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Wyniki wyszukiwania dla: IN VITRO CULTURES
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Biochemical Profile and In Vitro Therapeutic Properties of Two Euhalophytes, Halocnemum strobilaceum Pall. and Suaeda fruticosa (L.) Forske., Grown in the Sabkha Ecosystem in the Algerian Sahara
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Comparative in vitro studies on liposomal formulations of amphotericin Band its derivative, N-methyl-N-D-fructosyl amphotericin B methyl ester (MFAME)
PublikacjaMFAME, ester metylowy N-metylo-N-D-fruktozylo amfoterycyny B jest półsyntetyczną pochodną antybiotyku przeciwgrzybowego amfoterycyny B (AMB). W przeciwieństwie do wyjściowego antybiotyku pochodna ta jest nietoksyczna dla komórek zwierzęcych oraz tworzy rozpuszczalne sole rozpuszczalne w wodzie. Przeprowadzono badania porównawcze aktywności biologicznej wolnego antybiotyku i wolnej pochodnej oraz ich preparatów liposomalnych. Stosowano...
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2-Methoxyestradiol and Hydrogen Peroxide as Promising Biomarkers in Parkinson’s Disease
PublikacjaEstrogens function in numerous physiological processes including controlling brain cell growth and differentiation. 2-Meth- oxestradiol (2-ME2), a 17β-estradiol (E2) metabolite, is known for its anticancer effects as observed both in vivo and in vitro. 2-ME2 affects all actively dividing cells, including neurons. The study aimed to determine whether 2-ME2 is a potentially cancer-protective or rather neurodegenerative agent in a...
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Evidence for widespread occurrence of copper in Late Neolithic Poland? A deposit of Funnel Beaker Culture bone products at site 2 in Osłonki (Kuyavia, central Poland)
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1st Academic Conference "Areas of Finnish Studies: Language, Culture and Nation", organised on the occasion of the centenary of Finnish independence (Gdańsk, 15-16 May 2017)
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Genes encoding proteins regulating fatty acid metabolism and cellular response to lipids are differentially expressed in porcine luminal epithelium during long-term culture
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Exploring the impact of cultural context on eye-tracking studies of architectural monuments in selected European cities: Sustainable heritage management.
PublikacjaSustainable management of architectural heritage requires conducting an inclusive diagnosis of users’ opinions, considering both residents and tourists as the recipients of urban space. Given the cultural diversity within these groups, proposing the use of eye-trackers (ET) as an alternative to traditional public consultation prompts the need to assess the method’s advantages and disadvantages. It remains uncertain whether individuals...
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ICT for Global Competitiveness and Economic Growth in Emerging Economies: Economic, Cultural, and Social Innovations for Human Capital in Transition Economies
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Do people with dementia and mild cognitive impairments experience stigma? A cross-cultural investigation between Italy, Poland and the UK
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Methyl jasmonate as a control factor of the synthase squalene gene promoter and ginsenoside production in American ginseng hairy root cultured in shake flasks and a nutrient sprinkle bioreactor
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Rewitalizacja dzielnicy śródmiejskiej w oparciu o funkcje turystyki i kultury na przykładzie temple bar w Dublinie
Publikacjaartykuł zwiera opis studium przypadku rewitalizacji dzielnicy śródmiejskiej Temple Bar w Dublinie oparciu o wprowadzenie funkcje kulturalne i stworzenie tzw. kwartału kultury ('cultural quarter').jest to jeden z modelowych przykładów tzw. 'culture-led regeneration'.
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Regioselective synthesis of novel 4,5-diaryl functionalized 3,4-dihydropyrimidine-2(1H)-thiones via a non-Biginelli-type approach and evaluation of their in vitro anticancer activity
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Cancer stem cells and escape from drug-induced premature senescence in human lung tumor cells: implications for drug resistance and in vitro drug screening models
PublikacjaBadania z użyciem modelu komórek nowotworu płuc A549 wykazały, że komórki te po traktowaniu lekami uszkadzającymi DNA zatrzymują proliferację i wchodzą w stan starzenia komórkowego. Jednak post-inkubacja tych komórek prowadzi do powrotu do stanu proliferacji małej frakcji komórek. Wykazaliśy, że frakcja ta związana jest z obecnością komórek pierwotnych nowotworu w populacji komórek A549. Powrót do stanu proliferacji komóek A549...
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The Effect of Millisecond Pulsed Electric Fields (msPEF) on Intracellular Drug Transport with Negatively Charged Large Nanocarriers Made of Solid Lipid Nanoparticles (SLN): In Vitro Study
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Influence of Estradiol-17beta on Progesterone and Estrogen Receptor mRNA Expression in Porcine Follicular Granulosa Cells during Short-Term, In Vitro Real-Time Cell Proliferation
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Photoprotection and Antiaging Activity of Extracts from Honeybush (Cyclopia sp.)—In Vitro Wound Healing and Inhibition of the Skin Extracellular Matrix Enzymes: Tyrosinase, Collagenase, Elastase and Hyaluronidase
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Corporate social responsibility practices incomes and outcomes: Stakeholders' pressure, culture, employee commitment, corporate reputation, and brand performance. A Polish–German cross‐country study
PublikacjaThis study aims to compare employee perception of corporate social responsibility (CSR) practice incomes and outcomes in the construction industry in Poland and Germany. It proposes a model that examines the influence of stakeholder pressure, culture, and CSR practices on company brand performance, reputation, and employee identification. The findings suggest that the structure of relationships varies for project‐managed construction...
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Bionic relations as features of the author’s original concept of biomorphic plastic forms that belong to a place
PublikacjaThe article concerns the search for an architectural formula for living organically in the area of Pojezierze Kaszubskie [the Kashubian Lake Dis- trict]. The original project consisted in creating a series of biomorphic plastic forms that belong to the place. In this way, a set of alternative solutions was created in the form of small clay sculptures that account for bionic relationships between the newly created cultural elements...
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Preferences Towards Working in Culturally Diverse Teams at Different Stages of the Entrepreneurial Process
PublikacjaAs entrepreneurial teams become prevalent, it is important to study factors related to their creation and effectiveness. The goal of the current research was to analyze preferences towards working in a multicultural team (MCT) versus a single culture team (SCT) at different stages of the entrepreneurial process. The study involved students originating from various cultures with previous experience in both SCTs and MCTs as participants....
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Direct use of point clouds in real-time interaction with the cultural heritage in pandemic and post-pandemic tourism on the case of Kłodzko Fortress
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PRESERVATION THROUGH DIGITIZATION - STANDARDIZATION IN DOCUMENTATION OF BUILD CULTURAL HERITAGE USING CAPTURING REALITY TECHNIQUES AND HERITAGE/HISTORIC BIM METHODOLOGY
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The Influence of Antitumor Unsymmetrical Bisacridines on 3D Cancer Spheroids Growth and Viability
PublikacjaThe culture of 3D spheroids is a promising tool in drug development and testing. Recently, we synthesized a new group of compounds, unsymmetrical bisacridines (UAs), which exhibit high cytotoxicity against various human cell lines and antitumor potency against several xenografts. Here, we describe the ability of four UAs—C-2028, C-2041, C-2045, and C-2053—to influence the growth of HCT116 and H460 spheres and the viability of HCT116...
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Intercultural Challenges in Virtual Teams
Publikacja: Virtual teams are usually geographically dispersed and consist of members from different countries and cultures. They influences internal communication processes and can cause personal conflicts, misunderstandings or lack of trust. Intercultural diversity is also significant for goal setting and team effectiveness. The aim of this article is to check if virtual team members appreciate the cultural diversity or rather suffer from lack...
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Effect of in vitro gastro‐pancreatic digestion on antioxidant activity of low‐molecular‐weight (<3.5 kDa) peptides from dry‐cured pork loins with probiotic strains of LAB
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A new 1-nitro-9-aminoacridine derivative targeting yeast topoisomerase II able to overcome fluconazole-resistance
PublikacjaFungal resistance remains a significant threat and a leading cause of death worldwide. Thus, overcoming microbial infections have again become a serious clinical problem. Although acridine derivatives are widely analyzed as anticancer agents, only a few reports have demonstrated their antifungal activity. In an effort to develop biologically active antifungals, twelve novel C-857 (9-(2′ -hydroxyethylamino)-1-nitroacridine) and...
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Analiza posadowienia słupa powłokowego linii elektroenergetycznej na palach Vibro z wykorzystaniem programu SOFiSTiK 3D
PublikacjaPrzy wymiarowaniu fundamentu palowego w złożonych warunkach gruntowych należy wymagać zaawansowanej analizy uwzględniającej wszystkie kombinacje sił działających na konstrukcje. W artykule znaleźć można schemat obliczeń, posadowienia fundamentu płytowego na palach Vibro pod słup powłokowy wysokiego napięcia, z wykorzystaniem programu SOFiSTiK 3D. Bazując na standardowych metodach, ale stosując nowe, alternatywne podejścia wyznacza...
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32P-postabeling detection of DNA adducts formed by 4-methyl-1-nitro-9-aminoacridine C-1748
PublikacjaWykazano zdolność do tworzenia przez nową pochodną 1-nitroakrydyny o symbolu C-1748, adduktów z DNA komórek nowotworowych oraz z DNA w systemie bezkomórkowym.
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THE ROLE OF THE POLISH UNIVERSITIES IN SHAPING A NEW MOBILITY CULTURE - ASSUMPTIONS, CONDITIONS, EXPERIENCE. CASE STUDY OF GDANSK UNIVERSITY OF TECHNOLOGY, CRACOW UNIVERSITY OF TECHNOLOGY AND SILESIAN UNIVERSITY OF TECHNOLOGY
PublikacjaThe article expresses an idea of the privileged role of universities in the process of shaping the new culture for urban mobility. Mobility management of the academic community is adopted in order to indirectly influence a wider group of the population. The aim of the study was to investigate the situation at the Polish universities and the willingness of their authorities to implement integrated tools to manage the transportation...
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OVERLAP BETWEEN PERSONAL AND GROUP IDENTITY AND ITS RELATION WITH RADICAL PRO-GROUP ATTITUDES: DATA FROM A CENTRAL EUROPEAN CULTURAL CONTEXT
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Islam versus Architecture and Urban Order in the Time of Changes : Social and Cultural Aspects of Housing Architecture Transformation in the Arab Countries of Northern Africa
PublikacjaArtykuł jest omówieniem obserwacji tradycyjnej i współczesnej zabudowy mieszkaniowej przeprowadzonych przez autora w Algierii (1978) i Libii (1984-1988). Realizowane obecnie struktury i kultywowane formy zamieszkiwania wzorowane są na rozwiązaniach ''zachodnich'' odmiennych od rozwiązań tradycyjnych. Są one niedostosowane do wymogów środowiska naturalnego i pozostają w sprzeczności z zasadami określonymi przez Koran i sunnę. Rozdźwięk...
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Differential Response of MDA-MB-231 and MCF-7 Breast Cancer Cells to In Vitro Inhibition with CTLA-4 and PD-1 through Cancer-Immune Cells Modified Interactions
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Przemiany metaboliczne in vitro niesymetrycznych bisakrydyn w układach bezkomórkowych i w komórkach nowotworowych oraz określenie wpływu tych pochodnych na aktywność enzymów metabolizujących leki
PublikacjaPrzedmiotem badań prowadzonych w ramach niniejszej pracy doktorskiej są cztery niesymetryczne bisakrydyny: C-2028, C-2041, C-2045 i C-2053, wykazujące wysoką aktywność cytotoksyczną [Konopa i in. 2019]. Otrzymane wyniki wskazały, że każdy z pierścieni (imidazoakrydonu i 1-nitroakrydyny) obecny w strukturze badanych związków odgrywa inną rolę w wykazywanych przez nie właściwościach fizykochemicznych i biologicznych. Właściwości...
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In vitro biological evaluation of a novel folic acid-targeted receptor quantum dot−β−cyclodextrin carrier for C-2028 unsymmetrical bisacridine in the treatment of human lung and prostate cancers
PublikacjaTraditional small-molecule chemotherapeutics usually do not distinguish tumors from healthy tissues. However, nanotechnology creates nanocarriers that selectively deliver drugs to their site of action. This work is the next step in the development of the quantum dot−β−cyclodextrin−folic acid (QD−β−CD−FA) platform for targeted and selected delivery of C−2028 unsymmetrical bisacridine in cancer therapy.Herein, we report an initial...
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Phthalocyanines functionalized with 2-methyl-5-nitro-1H-imidazolylethoxy and 1,4,7-trioxanonyl moieties and the effect of metronidazole substitution on photocytotoxicity
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Vibro-Electrical Behavior of a Viscoelastic Piezo-Nanowire in an Elastic Substrate Considering Stress Nonlocality and Microstructural Size-Dependent Effects
PublikacjaThis research deals with dynamics response of a Pol/BaTiO3 nanowire including viscosity influences. The wire is also impressed by a longitudinal electric field. Hamilton's principle and Lagrangian strains are employed in conjunction with a refined higher-order beam theory in order to derive equations of motion. By combining nonlocality and small size...
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FTIR, NMR and kinetic studies of proton transfer reactions from nitro-substituted diarylmethanes to N-bases with guanidine character
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Nośność graniczna pali Vibro obciążonych osiowo na podstawie próbnych obciążeń statycznych i wyników sondowania CPT.
PublikacjaW odniesieniu od obecnych trendów optymalizacji w projektowaniu obiektów inżynierskich, dąży się do określania rzeczywistych wartości współoddziaływać podłoża gruntowego i konstrukcji. Pale Vibro, należą do grupy pali przemieszczeniowych z poszerzoną podstawą, charakteryzują się bardzo dużą nośnością, szczególnie w gruntach niespoistych. Wyniki próbnych obciążeń statycznych wskazują, że nośność pali Vibro jest znacznie większa...
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Gdańsk palimpsest. On obscuring and retrieving traces of memory
PublikacjaThe article deals with the problems of collective identity resulting from over one thousand year history of the city on the Motława river and the role of historical policy of the local authorities regarding the material cultural heritage of many nations and cultures. In our opinion, the palimpsestic (palimpsestueuse) character of the city plays a significant role in the discourse about the past of Gdańsk. We use that notion after...
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Potencjał kognitywno-kulturowy dzielnicy a innowacyjne strategie rehabilitacji w kontekście społecznej indywidualizacji. Studium przypadku: Mouraria, Lizbona = Innovative Public Space Rehabilitation Models to Create Cognitive-Cultural Urban Economy in the Age of Mass Individualisation. Case of Mouraria, Lisbon
PublikacjaInnovative Public Space Rehabilitation Models to Create Cognitive- -Cultural Urban Economy in the Age of Mass Individualisation. Case of Mouraria, Lisbon. This paper deals with the issue of sustainable urban rehabilitation interventions in city cores focused on value creation through culture-led development as a tool for building a cognitive city. The objective is to analyze cases of rehabilitation of public space by culture-led...
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Dilemmas of Identity in Contemporary Cities. The City of Gdansk as an Example
PublikacjaThe article is aimed to answer the question how, depending on the historical heritage, the collective memory, the physical space of the city and their images were shaped, through the politics of memory. All known cultures and languages distinguish the ‘self’ and the ‘other’, ‘us’ and ‘them’. Neither do we know cities which wish to differ in some particular way, although they can have numerous identities. Their multitude and diversity...
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O kulturowych i leksykalnych problemach tłumacza (na materiale języka fińskiego) [On cultural and lexical problems of a translator – based on the translations from Finnish]
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Multiwalled carbon nanotube/sulfanyl porphyrazine hybrids deposited on glassy carbon electrode — effect of nitro peripheral groups on electrochemical properties
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Expression of metalloproteinase 2 (MMP-2) and metalloproteinase 9 (MMP-9) in THP-1 macrophages cultured with three-dimensional titanium mini-plate systems used for surgical treatment of condylar fractures
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Profile and Content of Phenolic Compounds in Leaves, Flowers, Roots, and Stalks of Sanguisorba officinalis L. Determined with the LC-DAD-ESI-QTOF-MS/MS Analysis and Their In Vitro Antioxidant, Antidiabetic, Antiproliferative Potency
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Regionalne obserwatorium kultury w wojewwdztwie podlaskim - uwarunkowania i planowane kierunki rozwoju (Regional Cultural Observatory in the Podlaskie Voivodeship - Conditions and Development Trends)
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Zastosowanie założeń koncepcji efektuacji w organizowaniu wydarzenia kulturalnego – studium przypadku
PublikacjaThe paper presents how the effectuation model, which stems from the business studies, can be applied as a tool for analysing the activities undertaken as part of culture organisation. The key element of this model involves the control-based approach to the future instead of making predictions about the future. The outline of the theoretical background is followed by the results of the qualitative research, where the answers were...
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Ontology groups representing angiogenesis and blood vessels development are highly up-regulated during porcine oviductal epithelial cells long-term real-time proliferation – a primary cell culture approach
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Profiles of a broad spectrum of epigenetic DNA modifications in normal and malignant human cell lines: Proliferation rate is not the major factor responsible for the 5-hydroxymethyl-2′-deoxycytidine level in cultured cancerous cell lines
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Colour Terms in Five Linguistic Images of the World: The Semantic Perspective
PublikacjaSocial and cultural factors shape the linguistic perception of colour. At the same time, colour terms co-create the linguistic image of the world, which allows us to interpret reality and profile our statements and beliefs. This paper presents six basic colour terms: white, black, red, green, yellow, and blue (both as adjectives and as nouns) in the five different linguistic images of the world of the following languages: English,...
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Emission characterization and δ13C values of parent PAHs and nitro-PAHs in size-segregated particulate matters from coal-fired power plants
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