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Wyniki wyszukiwania dla: LYSOSOMAL CONTENT
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Genistein: a lysosomal stimulator for treatment of various lysosomal diseases
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Combined Therapies for Lysosomal Storage Diseases
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Introducing the concept of Decisional DNA-Based web content mining
PublikacjaPrzedstawiono koncepcje zastosowania struktury reprezentacji wiedzy opartej na decyzyjnym DNA w procesie wyszukiwania informacji w internecie. Dokonano analizy eksperymentow tak wspomaganego wyszukiwania oraz sformulowano wnioski na temat przyszlych badan prowadzacych do dalszej integracji procesu wyszukiwania z doswiadczeniami zdobytymi w trakcie tego wyszukiwania.
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Imidazoacridinone-dependent lysosomal photodestruction: a pharmacological Trojan horse approach to eradicate multidrug-resistant cancers
PublikacjaMultidrug resistance (MDR) remains a primary hindrance to curative cancer therapy. Thus, introduction of novel strategies to overcome MDR is of paramount therapeutic significance. Sequestration of chemotherapeutics in lysosomes is an established mechanism of drug resistance. Here, we show that MDR cells display a marked increase in lysosome number. We further demonstrate that imidazoacridinones (IAs), which are cytotoxic fluorochromes,...
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Factors and processes modulating phenotypes in neuronopathic lysosomal storage diseases
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THE AGRI-HOOD AND SLOW-SUBURB CONCEPT IN THE CONTEXT OF AN IN-BETWEEN CITY (ZWISCHENSTADT)
PublikacjaThe concept of an “in-between-city” (Zwischenstadt) interprets the urban sprawl in Europe as a new, evolving model of urban development, taking the form of urbanized landscapes, which does not correspond with the traditional understanding of urban design. The actual shape of an in-between-city reflects the today’s technology and economy generating new lifestyles: global trends coexist with the locality in a strong relation. The...
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The molecular mechanism of genistein action in lysosomal storage diseases: A transcriptomic approach
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The dying medium temperature impact on the final moisture content of pine wood at constant drying time
PublikacjaThe results of final moisture content of pine wood (Pinus sylvestris L.) after drying process are presented. The wood in the experiments was taken from the northern part of Pomeranian region in Poland. The drying process was performed in the experimental chamber equipped with the micro-jet heat exchanger. The air at temperatures of 40°C, 60°C, 80°C, 100°C and 120°C with relative humidity about 60% and atmospheric pressure was the...
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Data, Information, Knowledge, Wisdom Pyramid Concept Revisited in the Context of Deep Learning
PublikacjaIn this paper, the data, information, knowledge, and wisdom (DIKW) pyramid is revisited in the context of deep learning applied to machine learningbased audio signal processing. A discussion on the DIKW schema is carried out, resulting in a proposal that may supplement the original concept. Parallels between DIWK pertaining to audio processing are presented based on examples of the case studies performed by the author and her collaborators....
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The Phytoestrogen Genistein Modulates Lysosomal Metabolism and Transcription Factor EB (TFEB) Activation
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Abnormal Sphingolipid World in Inflammation Specific for Lysosomal Storage Diseases and Skin Disorders
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Photodynamic therapy of cancer with liposomal photosensitizers
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Current status of liposomal porphyrinoid photosensitizers
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BASECOL2023 scientific content
PublikacjaContext. The global context of making numerous data produced by researchers available requires collecting and organising the data, assigning meaningful metadata, and presenting the data in a meaningful and homogeneous way. The BASECOL database, which collects inelastic rate coefficients for application to the interstellar medium and to circumstellar and cometary atmospheres, meets those requirements. Aims. We aim to present the...
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Cyclosporine CsA—The Physicochemical Characterization of Liposomal and Colloidal Systems
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New Services for iTVP Content Providers to Manage Live and On-Demand Content Streaming
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The Role of Dimethyl Sulfoxide (DMSO) in Gene Expression Modulation and Glycosaminoglycan Metabolism in Lysosomal Storage Disorders on an Example of Mucopolysaccharidosis
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Context of Use
PublikacjaRaport techniczny - opis metody ''Context of Use'' wykorzystywanej w projektowaniu komunikacji człowiek-komputer oraz doskonaleniu interfejsu użytkownika.
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A novel concept of enhanced direct-contact condensation of vapour- inert gas mixture in a spray ejector condenser
PublikacjaAn analytical model of direct steam condensation (DCC) in the novel idea of spray ejector condenser (SEC) in the presence of inert gas has been developed. It is based on continuity, momentum and energy equations for the steam-carbon dioxide mixture and direct contact condensation mechanisms due to heat transfer and concentration. Crucial in the process of DCC is atomisation of the motive fluid in the ejector. The effect of atomised...
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Liposomal Nanoformulation as a Carrier for Curcumin and pEGCG—Study on Stability and Anticancer Potential
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PCR-Based Genotyping of Mycobacterium tuberculosis with New GC-Rich Repeated Sequences and IS6110 Inverted Repeats Used as Primers.
PublikacjaW pracy przedstawiono nową metodę genotypowania Mycobacterium tuberculosis. Zastosowanie oligonukleotydu Mtb1 5'-CCG-GCG-GGG-CCG-GCG-G lub Mtb2 5'-CGG-CGG-CAA-CGG-CGG-C wraz z oligonukleotydami specyficznymi do terminalnych sekwencji elementu insercyjnego IS6110 pozwala na różnicowanie szczepów Mycobacterium tuberculosis w metodzie PCR. Opracowana metoda może być wykorzystana w badaniach epidemiologicznych gruźlicy.
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One-tube cell lysis and DNA extraction procedure for PCR based detection of Mycobacterium ulcerans in aquatic insects, molluscs and fish.
PublikacjaMycobacterium ulcerans jest bakterią wywołującą choroby skóry u ludzi i zwierząt. W trakcie prowadzonych badań opracowano prostą w wykonaniu metodę ekstrakcji DNA Mycobacterium ulcerans z próbek środowiskowych oraz klinicznych. Opracowana metoda izolacji DNA może być przydatna w badaniu źródeł infekcji oraz dróg szerzenia się Mycobacterium ulcerans.
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PCR amplification with primers based on IS2404 and GC-rich repeated sequence reveals polymorphism in Mycobacterium ulcerans
PublikacjaOpracowano prostą w wykonaniu metodę genotypowania szczepów bakterii z gatunku Mycobacterium ulcerans. Polimorfizm genetyczny 32 badanych izolatów Mycobacterium ulcerans odzwierciedla ich geograficzne pochodzenie z rejonów Afryki Centralnej, Ameryki Południowej i Łacińskiej, Azji Południowo-Wschodniej, Malezji oraz Australii.
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Kryteria wytrzymałości gruntu na ścinanie w zagadnieniach geotechniki
PublikacjaPrzedstawiono wpływ zastosowania różnych kryteriów wytrzymałości gruntu na ścinanie w symulacjach numerycznych prostych praktycznych zagadnień geotechnicznych. Obliczenia wykonano metodą elementów skończonych w płaskim oraz osiowosymetrycznym stanie odkształcenia. Wyniki obliczeń porównano oraz poddano krytycznej dyskusji.
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Evaluation of zinc content in children’s hair
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Towards automatic classification of Wikipedia content
PublikacjaArtykuł opisuje podejście do automatycznej klasyfikacji artykułów w Wikipedii. Przeanalizowane zostały reprezentacje tekstu bazujące na treści dokumentu i wzajemnych powiązaniach. Przedstawiono rezultaty zastosowania klasyfikatora SVM.
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Information content of systems as a physical principle
PublikacjaTo explain the conceptual gap between classical and quantum and other, hypothetical descriptions of the world, several principles have been proposed. So far, all these principles have not explicitly included the uncertainty relation. Here we introduce an information content principle ( ICP ) which represents a constrained uncertainty principle. The principle, by taking into account the encoding and decoding properties of a single physical...
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Dynamic Content Internationalization in Web Applications
PublikacjaThis paper shows a concept for providing dynamic internationalization to web applications. Presented work is based on the Java Web Platform but described concepts can be successfully implemented on other platforms. It shows how textual data being part of web pages static and dynamic content can be localized dynamically during application runtime. All concepts presented were or are still being developed in an existing conference...
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Activity ofα1-Antitrypsin and Some Lysosomal Enzymes in the Blood Serum of Patients with Chronic Obstructive Pulmonary Disease after Smoking Cessation
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Modulation of expression of genes involved in glycosaminoglycan metabolism and lysosome biogenesis by flavonoids
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A CONTEXT IN RECOMMENDER SYSTEMS
PublikacjaRecommender systems aim to propose potentially interesting items to a user based on his preferences or previous interaction with the system. In the last decade, researcher found out that known recommendation techniques are not sufficient to predict user decisions. It has been noticed that user preferences strongly depend on the context in which he currently is. This raises new challenges for the researchers such as how to obtain...
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Content-Based Approach to Automatic Recommendation of Music
PublikacjaThis paper presents a content-based approach to music recommendation. For this purpose, a database which contains more than 50000 music excerpts acquired from public repositories was built. Datasets contain tracks of distinct performers within several music genres. All music pieces were converted to mp3 format and then parameterized based on MPEG-7, mel-cepstral and time-related dedicated parameters. All feature vectors are stored...
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Evaluation of the content of inorganic anions in tree saps
PublikacjaTree saps were once commonly used in the countries of Northern, Central and Eastern Europe. Although once almost forgotten, their popularity has been growing recently as part of an interest in organic food and traditional medicine. Tree saps, tapped mainly from birch and maple trees, are drunk both fresh and fermented or are used as raw material for the production of food products, e.g. syrups. The aim of this study was to determine...
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The lifecycle of a digital historical document: structure and content.
PublikacjaZaproponowno model cyklu wytwarzania dokumentu cyfrowego z papierowych oryginałów pisanych na maszynie i przedstawiono opracowany przez autorów i wdrożony w środowisku Państwowego Muzeum Stutthof w Sztutowie zestaw narzędziowy DOW do automatycznej ekstrakcji treści dokumentu. Istotę nowej metodologii, opracowanej w ramach projektu 5PR UE IST-33441 MEMORIAL, jest wykorzystanie informacji semantycznej w procesach segmentacji tła,...
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Image content description methods for a retrieval system.
PublikacjaArtykuł przedstawia metody opisu treści obrazu dla potrzeb systemu wyszukiwania. Omówiono deskryptory opisu treści obrazu oraz ich realizację w Systemie Wyszukiwania Obrazów.
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Content-based retrieval system as a telemedicine tool.
PublikacjaW artykule przedstawiono bazujący na treści system wyszukiwania jako narzędzie w telemedycynie. System taki umożliwia przeszukiwanie bazy wiedzy w celu uzyskania podobnych przypadków medycznych, wspomagając w ten sposób podejmowanie decyzji medycznych.
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Evaluation of mercury content in combustible tobacco products by employing cold vapor atomic absorption spectroscopy and considering the moisture content: a comprehensive study
PublikacjaPlants are mainly made up of water, which constitutes between 80 and 90% of their weight. Moisture factor comes across as one of the most important in tobacco products. Rapid determination of moisture content in tobacco products comes at neces- sity in any tobacco management plants (before and after production). Therefore, the concern has been raised in this study to evaluate the moisture content in four kinds of combustible tobacco...
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Impact of weeding methods on the content of nitrates in potato tubers
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Query-by-Shape interface for Content Based Image Retrieval
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The concentration of geothermal brines with iodine content by membrane distillation
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Gesture recognition framework for multimedia content viewer controlling
PublikacjaIn the paper a system for controlling a multimedia content viewer by hand gestures is presented. First, selected methods used for gesture recognition are described. Two different application cases of the system, i.e. for multimedia presentation purposes and for multimedia content viewing are outlined. Moreover, a proposal of improvement of the system combining these approaches is also given. The system work cycle is reviewed. The...
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Chromium content in the hair of children and students in Southern Poland
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Audio content analysis in the urban area telemonitoring system
PublikacjaArtykuł przedstawia możliwości rozwinięcie monitoringu miejskiego o automatyczną analizę dźwięku. Przedstawiono metody parametryzacji dźwięku, które możliwe są do zastosowania w takim systemie oraz omówiono aspekty techniczne implementacji. W kolejnej części przedstawiono system decyzyjny oparty na drzewach zastosowany w systemie. System ten rozpoznaje dźwięki niebezpieczne (strzał, rozbita szyba, krzyk) wśród dźwięków zarejestrowanych...
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Video content analysis in the urban area telemonitoring system
PublikacjaThe task of constant monitoring of video streams from a large number of cameras and reviewing the recordings in order to find a specified event requires a considerable amount of time and effort from the system operators and it is prone to errors. A solution to this problem is an automatic system for constant analysis of camera images being able to raise an alarm if a predefined event is detected. The chapter presents various aspects...
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Effect of water content on the characteristics of hydro-compacted nanosilica
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High temperature drying of beech with content of tension wood
PublikacjaThe presented artcle is focused on comparison of tension and normal wood of beech (Fagus sylvatica L.) in a high-temperature drying process. Samples of 26 mm thickness were selected from sapwood zone with different angle of growth rings. The article evaluated properties of tension and normal wood before and after drying process. Properties which are monitored were moisture, moisture gradients, covering tests, colour changes and...
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MINERAL CONTENT OF TREE SAP FROM THE SUBCARPATHIAN REGION
Publikacjabut also as medicinal substance in folk medicine. Traditionally, it was used to treat various conditions, mostly anaemia and chronic fatigue. This study has been designed to establish the content of metallic elements (sodium, potassium, calcium, magnesium, zinc and copper) in sap collected from eight different species (silver birch, downy birch, hornbeam, Norway maple, boxelder maple, black walnut, black alder and white willow)...
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The use of low-coherence interferometer for sugar content determination
PublikacjaIn this article, the implementation of low-coherence interferometer with signal processing in time domain for sugar content determination in aqueous solution is presented. The elaborated measurement set-up was tested with the use of synthesized source made of two low-coherence sources. The use of two sources with dedicated parameters enabled to obtain a proper metrological parameters of the measurement system. The elaborated low-coherence...
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Mercury content in beetroot and beetroot-based dietary supplements
PublikacjaTotal mercury (THg) concentrations in fifty-four beetroot-based DSs and seven lots of conventional and organic beetroots (divided into unpeeled, peeled, and skins) were determined by direct thermal decomposition-gold amalgamation cold vapour atomic absorption spectrometry. The analytical procedure was optimised and validated. The recovery (%) for Hg was 101.9 and 92.73 in BCR-463 and DOLT 4, respectively. The intermediate precision...
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Content malondialdehyde (MDA) in infant formulae and follow-on formulae
PublikacjaZbadano zawartość dialdehydu malonowego, szkodliwego dla zdrowia produktu oksydacji lipidów, w preparatach do początkowego MP i następnego MN żywienia niemowląt, w mleku ludzkim, nieprzetworzonym mleku krowim oraz w oleju sojowym i rzepakowym - składnikach MP i MN. W preparatach stwierdzono znaczne zawartości MDA, w zależności od stosowanej przez producenta technologii produkcji, sposobu pakowania oraz warunków przechowywania gotowego...