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Wyniki wyszukiwania dla: ADMINISTRATIVE CORRUPTION
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Activation of endogenous regenerative potential in mammals using epigenetic inhibitor zebularine
PublikacjaIn this work, a nucleoside inhibitor of DNA methyltransferases, zebularine, was investigated as a wound healing and regeneration promoting agent. It was found that a high dose of intraperitoneally delivered zebularine improved punch wound closure in the ear pinna in mice. Both cytidine, a zebularine analogue, and uridine, a zebularine metabolite, did not promote ear pinna hole closure. The effect of zebularine on ear pinna healing...
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Release systems based on self-assembling RADA16-I hydrogels with a signal sequence which improves wound healing processes
PublikacjaSelf-assembling peptides can be used for the regeneration of severely damaged skin. They can act as scaffolds for skin cells and as a reservoir of active compounds, to accelerate scarless wound healing. To overcome repeated administration of peptides which accelerate healing, we report development of three new peptide biomaterials based on the RADA16-I hydrogel functionalized with a sequence (AAPV) cleaved by human neutrophil elastase...
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Accelerated multi-objective design optimization of antennas by surrogate modeling and domain segmentation
PublikacjaMulti-objective optimization yields indispensable information about the best possible design trade-offs of an antenna structure, yet it is challenging if full-wave electromagnetic (EM) analysis is utilized for performance evaluation. The latter is a necessity for majority of contemporary antennas as it is the only way of achieving acceptable modeling accuracy. In this paper, a procedure for accelerated multi-objective design of...
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Recent advances in rapid multiobjective optimization of expensive simulation models in microwave and antenna engineering by Pareto front exploration
PublikacjaPractical engineering design problems are inherently multiobjective, that is, require simultaneous control of several (and often conflicting) criteria. In many situations, genuine multiobjective optimization is required to acquire comprehensive information about the system of interest. The most popular solution techniques are populationbased metaheuristics, however, they are not practical for handling expensive electromagnetic...
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The effect of reduced pressure on carbon dioxide flow boiling heat transfer in minichannels
Publikacja. In the paper presented are the results of the study on the effect of reduced pressure on flow boiling heat transfer data in minichannels as well as conventional ones. That effect renders that most of heat transfer correlations fail to return appropriate results of predictions. Mostly they have been developed for the reduced pressures from the range 0.1-0.3. The special correction has been postulated to the in-house model of flow...
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Estimation of Coherence Bandwidth for Underwater Acoustic Communication Channel
PublikacjaA shallow underwater acoustic communication channel is characterized by strong multipath propagation. The signal reaching the receiver consists of a direct waveform and a number of its delayed and suppressed replica. A significant time dispersion of the transmitted signal and selective fading of its spectrum are observed. Coherence bandwidth defines maximal bandwidth, wherein the channel amplitude characteristic remains constant...
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ADAPTATION OF ENGINEERING FEA-BASED ALGORITHMS TO LCF FAILURE AND MATERIAL DATA PREDICTION IN OFFSHORE DESIGN
PublikacjaThere is an ever growing industrial demand for quantitative assessment of fatigue endurance of critical structural details. Although FEA-based calculations have become a standard in engineering design, problems involving the Low-To-Medium cycle range (101-104) remain challenging. This paper presents an attempt to optimally choose material data, meshing density and other algorithm settings in the context of recent design of the...
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Speed dependency of temperature effects on road traffic noise
PublikacjaRecently, a new literature review on the influence of temperature on tire/road noise became available, based on a compilation of large amounts of data from empirical research. This review showed that the effect of temperature is roughly double of that previously assumed and taken account of in international standards. This makes temperature one of the main sources of error in measurement results. Furthermore, it suggested that...
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Torque capacity of multidisc wet clutch with reference to friction occurrence on its spline connections
PublikacjaIn this article developed mathematical model that includes friction occurrence on spline connections is presented. The work also contains results of experimental research on torque capacity of multidisc wet clutch. These results are expressed as a function of contact pressure for different number of friction surfaces. Due to increased interest in research concerning multidisc wet clutches it is essential to determine impact of...
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Numerically Efficient Miniaturization-Oriented Optimization of an Ultra-Wideband Spline-Parameterized Antenna
PublikacjaDesign of ultra-wideband radiators for modern handheld applications is a challenging task that involves not only selection of an appropriate topology, but also its tuning oriented towards balancing the electrical performance and size. In this work, a low-cost design of a compact, broadband, spline-parameterized monopole antenna has been considered. The framework used for the structure design implements trust-region-based methods,...
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HILS for the Design of Three-Wheeled Mobile Platform Motion Surveillance System with a Use of Energy Performance Index
PublikacjaCurrent tendency in mechatronic design requires the use of comprehensive development of an environment, which gives the possibility to prototype, design, simulate and integrate with dedicated hardware. The paper discusses the Hardware-In-the-Loop Simulations (HILS) mechatronic technique, used during the design of the surveillance system based on energy performance index. The presented test configuration (physical controller – emulated...
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Expedite EM-driven generation of Pareto-optimal trade-off curves for variable-turn on-chip inductors
PublikacjaThis work presents a novel approach to computationally efficient Pareto front identification for variable-turn on-chip inductors. The final outcome is a set of solutions that correspond to the best trade-offs between conflicting design objectives. Here, we consider minimising inductor area and, simultaneously, maximising its quality factor, while maintaining a specified inductance value at a given operating frequency. As opposed...
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A repeated game formulation of network embedded coding for multicast resilience in extreme conditions
PublikacjaComputer networks and data sharing applications are vital for our current society and fundamental for any available ICT solution, so that networking is considered as one of the key critical infrastructures and its correct behavior should be always enforced, even in case of disasters or severe execution conditions. Resilience is a strongly demanding nonfunctional requirement for current computer networks, and one of the key factors...
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Expedited Geometry Scaling of Compact Microwave Passives by Means of Inverse Surrogate Modeling
PublikacjaIn this paper, the problem of geometry scaling of compact microwave structures is investigated. As opposed to conventional structures (i.e., constructed using uniform transmission lines), re-design of miniaturized circuits (e.g., implemented with artificial transmission lines, ATSs) for different operating frequencies is far from being straightforward due to considerable cross-couplings between the circuit components. Here, we...
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Cavity-expansion approximation for projectile impact and penetration into sand
PublikacjaA one-dimensional problem of a spherical cavity expanding at a constant velocity from zero initial radius in an infinite granular medium, which has the first-kind self-similar solution, is considered. We are solving this dynamic spherical cavity-expansion problem to model rigid spheres penetrating into a granular media. Elastic–plastic deformation of the granular media is described in a barotropic approximation, using the high-pressure...
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A Development of a Capacitive Voltage Divider for High Voltage Measurement as Part of a Combined Current and Voltage Sensor
PublikacjaThis article deals with the development of capacitive voltage divider for high voltage measurements and presents a method of analysis and optimization of its parameters. This divider is a part of a combined voltage and current sensor for measurements in high voltage power networks. The sensor allows continuous monitoring of the network distribution status and performs a quick diagnosis and location of possible network failures....
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Anticancer imidazoacridinone C-1311 inhibits hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF) and angiogenesis
PublikacjaAntitumor imidazoacridinone C-1311 is a DNA-reactive topoisomerase II and FLT3 receptor tyrosine kinase inhibitor. Here, we demonstrate the mechanism of C-1311 inhibitory action on novel targets: hypoxia-inducible factor-1α (HIF-1α), vascular-endothelial growth factor (VEGF), and angiogenesis. In a cell-free system, C-1311 prevented HIF-1α binding to an oligonucleotide encompassing a canonical hypoxia-responsive element (HRE),...
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Glucosinolates from lepidium peruvianum as potential antiamnestic drugs
PublikacjaLepidium peruvianum (maca) (Brassicaceae) is a naturally occurring plant mainly in the high Andes of Peru. In recent years, it has been intensively researched in terms of its influence on various diseases and towards health improvement. Alzheimer’s disease is an incurable disease that most often affects adults over the age of 60. As since 2003 the US Food and Drug Administration (FDA) did not approve any new drug for Alzheimer’s...
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URBAN MENTORING JAKO NOWA TECHNIKA WPRÓŁPRACY W PROCESIE PLANOWANIA PARTCYPACYJNEGO
PublikacjaW 25 lat od powrotu demokracji opierającej się o neoliberalny paradygmat rozwoju kraju, Polska przyjęła Krajową Politykę Miejską 2030. Wraz z ustawą o rewitalizacji w nowoczesny sposób określa ona pole współpracy władz samorządowych i administracji z mieszkańcami, przejście do drugiej fazy rozwoju społeczeństwa demokratycznego – mieszkańców współgospodarzy przestrzeni miast. Powolna ewolucja tej relacji, silnie obarczonej dziedzictwem...
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Multi-objective design optimization of antenna structures using sequential domain patching with automated patch size deter-mination
PublikacjaIn this paper, a simple yet efficient and reliable technique for fully automated multi-objective design optimization of antenna structures using sequential domain patching (SDP) is discussed. The optimization procedure according to SDP is a two-step process: (i) obtaining the initial set of Pareto-optimal designs representing the best possible trade-offs between considered conflicting objectives, and (ii) Pareto set refinement...
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MINERAL CONTENT OF TREE SAP FROM THE SUBCARPATHIAN REGION
Publikacjabut also as medicinal substance in folk medicine. Traditionally, it was used to treat various conditions, mostly anaemia and chronic fatigue. This study has been designed to establish the content of metallic elements (sodium, potassium, calcium, magnesium, zinc and copper) in sap collected from eight different species (silver birch, downy birch, hornbeam, Norway maple, boxelder maple, black walnut, black alder and white willow)...
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Multi-fidelity robust aerodynamic design optimization under mixed uncertainty
PublikacjaThe objective of this paper is to present a robust optimization algorithm for computationally efficient airfoil design under mixed (inherent and epistemic) uncertainty using a multi-fidelity approach. This algorithm exploits stochastic expansions derived from the Non-Intrusive Polynomial Chaos (NIPC) technique to create surrogate models utilized in the optimization process. A combined NIPC expansion approach is used, where both...
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Cost-Efficient Measurement Platform and Machine-Learning-Based Sensor Calibration for Precise NO2 Pollution Monitoring
PublikacjaAir quality significantly impacts human health, the environment, and the economy. Precise real-time monitoring of air pollution is crucial for managing associated risks and developing appropriate short- and long-term measures. Nitrogen dioxide (NO2) stands as a common pollutant, with elevated levels posing risks to the human respiratory tract, exacerbating respiratory infections and asthma, and potentially leading to chronic lung...
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A novel one-variable first-order shear deformation theory for biaxial buckling of a size-dependent plate based on Eringen’s nonlocal differential law
PublikacjaPurpose – This paper aims to present a new one-variable first-order shear deformation theory (OVFSDT) using nonlocal elasticity concepts for buckling of graphene sheets. Design/methodology/approach – The FSDT had errors in its assumptions owing to the assumption of constant shear stress distribution along the thickness of the plate, even though by using the shear correction factor (SCF), it has been slightly corrected, the errors...
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Dissolved and colloidal organic nitrogen removal from WWTP effluents and reject waters using physical-chemical processes
PublikacjaFour physical-chemical processes were compared in terms of the efficiencies of dissolved and colloidal organic nitrogen (DON and CON) removal from the secondary effluents (SE) and reject water from full-scale biological nutrient removal activated sludge systems. Adsorption on activated carbon was most efficient and allowed to remove from the SE up to 80% and 100% of DON and CON, respectively. High efficiencies of DON removal from...
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A Method for Determination and Compensation of a Cant Influence in a Track Centerline Identification Using GNSS Methods and Inertial Measurement
PublikacjaAt present, the problem of rail routes reconstruction in a global reference system is increasingly important. This issue is called Absolute Track Geometry, and its essence is the determination of the axis of railway tracks in the form of Cartesian coordinates of a global or local coordinate system. To obtain such a representation of the track centerline, the measurement methods are developed in many countries mostly by the using...
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Simulation-driven design of compact ultra-wideband antenna structures
PublikacjaPurpose–The purpose of this paper is to investigate strategies and algorithms for expedited designoptimization and explicit size reduction of compact ultra-wideband (UWB) antennas.Design/methodology/approach–Formulation of the compact antenna design problem aiming atexplicit size reduction while maintaining acceptable electrical performance is presented. Algorithmicframeworks are described suitable for handling various design situations...
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Inverse Modeling and Optimization of CSRR-based Microwave Sensors for Industrial Applications
PublikacjaDesign optimization of multivariable resonators is a challenging topic in the area of microwave sensors for industrial applications. This paper proposes a novel methodology for rapid re-design and parameter tuning of complementary split-ring resonators (CSRRs). Our approach involves inverse surrogate models established using pre-optimized resonator data as well as analytical correction techniques to enable rapid adjustment of geometry...
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Low-Cost Automated Design of Compact Branch-Line Couplers
PublikacjaBranch-line couplers (BLCs) are important components of wireless communication systems. Conventional BLCs are often characterized by large footprints which make miniaturization an important prerequisite for their application in modern devices. State-of-the-art approaches to design of compact BLCs are largely based on the use of high-permittivity substrates and multi-layer topologies. Alternative methods involve replacement of transmission-line...
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ANALIZA KOLORÓW SCEN FILMOWYCH W KONTEKŚCIE COLOR GRADINGU
PublikacjaW artykule przedstawiono zagadnienia związane z kolorowaniem sceny filmowej. W pracy przedyskutowano główne aspekty obróbki koloru obrazu filmowego oraz omówiono definicje pojęć związanych z kolorowaniem sceny, tj.: color correction oraz color gradingu. Opisano teorie psychologii koloru oraz ich praktyczne wykorzystanie w filmie i odniesiono je do podstawowych gatunków filmowych i modeli emocji. Następnie przedyskutowano założenia...
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Suppression of Supply Current Harmonics of 18-Pulse Diode Rectifier by Series Active Power Filter with LC Coupling
PublikacjaThe reported research aims at improving the quality of three-phase rectifier supply currents. An effective method consists of adding properly formed booster voltages to the fundamental supply voltages using a series active filter. In the proposed solution, the booster voltages are generated by three single-phase systems consisting of inverters, LC filters, and single-phase transformers. The application of LC couplings ensures low...
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Validation and modification of HPLC method for monitoring acetaminophen plasma concentrations in patients with chronic pancreatitis
PublikacjaBackground. Pancreatitis is the inflammation of the pancreas. The infl ammation may occur suddenly and resolve in a few days with the treatment in case of acute pancreatitis (AP). Chronic pancreatitis (CP) is a persistent inflammation of the pancreas that results in irreversible morphological changes and impairment of both exocrine and endocrine functions. Abdominal...
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DL_MG: A Parallel Multigrid Poisson and Poisson–Boltzmann Solver for Electronic Structure Calculations in Vacuum and Solution
PublikacjaThe solution of the Poisson equation is a crucial step in electronic structure calculations, yielding the electrostatic potential -- a key component of the quantum mechanical Hamiltonian. In recent decades, theoretical advances and increases in computer performance have made it possible to simulate the electronic structure of extended systems in complex environments. This requires the solution of more complicated variants of the...
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Static magnetic multipole susceptibilities of the relativistic hydrogenlike atom in the ground state: Application of the Sturmian expansion of the generalized Dirac-Coulomb Green function
PublikacjaWe study far- and near-field magnetic and electric multipole moments induced in the ground state of the Dirac one-electron atom placed in a weak 2L-pole magnetostatic field. The analysis is carried out within the framework of the first-order Rayleigh-Schrödinger perturbation theory, with the use of the Sturmian expansion of the generalized Dirac-Coulomb Green function [Szmytkowski, J. Phys. B 30, 825 (1997);J. Phys. B 30, 2747(E)...
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Determinants of trade balance in Polish and Czech manufacturing sectors
PublikacjaResearch background: A strong industrial base is essential for achieving long-term sustainable economic growth and export competitiveness. In that sense, manufacturing remains a significant contributor to exports in the CEE countries. However, its role and its influence vary between CEE economies and change over time. Purpose of the article: The main objective of this paper is to compare the determinants of the international competitiveness,...
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Entanglement of genuinely entangled subspaces and states: Exact, approximate, and numerical results
PublikacjaGenuinely entangled subspaces (GESs) are those subspaces of multipartite Hilbert spaces that consist only of genuinely multiparty entangled pure states. They are natural generalizations of the well-known notion of completely entangled subspaces, which by definition are void of fully product vectors. Entangled subspaces are an important tool of quantum information theory as they directly lead to constructions of entangled states,...
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Organisational methods in teaching ergonomics
PublikacjaCivilisation generates many problems connected with job, which cannot be resolved by one field of science that deals with matters fragmentarily, only from its own point of view. Ergonomics, i.e. synthetic knowledge about job, can solve these problems by using the resources of many fields, e.g. physiology, psychology, technical science or economy. The achievements of these fields are used in ergonomics and thus problems connected...
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Buckling analysis of piezo-magnetoelectric nanoplates in hygrothermal environment based on a novel one variable plate theory combining with higher-order nonlocal strain gradient theory
PublikacjaIn the present investigation, a new first-order shear deformation theory (OVFSDT) on the basis of the in-plane stability of the piezo-magnetoelectric composite nanoplate (PMEN) has been developed, and its precision has been evaluated. The OVFSDT has many advantages compared to the conventional first-order shear deformation theory (FSDT) such as needless of shear correction factors, containing less number of unknowns than the existing...
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Wastewater treatment by means of Advanced Oxidation Processes at basic pH conditions: A review
PublikacjaAdvanced oxidation processes (AOPs) have been used as an alternative and effective option for treatment of industrial wastewater, especially in the case of the non-biodegradable compounds. Despite of several well developed AOPs, the majority of them are effective only at acidic or neutral pH, namely Fenton related processes, making the list of available effective advanced oxidation technologies strongly limited. In many cases,...
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Measurement of Seafloor Acoustic Backscatter Angular Dependence at 150 kHz Using a Multibeam Echosounder
PublikacjaAcoustic seafloor measurements with multibeam echosounders (MBESs) are currently often used for submarine habitat mapping, but the MBESs are usually not acoustically calibrated for backscattering strength (BBS) and cannot be used to infer absolute seafloor angular dependence. We present a study outlining the calibration and showing absolute backscattering strength values measured at a frequency of 150 kHz at around 10–20 m water...
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Expedited Acquisition of Database Designs for Reduced-Cost Performance-Driven Modeling and Rapid Dimension Scaling of Antenna Structures
PublikacjaFast replacement models have been playing an increasing role in high-frequency electronics, including the design of antenna structures. Their role is to improve computational efficiency of the procedures that normally entail large numbers of expensive full-wave electromagnetic (EM) simulations, e.g., parametric optimization or uncertainty quantification. Recently introduced performance-driven modeling methods, such as the nested...
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Modeling protein structures with the coarse-grained UNRES force field in the CASP14 experiment
PublikacjaThe UNited RESidue (UNRES) force field was tested in the 14th Community Wide Experiment on the Critical Assessment of Techniques for Protein Structure Prediction (CASP14), in which larger oligomeric and multimeric targets were present compared to previous editions. Three prediction modes were tested (i) ab initio (the UNRES group), (ii) contact-assisted (the UNRES- contact group), and (iii) template-assisted (the UNRES-template...
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The innovative approach for using pavement as a fire prevention measure in tunnels
PublikacjaThe paper consists of two main parts: first presents study regarding the typically used pavement structures in tunnels and the second part: the first fire trials of the poroelastic SEPOR (Safe, Eco-friendly POroelastic Road Surface) mixture which was designed to be used among other uses in tunnels. In the first part of the paper different pavement materials, such as cement concrete, asphalt concrete, stone mastic asphalt and porous...
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Statistical Data Pre-Processing and Time Series Incorporation for High-Efficacy Calibration of Low-Cost NO2 Sensor Using Machine Learning
PublikacjaAir pollution stands as a significant modern-day challenge impacting life quality, the environment, and the economy. It comprises various pollutants like gases, particulate matter, biological molecules, and more, stemming from sources such as vehicle emissions, industrial operations, agriculture, and natural events. Nitrogen dioxide (NO2), among these harmful gases, is notably prevalent in densely populated urban regions. Given...
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Estimation of the Regenerative Braking Process Efficiency in Electric Vehicles
PublikacjaIn electric and hybrid vehicles, it is possible to recover energy from the braking process and reuse it to drive the vehicle using the batteries installed on-board. In the conditions of city traffic, the energy dissipated in the braking process constitutes a very large share of the total resistance to vehicle motion. Efficient use of the energy from the braking process enables a significant reduction of fuel and electricity consumption...
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An advanced tool integrating failure and sensitivity analysis into novel modeling of the stormwater flood volume
PublikacjaAn innovative tool for modeling the specific flood volume was presented that can be applied to assess the need for stormwater network modernization as well as for advanced flood risk assessment. Field measurements for a catchment area in Kielce, Poland, were used to apply the model and demonstrate its usefulness. This model extends the capability of recently developed statistical and machine learning hydrodynamic models developed...
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Precise Point Positioning Method Based on Wide-lane and Narrow-lane Phase Observations and Between Satellites Single Differencing
PublikacjaThe issue of using PPP method in position determination was formed in 1997. In most developed methods, ionospheric-free linear combination is used in order to eliminate the impact of the ionospheric delay. However, this approach does not provide the directly determination of the total value of the ambiguities, and the ambiguities for the individual signals. Therefore, in many publications methods of avoiding these deficiencies...
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Accelerated Gradient-Based Optimization of Antenna Structures Using Multi-Fidelity Simulations and Convergence-Based Model Management Scheme
PublikacjaThe importance of numerical optimization has been steadily growing in the design of contemporary antenna structures. The primary reason is the increasing complexity of antenna topologies, [ a typically large number of adjustable parameters that have to be simultaneously tuned. Design closure is no longer possible using traditional methods, including theoretical models or supervised parameter sweeping. To ensure reliability, optimization...
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Regional resting state perfusion variability and delayed cerebrovascular uniform reactivity in subjects with chronic carotid artery stenosis
PublikacjaThe aim of this study was to assess regional perfusion at baseline and regional cerebrovascular resistance (CVR) to delayed acetazolamide challenge in subjects with chronic carotid artery stenosis.Sixteen patients (ten males) aged 70.94±7.71 with carotid artery stenosis ≥90% on the ipsilateral side and ≤50% on the contralateral side were enrolled into the study. In all patients, two computed tomography perfusion examinations were...
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DNA-reactive anticancer imidazoacridinone C-1311 is a new inhibitor of hypoxia-inducible factor 1 alpha, vascular endothelial growth factor and tumor angiogenesis
PublikacjaHypoxia-inducible factor 1 (HIF-1) plays a critical role for tumor adaptation to hypoxia and promotes angiogenesis. Antitumor imidazoacridinone C-1311 is a DNA reactive topoisomerase II and FLT3 receptor tyrosine kinase inhibitor selected for phase II clinical trials for breast cancer. Here, we demonstrate the new mechanism of C-1311 action involving HIF-1a, vascular endothelial growth factor (VEGF) and angiogenesis as additional...