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Wyniki wyszukiwania dla: epigenetic remodelling
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Transcriptional activity of epigenetic remodeling genes declines in keratinocytes after in vitro expansion
PublikacjaPURPOSE: In vitro expansion is an invaluable method to obtain keratinocytes in amounts necessary for effective transplantation therapies. In vitro cell culturing provokes questions concerning potential epigenetic alterations occurring in expanded cells in the context of usefulness for transplantation and safety. The purpose of this study was to investigate as to whether keratinocyte expansion is associated with changes in the activity...
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The role of epigenetics in regeneration
PublikacjaComplex changes in chromatin structure and at the transcriptional level occur from the creation of a single parental gamete throughout fertilization, embryo development and the life of an adult organism. Epigenetic changes, such as methylation and hydroxymethylation of DNA or histone methylation and acetylation, are an important part of these processes. Epigenetic regulation has an essential influence on gene expression level. DNA...
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Genetic and Epigenetic Aspects of Atopic Dermatitis
PublikacjaAtopic dermatitis is a heterogeneous disease, in which the pathogenesis is associated with mutations in genes encoding epidermal structural proteins, barrier enzymes, and their inhibitors; the role of genes regulating innate and adaptive immune responses and environmental factors inducing the disease is also noted. Recent studies point to the key role of epigenetic changes in the development of the disease. Epigenetic modifications...
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Urinary Measurement of Epigenetic DNA Modifications: A Non-Invasive Assessment of the Whole-Body Epigenetic Status in Healthy Subjects and Colorectal Cancer Patients
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A New Epigenetic Mechanism of Temozolomide Action in Glioma Cells
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Epigenetic-Based Therapy—A Prospective Chance for Medulloblastoma Patients’ Recovery
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Global DNA demethylation as an epigenetic marker of human brain metastases
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Revealing the epigenetic effect of temozolomide on glioblastoma cell lines in therapeutic conditions
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Enigmatic 5-hydroxymethyluracil: Oxidatively modified base, epigenetic mark or both?
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Activation of endogenous regenerative potential in mammals using epigenetic inhibitor zebularine
PublikacjaIn this work, a nucleoside inhibitor of DNA methyltransferases, zebularine, was investigated as a wound healing and regeneration promoting agent. It was found that a high dose of intraperitoneally delivered zebularine improved punch wound closure in the ear pinna in mice. Both cytidine, a zebularine analogue, and uridine, a zebularine metabolite, did not promote ear pinna hole closure. The effect of zebularine on ear pinna healing...
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Epigenetic regulation and regeneration: the search for differentially methylated genes in the MRL mouse
PublikacjaThe MRL mouse is an inbred laboratory strain, which was developed in the 60’s of the 20th century and has been extensively used as a model of lupus erythematosus. The regenerative abilities of the strain were discovered in the 90' when the MRL mouse was shown to close 2 mm hole punches made in the ear pinnae four weeks after injury without scarring. The phenomenon has not been observed in other mouse strains, where the holes...
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Epigenetic inhibitor zebularine activates ear pinna wound closure in the mouse
PublikacjaBackground:Most studies on regenerative medicine focus on cell-based therapies and transplantations.Small-molecule therapeutics, though proved effective in different medical conditions, have not been extensivelyinvestigated in regenerative research. It is known that healing potential decreases with development and devel-opmental changes are driven by epigenetic mechanisms, which suggests epigenetic repression of regenerativecapacity.Methods:We...
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The influence of pre- and postharvest treatments on selected biological and epigenetic activities of Brassica sprouts
PublikacjaIntroduction The Brassica vegetables are rich in glucosinolates (GLs), which are enzymatically hydrolysed to bioactive isothiocynates (ITC) and indoles, regarded as the most promising chemopreventing agents. However, in the majority of brassica sprouts the GL conversion into these beneficial derivatives occurs at the level of about 1 %, while in cabbage leaves exceeds 70%. Since sprouts represent plant material, which is frequently...
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Examination of epigenetic inhibitor zebularine in treatment of skin wounds in healthy and diabetic mice
PublikacjaDNA methyltransferase inhibitor zebularine was proven to induce regeneration in the ear pinna in mice. We utilized a dorsal skin wound model to further evaluate this epigenetic inhibitor in wound healing. Full-thickness excisional wounds were made on the dorsum of 2 and 10-month-old healthy BALB/c and 3 and 8-month-old diabetic (db/db) mice, followed by topical or intraperitoneal zebularine delivery. Depending on the strain, age,...
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TLC-based detection of methylated cytosine: application to aging epigenetics
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Nanosized zinc, epigenetic changes and its relationship with DMBA induced breast cancer in rats
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Epigenetic modifications and NF-κB pathway activity in Cu,Zn-SOD-deficient mice
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Epigenetic Basis of Regeneration: Analysis of Genomic DNA Methylation Profiles in the MRL/MpJ Mouse
PublikacjaEpigenetic regulation plays essential role in cell differentiation and dedifferentiation, which are the intrinsic processes involved in regeneration. To investigate the epigenetic basis of regeneration capacity, we choose DNA methylation as one of the most important epigenetic mechanisms and the MRL/MpJ mouse as a model of mammalian regeneration known to exhibit enhanced regeneration response in different organs. We report the...
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Pathogenesis of psoriasis in the “omic” era. Part II. Genetic, genomic and epigenetic changes in psoriasis
PublikacjaPsoriasis is a multifactorial disease in which genetic, environmental and epigenetic factors regulating gene expression play a key role. In the “genomic era”, genome-wide association studies together with target genotyping platforms performed in different ethnic populations have found more than 50 genetic susceptible markers associated with the risk of psoriasis which have been identified so far. Up till now, the strongest association...
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Mass spectrometry reveals the presence of specific set of epigenetic DNA modifications in the Norway spruce genome
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Characteristic profiles of DNA epigenetic modifications in colon cancer and its predisposing conditions—benign adenomas and inflammatory bowel disease
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Comparison of the Absolute Level of Epigenetic Marks 5-Methylcytosine, 5-Hydroxymethylcytosine, and 5-Hydroxymethyluracil Between Human Leukocytes and Sperm1
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Are 8-oxoguanine (8-oxoGua) and 5-hydroxymethyluracil (5-hmUra) oxidatively damaged DNA bases or transcription (epigenetic) marks?
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Changes in Epigenetic Patterns Related to DNA Replication in Vicia faba Root Meristem Cells under Cadmium-Induced Stress Conditions
PublikacjaExperiments on Vicia faba root meristem cells exposed to 150 µM cadmium chloride (CdCl2) were undertaken to analyse epigenetic changes, mainly with respect to DNA replication stress. Histone modifications examined by means of immunofluorescence labeling included: (1) acetylation of histone H3 on lysine 56 (H3K56Ac), involved in transcription, S phase, and response to DNA damage during DNA biosynthesis; (2) dimethylation of histone...
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In vivo evidence of ascorbate involvement in the generation of epigenetic DNA modifications in leukocytes from patients with colorectal carcinoma, benign adenoma and inflammatory bowel disease
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Integrated membrane bioreactors modelling: A review on new comprehensive modelling framework
PublikacjaIntegrated Membrane Bioreactor (MBR) models, combination of biological and physical models, have been representing powerful tools for the accomplishment of high environmental sustainability. This paper, produced by the International Water Association (IWA) Task Group on Membrane Modelling and Control, reviews the state-of-the-art, identifying gaps for future researches, and proposes a new integrated MBR modelling framework. In...
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The HRCT image analysis for quantitative description of peripheral airways remodelling.
PublikacjaPrzedstawiono analizę obrazów HRCT dla ilościowego opisu remodelingu dróg oddechowych. Zaproponowano metodologię postępowania w przypadku przekształceń geometrycznych celem uzyskania dokładnych wartości parametrów opisujących kształt.
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Profiles of a broad spectrum of epigenetic DNA modifications in normal and malignant human cell lines: Proliferation rate is not the major factor responsible for the 5-hydroxymethyl-2′-deoxycytidine level in cultured cancerous cell lines
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Probability modelling of vessel collisions
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Modelling of the Svalbard fjord Hornsund
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Numerical Modelling of Structures with Uncertainties
PublikacjaThe nature of environmental interactions, as well as large dimensions and complex structure of marine offshore objects, make designing, building and operation of these objects a great challenge. This is the reason why a vast majority of investment cases of this type include structural analysis, performed using scaled laboratory models and complemented by extended computer simulations. The present paper focuses on FEM modelling...
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Descriptive Modelling of Virtual Transactions.
PublikacjaArtykuł prezentuje opisowy model transakcji detalicznych, w którym ich znaczenie (IOR) wyrażone przez strukturę sprzedaży i udział w rynku jest uwarunkowane funkcjonalnością (FUN), na którą wpływają w sposób zwrotny trzy grupy czynników : technologicznych, (TFG) ludzkich (HFG) oraz rynkowych (MFG).
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Modelling of foundations for supporting structures.
PublikacjaW pracy przedstawiono problemy współpracy fundamentów konstrukcji wsporczych z otaczającym ośrodkiem gruntowym w warunkach przestrzennego stanu odkształcenia. Przedstawiono możliwości analizy odporu granicznego podłoża i przemieszczeń fundamentów sztywnych obciążonych siłą poziomą lub momentem. Porównano modelowanie fizyczne zjawisk z modelowaniem matematycznym z wykorzystaniem symulacji numerycznych opartych na analizie płaskiego...
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Method of Skeletal System Modelling
PublikacjaAn original method of skeletal system modelling is presented in detail. Using DICOM images obtained from CT and PET tests, shell models of nine bones were created (humerus, radius, ulna, scapula, clavicle, femur, tibia, fibula, pelvis). Two methods of bone behaviour are also proposed, the first method treating the bone as a solid structure and the second method treating the bone as a complex porous structure. The behaviour of model...
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Modelling of engineering materials with microstructure
PublikacjaArtykuł omawia różne modele do opisu lokalizacji odkształceń w postaci rys i stref ścinania w materiałach budowlanych takich jak grunt i beton. Zastosowane modele mechaniki ośrodka ciągłego i modele dyskretne.
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Correction: Profiles of a broad spectrum of epigenetic DNA modifications in normal and malignant human cell lines: Proliferation rate is not the major factor responsible for the 5-hydroxymethyl-2′-deoxycytidine level in cultured cancerous cell lines
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Modelling of elastic response of granular media
PublikacjaW pracy przedstawiono opis gruntowego ośrodka ziarnistego w ujęciu jego nieciągłości.Podano przejście opisu tego ośrodka do opisu ośrodka gruntowego ciągłego. Podano rozwiązania ciągłe stanu naprężenia wg. rozwiązania Mindlina. Podano określenie wartości parametrów sprężystych ośrodka ciągłego przy bardzo małych odkształceniach. Przeanalizowano wpływ różnych czynników na określenie modułu odkształcenia sprężystego. Podano sposób...
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Modelling of pipes conveying flowing liquid
PublikacjaThe paper introduces the method of modal reduction of system which consists of pipe with flowing liquid. The concept of hybrid model is proposed. The system model consists of two parts, the modal model and the finite elements model. The modal model represents linear, self-adjoined part of the system, while simple lumped technique is applied for modelling of Coriolis phenomena.
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Systemic approach to modelling the human brain
PublikacjaW prezentacji przedstawia się ogólną koncepcję w pełni autonomicznego systemu decyzyjnego dla robota (awatara, linguabota), zdolnego reagować na bodźce ze środowiska oraz opartego na opracowanym matematycznym modelu psychologii poznawczej człowieka, z elementami psychologii osobowości., uwzględniającymi 'potrzeby', 'emocje', 'nastrój' oraz elementy 'woli'.
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Modelling of vibrations of a liquid filled tank
PublikacjaPrzeprowadzono analizę teoretyczną i numeryczną zbiorników długich i krótkich wypełnionych całkowicie lub częściowo cieczą. Wyznaczenie obciążeń hydrodynamicznych dotyczy bezpośrednio wytrzymałości konstrukcji samego zbiornika, a przez to pozwala określić wytrzymałość konstrukcyjną całego kadłuba. Szczególne wymagania stawiane są zbiornikom do przewozu cieczy radioaktywnych, gdyż należy zapewnić bardzo wysoki stopień bezpieczeństwa...
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On FE modelling of fully saturated soils
PublikacjaPrzedstawiono podstawy modelowania gruntów nasyconych w ramach metody elementów skończonych. Przedstawiono szczegółowo podstawowe równania różniczkowe problemu oraz ich słabą formę potrzebną w dyskretyzacji w metodzie elementów skończonych. Porównano dwie podstawowe metody formułowania elementów skończonych: uproszczoną u-p oraz pełną u-p-w. Omówiono podstawowe różnice i ograniczenia metody uproszczonej. Artykuł w swej rozszerzonej...
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Control System Modelling for Superconducting Accelerator
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Equilibrium price - modelling, forecast and application
PublikacjaNowoczesną gospodarkę charakteryzuje wzrastające znaczenie cen. Znajomość ogólnych zasad mechanizmu kształtującego ceny oraz analizy cen umożliwiają przedsiębiorstwom przewidzenie ceny równowagi i podjęcie przynoszącej zyski decyzji, zwłaszcza na rynku oligopolu homogenicznego, gdzie przedsiębiorcy muszą brać pod uwagę reakcję konkurencji. Przedstawiony w artykule, dynamiczny model ekonometryczny cen benzyny, na rynku paliw płynnych...
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Modelling of Geared Multi-Rotor System
PublikacjaIn the paper the method of modelling a speed-varying geared rotor system is presented. The proposed approach enables us to obtain an accurate low-order lumped parameter representation of the investigated system. The final model consists of reduced modal models of an undamped beam/torsional shaft system as well as a spatially lumped model of other linear and nonlinear phenomena including gear mesh interaction.
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The modelling method of discrete-continuous systems
PublikacjaThe paper introduces a method of discrete-continuous systems modelling. In the proposed method a three-dimensional system is divided into finite elements in only two directions, with the third direction remaining continuous. The thus obtained discrete-continuous model is described by a set of partial differential equations. General difference equations of discrete system are obtained using the rigid finite element method. The limit...
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Modelling of cutting by means of fracture mechanics
PublikacjaThe suitability of modern fracture mechanic theory was proved for the estimation of the cutting force and the cutting specific resistance. This paper shows modification of Ernst-Merchant theory and its application for determination some other properties of wood sample. This theory is acceptable for evaluation of shear yield stresses and shear plane angle. Sawing by gang saw machine was used as a process similar to the orthogonal...
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MODELLING OF CUTTING BY MEANS OF FRACTURE MECHANICS
PublikacjaThe suitability of modern fracture mechanic theory was proved for the estimation of the cutting force and the cutting specific resistance. This paper shows modification of Ernst-Merchant theory and its application for determination some other properties of wood sample. This theory is acceptable for evaluation of shear yield stresses and shear plane angle. Sawing by gang saw machine was used as a process similar to the orthogonal...
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Risk Modelling for Passages in Approach Channel
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GIS Integrated Modelling of a Himalayan Landscape
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Study of a plate modelling a dock gate
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