano metodę zagospodarowania krzemowych ogniw fotowoltaicznych, wycofanych z użycia. Dla ogniw PV z krystalicznego krzemu prowadzono następujące po sobie procesy usuwania: powłok metalicznych, warstwy antyrefleksyjnej i złącza n-p przez wytrawianie. Skład roztworów trawiących dostosowywano do różnych rodzajów ogniw krzemowych. W celu opracowania uniwersalnej kąpieli trawiącej konieczne jest wprowadzanie pewnych modyfikacji...
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Processes and pathways of nutrients, selected heavy metal and arsenic removal from surface runoff from the agricultural and urban catchments in floating treatment wetlands - microcosm study nutrients results
Dane BadawczeA dataset containing results of nutrients (N and P) concentrations in synthetic effluents (simulating surface runoff contaminated with nutrients, metals - Cu, Cd, and Pb, and metalloid - As) treated with 4 native macrophytes: Phragmites australis, Iris pseudacorus, Typha latifolia, and Alisma plantago aquatica. Nitrogen and phosphorus (total phosphorus,...
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Evidence of mutations conferring resistance to clarithromycin in wastewater and activated sludge
PublikacjaThe occurrence of clarithromycin in wastewater samples and of the activated sludge bacteria possibly resistant to this pharmaceutical was the object of the study. Samples of wastewater or activated sludge were taken from a municipal wastewater treatment plant in summer and winter and characterised regarding their clarithromycin concentrations and the presence of nucleic acid fragments (Cla-sequences) known to be responsible for...
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Mechanical strength of stems in aquatic macrophytes
PublikacjaSummary: In populations of submerged macrophytes, individuals are selected in terms of resistance to the effect of hydrodynamic forces. The aim of this study was to check whether individuals growing in river water are more tensile and bending resistant than plants occurring in places not exposed to flow stress. We determined the ultimate tensile strength of stems in four macrophyte species, Potamogeton natans, P. pectinatus, Batrachium...
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Expression of metalloproteinase 2 (MMP-2) and metalloproteinase 9 (MMP-9) in THP-1 macrophages cultured with three-dimensional titanium mini-plate systems used for surgical treatment of condylar fractures
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13th International Conference on Conservative Management of Spinal Deformities and First Joint Meeting of the International Research Society on Spinal Deformities and the Society on Scoliosis Orthopaedic and Rehabilitation Treatment – SOSORT-IRSSD 2016 meeting
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New Peptide Based Fluconazole Conjugates with Expanded Molecular Targets
PublikacjaInfections of Candida spp. etiology are frequently treated with azole drugs. Among azoles, the most widely used in the clinical scenario remains fluconazole (FLC). Promising results in treatment of dangerous, systemic Candida infections demonstrate the advantages of combined therapies carried out with combinations of at least two different antifungal agents. Here, we report five conjugates composed of covalently linked FLC and...
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The sensitivity of bacteria to heavy metals in presence of mineral ship motor oil in coastal marine sediments and waters.
PublikacjaThe sensitivity of bacteria, isolated from coastal marine sediments and waters of Sopot beach, Gdańsk Bay (Poland), to heavy metals in the presence of mineral ship motor oil were studied. All isolated heterotrophic bacteria were resistant to the 0.1 mM lead concentration occurring in the environment. Metal resistance of bacteria isolated from coastal water was strongly related to mineral ship motor oil concentration. At 0.1% mineral...
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Identification and antimicrobial susceptibility of fecal coliforms isolated from surface water
Publikacjaof 274 fecal coliforms isolated from two watercourses influencing the costal water quality of the gdańsk and the puck bay, 265 were identified as escherichia coli. the remained strains belonged to: acinetobacter spp. (n=1), enterobacter spp. (n=3), klebsiella spp. (n=4) and shigella spp. (n=1). the susceptibility of 222 e. coli was tested against 19 antimicrobial agents: aminoglycosides, carbapenems, cephalosporines, folate antagonists,...
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Numerical and experimental investigation of rotational stiffness of zed-purlins connection with sandwich panels
PublikacjaA rotational resistant stiffness of the zed-purlins connection with sandwich panels is investigated. A simple finite element method model of the connection is proposed. The numerical analysis of the model performed by ABAQUS software, in physically linear and geometrically nonlinear ranges, leads to the rotational resistant stiffness sought. The numerical solution obtained is verified experimentally. Two variants of distribution...
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Increasing the lifetime of engineering structures through the use of composite laggings
PublikacjaThe use of composite laggings prevents concrete (chemical and biological) corrosion. Columns coated with composite or reinforced composite are more resistant to negative environmental impact on concrete or steel. The mechanical properties of the reinforced casing also cause that these types of columns are more resistant to lateral forces. The applied casing limits carbonization of concrete and cyclical freezing and thawing with...
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Nonlinear impedance as a function of A.C. voltage and temperature for Bi2VO5.5 ceramic of thickness 2.52 mm (after first heat-treatment at 913 K) was measured at different frequencies with impedance spectroscopy method
Dane BadawczeThe nonlinear electrical properties of Bi2VO5.5 ceramic of thickness 2.52 mm was measured by impedance spectroscopy method.
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Tetracycline and ampicillin resistance of Escherichia coli strains of surface water origin: the potential for horizontal transfer of resistance genes = Oporność na tetracyklinę i ampicylinę szczepów Escherichia Coli wyizolowanych z wody powierzchniowej : możliwość horyzontalnego przenoszenia genów oporności
PublikacjaThe aim of this preliminary study was to assess the occurrence and molecular diversity of tetracycline and ampicillin resistance genes carried by Escherichia coli present in surface water. Bacterial strains were isolated from two watercourses (the Reda River and the Oliwski Stream) that influence the quality of coastal waters in the Gdańsk Bay (Northern Poland) by direct discharge. The bacterial drug susceptibility, tested against...
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Bacteriophages as potential tools for use in antimicrobial therapy and vaccine development
PublikacjaThe constantly growing number of people suffering from bacterial, viral, or fungal infections, parasitic diseases, and cancers prompts the search for innovative methods of disease prevention and treatment, especially based on vaccines and targeted therapy. An additional problem is the global threat to humanity resulting from the increasing resistance of bacteria to commonly used antibiotics. Conventional vaccines based on bacteria...