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Wyniki wyszukiwania dla: IN VITRO BIODEGRADATION
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Projektowanie, synteza oraz badanie aktywności biologicznej nowych inhibitorów sulfatazy steroidowej (STS) na bazie amidosiarczanowych pochodnych triazoli i oksadiazoli
PublikacjaNiniejsza dysertacja dotyczy szeregu badań z wykorzystaniem technik modelowania molekularnego oraz metod syntezy nowych inhibitorów STS opartych o rdzenie pierścieni heterocyklicznych 1,2,3-triazolu oraz 1,2,4-oksadiazolu. Aktywność inhibicyjna otrzymanych pochodnych została oznaczona w testach in vitro z wykorzystaniem enzymu wyizolowanym z łożyska ludzkiego oraz znakowanym radioizotopowo siarczanem estronu, a także w teście komórkowych...
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Wastewater Engineering 2020/21 (Environmental Engineering, II stopnia, stacjonarne, II semestr))
Kursy OnlineWastewater sources and flows Wastewater characterization based on physical and biodegradation criteria Preliminary treatment unit operations (screens, grit chambers, primary clarifiers) Biological processes (suspended growth vs. attached growth, hybrid systems, granular sludge) for wastewater treatment. Principles of biological nutrient removal (nitrification, denitrification, enhanced biological P removal, anammox). Implementation...
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Ryszard Andruszkiewicz prof. dr hab. inż.
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Electrophoretic deposition and characterization of composite chitosan/Eudragit E 100 or poly(4-vinylpyridine)/mesoporous bioactive glass nanoparticles coatings on pre-treated titanium for implant applications
PublikacjaTitanium implants are surface-modified to achieve bioactivity and often antibacterial properties. Such surface coatings may increase corrosion degradation and be weakly attached to the substrate. In the present research, biodegradable composite coatings, investigated so far as smart environment-sensitive, slowly releasing silver to the implant neighborhood, were produced as a combination of chitosan (CS) with Eudragit E 100 (EE100)...
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Accumulation of volatile constituents in agar and bioreactor shoot cultures of Verbena officinalis L.
PublikacjaIn vitro shoot cultures of common vervain (Verbena officinalis L., Verbenaceae) were established and evaluated for essential oil content. The shoots were maintained as stationary microshoot culture, grown on Schenk–Hildebrandt medium supplemented with 9.84 µM of 2-isopentenyladenine and 1.0 µM of thidiazuron. The shoots were further adapted to grow in two temporary immersion bioreactors (RITA and Plantform), using Schenk–Hildebrandt...
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The Influence of COD Fraction Forms and Molecules Size on Hydrolysis Process Developed by Comparative OUR Studies in Activated Sludge Modelling
PublikacjaThe activated sludge models (ASMs) commonly used by the International Water Association (IWA) task group are based on chemical oxygen demand (COD) fractionations. However, the proper evaluation of COD fractions, which is crucial for modelling and especially oxygen uptake rate (OUR) predictions, is still under debate. The biodegradation of particulate COD is initiated by the hydrolysis process, which is an integral part of an ASM....
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Preparation and characterization of biodegradable and compostable PLA/TPS/ESO compositions
PublikacjaIn this study, biodegradable and compostable compositions, derived from totally natural feedstock/raw materials, namely polylactide (PLA), potato thermoplastic starch (TPS) and plant glycerin have been made by melt extrusion with epoxydized soybean oil (ESO) as reactive modifier in order to improve PLAs ductility and reduce the products cost without compromising biodegradation. The obtained PLA/mTPS(0,5ESO)[75/25] and PLA/ mTPS(2ESO)[75/25]...
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Obliczanie nośności i osiadania pali pojedynczych na podstawie badań sondą Statyczną CPT.
PublikacjaOmówiono metodę obliczania nośności i osiadania pali z uwzględnieniem bezpośredniego wykorzystania wyników badań sondą statyczną CPT. Dla oceny krzywej osiadania zastosowano funkcje transformacyjne. Przedstawiono analizę wykorzystując wyniki próbnych obciążeń statycznych dla 94 pali Vibro-Fundex. Zaproponowane korelacje zostały zweryfikowane przy wykorzystaniu procedury weryfikacji hipotez statystycznych.
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Studies of the effects of antifungal cationic derivatives of amphotericin B on human erythrocytes.
PublikacjaBadano nową grupę kationowych pochodnych amfoterycyny B pod kątem zależności pomiędzy ich zdolnością do asocjacji i selektywną toksycznością. We wszystkich przypadkach stosowano amfoterycynę B jako związek odniesienia. Jako miarę efektu toksycznego in vitro badanych związków stosowano wypływ wewnątrzkomórkowego potasu oraz hemolizę. Miarą aktywności przeciwgrzybowej był MIC i utrata potasu wewnatrzkomórkowego. Do oceny stopnia...
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Structural factors affecting affinity of cytotoxic oxathiole-fused chalcones toward tubulin
PublikacjaSynthesis, in vitro cytotoxic activity, and interaction with tubulin of (E)-1-(6-alkoxybenzo[d][1,3]oxathiol- 5-yl)-3-phenylprop-2-en-1-one derivatives (2) are described. Some of the compounds demonstrated cytotoxic activity at submicromolar concentrations, and the activity could be related to interaction with tubulin at the colchicine binding site. Interaction of selected derivatives with tubulinwas evaluated using molecular modeling,...
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Molecular Umbrella as A Nanocarrier for Antifungals
PublikacjaA molecular umbrella composed of two O‐sulfated cholic acid residues was applied for the construction of conjugates with cispentacin, containing a “trimethyl lock” (TML) or o‐dithiobenzylcarbamoyl moiety as a cleavable linker. Three out of five conjugates demonstrated antifungal in vitro activity against C. albicans and C. glabrata but not against C. krusei, with MIC90 values in the 0.22–0.99 mM range and were not hemolytic. Antifungal...
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Antimicrobial Activity of Chimera Peptides Composed of Human Neutrophil Peptide 1 (HNP-1) Truncated Analogues and Bovine Lactoferrampin
PublikacjaThree chimera peptides composed of bovine lactoferrampin and the analogue of truncated human neutrophil peptide 1 were synthesized by the solid-phase method. In two compounds peptide chains were connected via isopeptide bond, whereas in the third one disulfide bridge served as a linker. All three chimeras displayed significantly higher antimicrobial activity than the constituent peptides as well as their equimolar mixtures. The...
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Badania bioaktywności z wykorzystaniem komórek kościotwórczych na tytanie pokrytym chitozanem = Bioactivity studies using osteogenic cells on titanium coated with chitosan
PublikacjaChitosan is a natural polymer from the group of polysaccharides, which has found wide application in biomedical applications to induce bioactivity of implant. The studies described were carried out test imposition of chitosan membranes with varying degrees of deacetylation on the surface of titanium, and then check the bioactivity of the material in vitro, using osteogenic cells MC3T3-E1. Titanium surface before imposition of...
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Smart acoustic band structures
PublikacjaSmart acoustic band structures exhibit very interesting and non-standard physical properties due to the periodic nature of their certain characteristic on different scale levels. They manifest mostly in their frequency spectra as socalled frequency band-gaps or stop-bands, what has a great impact on the behaviour of these structures in relation to the propagation of vibro-acoustic signals that can be transmitted through the structures...
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Determination of the bearing capacity of pile foundations based on CPT test results
PublikacjaAnalityczne określanie pełnej krzywej obciążenie - osiadanie na podstawie parametrów geotechnicznych wciąż stanowi bardzo trudne zadanie naukowe i inżynierskie. W pracy przedstawiono metodę bezpośredniego wykorzystania oporów na stożku sondy statycznej do określania pełnej krzywej osiadania dla pali Vibro-Fundex. W sumie jako materiał weryfikacyjny wykorzystano 94 próbne obciążenia statyczne pali.
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Prime-Boost Vaccination with Toxoplasma Lysate Antigen, but Not with a Mixture of Recombinant Protein Antigens, Leads to Reduction of Brain Cyst Formation in BALB/c Mice
PublikacjaIntroduction Infection with the ubiquitous parasite Toxoplasma gondii is a threat for immunocompro- mised patients and pregnant women and effective immune-prophylaxis is still lacking. Methods Here we tested a mixture of recombinant T . gondii antigens expressed in different develop- mental stages, i.e., SAG1, MAG1 and GRA7 (SMG), and a lysate derived from T . gondii tachyzoites (TLA) for prophylactic vaccination against cyst formation....
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Generation of biodiesel and glycerol from waste of rice industries in Brazil
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Process of convergence in EU
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Process Engineering in Circular Economy
Kursy OnlineKurs jest przeznaczony dla doktorantów szkoły doktorskiej w dyscyplnach: inżynieria lądowa i transport (SzD), III stopnia, stacjonarne inżynieria środowiska, górnictwo i energetyka (SzD), III stopnia, stacjonarne The course is addressed to PhD students of the doctoral school in disciplines: civil engineering and transport environmental engineering, mining and power engineering Course type: lecture Total hours of...
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Change Detection in Signals 2023
Kursy OnlineChange Detection in Signals - files for students.
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Spectroscopy Methods in Nanotechnology 2023
Kursy OnlineCourse for 2nd degree Students of Nanotechnology, specialization Nanostructures and computer simulations in materials science, sem. 2. The aim of the course is to discuss the basic theoretical and practical issues of spectroscopy and presentation of the various types of spectroscopic methods and ways to interpret spectra, with particular attention paid to the possibility of their use in the study of nanostructured systems.
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[ZiJ] Empirical research in Management
Kursy OnlineDyscyplina: nauki o zarządzaniu i jakości Zajęcia obowiązkowe dla doktorantów I i II roku Prowadzący: dr inż. Wioleta Kucharska Liczba godzin: 30 Forma zajęć: laboratoria Discipline: management and quality Obligatory course for 1st and 2nd-year PhD students Academic teacher: dr inż. Wioleta Kucharska Total hours of training: 30 teaching hours Course type: laboratories
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Passive Methods in Heat Transport
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Law and Ethics in Science
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ICT in Management, Spring 2022
Kursy Online„ ICT w zarządzaniu licencjami” dla studentów studiów z zarządzania, edycja 2022 „ ICT w sklepie ” dla studentów BiM edycja 2022
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IT project management in business
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Corrosion in Theory and Practice
Kursy Onlinestopień: II, semestr: II
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Spectroscopy Methods in Nanotechnology 2022
Kursy OnlineCourse for 2nd degree Students of Nanotechnology, specialization Nanostructures and computer simulations in materials science, sem. 2. The aim of the course is to discuss the basic theoretical and practical issues of spectroscopy and presentation of the various types of spectroscopic methods and ways to interpret spectra, with particular attention paid to the possibility of their use in the study of nanostructured systems.
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Forecasting and optimalization in logistics
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Management in space industry WiMiO
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Surrogate methods in system engineering
Kursy Online{mlang pl} Dyscyplina: Automatyka, Elektronika i Elektrotechnika Zajęcia fakultatywne dla doktorantów II roku Prowadzący: dr hab. inż. Adrian Bekasiewicz Liczba godzin: 15 h Forma zajęć: wykład {mlang} {mlang en} Discipline: control, electronic and electrical engineering Facultative course for 2nd year PhD students Academic teacher: dr hab. inż. Adrian Bekasiewicz Total hours of training: 15 teaching hours Course...
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[EiF] Empirical research in Economics
Kursy Online{mlang pl} Dyscyplina: EiF Zajęcia obowiązkowe dla doktorantów I roku Prowadzący: A. Parteka / J. Wolszczak - Derlacz, F. Venturini Liczba godzin: 30 Forma zajęć: laboratoria {mlang} {mlang en} Discipline: EiF Obligatory course for 1st-year PhD students Academic teacher: A. Parteka / J. Wolszczak - Derlacz, F. Venturini Total hours of training: 30 teaching hours Course type: Laboratories {mlang}
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Ecological solutions in contemporary architecture
Kursy OnlineThis lecture aims to equip you with a comprehensive understanding of ecological architecture and inspire you to integrate these principles into your future projects.
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HR management - Bachelor in management
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Process engineering in circular economy
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Advances in Functional Materials 2024
Kursy OnlineOur summer school on Advances in Functional Materials 2024 aims to bring together young scientists (Ph.D. and MSc students) with specialists in materials engineering. You will be able to follow our lectures, and laboratory classes so you can practice what you have learned. This course consists of 40 hours of direct contact classes - 30 hours of lectures and 10 hours of laboratory classes delivered by our specialists from the Advanced...
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ICT in Management - Spring 2024
Kursy OnlineICT in Management course for Bachelor in Management students (Spring 2024 edition)
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2024 Microscopy in Environmental Monitoring
Kursy OnlineThe online repository will be used to teach students by presenting them lectures about variable aspects of microscopy techniques used in environmental monitoring.
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Daylight in Architecture 2022/23
Kursy OnlineTutor: Professor Claudia Naves David Amorim (University of Brasilia) Project: 60 h (lectures + online platform + individual consultations) With a support of e-platform NLITED educational content; http://lms.nlited.eu/, Students will become familiar with the different methods of daylight assessment within the built environment. Innovative daylight design is understood as a better user-centred and energy-efficient design strategy. The...
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Spectroscopy Methods in Nanotechnology 2024
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Process engineering in circular economy
Kursy OnlineDefinition and principles of the circular economy (CE). The transition from a linear model to a circular model. Business models for the CE. Circular design and innovation. CE assessment carbon footprint, life cycle assessment. Case studies of the cities implementing the CE concept. CE policy and legislation (EU and Poland). Wastewater treatment plants as an element of the CE. Energy and nutrient recovery technologies in wastewater...
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Recent advances in transcription regulation
Kursy OnlineRecent advances in transcription regulation
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Modern Techniques in Control Theory
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Modelling in machine design (PG_00057377)
Kursy Onlinegoal of the subject is to show how simple enginnering models reflect the reality and how contemporary FEM calulations can illustrate the operation of machine elements
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Applications of AI in Enterprise
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L23_24 Artificial Intelligence in Healthcare
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Inhibitors of amino acids biosynthesis as antifungal agents
PublikacjaFungal microorganisms, including the human pathogenic yeast and filamentous fungi, are able to synthesize all proteinogenic amino acids, including nine that are essential for humans. A number of enzymes catalyzing particular steps of human-essential amino acid biosynthesis are fungi specific. Numerous studies have shown that auxotrophic mutants of human pathogenic fungi impaired in biosynthesis of particular amino acids exhibit...
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Inhibition of amyloid fibril formation of hen egg white lysozyme by trimethylamine N-oxide at low pH
PublikacjaIn vitro inhibition of the formation of fibrous aggregates of proteins (amyloids) has gained increasing attention due to the number of diseases associated with protein misfolding and fibrillation. An interesting group of compounds for which pronounced activity against this phenomenon can be expected consists of low molecular weight substances (osmolytes) which have the ability to change protein stability. Here we investigate the...
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Therapeutic Potential of Multifunctional Derivatives of Cholinesterase Inhibitors
PublikacjaThe aim of this work is review of tacrine analogues from the last three years, which were not included in the latest review work, donepezil and galantamine hybrids from 2015 and rivastigmine derivatives from 2014. In this account we summarize the efforts toward the development and characterization of non-toxic inhibitors of cholinesterases based on mentioned drugs with various interesting additional properties such as antioxidant,...
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Quest for the Molecular Basis of Improved Selective Toxicity of All-Trans Isomers of Aromatic Heptaene Macrolide Antifungal Antibiotics
PublikacjaThree aromatic heptaene macrolide antifungal antibiotics, Candicidin D, Partricin A (Gedamycin) and Partricin B (Vacidin) were subjected to controlled cis-trans to all trans photochemical isomerization. The obtained all-trans isomers demonstrated substantially improved in vitro selective toxicity in the Candida albicans cells: human erythrocytes model. This effect was mainly due to the diminished hemotoxicity. The molecular modeling...