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Reverse vaccinology-based prediction of a multi-epitope SARS-CoV-2 vaccine and its tailoring to new coronavirus variants
PublikacjaThe genome feature of SARS-CoV-2 leads the virus to mutate and creates new variants of concern. Tackling viral mutations is also an important challenge for the development of a new vaccine. Accordingly, in the present study, we undertook to identify B- and T-cell epitopes with immunogenic potential for eliciting responses to SARS-CoV-2, using computational approaches and its tailoring to coronavirus variants. A total of 47 novel...
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Reverse vaccinology-based prediction of a multi-epitope SARS-CoV-2 vaccine and its tailoring to new coronavirus variants
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On asymptotic periodicity of kernel double Markovian operators
PublikacjaIt is proved that a kernel, doubly Markovian operator T is asymptotically periodic if and only if its deterministic σ-field Σd(T)(equivalently Σd(T∗)) is finite. It follows that kernel doubly Markovian operator T is asymptotically periodic if and only if T∗ is asymptotically periodic.
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New type T-Source inverter
PublikacjaThis paper presents different topologies of voltage inverters with alternative input LC networks. The basic topology is known in the literature as a Z-source inverter (ZSI). Alternative passive networks were named by the authors as T-sources. T-source inverter has fewer reactive components in comparison to conventional Z-source inverter. The most significant advantage of the T-source inverter (TSI) is its use of a common voltage...
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On Tradeoffs Between Width- and Fill-like Graph Parameters
PublikacjaIn this work we consider two two-criteria optimization problems: given an input graph, the goal is to find its interval (or chordal) supergraph that minimizes the number of edges and its clique number simultaneously. For the interval supergraph, the problem can be restated as simultaneous minimization of the path width pw(G) and the profile p(G) of the input graph G. We prove that for an arbitrary graph G and an integer t ∈ {1,...
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Empirical Relationship Describing Total Convective and Radiative Heat Loss in Buildings
PublikacjaOn the basis of theoretical considerations of convective-radiative heat transfer, a relationship was developed enabling the total convective and radiative heat flux QC+R emitted from any object at tw and its surroundings at t∞ to be calculated from known values of the surface temperature of such an object, i.e., the known temperature difference Δt=tw - t∞ and average air temperature Tav. This relationship is applied to thermal...
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A lower bound on the double outer-independent domination number of a tree
PublikacjaA vertex of a graph is said to dominate itself and all of its neighbors. A double outer-independent dominating set of a graph G is a set D of vertices of G such that every vertex of G is dominated by at least two vertices of D, and the set V(G)D is independent. The double outer-independent domination number of a graph G, denoted by gamma_d^{oi}(G), is the minimum cardinality of a double outer-independent dominating set of G. We...
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Numerical analysis of CO2-water separation in a horizontal double T-junction
PublikacjaCarbon dioxide is considered one of the main factors leading to global warming. Considering the significant impacts of CO2 on climate change, various technologies have been developed in recent decades to control carbon emission, such as for example CO2 capture and storage. The developed cycle of a negative CO2 emission power plant includes some devices, out of which, separator plays an indispensable role. To this end, T-junction...
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Fabrication of La-Doped Bi4Ti3O12 Ceramics
PublikacjaLa-modified Bi4Ti3O12 is a typical ferroelectric, piezoelectric and electro-optic material, having relatively low coercive field, low dielectric constant, high Curie temperature and high breakdown strength. Goal of the present research was to apply mixed oxide method for fabrication of BiTLax ceramics, study its chemical composition, crystalline structure and microstructure. The compound BiTLax for x=0, 0.25, 0.5, 0.75 ceramic...
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Four-Port Circulator Using Reduced Ground Plane Ferrite Coupled Line Junction
PublikacjaIn this paper the investigations of four-port circula-tor using longitudinally magnetized ferrite coupled line section are presented. The device is designed by cascading ferrite section with magic-T junction ensuring its even and odd mode excitation. The scattering parameters of ferrite coupled line junction are calculated using own software and verified with the use of commercial software. The even and odd excitation of ferrite...
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Limiting distribution of the three-state semi-Markov model of technical state transitions of ship power plant machines and its applicability in operational decision-making.
PublikacjaThe article presents the three-state semi-Markov model of the process {W(t): t 0} of state transitions of a ship power plant machine, with the following interpretation of these states: s1 – state of full serviceability, s2 – state of partial serviceability, and s3 – state of unserviceability. These states are precisely defined for the ship main engine (ME). A hypothesis is proposed which explains the possibility of application...
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Measurements of raising of 160EC pantograph type
Dane BadawczeIn this description the results of the experiment and also simulation performed on the total assembly of the 160 EC pantograph type is given. Multibody dynamics of pantograph rising due to external torque and forces are measured for parameter validation of the pantograph model.
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Existence of Two Periodic Solutions to General Anisotropic Euler-Lagrange Equations
PublikacjaAbstract. This paper is concerned with the following Euler-Lagrange system d/dtLv(t,u(t), ̇u(t)) =Lx(t,u(t), ̇u(t)) for a.e.t∈[−T,T], u(−T) =u(T), Lv(−T,u(−T), ̇u(−T)) =Lv(T,u(T), ̇u(T)), where Lagrangian is given by L=F(t,x,v) +V(t,x) +〈f(t),x〉, growth conditions aredetermined by an anisotropic G-function and some geometric conditions at infinity.We consider two cases: with and without forcing termf. Using a general version...
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Marek Czachor prof. dr hab.
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Toxoplasma gondii Recombinant antigen AMA1: Diagnostic Utility of Protein Fragments for the Detection of IgG and IgM Antibodies
PublikacjaToxoplasma gondii is an important zoonotic protozoan that infects a wide variety of vertebrates as intermediate hosts. For this reason, the diagnosis of this disease is very important and requires continuous improvement. One possibility is to use recombinant antigens in serological tests. Apical membrane antigen 1 (AMA1), a protein located in specific secretory organelles (micronemes) of T. gondii, is very interesting in regard...
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The influence of Nigella sativa essential oil on proliferation, activation, and apoptosis of human T lymphocytes in vitro
PublikacjaIn previous work, we tested the immunomodulatory effect of Nigella sativa (NS) fatty oil. Our results demonstrated that unrefined, obtained by cold pressing black cumin seed oil inhibited lymphocytes’ proliferation and induced their apoptosis in a dose-dependent manner. In this study, we examined the immunomodulatory properties of essential oil (EO) obtained from the NS seeds by hydrodistillation and its two main constituents:...
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Toxoplasma gondii recombinant antigens as tools for serodiagnosis of human toxoplasmosis: current status of studies
PublikacjaToxoplasma gondii is a parasitic protozoan which is the cause of toxoplasmosis. Although human toxoplasmosis in healthy adults is usually asymptomatic, serious disease can occur in the case of congenital infections and immunocompromised individuals. Furthermore, despite the exact recognition of its etiology, it still presents a diagnostic problem. Diagnosis of toxoplasmosis is mainly based on the results of serological tests detecting...
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An upper bound for the double outer-independent domination number of a tree
PublikacjaA vertex of a graph is said to dominate itself and all of its neighbors. A double outer-independent dominating set of a graph G is a set D of vertices of G such that every vertex of G is dominated by at least two vertices of D, and the set V(G)\D is independent. The double outer-independent domination number of a graph G, denoted by γ_d^{oi}(G), is the minimum cardinality of a double outer-independent dominating set of G. We prove...
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Mountain pass solutions to Euler-Lagrange equations with general anisotropic operator
PublikacjaUsing the Mountain Pass Theorem we show that the problem \begin{equation*} \begin{cases} \frac{d}{dt}\Lcal_v(t,u(t),\dot u(t))=\Lcal_x(t,u(t),\dot u(t))\quad \text{ for a.e. }t\in[a,b]\\ u(a)=u(b)=0 \end{cases} \end{equation*} has a solution in anisotropic Orlicz-Sobolev space. We consider Lagrangian $\Lcal=F(t,x,v)+V(t,x)+\langle f(t), x\rangle$ with growth conditions determined by anisotropic G-function and some geometric conditions...
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T-colorings, divisibility and circular chromatic number
PublikacjaLet T be a T-set, i.e., a finite set of nonnegative integers satisfying 0 ∈ T, and G be a graph. In the paper we study relations between the T-edge spans espT (G) and espd⊙T (G), where d is a positive integer and d ⊙ T = {0 ≤ t ≤ d (max T + 1): d |t ⇒ t/d ∈ T} . We show that espd⊙T (G) = d espT (G) − r, where r, 0 ≤ r ≤ d − 1, is an integer that depends on T and G. Next we focus on the case T = {0} and show that espd⊙{0} (G) =...
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THREE-LEVEL F-TYPE INVERTER
PublikacjaGiven the recent available IGBT switch modules up to 6.5 kV, 1200 A rating, the prospect of the diode-free variant topology of the three-level neutral-point-clamped (3-level, T-type) inverter in certain medium voltage applications is bright; due to its small part count and low conduction losses compared to the diode-clamped NPC inverter. However, within this voltage range, the input dc voltage rating of 50% of the switches per...
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The hydration of the protein stabilizing agents: trimethylamine-N-oxide, glycine and its N-methylderivatives - the volumetric and compressibility studies
PublikacjaThe densities at T = (288.15, 293.15, 298.15, 303.15, and 308.15) K and sound velocities at T = 298.15 K have been measured for aqueous solutions of trimethylamine-N-oxide, glycine, N-methylglycine (sarcosine), N,N-dimethylglycine, N,N,N-trimethylglycine (betaine). From these data the apparent molar volumes, VΦ, the apparent molar isentropic compressions, KS,Φ, and the solvation numbers of solutes have been determined. The concentration...
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Human subarachnoid space width oscillations in the resting state
PublikacjaAbnormal cerebrospinal fluid (CSF) pulsatility has been implicated in patients suffering from various diseases, including multiple sclerosis and hypertension. CSF pulsatility results in subarachnoid space (SAS) width changes, which can be measured with near-infrared transillumination backscattering sounding (NIR-T/BSS). The aim of this study was to combine NIR-T/BSS and wavelet analysis methods to characterise the dynamics of the...
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Homoclinic solutions for a class of the second order Hamiltonian systems
PublikacjaW niniejszej pracy badamy istnienie orbit homoklinicznych dlaukładu Hamiltonowskiego drugiego rzędu: q^{..} + V_{q}(t,q) = f(t), gdzie V z iloczynu kartezjańskiego R x R^{n} do R jest postaciV(t,q) = -K(t,q) + W(t,q). Zakładamy, ze V jest T-okresowe ze względuna zmienną t, K spełnia tzw. ''pinching'' warunek, W jest superliniowew nieskończoności, a norma f w L^{2} jest wystarczająco mała.Orbitę homokliniczną takiego układu znajdujemy...
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Almost homoclinics for nonautonomous second order Hamiltonian systems by a variational approach
PublikacjaW artykule badamy problem istnienia rozwiązań prawie homoklinicznych dla nieautonomicznych układów Hamiltona w R^n z potencjałem V(t,x) postaci -1/2(L(t)x,x)+W(t,x) oraz zaburzeniem f(t) (ang. forcing term) z L^2. Zakładamy, że L jest funkcją ciągłą z prostej w zbiór macierzy kwadratowych nxn taką, że macierze L(t) są symetryczne i dodatnio określone jednostajnie względem zmiennej t. Potencjał W(t,x) jest klasy C^1 i nadkwadratowy...
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Study of Integer Spin S = 1 in the Polar Magnet β-Ni(IO3)2
PublikacjaPolar magnetic materials exhibiting appreciable asymmetric exchange interactions can potentially host new topological states of matter such as vortex-like spin textures; however, realizations have been mostly limited to half-integer spins due to rare numbers of integer spin systems with broken spatial inversion lattice symmetries. Here, we studied the structure and magnetic properties of the S = 1 integer spin polar magnet β-Ni(IO3)2...
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Implementation of IMS/NGN Transport Stratum Based on the SDN Concept
PublikacjaThe paper presents the development and verification of software and a testbed aiming to demonstrate the ability of two telecommunication network concepts—Next Generation Network (NGN) and Software-Defined Networking (SDN)—to cooperate. The proposed architecture includes components of the IP Multimedia Subsystem (IMS) in its service stratum and of the SDN (controller and programmable switches) in its transport stratum, providing...
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The Realization of NGN Architecture for ASON/GMPLS Network
PublikacjaFor the last decades huge efforts of telecommunication,Internet and media organizations have been focusingon creating standards and implementing one common networkdelivering multimedia services - Next Generation Network.One of the technologies which are very likely to beused in NGN transport layer is ASON/GMPLS optical network.The implementation of ASON/GMPLS technology usingopen source software and its results are the subject...
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Effects of V2O5 Additive on Structure and Dielectric Properties of BiNbO4 Ceramics
PublikacjaGoal of the present research was to investigate the influence of V2O5 additive on the structure and dielectric properties of BiNbO4 ceramics. To fabricate BiNbO4 ceramics with V2O5 added the solid state reaction route and pressureless sintering was utilized. Thus obtained ceramics was characterized in terms of its microstructure (SEM), chemical composition (EDS), phase composition and crystalline structure (X-ray phase and structural...
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Products of Photo- and Thermochemical Rearrangement of 19-Membered di-tert-Butyl-Azoxybenzocrown
PublikacjaThe preparation and characterization of products of the photochemical and thermochemical rearrangements of 19-membered azoxybenzocrowns with two, bulky, tert-butyl substituents in benzene rings in the para positions to oligooxyethylene fragments (meta positions to azoxy group, i.e., t-Bu-19-Azo-O have been presented. In photochemical rearrangement, two colored typical products were expected, i.e., 19-membered o-hydroxy-m,m′-di-tert-butyl-azobenzocrown...
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Reactivity of Phosphanylphosphinidene Complex of Tungsten(VI) toward Phosphines: A New Method of Synthesis of catena-Polyphosphorus Ligands
PublikacjaThe reactivity of an anionic phosphanylphosphinidene complex of tungsten(VI), [(2,6-i-Pr2C6H3N)2(Cl)- W(η2-t-Bu2P=P)]Li·3DME toward PMe3, halogenophosphines, and iodine was investigated. Reaction of the starting complex with Me3P led to formation of a new neutral phosphanylphosphinidene complex, [( 2,6-i-Pr2C6H3N)2(Me3P)W(η2-t-Bu2P=P)]. Reactions with halogenophosphines yielded new catena-phosphorus complexes. From reaction with...
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The reactivity of 1,1-dichloro-2,2-di-tert-butyldiphosphane towards lithiated metal carbonyls: a new entry to phosphanylphosphinidene dimers
PublikacjaReactions of [Cp*(OC)3M]Li (Cp* = C5Me5, M = Mo, W) towards t-Bu2P–PCl2 lead to the formation of phosphanylphosphinidene dimers [Cp*(OC)3M(η2-t-Bu2P–P)]2 in fairly good yields. The formation of a tetraphosphorus ligand proceeds via reductive dimerization of t-Bu2P–P units. NMR, X-ray investigations and DFT calculations show that the resulting tetraphosphorus ligand has a structure of dication t-Bu2P+=P–P=P+t-Bu2.
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A Strategy to Locate Fixed Points and Global Perturbations of ODE’s: Mixing Topology with Metric Conditions
PublikacjaIn this paper we discuss a topological treatment for the planar system z' = f (t, z) + g(t, z) where f and g are T -periodic in time and g(t, z) is bounded. Namely, we study the effect of g(t, z) in two different frameworks: isochronous centers and time periodic systems having subharmonics. The main tool employed in the proofs consists of a topological strategy to locate fixed points in the class of orientation preserving embedding...
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Własności kwantowe przemian energetycznych zachodzących w silnikach o zapłonie samoczynnym = Quantum properties of energy transformation in diesel engines
PublikacjaW pracy uzasadniono, że w badaniach własności energetycznych silników spalinowych o zapłonie samoczynnym należy uwzględnić istniejącą w ich eksploatacji przypadkowość i nieprzewidywalność zdarzeń. Nawiązano do osiągnięć mechaniki kwantowej wskazując na wynikający z nich postulat, że wielkości nazywane komplementarnymi, mają istotną własność, która polega na tym, że niemożliwy jest jednoczesny i zarazem dokładny pomiar ich wartości....
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Geminate-pair dissociation yield in systems with exponential energetic disorder — A Monte Carlo study
PublikacjaGeminate electron–hole recombination in systems with exponential energetic disorder is studied by Monte Carlo method. The field and temperature dependencies of geminate-pair dissociation probability are calculated. It is established that the dissociation yield of carrier pairs depends mainly on the extent of carrier thermalization, which influences the Einstein relationship. The approximate limiting temperature is given by Te =...
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Almost homoclinic solutions for the second order Hamiltonian systems
PublikacjaW niniejszej pracy badam istnienie rozwiązań prawie homoklinicznych (almost homoclinic) dla układu Hamiltona rzędu drugiego (układu Newtona): ü(t) + V_{u}(t,u) = f(t), gdzie t є R, u є R^{n}, V(t,u) = -K(t,u) + W(t,u), K,W: R x R^{n} → R są klasy C^{1}, K spełnia warunek ''pinching'', W_{u}(t,u)=o(|u|), gdy |u| → 0 jednostajnie względem t, f: R → R^{n} jest funkcją ciągłą, niezerową i odpowiednio małą w L^{2}(R,R^{n}). Przy tych...
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CONCRETE MIX DESIGN USING SIMPLE EQUATIONS
PublikacjaThe behaviour of concrete, whether fresh or har dened, depends basically on the beha viour of its components and the r elationship between them, ther efore, obtaining a concr ete with cer tain pr operties depends fundamentally on the concr ete mix design. Concr ete mix design gener ally includes two main steps: 1-Selection of the main components suitable for the concr...
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Super Dominating Sets in Graphs
PublikacjaIn this paper some results on the super domination number are obtained. We prove that if T is a tree with at least three vertices, then n2≤γsp(T)≤n−s, where s is the number of support vertices in T and we characterize the extremal trees.
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Isolation Number versus Domination Number of Trees
PublikacjaIf G=(VG,EG) is a graph of order n, we call S⊆VG an isolating set if the graph induced by VG−NG[S] contains no edges. The minimum cardinality of an isolating set of G is called the isolation number of G, and it is denoted by ι(G). It is known that ι(G)≤n3 and the bound is sharp. A subset S⊆VG is called dominating in G if NG[S]=VG. The minimum cardinality of a dominating set of G is the domination number, and it is denoted by γ(G)....
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T-SL, T-SLF i T-DSATUR - nowe heurystyki dla problemu przydziału częstotliwości
PublikacjaNiniejszy artykuł poświęcony został algorytmom T-SL, T-SLF i T-DSATUR - nowym heurystykom dla problemu przydziału częstotliwości. Zawiera opis algorytmów, omówienie ich teoretycznych własności oraz wyniki testów komputerowych, którym zostały poddane.
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The Suzuki model of the multipath fading channel
Dane BadawczeThe dataset contains the results of simulations that are part of the research on modelling the multipath fading in the communication channel. The Suzuki fading envelope is generated using the Monte-Carlo simulation (MCS) in the LabVIEW programming environment.
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In vitro affinity of Deinococcus radiodurans MutS towards mismatched DNA exceeds that of its orthologues from Escherichia coli and Thermus thermophilus
PublikacjaThe mismatch binding protein MutS is responsible for the recognition of mispaired and unpaired bases, which is the initial step in DNA repair. Among the MutS proteins most extensively studied in vitro are those derived from Thermus thermophilus, Thermus aquaticus and Escherichia coli. Here, we present the first report on the in vitro examination of DNA mismatch binding activity of MutS protein from Deinococcus radiodurans and confront...
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MIEJSKIE PROJEKTY OŚWIETLENIOWE W KONTEKŚCIE REWITALIZACJI
PublikacjaUrban Lighting in the Context of Regeneration Processes. The article presents how multi-layered urban lighting projects fi t into the programs of integrated activities to improve the living conditions of the local community, the surrounding space, and its economic relations. The role of the electric lighting in revealing the night image of the city, its promotion and public spaces transformations off ering new impressions to city...
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The lognormal model of the multipath fading channel
Dane BadawczeThe dataset contains the results of simulations that are part of the research on modelling the multipath fading in the communication channel. The lognormal fading envelope is generated using the Monte-Carlo simulation (MCS) in the LabVIEW programming environment.
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Interpolation properties of domination parameters of a graph
PublikacjaAn integer-valued graph function π is an interpolating function if a set π(T(G))={π(T): T∈TT(G)} consists of consecutive integers, where TT(G) is the set of all spanning trees of a connected graph G. We consider the interpolation properties of domination related parameters.
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Evaluation of a PCR Melting Profile method for intra-species differentiation of Trichophyton rubrum and Trichophyton interdigitale
PublikacjaW celu identyfikacji źródła infekcji spowodowanych przez dermatofity, jak i drogi ich transmisji, istnieje potrzeba szukania nowych metod, które pozwolą na głębokie zróżnicowanie genetyczne szczepów w obrębie rodzaju. W pracy po raz pierwszy pokazano zastosowanie techniki PCR MP opartej o adaptory oligonukleotydowe i różnice w temperaturze topnienia fragmentów restrykcyjnych DNA w reakcji PCR do wewnątrzgatunkowego typowania dermatofitów....
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Reconfiguring Minimum Dominating Sets in Trees
PublikacjaWe provide tight bounds on the diameter of γ-graphs, which are reconfiguration graphs of the minimum dominating sets of a graph G. In particular, we prove that for any tree T of order n ≥ 3, the diameter of its γ-graph is at most n/2 in the single vertex replacement adjacency model, whereas in the slide adjacency model, it is at most 2(n − 1)/3. Our proof is constructive, leading to a simple linear-time algorithm for determining...
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Cubane Like Structure of a Silanethiol Primary Amine Assembly a Novel, Unusual Hydrogen Bond Pattern.
PublikacjaMetodą rentgenowskiej analizy strukturalnej wyznaczono struktury krystaliczne i cząsteczkowe trzech soli amoniowych: (t-BuO)3SiS(-)H3N(+)Bu-t, (i-PrO)3SiS(-)H3N(+)Bu-t i (t-BuO)3SiS(-)H3N(+)(CH2)2CH(CH3)2. Wszystkie trzy związki w ciele stałym tworzą tetramery w których atomy S i N wyznaczają w przybliżeniu naroża sześcianu. Trwałość tych agregatów, oprócz sił elektrostatycznego przyciągania, zapewnia sieć wiązań wodorowych N-H
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Parity vertex colouring of graphs
PublikacjaA parity path in a vertex colouring of a graph is a path along which each colour is used an even number of times. Let Xp(G) be the least number of colours in a proper vertex colouring of G having no parity path. It is proved that for any graph G we have the following tight bounds X(G) <= Xp(G) <=|V(G)|− a(G)+1, where X(G) and a(G) are the chromatic number and the independence number of G, respectively. The bounds are improved for...
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Dissimilar underwater wet welding of HSLA steels
PublikacjaThe high-strength low-alloy S460ML and S460N steels were chosen for underwater wet welding of dissimilar T-joints using covered electrodes. For improving the quality of joints, the temper bead welding (TBW) method was used. The application of TBW in pad welding conditions has been investigated earlier but the possibility of usage of this technique in welded joints was not analyzed. The main aim of the study was to check the influence...